基本信息

赵华山  男  博导  深圳市"孔雀计划"海外高层次人才

中国科学院深圳先进技术研究院
电子邮件: hs.zhao@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码: 518055

研究领域

(1)神经内分泌疾病与多肽分子靶向

(2)皮肤损伤修复与功能药物筛选


招生信息

   
招生专业
071010-生物化学与分子生物学
071008-发育生物学
071009-细胞生物学

教育背景

2009-09--2015-06   中国科学院大学   博士

工作经历


工作简历
2020-01~现在, 中国科学院深圳先进技术研究院, 高级工程师
2017-05~2020-01,中国科学院深圳先进技术研究院, 助理研究员
2015-06~2016-11,美国威斯康星大学麦迪孙分校, 博士后
社会兼职

Guest Associate Editor, Frontiers in Cell and Developmental Biology, 2022-2023

教授课程

   
《生物技术前沿》

专利与奖励


专利成果

(1) 一种能够激活原始卵泡的3D打印人造卵巢生物支架及其人造卵巢和用途,2017.11.7,ZL201711085422.3

(2) 一种GPR1拮抗多肽及其衍生物与应用,2017.12.19,ZL201711376676.0

(3) 一种GPR1拮抗多肽及其衍生物与应用,2017.12.19,ZL201711378062.6

(4) 一种拉丝式3D打印方法及拉丝式3D打印机,2017.12.13,ZL201711332813.0

(5) 一种微型膜内切除装置,2019.4.8 201820616303.X

(6) 一种旋转式3D打印机,2017.12.13,ZL201721735486.9

(7) 一种拉丝式3D打印机,2017.12.13,ZL201721736347.8

(8) 一种基于毛囊干细胞和硅凝胶敷料的皮肤重建方法,2013.10.17,ZL201310487717.9

以上专利均已授权,另有13项专利已获得申请号。

奖励

参与的“妊娠期代谢性疾病及母子两代风险防空新策略”项目,获得2022年深圳市科技进步二等奖,完成人中本人排第7

出版信息


发表论文

(1) Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN. Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. Sci Adv. 2023 Nov 3;9(44):eadi4777. doi: 10.1126/sciadv.adi4777.

(2) Xiong Y, Ma C, Li Q, Zhang W, Zhao H, Ren P, Zhang K, Lei X. Melatonin ameliorates simulated-microgravity-induced mitochondrial dysfunction and lipid metabolism dysregulation in hepatocytes. FASEB J. 2023 Sep;37(9):e23132. doi: 10.1096/fj.202301137R.

(3) Lin J, Li Q, Lei X, Zhao H*. The emerging roles of GPR158 in the regulation of the endocrine system. Front Cell Dev Biol. 2022 Nov 18;10:1034348. doi: 10.3389/fcell.2022.1034348.(*通讯作者)

(4) Yu M, Yang Y, Zhao H, Li M, Chen J, Wang B, Xiao T, Huang C, Zhao H, Zhou W, Zhang JV. Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression. Front Pharmacol. 2022 Nov 29;13:985618. doi: 10.3389/fphar.2022.985618.

(5) Yu M, Yang Y, Huang C, Ge L, Xue L, Xiao Z, Xiao T, Zhao H, Ren P, Zhang JV. Chemerin: A Functional Adipokine in Reproductive Health and Diseases. Biomedicines. 2022 Aug 7;10(8):1910. doi: 10.3390/biomedicines10081910.

(6) Ma C.; Xiong Y.; Han P.; Zhang X.; Cao Y.; Wang B.; Zhao H.; Duan E.; Zhang J.V.; Lei X. Simulated Microgravity Potentiates Hematopoietic Differentiation of Human Pluripotent Stem Cells and Supports Formation of 3D Hematopoietic Cluster. Front Cell Dev Biol 2021, 9, 797060, doi:10.3389/fcell.2021.797060.

(7) Li R., Ma C., Xiong Y., Zhao H., Yang Y., Xue L., Wang B., Xiao T., Chen J., Lei X., Ma B., Zhang J. An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis. Biomolecules. 2021, 11, p857. DOI 10.3390/biom11060857.

(8) Sun L.; Yang Y.; Wang M.; Zhao H.; Xiao T.; Li M.; Wang B. ; Huang C.; Ren P.; Zhang J. Inhibition of Col6a5 Improve Lipid Metabolism Disorder in Dihydrotestosterone-Induced Hyperandrogeni. Front Cell Dev Biol. 2021, 9, 669189. DOI 10.3389/fcell.2021.669189.

(9) Huang B.#, Zhu W.#, Zhao H.#, Zeng F., Wang E., Wang H., Chen J., Li M., Huang C., Ren L., Niu J., Zhang J. Placenta-derived Osteoprotegerin is Required for Glucose Homeostasis in Gestational Diabetes Mellitus [J]. Front Cell Dev Biol. 2020: 8. doi: 10.3389/fcell.2020.563509. (#并列第一作者)

(10) Zhang H., Zhao H., Wang X., Cui X., Jin L. Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol [J]. BMC developmental biology. 2020: 3.

(11) Huang B.#, Zhao H.#, Huang C.#, Wu L., Xiang L., Chen J., Wang B., Xiao T., Li M., Ren L., Niu J., Zhang J. V. CMKLR1 deficiency attenuates androgen-induced lipid accumulation in mice [J]. American journal of physiology Endocrinology and metabolism. 2020: E371-E80. (#并列第一作者)

(12) Chen Z., Zhang J., Yuan A., Han J., Tan L., Zhou Z., Zhao H., Su R., Huang B., Wang B., Sun B., Fan X., Yang Q. R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells [J]. Am J Physiol Cell Physiol. 2020: C664-C74.

(13) Zhao H., Yan D., Xiang L., Huang C., Li J., Yu X., Huang B., Wang B., Chen J., Xiao T., Ren P. G., Zhang J. V. Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice [J]. Cellular and molecular life sciences: CMLS. 2019: 355-67.

(14) Huang B.#, Huang C.#, Zhao H.#, Zhu W., Wang B., Wang H., Chen J., Xiao T., Niu J., Zhang J. Impact of GPR1 signaling on maternal high-fat feeding and placenta metabolism in mice [J]. American journal of physiology Endocrinology and metabolism. 2019: E987-E97. (#并列第一作者)

(15) Qiao J.#, Zhao H.#, Zhang Y., Peng H., Chen Q., Zhang H., Zheng X., Jin Y., Ni H., Duan E., Guo Y. GPR39 is region-specifically expressed in mouse oviduct correlating with the Zn(2+) distribution [J]. Theriogenology. 2017: 98-105. (#并列第一作者)

(16) Li M., Zhao H., Ananiev G. E., Musser M. T., Ness K. H., Maglaque D. L., Saha K., Bhattacharyya A., Zhao X. Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells [J]. Stem cells. 2017: 158-69.

(17) Zhang H.#, Zhao H.#, Qiao J.#, Zhang S., Liu S., Li N., Lei X., Ning L., Cao Y., Duan E. Expansion of Hair Follicle Stem Cells Sticking to Isolated Sebaceous Glands to Generate in Vivo Epidermal Structures [J]. Cell transplantation. 2016: 2071-82. (#并列第一作者)

(18) Li N., Liu S., Zhang H., Deng Z., Zhao H., Zhao Q., Lei X., Ning L., Cao Y. J., Wang H., Liu S., Duan E. Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles [J]. Int J Mol Sci. 2016: 582.

(19) Zhao H., Qiao J., Zhang S., Zhang H., Lei X., Wang X., Deng Z., Ning L., Cao Y., Guo Y., Liu S., Duan E. GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing [J]. Scientific reports. 2015: 7913.

(20) Zhang H., Zhang S., Zhao H., Qiao J., Liu S., Deng Z., Lei X., Ning L., Cao Y., Zhao Y., Duan E. Ovine Hair Follicle Stem Cells Derived from Single Vibrissae Reconstitute Haired Skin [J]. Int J Mol Sci. 2015: 17779-97.

(21) Wang F., Tidei J. J., Polich E. D., Gao Y., Zhao H., Perrone-Bizzozero N. I., Guo W., Zhao X. Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis [J]. Proceedings of the National Academy of Sciences of the United States of America. 2015: E4995-5004.

(22) Liu S., Wang X., Zhao Q., Liu S., Zhang H., Shi J., Li N., Lei X., Zhao H., Deng Z., Cao Y., Ning L., Xia G., Duan E. Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27(KIP(1))/p15(INK(4)b) signaling [J]. Cellular and molecular life sciences: CMLS. 2015: 2949-60.

(23) Wang X., Liu S., Zhao Q., Li N., Zhang H., Zhang X., Lei X., Zhao H., Deng Z., Qiao J., Cao Y., Ning L., Liu S., Duan E. Three-dimensional hydrogel scaffolds facilitate in vitro self-renewal of human skin-derived precursors [J]. Acta biomaterialia. 2014: 3177-87.

(24) Lei X., Deng Z., Zhang H., Zhao H., Zhou J., Liu S., Chen Q., Ning L., Cao Y., Wang X., Zhang X., Duan E. Rotary suspension culture enhances mesendoderm differentiation of embryonic stem cells through modulation of Wnt/beta-catenin pathway [J]. Stem cell reviews. 2014: 526-38.

(25) Zhang H., Zhang Y., Zhao H., Zhang Y., Chen Q., Peng H., Lei L., Qiao J., Shi J., Cao Z., Duan E., Jin Y. Hormonal regulation of ovarian bursa fluid in mice and involvement of aquaporins [J]. PloS one. 2013: e63823.

(26) Zhang Y., Zhao H., Peng H., Hu Z., Ning L., Cao Y., Tan Y., Duan E. GPR39, a putative receptor of Zn2+, is region specifically localized in different lobes of the mouse prostate [J]. Urology. 2011: 1010 e1-6.


预印本文章

(1) Zhao Huashan, et al. Metabolitin-based molecular drug delivery by targeting GPR158 in glioblastoma. bioRxiv. 2021. DOI: 10.1101/2021.12.13.472376.(关于脑胶质瘤靶向投递的研究)

(2) Zhao Huashan, et al. Bioinspired Long-Wavelength Excitable Near-Infrared AIEdots for Endometriosis Targeting and Image-Guided Surgery. ChemRxiv. 2021. DOI: 10.26434/chemrxiv.14131775.v1.(关于子宫内膜异位症靶向手术导航的研究)


科研活动

   
科研项目

(1)  深圳市基础研究专项(自然科学基金)重点项目,2023/02-2026/02,合作方负责人
(2)  高校委托项目,2022/10-2024/03,横向课题负责人
(3)  广东省自然科学基金项目,2018/05-2021/04,负责人
(4)  中科院先导专项A类项目,2018/01-2019/12,参与人


指导学生

已指导学生

张秀文  硕士研究生  085204-材料工程  

向春柏  硕士研究生  085204-材料工程  

现指导学生

黄妍虹  硕士研究生  086000-生物与医药  

马小溪  硕士研究生  086000-生物与医药  

柴德智  硕士研究生  086000-生物与医药  

林锦菊  硕士研究生  086000-生物与医药  

黄耀栋  硕士研究生  085600-材料与化工