Molecular Evolution and Genome Diversity

1986.9-1991.7  Kunming Institute of Zoology, CAS, Kunming, China Ph.D. Genetics Zoology

1982.9-1986.7  Fudan University, Shanghai B.S. Biochemistry

2012-  Deputy president, Chinese  Academy of Sciences

2007.11-  Director, State Key Laboratory of Genetic Resources, Kunming Institute of Zoology, the Chinese Academy of Sciences

2005.3-2012  Director, Kunming Institute of Zoology, the Chinese  Academy of Sciences

1996.7-  Director, Yunnan Laboratory of Molecular Biology of Domestic Animals

1996.7-2005.3  Vice Director, Kunming Institute of Zoology, the Chinese Academy of Sciences

1995.8-2000.9  Professor & Director, Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences

1992.8-1995.8  Postdoctoral fellow, San Diego Zoo, Center for Reproduction of Endangered Species (CRES)

2009  The 2th Achievement Award for Life Sciences of Tan Jiazhen

2006  ChangJiang River Scholar Accomplishment Award, First Grade

2005  Prizes of Outstanding Contribution for Science & Technologies of Yunnan Province

2004  Ho Leung Ho Lee Prize for Science and Technology, Ho Leung Ho Lee Foundation

2004  Prizes for Innovation of Life Sciences（Conference of Global Chinese biological scientist）

2004  May 4th Youth Medal of China

2002  Biodiversity Leadership Awards, Bay and Paul Foundations, USA

1996  The 3rd Prizes for Young Scientists of China, the Government of China

1994  Pace-setter for Young Scientists & Technologies of China, the Government of China

2014  Natural Science Prizes of China, Second Grade（Genome Diversity and Evolution of Asian）

2013  Natural Science Prizes of Yunnan Province, First Grade,（Molcular mechanism of adaptive evolution of animals）

2010  Natural Science Prizes of Yunnan Province, First Grade（Molecular Phylogeny of Eutheria (Placental Mammals）

2006  Natural Science Prizes of China, Second Grade（Mitochondrial Genomic Diversity and History of Human Population in East Asia）

2005  Natural Science Prizes of Yunnan Province, First Grade（Mitochondrial Genomic Diversity and History of Human Population in East Asia）

2005  Progress Prize in Science and Technology of Yunnan Province, First Grade (癌基因和抑癌基因在乳腺癌发生中的作用的分子病理研究)

2001  Natural Science Prizes of Yunnan Province, First Grade（Study on the biology of Yunnan Snub-nosed monkey）

1997  Natural Science Prizes of China, Third Grade（Cellular and Molecular Evolution of endemic and rare animals in China）

1996  Natural Science Prizes of Yunnan Province, First Grade（Molecular evolution of genus Macaca）

2013.9-  Director, Chinese Society of Genetics

2008.6-  Vice Director, China Committee of the International Barcode of Life project

2007.11-  Academician of Third World Academy of Sciences (TWAS)

2003.10-  Distinguished Professor, Yunnan University

2003.10-  Academician of the Chinese Academy of Sciences

2013.1-  Editorial Board, Human Molecular Genetics

2013.1-  Editorial Board, Scientific Reports

2011.4-  Editorial Board, Journal of Heredity

2010.7  Editorial Board, Genome Biology and Evolution

2007.1-2011.4  Editorial Board, Animal Genetics

2001-2005  Editorial Board, Cell Resesrch

1.    Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation. Nat Genet 48(8):947-52, 2016, Correspondence author

2.    Olfactory genes in Tibetan wild boar. Nat Genet 48(9):972-73, 2016, Correspondence author

3.    Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication. Cell Res 26:556-73, 2016, Correspondence author

4.    Out of southern East Asia: the natural history of domestic dogs across the world. Cell Res 26:21-33, 2016, Correspondence author

5.    Questioning the evidence for a Central Asian domestication origin of dogs. PNAS 113:e2554, 2016, Correspondence author

6.    Divergence of dim-light vision among bats (order: Chiroptera) as estimated by molecular and electrophysiological methods. Sci Rep 5:11531, 2015, Correspondence author

7.    Genetic adaptations of the plateau zokor in high-elevation burrows. Sci Rep 5:17262, 2015, Correspondence author

8.    DNA methylation signatures of long intergenic noncoding RNAs in porcine adipose and muscle tissues. Sci Rep 5:15435, 2015, Correspondence author

9.    DomeTree: a canonical toolkit for mitochondrial DNA analyses in domesticated animals. Mol Ecol Res 15:1238-42, 2015, Correspondence author

10.  Caveats about interpretation of ancient chicken mtDNAs from northern China. PNAS 112(16):E1970-71, 2015, Correspondence author

11.  Genomic analyses reveal potential independent adaptation to high altitude in Tibetan chickens. Mol Biol Evol 32:1880-89, 2015, Correspondence author

12.  Integrative analyses of RNA-editing, alternative splicing, and expression of young genes in human brain transcriptome by deep RNA-sequencing. J Mol Cell Biol 7(4):314-25, 2015, Correspondence author

13.  DoGSD: the dog and wolf genome SNP database. Nucleic Acids Res 43:D777-83, 2015, Correspondence author

14.  Tempo and mode of recurrent polyploidization in the Carassius auratus species complex (Cypriniformes, Cyprinidae). Heredity 112(4):415-27, 2014, Correspondence author

15.  Retrieving Y chromosomal haplogroup trees using GWAS data. Eu J Hum Genetics 22:1046-50, 2014, Correspondence author

16.  Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau. Genome Biol Evol 6(8):2122-28, 2014, Correspondence author

17.  Domestication Genomics: Evidence from Animals. Annu Rev Anim Biosci 2:65-84, 2014, Correspondence author

18.  TNF-308 G/A Polymorphism and Risk of Acne Vulgaris: A Meta-Analysis. Plos One 9(2):e87806, 2014, Correspondence author

19.  Genome-Wide Identification of Long Intergenic Noncoding RNA Genes and Their Potential Association with Domestication in Pigs. Genome Biol Evol 6(6):1387-92, 2014, Correspondence author

20.  Population Variation Revealed High-Altitude Adaptation of Tibetan Mastiffs. Mol Biol Evol 31(5):1200-05, 2014, Correspondence author

21.  Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne. Nat Commun 5:2870, 2014, Correspondence author

22.  Mitochondrial Genomes of Domestic Animals Need Scrutiny. Mol Ecol 23:5393-97, 2014, Correspondence author

23.  Mitogenomic analyses propose positive selection inmitochondrial genes for high-altitude adaptation in galliform birds. Mitochondrion 18:70-75, 2014, Correspondence author

24.  Evolutionary and Functional Novelty of Pancreatic Ribonuclease: a Study of Musteloidea (order Carnivora). Sci Rep 4:e5070, 2014, Correspondence author

25.  Chicken domestication: an updated perspective based on mitochondrial genomes. Heredity 110:277-82, 2013, Correspondence author

26.  Geological events play a larger role than Pleistocene climatic fluctuations in the genetic structure of the montane stream-dwelling frog Quasipaa boulengeri (Anura: Dicroglossidae) in southern China. Mol Ecol 22:1120-33, 2013, Correspondence author

27.  Cold code: the global initiative to DNA barcode amphibians and nonavian reptiles. Mol Ecol Resour 13:161-67, 2013, Correspondence author

28.  Diversification of rhacophorid frogs provides evidence for accelerated faunal exchange between India and Eurasia during the Oligocene. PNAS 110:3441-46, 2013, Correspondence author

29.  The genomics of selection in dogs and the parallel evolution between dogs and humans. Nat Commun 4:1860, 2013, Correspondence author

30.  Artificial selection on brain-expressed genes during the domestication of dog. Mol Biol Evol 30:1867-76, 2013, Correspondence author

31.  Draft genome sequence of the Tibetan antelope. Nat Commun 4:1858, 2013, Correspondence author

32.  Speciation in the Rana chensinensis species complex and its relationship to the uplift of the Qinghai-Tibetan Plateau. Mol Evol 21(4):960-73, 2012, Correspondence author

33.  Revisiting the role of the Himalayas in peopling Nepal: insights from mitochondrial genomes. J Hum Genet 57(4):228-34, 2012, Correspondence author

34.  Multiple episodes of convergence in genes of the dim light vision pathway in bats. PLos One 7(4):e34564, 2012, Correspondence author

35.  The Origin and Evolution of Variable Number Tandem Repeat of CLEC4M Gene in the Global Human Population. Plos One 7(1), 2012, Correspondence author

36.  Positive selection on the gene RNASEL: correlation between patterns of evolution and function. Mol Biol Evol 29(10):3161-68, 2012, Correspondence author

37.  Origins of domestic dog in Southern  East Asia is supported by analysis of Y-chromosome DNA. Heredity 108(5):507-14, 2012, Correspondence author

38.  Universal COI primers for DNA barcoding amphibians. Mol Ecol Resour 12(2):247-58, 2012, Correspondence author

39.  Difference in selection driver Olfactory receptor genes in different directions in dogs and wolf. Mol Biol Evol 29(11):3475-84, 2012, Correspondence author

40.  Quaternary palaeoenvironmental oscillations drove the evolution of the Eurasian Carassius auratus complex (Cypriniformes, Cyprinidae). J. Biogeogr 39(12):2264-78, 2012, Correspondence author

41.  Patrilineal Perspective on the Austronesian Diffusion in Mainland Southeast Asia. Plos One 7(5), 2012, Correspondence author

42.  Genetic Adaptation of the Hypoxia-Inducible Factor Pathway to Oxygen Pressure among Eurasian Human Populations. Mol Biol Evol 29(11):3359-70, 2012, Correspondence author

43.  Parallel Evolution of Auditory Genes for Echolocation in Bats and Toothed Whales. PLos Genet 8(6):e1002788, 2012, Correspondence author

44.  Mitogenomic analysis of Chinese snub-nosed monkeys: Evidence of positive selection in NADH dehydrogenase genes in high-altitude adaptation. Mitochondrion 11(3):497-503, 2011, Correspondence author

45.  On the phylogeny of Mustelidae subfamilies: analysis of seventeen nuclear non-coding loci and mitochondrial complete genomes. Bmc Evol Biol 11, 2011, Correspondence author

46.  Phylogenetic Utility of Nuclear Introns in Interfamilial Relationships of Caniformia (Order Carnivora). Systematic Biology 60(2):175-87, 2011, Correspondence author

47.  Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia. Plos One 6(10), 2011, Correspondence author

48.  Different level of population differentiation among human genes. Bmc Evol Biol 11, 2011, Correspondence author

49.  Eukaryotic origin of a metabolic pathway in virus by horizontal gene transfer. Genomics 98(5):367-69, 2011, Correspondence author

50.  De Novo Origin of Human Protein-Coding Genes. Plos Genet 7(11), 2011, Correspondence author

51.  Mitochondrial DNA evidence supports northeast Indian origin of the aboriginal Andamanese in the Late Paleolithic. J Genet Genomics 38:117-22, 2011, Correspondence author

52.  Uncovering the Profile of Somatic mtDNA Mutations in Chinese Colorectal Cancer Patients. Plos One 6(6), 2011, Correspondence author

53.  Evaluating the Roles of Energetic Functional Constraints on Teleost Mitochondrial-Encoded Protein Evolution. Mol Biol Evol 28(1):39-44, 2011, Correspondence author

54.  Inferring the Population Expansions in Peopling of Japan. Plos One 6(6), 2011, Correspondence author

55.  Inland post-glacial dispersal in East  Asia revealed by mitochondrial haplogroup M9ab. Bmc Biology 9, 2011, Correspondence author

56.  Tracing the legacy of the early Hainan Islanders-a perspective from mitochondrial DNA. Bmc Evol Biol 11, 2011, Correspondence author

57.  Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population. Experimental Gerontology 46(6):511-15, 2011, Correspondence author

58.  Reticulate evolution: frequent introgressive hybridization among chinese hares (genus lepus) revealed by analyses of multiple mitochondrial and nuclear DNA loci. Bmc Evol Biol 11, 2011, Correspondence author

59.  Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region. Mol Biol Evol 28(1):513-22, 2011, Correspondence author

60.  Multi-Locus Analysis Reveals A Different Pattern of Genetic Diversity for Mitochondrial and Nuclear DNA between Wild and Domestic Pigs in East Asia. Plos One 6(10), 2011, Correspondence author

61.  Highly variable recessive lethal or nearly lethal mutation rates during germ-line development of male Drosophila melanogaster. PNAS 108(38):15914-19, 2011, Correspondence author

Molecular evolution and genome biodiversity. Investigations involve five correlated areas: genome diversity and adapt ive evolution; origin of domestic animals and artificial selection; human & animls genetics and evolution:

Ø       Genome diversity and adaptive evolution

Integrated with habitat and behavioral data, we investigate genomic variation, how (and why) the variations are selected , and the evolutionary forces underlying adaptation. Explore the fate of duplicate genes, how novel gene functions, new gene pathways, and gene networks evolved.

Ø       Origin of domestic animals and artificial selection

Our studies into the origin and genetic diversity of economically important domestic animals identify their unrecorded history. Genomic comparisons elucidate the genetic bases of domestication, and discover changes in genes or genomic elements that contribute to domestication.

Ø       Human & animals genetics and evolution

已指导学生

姚永刚  01  19175  

吕雪梅  01  20753  

何德  01  19175  

王成业  01  19175  

李英  01  19175  

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孙昌  01  19175  

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李海鹏  02  20798  

肖瑞  02  19182  

王晓霞  02  20798  

刘仲敏  02  20798  

张云武  02  20798  

罗静  02  20798  

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沈永义  01  19180  

王文智  01  19180  

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郝晓丹  01  19180  

周炜帏  01  19180  

刘菲  02  19180  

杨军校  01  19180  

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吴宏  01  19180  

汪轩  02  19180  

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叶凌群  01  19180  

尹婷婷  01  19180  

曾琳  01  19180  

胡靖扬  01  19180  

黄翠萍  01  19180  

李明莉  02  19180  

黎武略  02  19180  

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李建波  01  19180  

吕梦蝶  01  19180  

王运梅  01  19180  

周其俊  02  63228  

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