生物纳米材料、分子诊断、分子影像等

   

071010-生物化学与分子生物学

稀土纳米医学，分子诊断， 医学检验分析

2008-09--2013-05   德国慕尼黑工业大学   博士研究生
2004-09--2007-06   北京师范大学   硕士研究生

   

2017-12~现在, 中国科学院福建物质结构研究所, 研究员 课题组长
2013-12~2017-12,中国科学院福建物质结构研究所, 副研究员 课题组长

2022-12-01-2025-12-29,中国侨联特聘专家委员会会专家, 委员
2020-01-01-2024-01-01,中国稀土学会稀土生物医学专业委员会, 秘书长
2019-07-01-今,中国生物医学工程学会医学物理分会青委会委员, 青年委员
2015-12-01-今,中国光学学会生物医学光子学委员, 委员

   

（1） 福建省科技进步奖, 三等奖, 省级, 2022
（2） 稀土科学技术奖, 一等奖, 其他, 2021
（3） 福建省抗击新冠肺炎疫情先进个人, , 省级, 2020
（4） 国家有突出贡献中青年专家, 国家级, 2020
（5） 国家百千万人才工程, 国家级, 2020
（6） 福建省****, , 省级, 2015

[1] 张云, 宋良, 张肖, 刘宁. 一种COVID-19抗原检测卡、其制备方法和应用. CN112730832B, 2022-05-24.
[2] 张云, 史俊朋, 彭珊珊. 一种可自激活的紫外长余辉发光材料及其制备方法. CN: CN114231278A, 2022-03-25.
[3] 张云, 宋良, 明丽艳, 张肖. 稀土掺杂纳米探针及制备及新冠状病毒检 测探针. CN111234819B, 2022-02-08.
[4] 张云, 史俊朋, 钟红芸, 柳林. 一种紫外和近红外双发射的长余辉材料及其制备方法. 202210966834.2, 2021-08-11.
[5] 周山勇, 马恩, 黄丽冰, 杨鸿艺, 叶斯哲, 张云, 陈卓, 陈学元. 一种宽波段时间分辨荧光免疫分析装置及分析方法. CN: CN113075175A, 2021-07-06.
[6] 张云, 张肖, 宋良. 心肺五联检测试剂盒及其稀土纳米荧光检测卡和检测方法. CN: CN111308103A, 2020-06-19.
[7] 田向东, 张云, 李剑锋. 银纳米棒的合成以及基于其制备表面增强拉曼光谱基底. CN: CN107243626A, 2017-10-13.
[8] 张云, 张肖, 杨福太. 一种时间分辨荧光定量检测尿微量白蛋白的试剂盒及方法. CN: CN106872420A, 2017-06-20.
[9] 张云, 王选东, 卢灿忠, 刘小龙, 田向东. 用于肿瘤MRI/CT成像和光热治疗的多功能纳米探针及应用. CN: CN104689346A, 2015-06-10.

   

[1] Junpeng Shi, Xia Sun, Liang Song, Maochun Hong, Quan Yuan, Yun Zhang. Inorganic persistent luminescence materials: Emerging optical theranostic agents. PROGRESS IN MATERIALS SCIENCE[J]. 2024, 第 6 作者  通讯作者  142(null): http://dx.doi.org/10.1016/j.pmatsci.2024.101246.
[2] Yan Gao, Junpeng Shi, Chen Wu, Longlong Cao, Lin Liu, Jinyuan Wang, XiaofangLuo, Xiao Zhang, Yun Zhang. Functional Green-Emitting Mn2+-doped Zinc Germanate Persistent Luminescent Nanoparticles for Dual-Mode Immunochromatographic Detection. Analytical Chemistry[J]. 2024, 第 9 作者  通讯作者  null(null): 
[3] Jingwang Qin, Xiangdong Tian, Siying Liu, Zhengxia Yang, Dawei Shi, Sihong Xu, Yun Zhang. Rapid classification of SARS-CoV-2 variant strains using machine learning-based label-free SERS strategy. TALANTA[J]. 2024, 第 7 作者  通讯作者  267(null): http://dx.doi.org/10.1016/j.talanta.2023.125080.
[4] Xiaofang Luo, Junpeng Shi, Ruoping Wang, Longlong Cao, Yan Gao, Jinyuan Wang, Maochun Hong, Xia Sun, Yun Zhang. Near-Infrared Persistent Luminescence Nanoprobe for Early Detection of Atherosclerotic Plaque. Acs Nano[J]. 2024, 第 9 作者  通讯作者  
[5] Peng, Shanshan, Wang, Lizhen, Liu, Lin, Song, Liang, Shi, Junpeng, Zheng, Hanrun, Xu, Jixuan, Rong, Rui, Zhang, Yun. Inhibition of Pro-Survival Autophagy Induced by Rare-Earth Nanocomposites for Promoting Photothermal Therapy of Visualized Tumors. ADVANCED HEALTHCARE MATERIALS[J]. 2023, 第 9 作者  通讯作者  12(2): http://dx.doi.org/10.1002/adhm.202202117.
[6] Peng Lin, Junpeng Shi, Ye Lin, Qian Zhang, Kexin Yu, Lin Liu, Liang Song, Yile Kang, Maochun Hong, Yun Zhang. Near-Infrared Persistent Luminescence Nanoprobe for Ultrasensitive Image-Guided Tumor Resection. ADVANCED SCIENCE[J]. 2023, 第 10 作者  通讯作者  
[7] Wang, Ruoping, Shi, Junpeng, Zhang, Qian, Peng, Qiang, Sun, Xia, Song, Liang, Zhang, Yun. Dual-Triggered Near-Infrared Persistent Luminescence Nanoprobe for Autofluorescence-Free Imaging-Guided Precise Therapy of Rheumatoid Arthritis. ADVANCED SCIENCE[J]. 2023, 第 7 作者  通讯作者  10(4): http://dx.doi.org/10.1002/advs.202205320.
[8] Lin, Peng, Shi, Junpeng, Ming, Liyan, Sheng, Yangyang, Song, Liang, Hong, Maochun, Zhang, Yun. An intelligent persistent luminescence nanoplatform with high-efficiency O-2 utilization for continuous hypoxic tumors treatment. CHEMICAL ENGINEERING JOURNAL[J]. 2022, 第 7 作者  通讯作者  442: http://dx.doi.org/10.1016/j.cej.2022.135638.
[9] Hongzhang He, Lingjun Cheng, Yinghao He, Jiaming Chen, Liang Song, Yuanyuan Yang, Yun Zhang, Zhenyu Lin, Guolin Hong. Dual-enzyme cascade amplification electrochemical biosensor for human papillomavirus based on DNA nanoflower structure. SENSORS AND ACTUATORS: B. CHEMICAL. 2022, 第 7 作者  通讯作者  371: http://dx.doi.org/10.1016/j.snb.2022.132532.
[10] Liu, Lin, Peng, Shanshan, Lin, Peng, Wang, Ruoping, Zhong, Hongyun, Sun, Xia, Song, Liang, Shi, Junpeng, Zhang, Yun. High-level information encryption based on optical nanomaterials with multi-mode luminescence and dual-mode reading. INORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 9 作者  通讯作者  9(17): 4433-4441, http://dx.doi.org/10.1039/d2qi00889k.
[11] Jiang, Huimin, Wang, Ruoping, Zhang, Qian, Song, Liang, Sun, Xia, Shi, Junpeng, Zhang, Yun. A dual-functional nanoplatform based on NIR and green dual-emissive persistent luminescence nanoparticles for X-ray excited persistent luminescence imaging and photodynamic therapy. NANOSCALE[J]. 2022, 第 7 作者  通讯作者  14(41): 15451-15461, http://dx.doi.org/10.1039/d2nr03631b.
[12] Liu, Lin, Shi, Junpeng, Li, Yiang, Peng, Shanshan, Zhong, Hongyun, Song, Liang, Zhang, Yun. Disguise as fluorescent powder: Ultraviolet-B persistent luminescence material without visible light for advanced information encryption and anti-counterfeiting applications. CHEMICAL ENGINEERING JOURNAL[J]. 2022, 第 7 作者  通讯作者  430: http://dx.doi.org/10.1016/j.cej.2021.132884.
[13] Lin Liu, Yun Zhang, Shanshan Peng, Liang Song, Junpeng Shi. Closing the Deep-Blue Gap: Realizing Narrow-Band Deep-Blue Emission with Strong n‑UV Excitation by Cationic Substitution for Full-Spectrum Warm W‑LED Lighting. ACS Sustainable Chemistry & Engineering[J]. 2022, 第 2 作者  通讯作者  
[14] Liu, Lin, Shi, Junpeng, Sun, Xia, Zhang, Yongqu, Qin, Jingwang, Peng, Shanshan, Xu, Jixuan, Song, Liang, Zhang, Yun. Thermo-responsive hydrogel-supported antibacterial material with persistent photocatalytic activity for continuous sterilization and wound healing. COMPOSITES PART B-ENGINEERING[J]. 2022, 第 9 作者  通讯作者  229: http://dx.doi.org/10.1016/j.compositesb.2021.109459.
[15] Liu, Lin, Peng, Shanshan, Guo, Yuxuan, Lin, Ye, Sun, Xia, Song, Liang, Shi, Junpeng, Zhang, Yun. Designing X-ray-Excited UVC Persistent Luminescent Material via Band Gap Engineering and Its Application to Anti-Counterfeiting and Information Encryption. ACS APPLIED MATERIALS & INTERFACES[J]. 2022, 第 8 作者  通讯作者  14(36): 41215-41224, 
[16] Ming, Liyan, Song, Liang, Xu, Jixuan, Wang, Ruoping, Shi, Junpeng, Chen, Min, Zhang, Yun. Smart Manganese Dioxide-Based Lanthanide Nanoprobes for Triple-Negative Breast Cancer Precise Gene Synergistic Chemodynamic Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 第 7 作者  通讯作者  13(30): 35444-35455, http://dx.doi.org/10.1021/acsami.1c08927.
[17] Sun, Xia, Song, Liang, Liu, Nian, Shi, Junpeng, Zhang, Yun. Chromium-Doped Zinc Gallate Near-Infrared Persistent Luminescence Nanoparticles in Autofluorescence-Free Biosensing and Bioimaging: A Review. ACS APPLIED NANO MATERIALS. 2021, 第 5 作者  通讯作者  4(7): 6497-6514, http://dx.doi.org/10.1021/acsanm.1c01115.
[18] Ye, Huiming, Song, Liang, Zhang, Fuhui, Li, Juan, Su, Zhiying, Zhang, Yun. Highly Sensitive Electrochemical Detection of Folic Acid by Using a Hollow Carbon Nanospheres@molybdenum Disulfide Modified Electrode. ANALYTICAL SCIENCES[J]. 2021, 第 6 作者  通讯作者  37(4): 575-580, http://dx.doi.org/10.2116/analsci.20P297.
[19] Siying Liu, Qiushi Hu, Fangrong Zhang, Hongjing Gu, Xinrui Wang, Shuang Li, Lei Xue, Madl Tobias, Yun Zhang, Lei Zhou. Wide-Range, Rapid, and Specific Identification of Pathogenic Bacteria by Surface-Enhanced Raman Spectroscopy. ACS SENSORS[J]. 2021, 第 9 作者  通讯作者  
[20] Wang, Ruoping, Shi, Junpeng, Song, Liang, Zheng, Shenghui, Liu, Xiaolong, Hong, Maochun, Zhang, Yun. Sustained Antitumor Immunity Based on Persistent Luminescence Nanoparticles for Cancer Immunotherapy. Advanced Functioanl Materials[J]. 2021, 第 7 作者  通讯作者  31(52): http://dx.doi.org/10.1002/adfm.202106884.
[21] Shi, Junpeng, Sun, Xia, Zheng, Shenghui, Song, Liang, Zhang, Fangrong, Madl, Tobias, Zhang, Yun, Zhang, Hongwu, Hong, Maochun. Tin-Doped Near-Infrared Persistent Luminescence Nanoparticles with Considerable Improvement of Biological Window Activation for Deep Tumor Photodynamic Therapy. ACSAPPLIEDBIOMATERIALS[J]. 2020, 第 7 作者  通讯作者  3(9): 5995-6004, 
[22] Han, Yu, Wu, SiRong, Tian, XiangDong, Zhang, Yun. Optimizing the SERS Performance of 3D Substrates through Tunable 3D Plasmonic Coupling toward Label-Free Liver Cancer Cell Classification. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 第 4 作者  通讯作者  12(26): 28965-28974, https://www.webofscience.com/wos/woscc/full-record/WOS:000546698600005.
[23] Li, Xin, Tian, Xiangdong, Liu, Siying, Wu, Chen, Han, Yu, Meng, Lingyi, Song, Liang, Zhang, Yun. Self-assembled vertically aligned silver nanorod arrays prepared by evaporation-induced method as high-performance SERS substrates. JOURNAL OF MATERIALS SCIENCE[J]. 2020, 第 8 作者  通讯作者  55(28): 14019-14030, https://www.webofscience.com/wos/woscc/full-record/WOS:000543071300006.
[24] Zhong, Rong, Wang, Ruoping, Hou, Xuemei, Song, Liang, Zhang, Yun. Polydopamine-doped virus-like structured nanoparticles for photoacoustic imaging guided synergistic chemo-/photothermal therapy. RSC ADVANCES[J]. 2020, 第 5 作者  通讯作者  10(31): 18016-18024, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000537264400006.
[25] Li, Yang, Lin, Jinyan, Cai, Zhixiong, Wang, Peiyuan, Luo, Qiang, Yao, Cuiping, Zhang, Yun, Hou, Zhenqing, Liu, Jingfeng, Liu, Xiaolong. Tumor microenvironment-activated self-recognizing nanodrug through directly tailored assembly of small-molecules for targeted synergistic chemotherapy. JOURNAL OF CONTROLLED RELEASE[J]. 2020, 第 7 作者321: 222-235, http://dx.doi.org/10.1016/j.jconrel.2020.02.025.
[26] Cao, Wei, Wang, Xuandong, Song, Liang, Wang, Peiyuan, Hou, Xuemei, Zhang, Huicong, Tian, Xiangdong, Liu, Xiaolong, Zhang, Yun. Folic acid-conjugated gold nanorod@polypyrrole@Fe3O4 nanocomposites for targeted MR/CT/PA multimodal imaging and chemo-photothermal therapy. RSC ADVANCES[J]. 2019, 第 9 作者  通讯作者  9(33): 18874-18887, https://www.webofscience.com/wos/woscc/full-record/WOS:000473058600020.
[27] Liu, Rong, Zhang, Huicong, Zhang, Fangrong, Wang, Xuandong, Liu, Xiaolong, Zhang, Yun. Polydopamine doped reduced graphene oxide/mesoporous silica nanosheets for chemo-photothermal and enhanced photothermal therapy. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS[J]. 2019, 第 6 作者  通讯作者  96: 138-145, http://dx.doi.org/10.1016/j.msec.2018.10.093.
[28] Zhang, Huicong, Wang, Xuandong, Wang, Peiyuan, Liu, Rong, Hou, Xuemei, Cao, Wei, Zhong, Rong, Liu, Xiaolong, Zhang, Yun. One-pot synthesis of biodegradable polydopamine-doped mesoporous silica nanocomposites (PMSNs) as pH-sensitive targeting drug nanocarriers for synergistic chemo-photothermal therapy. RSC ADVANCES[J]. 2018, 第 9 作者  通讯作者  8(65): 37433-37440, https://www.webofscience.com/wos/woscc/full-record/WOS:000450973500052.
[29] Liu, SiYing, Tian, XiangDong, Zhang, Yun, Li, JianFeng. Quantitative Surface-Enhanced Raman Spectroscopy through the Interface-Assisted Self-Assembly of Three-Dimensional Silver Nanorod Substrates. ANALYTICAL CHEMISTRY[J]. 2018, 第 3 作者  通讯作者  90(12): 7275-7282, https://www.webofscience.com/wos/woscc/full-record/WOS:000436028800028.
[30] Liu, Rong, Wang, Xuandong, Ye, Jun, Xue, Ximei, Zhang, Fangrong, Zhang, Huicong, Hou, Xuemei, Liu, Xiaolong, Zhang, Yun. Enhanced antibacterial activity of silver-decorated sandwich-like mesoporous silica/reduced graphene oxide nanosheets through photothermal effect. NANOTECHNOLOGY[J]. 2018, 第 9 作者  通讯作者  29(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000423845700004.
[31] Zhou, Dan, Tang, Weiwei, Liu, Xinli, An, HanXiang, Zhang, Yun. Clinical verification of plasma messenger RNA as novel noninvasive biomarker identified through bioinformatics analysis for lung cancer. ONCOTARGET[J]. 2017, 第 5 作者  通讯作者  8(27): 43978-43989, https://www.webofscience.com/wos/woscc/full-record/WOS:000405498000032.
[32] Tian, XiangDong, Lin, Ying, Dong, JinChao, Zhang, YueJiao, Wu, SiRong, Liu, SiYing, Zhang, Yun, Li, JianFeng, Tian, ZhongQun. Synthesis of Ag Nanorods with Highly Tunable Plasmonics toward Optimal Surface-Enhanced Raman Scattering Substrates Self-Assembled at Interfaces. ADVANCED OPTICAL MATERIALS[J]. 2017, 第 7 作者  通讯作者  5(21): https://www.webofscience.com/wos/woscc/full-record/WOS:000414353100011.
[33] Dan Zhou, Weiwei Tang, Guoqiang Su, Mingquan Cai, HanXiang An, Yun Zhang. PCDH18 is frequently inactivated by promoter methylation in colorectal cancer. SCIENTIFIC REPORTS[J]. 2017, 第 6 作者  通讯作者  7(1): https://doaj.org/article/86ea3e61d1f44fe1b263cc2f241253d6.
[34] Tian, XiangDong, Chen, Shu, Zhang, YueJiao, Dong, JinChao, Panneerselvam, Rajapandiyan, Zhang, Yun, Yang, ZhiLin, Li, JianFeng, Tian, ZhongQun. Self-assembly of subwavelength nanostructures with symmetry breaking in solution. NANOSCALE[J]. 2016, 第 6 作者  通讯作者  8(5): 2951-2959, https://www.webofscience.com/wos/woscc/full-record/WOS:000369591400055.
[35] Zhang, Yun, Madl, Tobias, Bagdiul, Ivona, Kern, Thomas, Kang, HyunSeo, Zou, Peijian, Maeusbacher, Nina, Sieber, Stephan A, Kraemer, Angela, Sattler, Michael. Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition. NUCLEIC ACIDS RESEARCH[J]. 2013, 第 1 作者41(2): 1343-1354, http://dx.doi.org/10.1093/nar/gks1097.
[36] Deng, Zhengtao, Zhang, Yun, Yue, Jiachang, Tang, Fangqiong, Wei, Qun. Green and orange CdTe quantum dots as effective pH-sensitive fluorescent probes for dual simultaneous and independent detection of viruses. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2007, 第 2 作者111(41): 12024-12031, http://www.corc.org.cn/handle/1471x/2381432.

   

（ 1 ） 小型化免疫荧光医学检测系统, 负责人, 地方任务, 2013-12--2016-12
（ 2 ） 中科院海西院课题组启动经费, 负责人, 中国科学院计划, 2014-01--2016-12
（ 3 ） 前体mRNA剪切因子SF1磷酸化的结构变化与动力学研究 , 负责人, 地方任务, 2014-01--2016-12
（ 4 ） 前体mRNA剪切因子SF1磷酸化的结构与功能研究, 负责人, 国家任务, 2015-01--2017-12
（ 5 ） Characterization of residual structure in the disordered APC tumor suppressor protein, 负责人, 国家任务, 2015-01--2015-12
（ 6 ） 小型化稀土发光医学检测系统, 负责人, 地方任务, 2015-09--2017-09
（ 7 ） 新型稀土发光医学检测系统, 负责人, 地方任务, 2016-01--2018-12
（ 8 ） 长余辉纳米发光材料及其生物应用, 负责人, 地方任务, 2017-09--2020-09
（ 9 ） 稀土掺杂长余辉纳米发光材料及其在生物医学领域的应用, 负责人, 研究所自主部署, 2018-01--2022-12
（ 10 ） 基于稀土纳米荧光探针的危重疾病体外检测试剂盒研制, 负责人, 研究所自主部署, 2018-12--2019-05
（ 11 ） 小型化时间分辨荧光医疗检测系统的研发与产业化, 负责人, 地方任务, 2018-01--2020-12
（ 12 ） 基于稀土纳米探针的新型冠状病毒（2019-nCoV）IgM/IgG抗体即时检测试剂盒研制, 负责人, 研究所自主部署, 2020-02--2021-01
（ 13 ） 精准稀土纳米生物医学诊疗一体化探针及时空分辨多模式活体成像系统研制, 参与, 研究所自主部署, 2021-03--2024-03
（ 14 ） 基于稀土纳米发光新材料的全自动免疫学 检测方法及其在妇儿领域的应用, 负责人, 地方任务, 2021-12--2025-11
（ 15 ） 生物医用光电材料, 负责人, 研究所自主部署, 2022-08--2025-12
（ 16 ） 稀土生物医学材料及关键应用技术研发, 负责人, 地方任务, 2023-08--2026-07

（1）精准稀土荧光纳米探针及肿瘤诊疗应用   第五届光学青年科学家论坛   2022-09-18
（2）精准稀土诊疗探针的构建及应用研究   中国稀土学会2021学术年会   2021-10-21
（3）稀土发光纳米材料生物医学应用   土元素镧铈钇应用研究研讨会暨广东省稀土产业技术联盟成立大会   2019-11-15
（4）phosphorylation and U2AF65 binding of the N-terminal domain of SF1 during 3’ splice site recognition.   Yun Zhang   2012-06-09