生物磁共振波谱

   

070302-分析化学

核磁共振波谱学

1999-09--2002-06   中国科学院武汉物理与数学研究所   博士学位
1993-09--1999-06   西北大学   硕士学位

-- 研究生

-- 博士

   

2010-10~现在, 中国科学院武汉物理与数学研究所, 研究员
2002-12~2010-09,中国科学院武汉物理与数学研究所, 副研究员
2002-08~2002-11,中国科学院武汉物理与数学研究所, 助理研究员

磁共振前沿
液体核磁共振实验

   

（1） 生物体系中分子间相互作用的核磁共振研究, 一等奖, 省级, 2006

[1] 袁斌, 蒋滨, 张许, 刘买利. 核磁共振浓度排序谱的构建方法. CN: CN112986307A, 2021-06-18.

   

[1] Caixiang Liu, Fangfang Chen, Xinyu Fan, Biao Liu, Xin Chai, Sipei He, Tao Huang, Xiaohua Wang, Laixing Liu, Huili Liu, Danyun Zeng, Bin Jiang, Xu Zhang, Maili Liu. Combined NMR and MS-based metabonomics and real-time PCR analyses reveal dynamic metabolic changes of Ganoderma lucidum during fruiting body growing. FOOD RESEARCH INTERNATIONAL. 2024, 180: http://dx.doi.org/10.1016/j.foodres.2024.114056.
[2] 刘彪, 刘才香, 柴鑫, 范新玉, 黄滔, 占建华, 朱勤俊, 曾丹云, 龚洲, 禾立春, 杨运煌, 周欣, 蒋滨, 张许, 刘买利. Real-Time NMR-Based Drug Discovery to Identify Inhibitors against Fatty Acid Synthesis in Living Cancer Cells. Analytical Chemistry[J]. 2024, 96(7): 3034-3043, [3] 王倩倩, 苗志伟, 肖雄杰, 张许, 杨代文, 蒋滨, 刘买利. Prediction of order parameters based on protein NMR structure ensemble and machine learning. Journal of Biomolecular NMR[J]. 2024, https://doi.org/10.1007/s10858-024-00435-w.
[4] 占建华, 曾丹云, 肖雄, 方仲佩, 黄滔, 赵蓓蓓, 朱勤俊, 刘才香, 蒋滨, 周欣, 李从刚, 禾立春, 杨代文, 刘买利, 张许. Real-time observation of conformational changes and translocation of endogenous cytochrome c within intact mitochondria. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2024, 146(7): 4455-4466, [5] Zhongpei Fang, Tao Huang, Xin Chai, Jianhua Zhan, Qinjun Zhu, Peng Sun, Danyun Zeng, Caixiang Liu, Bin Jiang, Lichun He, Xin Zhou, Maili Liu, Xu Zhang. Protein methylation characterization using NMR without isotopic labeling. TALANTA[J]. 2024, 268: http://dx.doi.org/10.1016/j.talanta.2023.125289.
[6] 王远方, 王小花, 舒畅, 张许, 刘买利, 曾丹云. 溶液中 ATAD2 溴结构域聚集行为的研究. 波谱学杂志[J]. 2023, 40(2): 169-178, [7] Chen, Biying, Shi, Biru, Ge, Xiaoyan, Fu, Zhifei, Yu, Haiyang, Zhang, Xu, Liu, Caixiang, Han, Lifeng. Integrated metabolic and transcriptomic profiles reveal the germination-associated dynamic changes for the seeds of Cassia obtusifolia L.. PHYTOCHEMICAL ANALYSIS[J]. 2023, 34(2): 240-253, http://dx.doi.org/10.1002/pca.3200.
[8] Yang, Yuqi, Baolong Wang, Xu Zhang, Hongchuang Li, Sen Yue, Yifan Zhang, Yunhuang Yang, Maili Liu, Chaohui Ye, Peng Huang, Xin Zhou. Activatable Graphene Quantum-Dot-Based Nanotransformers for Long-Period Tumor Imaging and Repeated Photodynamic Therapy. Advanced Materials[J]. 2023, 35(23): 2211337-, https://onlinelibrary.wiley.com/doi/10.1002/adma.202211337.
[9] Caixiang Liu, Fangfang Chen, Laixing Liu, Xinyu Fan, Huili Liu, Danyun Zeng, Xu Zhang. The Different Metabolic Responses of Resistant and Susceptible Wheats to Fusarium graminearum Inoculation. METABOLITES[J]. 2022, 12(727): https://doaj.org/article/14dc65064fb4451e99dbc3b52a3028b0.
[10] Yu, Gangjin, Wang, Guan, Duan, Mojie, Jiang, Bin, Zhang, Xu, Li, Conggang, He, Lichun, Liu, Maili. Self-Assembled Oligopeptide (FK)(4) as a Chiral Alignment Medium for the Anisotropic NMR Analysis of Organic Compounds. ACS APPLIED MATERIALS & INTERFACES[J]. 2022, 14(25): 29223-29229, http://dx.doi.org/10.1021/acsami.2c05506.
[11] Jianhua Zhan, Guangqing Zhang, Xin Chai, Qinjun Zhu, Peng Sun, Bin Jiang, Xin Zhou, Xu Zhang, Maili Liu. NMR Reveals the Conformational Changes of Cytochrome C upon Interaction with Cardiolipin. LIFE[J]. 2021, 11(10): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540660/.
[12] Yuan, Bin, Zhang, Xu, Kamal, Ghulam Mustafa, Jiang, Bin, Liu, Maili. Accurate estimation of diffusion coefficient for molecular identification in a complex background. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2020, 412(19): 4519-4525, http://dx.doi.org/10.1007/s00216-020-02693-7.
[13] Wang, Xiaohua, Zou, Wei, Kamal, Ghulam Mustafa, Wang, Jie, Zhou, Mi, Chen, Li, Jiang, Bin, Khalid, Muhammad, Zhang, Xu, Liu, Maili. An untargeted C-13 isotopic evaluation approach for the discrimination of fermented food matrices at natural abundance: Application to vinegar. TALANTA[J]. 2020, 210: http://dx.doi.org/10.1016/j.talanta.2019.120679.
[14] Hong Wan, Yafeng Tian, Haipeng Jiang, Xu Zhang, Xiulian Ju. A NMR-based drug screening strategy for discovering active substances from herbal medicines: Using Radix Polygoni Multiflori as example. JOURNAL OF ETHNOPHARMACOLOGY. 2020, 254: http://dx.doi.org/10.1016/j.jep.2020.112712.
[15] Yunyan Li, Wenping Mao, Chaoyang Liu, Xu Zhang, Junfeng Wang. Quantitative Determination of Fatty Acid Compositions in Edible Oils Using J-Selective 13C QDEPT. 2019, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=2&recid=&FileName=SSJD1DEBC013B96DBAB4ADC7E732682A19EC&DbName=SSJD_01&DbCode=SSJD&yx=&pr=&URLID=&bsm=.
[16] Zhang, Liang, Chai, Xin, Sun, Peng, Yuan, Bin, Jiang, Bin, Zhang, Xu, Liu, Maili. The Study of the Aggregated Pattern of TX100 Micelle by Using Solvent Paramagnetic Relaxation Enhancements. MOLECULES[J]. 2019, 24(9): https://doaj.org/article/16f467af2bfe4405a33ff27fd18f982d.
[17] Zhang, Liang, Chai, Xin, Sun, Peng, Zhu, Qinjun, Zhang, Xu, Liu, Maili. Characterization of the aggregated pattern of CHAPS using solvent paramagnetic relaxation enhancements. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2018, 555: 332-338, http://dx.doi.org/10.1016/j.colsurfa.2018.07.008.
[18] Sun, Peng, Wang, Qianwen, Yuan, Bin, Zhu, Qinjun, Jiang, Bin, Li, Conggang, Lan, Wenxian, Cao, Chunyang, Zhang, Xu, Liu, Maili. Monitoring alkaline transitions of yeast iso-1 cytochrome c at natural isotopic abundance using trimethyllysine as a native NMR probe. CHEMICAL COMMUNICATIONS[J]. 2018, 54(89): 12630-12633, http://ir.wipm.ac.cn/handle/112942/13200.
[19] Xiao, Xiongjie, Hu, Mary, Zhang, Xu, Hu, Jian Zhi. NMR-based Metabolomics Analysis of Liver from C57BL/6 Mouse Exposed to Ionizing Radiation. RADIATION RESEARCH[J]. 2017, 188(1): 44-55, http://dx.doi.org/10.1667/RR14602.1.
[20] Yuan, Bin, Ding, Yiming, Kamal, Ghulam M, Shao, Limin, Zhou, Zhiming, Jiang, Bin, Sun, Peng, Zhang, Xu, Liu, Maili. Reconstructing diffusion ordered NMR spectroscopy by simultaneous inversion of Laplace transform. JOURNAL OF MAGNETIC RESONANCE[J]. 2017, 278: 1-7, http://dx.doi.org/10.1016/j.jmr.2017.03.004.
[21] Wang, Xiaohua, Wang, Jie, Kamal, Ghulam Mustafa, Jiang, Bin, Sun, Peng, Zhang, Xu, Liu, Maili. Characterization and Comparison of Commercial Chinese Cereal and European Grape Vinegars Using H-1 NMR Spectroscopy Combined with Multivariate Analysis. CHINESE JOURNAL OF CHEMISTRY[J]. 2016, 34(11): 1183-1193, http://ir.wipm.ac.cn/handle/112942/9977.
[22] Feng Yitao, Zhang Lu, Wu Shaowen, Liu Zhijun, Gao Xin, Zhang Xu, Liu Maili, Liu Jianwei, Huang Xuhui, Wang Wenning. Conformational Dynamics of apo-GlnBP Revealed by Experimental and Computational Analysis.. ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH). 2016, [23] Guo, Qianni, Zeng, Qingbin, Jiang, Weiping, Zhang, Xiaoxiao, Luo, Qing, Zhang, Xu, Bouchard, LouisS, Liu, Maili, Zhou, Xin. A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized Xe-129 Molecular Clamp Probe. CHEMISTRYAEUROPEANJOURNAL[J]. 2016, 22(12): 3967-3970, http://dx.doi.org/10.1002/chem.201600193.
[24] Ghulam Mustafa Kamal, Xiaohua Wang, Bin Yuan, Jie Wang, Peng Sun, Xu Zhang, Maili Liu. Compositional differences among Chinese soy sauce types studied by 13 C NMR spectroscopy coupled with multivariate statistical analysis. TALANTA. 2016, 89-99, http://dx.doi.org/10.1016/j.talanta.2016.05.033.
[25] Ghulam Mustafa Kamal, Bin Yuan, Abdullah Ijaz Hussain, Jie Wang, Bin Jiang, Xu Zhang, Maili Liu. 13C-NMR-Based Metabolomic Profiling of Typical Asian Soy Sauces. MOLECULES. 2016, 21(9): https://doaj.org/article/03ff7f25da5944eda056ffcd398588de.
[26] Feng, Yue, Zhu, Hang, Zhang, Xu, Wang, Xuxia, Xu, Fuqiang, Tang, Huiru, Ye, Chaohui, Liu, Maili. NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation. PLOS ONE[J]. 2015, 10(10): http://ir.wipm.ac.cn/handle/112942/9031.
[27] Jiang, Bin, Yu, Binhan, Zhang, Xu, Liu, Maili, Yang, Daiwen. A N-15 CPMG relaxation dispersion experiment more resistant to resonance offset and pulse imperfection. JOURNAL OF MAGNETIC RESONANCE[J]. 2015, 257: 1-7, https://www.webofscience.com/wos/woscc/full-record/WOS:000358339700001.
[28] Wang, Guifang, Zhang, ZeTing, Jiang, Bin, Zhang, Xu, Li, Conggang, Liu, Maili. Recent advances in protein NMR spectroscopy and their implications in protein therapeutics research. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2014, 406(9-10): 2279-2288, http://dx.doi.org/10.1007/s00216-013-7518-5.
[29] 张许. 血浆与蛋白质-药物相互作用的个体差异的磁共振表征方法. Anal Chem. 2013, [30] 张许. Avr-Piz-t蛋白质的溶液结构. J Biomol NMR. 2013, [31] 张许. 生物分子配体识别的辐射阻尼waterLOGSY技术. J Biomol NMR. 2013, [32] 张许. NASA：NMR谱中噪音和伪峰同时抑制技术. Anal Chem. 2013, [33] 张许. 年龄和性别相关的大鼠皮层和小脑皮质的代谢变化. Brain Res. 2013, [34] 张许. 氯化钠浓度和温度度CHAPS胶束性质的影响. J. Phys. Chen. B. 2011, [35] 张许. 浓度相关的CHAPS胶束形态研究. J. Phys. Chen. B. 2010, [36] 张许. 非均匀采样快速多维谱的网格化重建技术. J Magn Reson. 2010, [37] 张许. 脉冲宽度对组合“水门”实验的影响. J Magn Reson. 2010, 

   

（ 1 ） 14N核磁共振研究赖氨酸三甲基化蛋白质的相互作用动力学, 主持, 国家级, 2011-01--2013-12
（ 2 ） 蛋白质动态学研究的新技术新方法, 参与, 国家级, 2013-01--2014-12
（ 3 ） 高效药物初步筛选和毒性评估的磁共振波谱分析, 主持, 省级, 2015-08--2017-08
（ 4 ） 甲基化生物大分子NMR检测新技术, 主持, 国家级, 2017-01--2020-12
（ 5 ） 活体小动物磷脂特异性磁共振谱仪系统研制, 主持, 部委级, 2017-01--2018-12
（ 6 ） 细胞内蛋白质结构和互作的原位NMR 分析新技术与新方法, 主持, 国家级, 2017-07--2022-06
（ 7 ） 基于核磁共振的磷脂异常代谢药物高内涵筛选技术研究, 主持, 国家级, 2020-01--2023-12

（1）Monitoring of Choline phosphorylation in Intact Cells by NMR   第十八届北京分析测试学术报告会暨展览会   2019-10-23
（2）The conformation of cytochome c - a ROS scavenger in mitochondria   第十八届北京分析测试学术报告会暨展览会   2019-10-23
（3）Study of the multiple conformation of yeast cytochrome c   第三届全国生物磁共振研讨会   2019-05-29
（4）白蛋白与棕榈酸相互作用的核磁共振研究   中国化学会第十三届全国分析化学年会   2018-06-14
（5）天然同位素丰度蛋白质核磁共振谱的简化   第二届全国生物磁共振研讨会   张许   2017-10-19
（6）Differentiation of Asian Soy Sauces by Multivariate Analysis of 13CNMR Profiles   第16届北京分析测试学术报告会暨展览会   Ghulam Mustafa Kamal   2015-10-27
（7）Using DOSY to Determine Chemical Exchange Rate Constants   第16届北京分析测试学术报告会暨展览会   Bin Yuan   2015-10-27

已指导学生

李钊  硕士研究生  070208-无线电物理  

程鹏  硕士研究生  070208-无线电物理  

李雪  硕士研究生  070208-无线电物理  

王晶婧  硕士研究生  070302-分析化学  

孙鹏  博士研究生  070302-分析化学  

聂莉莎  硕士研究生  085238-生物工程  

王倩文  博士研究生  070302-分析化学  

李楠  硕士研究生  070208-无线电物理  

张亮  博士研究生  070302-分析化学  

肖雄杰  博士研究生  070302-分析化学  

汪旋  博士研究生  070302-分析化学  

陈瑶  硕士研究生  070302-分析化学  

方仲佩  硕士研究生  085238-生物工程  

现指导学生

张广庆  博士研究生  070302-分析化学  

王远方  硕士研究生  070302-分析化学  

占建华  博士研究生  070302-分析化学  

胡琴  硕士研究生  086000-生物与医药  

方仲佩  博士研究生  070302-分析化学