药物化学、药物合成化学、药物发现和开发

2022年招收硕士研究生一名，要求本科专业为化学、药学或者相关专业

100701-药物化学

药物化学
药物合成
新药发现

2005-09--2008-06   山东大学   博士研究生/博士
2002-09--2005-06   青岛科技大学   硕士研究生/硕士
1999-09--2002-06   聊城大学   本科/学士学位

博士研究生

博士

   

[1] 赵桂龙. Study on structure-activity relationship (SAR) of simplified mirogabalin derivatives as voltage-gated calcium channel α2δ ligands for the treatment of chronic neuropathic pain. Medicinal Chemistry Research[J]. 2023, https://link.springer.com/article/10.1007/s00044-022-03006-6.
[2] 赵桂龙. Review of voltage-gated calcium channel α2δ subunit ligands for the treatment of chronic neuropathic pain and insight into structure-activity relationship (SAR) by pharmacophore modeling. Current Medicinal Chemistry[J]. 2022, https://www.eurekaselect.com/article/122350.
[3] Wu, Jingwei, Zhang, Huan, Zhao, Guilong, Wang, Runling. Allosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020). CURRENT MEDICINAL CHEMISTRYnull. 2021, 28(19): 3825-3842, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000663836500007.
[4] Wu, Jingwei, Yin, Ling, Liu, Yuqiang, Zhang, Huan, Xie, Yafei, Wang, Runling, Zhao, Guilong. Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2019, 29(3): 383-388, http://dx.doi.org/10.1016/j.bmcl.2018.12.036.
[5] Zhang, Shuo, Shi, Xinhua, Li, Jichao, Hou, Zitong, Song, Zihe, Su, Xiaofeng, Peng, Dan, Wang, Feng, Yu, Yitao, Zhao, Guilong. Nickel-Catalyzed Amidoalkylation Reaction of gamma-Hydroxy Lactams: An Access to 3-Substituted Isoindolinones. ACS OMEGA[J]. 2019, 4(21): 19420-19436, https://www.webofscience.com/wos/woscc/full-record/WOS:000497960900052.
[6] Wei, Peng, Liu, Lingyan, Wen, Ying, Zhao, Guilong, Xue, Fengfeng, Yuan, Wei, Li, Ruohan, Zhong, Yaping, Zhang, Mengfan, Yi, Tao. Release of Amino- or Carboxy-Containing Compounds Triggered by HOCl: Application for Imaging and Drug Design. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(14): 4547-4551, [7] Cai, Wenqing, Wu, Jingwei, Liu, Wei, Xie, Yafei, Liu, Yuqiang, Zhang, Shuo, Xu, Weiren, Tang, Lida, Wang, Jianwu, Zhao, Guilong. Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of A Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor. MOLECULES[J]. 2018, 23(2): http://dx.doi.org/10.3390/molecules23020252.

从事代谢性疾病、中枢神经系统疾病和肿瘤等领域的新药发现研究

（ 1 ） 基于若干丰产天然产物分子骨架的电压门控钙离子通道α2δ亚基配体的构效关系研究, 主持, 省级, 2021-01--2023-12
（ 2 ） 基于螺桨烷结构的电压门控钙离子通道α2δ亚基配体的合成和体外活性研究, 主持, 省级, 2021-01--2023-12