以解析动植物对病原和虫媒的抗性机制为目的，本研究组的研究重点为：1）非编码RNA在机体抗性反应过程中功能；2）细胞器互作对机体抗性反应的意义。

   

0710Z1-基因组学
071007-遗传学
071010-生物化学与分子生物学

表观遗传学
分子生物学
细胞生物学

2001-09--2007-12   北京大学   博士
1997-09--2001-07   南开大学   本科

   

2014-03~2024-06,中国科学院动物研究所, 研究员
2008-01~2014-02,加州大学, 博士后/助理研究员

2022-12-30-2027-12-29,中国昆虫学会, 理事
2021-10-31-2027-12-31,中国昆虫学会第十一届理事会媒介昆虫与病原互作专委会, 副主任
2017-10-01-2022-10-01,中国植物病理学会第十一届理事会病毒专业委员会委员,
2017-10-01-2022-10-01,中国昆虫学会第十届理事会昆虫比较免疫与互作专业委员会委员,
2017-10-01-2022-10-01,中国植物保护学会第十二届理事会青年工作委员会委员,
2017-10-01-2022-10-01,中国植物病毒学会第十一届理事会青年委员会委员,

媒介生物学
表观遗传学
病原与媒介

   

（ 1 ） 一种特异性检测槟榔黄化植原体的巢式引物组、试剂盒及其检测方法, 发明专利, 2023, 第 1 作者, 专利号: 2023101100072190

（ 2 ） 一种RNA解旋酶3及其编码基因和应用, 专利授权, 2019, 第 1 作者, 专利号: CN109777792A

   

[1] 黄娟, 赵一鸣, 刘莎莎, 陈亚秋, 杜猛, 王乾, 张杰, 杨献光, 陈金锋, 张晓明. RH20, a phase-separated RNA helicase protein, facilitates plant resistance to viruses. Plant Science[J]. 2024, 第 10 作者  通讯作者  null(null): https://doi.org/10.1016/j.plantsci.2024.112176.
[2] zhirui yang, Guangyao Li, Yongliang Zhang, Fangfang Li, Tao Zhou, Jian Ye, Xianbing Wang, 张晓明, Zongtao Sun, Xiaorong Tao, Ming Wu, Wu JianGuo, Yi Li. Crop antiviral defense: Past and future perspective. 中国科学:生命科学(英文版)[J]. 2024, 第 8 作者null(null): 
[3] Tengfei Lu, Yannan Ji, Mengmeng Chang, 张晓明, Yanhong Wang, Zhen Zou. The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus. BMC BIOLOGY[J]. 2024, 第 4 作者22(null): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10795361/.
[4] 宋双伟, 王乾, 霍梁霄, 谢立强, 陈佳琦, 崔红光, 戴兆基, 康锦瑞, 李毅, 郭伟, 陈金锋, 康乐, 张晓明. The phytoplasma (Candidatus Phytoplasma arecae) is the crucial pathogen to cause areca palm yellow leaf disease. Science Bulletin[J]. 2024, 第 13 作者  通讯作者  null(null): https://doi.org/10.1016/j.scib.2024.10.020.
[5] Juan Huang, Wenling Zhou, Xiaoming Zhang, Yi Li. Roles of long non-coding RNAs in plant immunity.. PLOS PATHOGENS[J]. 2023, 第 3 作者  通讯作者  19(5): https://doaj.org/article/46de7aff2d614e79bbb414531ccc0b83.
[6] 张晓明. Plant Virology in the 21st Century in China: Recent Advances and Future Directions. 植物学报（英文版）[J]. 2023, 第 1 作者https://onlinelibrary.wiley.com/doi/10.1111/jipb.13580.
[7] 李琦, 刘洋, 张晓明. Biomolecular condensates in plant RNA silencing: insights into formation, function, and stress responses. The Plant Cell[J]. 2023, 第 3 作者  通讯作者  https://doi.org/10.1093/plcell/koad254.
[8] Yang Liu, Jian Rao, Yingjie Mi, Lan Chen, Lijuan Feng, Qi Li, Jianing Geng, Xianguang Yang, Xiangjiang Zhan, Lili Ren, Jinfeng Chen, Xiaoming Zhang. SARS-CoV-2 RNAs are processed into 22-nt vsRNAs in Vero cells. FRONTIERS IN IMMUNOLOGY[J]. 2022, 第 12 作者  通讯作者  13: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650353/.
[9] 杜娟, 张晓明. Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana. BMC Plant Biology[J]. 2022, 第 2 作者  通讯作者  22(576): 
[10] Liu, Ningkun, Xu, Yanzhuo, Li, Qi, Cao, Yuxin, Yang, Dechang, Liu, Shasha, Wang, Xiaokang, Mi, Yingjie, Liu, Yang, Ding, Chenxi, Liu, Yan, Li, Yong, Yuan, YaoWu, Gao, Ge, Chen, Jinfeng, Qian, Weiqiang, Zhang, Xiaoming. A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth. CELL HOST & MICROBE[J]. 2022, 第 17 作者  通讯作者  30(8): 1124-+, http://dx.doi.org/10.1016/j.chom.2022.07.001.
[11] Yang Cheng, Tengfei Lu, Junliang Guo, Zhe Lin, Qiao Jin, Xiaoming Zhang, Zou, Zhen. Helicoverpa armigera miR-2055 regulates lipid metabolism via fatty acid synthase expression. OPEN BIOLOGY[J]. 2022, 第 6 作者  通讯作者  12(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889172/.
[12] Gao, Wenrui, Liu, Yan, Huang, Juan, Chen, Yaqiu, Chen, Chen, Lu, Lu, Zhao, Hongwei, Men, Shuzhen, Zhang, Xiaoming. MES7 Modulates Seed Germination via Regulating Salicylic Acid Content in Arabidopsis. PLANTS-BASEL[J]. 2021, 第 9 作者  通讯作者  10(5): http://dx.doi.org/10.3390/plants10050903.
[13] Li, Qi, Liu, Ningkun, Liu, Qing, Zheng, Xingguo, Lu, Lu, Gao, Wenrui, Liu, Yang, Liu, Yan, Zhang, Shicheng, Wang, Qian, Pan, Jing, Chen, Chen, Mi, Yingjie, Yang, Meiling, Cheng, Xiaofei, Ren, Guodong, Yuan, YaoWu, Zhang, Xiaoming. DEAD-box helicases modulate dicing body formation in Arabidopsis. SCIENCE ADVANCES[J]. 2021, 第 18 作者  通讯作者  7(18): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081359/.
[14] 张晓明. Determining the phase separation characteristics of plant proteins. Current Protocols. 2021, 第 1 作者  通讯作者  
[15] Wenrui Gao, Yan Liu, Juan Huang, Yaqiu Chen, Chen Chen, Lu Lu, Hongwei Zhao, Shuzhen Men, Xiaoming Zhang. MES7 Modulates Seed Germination via Regulating Salicylic Acid Content in Arabidopsis. PLANTS[J]. 2021, 第 9 作者  通讯作者  10(903): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146826/.
[16] Zhang, Bin, Zhao, Lilin, Ning, Jing, Wickham, Jacob D, Tian, Haokai, Zhang, Xiaoming, Yang, Meiling, Wang, Xiangming, Sun, Jianghua. miR-31-5p regulates cold acclimation of the wood-boring beetle Monochamus alternatus via ascaroside signaling. BMC BIOLOGY[J]. 2020, 第 6 作者18(1): https://doaj.org/article/e97c30c21f1b45aaae9bf931998f8684.
[17] Liu, Yan, Gao, Wenrui, Wu, Shuangyang, Lu, Lu, Chen, Yaqiu, Guo, Junliang, Men, Shuzhen, Zhang, Xiaoming. AtXRN4 Affects the Turnover of Chosen miRNA*s in Arabidopsis. PLANTS-BASEL[J]. 2020, 第 8 作者  通讯作者  9(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000525315000120.
[18] Liu, Yan, Gao, Wenrui, Wu, Shuangyang, Lu, Lu, Chen, Yaqiu, Guo, Junliang, Men, Shuzhen, Zhang, Xiaoming. AtXRN4 Affects the Turnover of Chosen miRNA*s in Arabidopsis. PLANTS-BASEL[J]. 2020, 第 8 作者  通讯作者  9(3): http://dx.doi.org/10.3390/plants9030362.
[19] 杨美玲, 李琦, 陈佳琦, 张晓明. RNA沉默转基因技术在植物抗病虫害研究中的作用. 植物保护[J]. 2020, 第 4 作者46(4): 1-6, http://lib.cqvip.com/Qikan/Article/Detail?id=7102377879.
[20] Yang, Meiling, Xu, Zhongtian, Zhao, Wan, Liu, Qing, Li, Qiong, Lu, Lu, Liu, Renyi, Zhang, Xiaoming, Cui, Feng. Rice stripe virus-derived siRNAs play different regulatory roles in rice and in the insect vector Laodelphax striatellus. BMC PLANT BIOLOGY[J]. 2018, 第 8 作者  通讯作者  18(1): https://doaj.org/article/2c97b2bfd9f740be8dc9383269579f60.
[21] Zhao Wan, Xu Zhongtian, Zhang Xiaoming, Yang Meiling, Kang Le, Liu Renyi, Cui Feng. Genomic variations in the 3′‐termini of Rice stripe virus in the rotation between vector insect and host plant. THE NEW PHYTOLOGIST[J]. 2018, 第 3 作者219(3): 1085-1096, 
[22] Zhao, Wan, Xu, Zhongtian, Zhang, Xiaoming, Yang, Meiling, Kang, Le, Liu, Renyi, Cui, Feng. Genomic variations in the 3'-termini of Rice stripe virus in the rotation between vector insect and host plant. NEW PHYTOLOGIST[J]. 2018, 第 3 作者219(3): 1085-1096, https://www.webofscience.com/wos/woscc/full-record/WOS:000438353300021.
[23] JuanHuang, MeilingYang, andXiaomingZhang. The function of small RNAs in plant biotic stress response. Journal of Integrative Plant Biology[J]. 2016, 58(4): 312-327, https://www.jipb.net/EN/10.1111/jipb.12463.
[24] Juan Huang, Meiling Yang, Xiaoming Zhang. The function of small RNAs in plant biotic stress response. 植物学报：英文版[J]. 2016, 第 3 作者312-327, http://lib.cqvip.com/Qikan/Article/Detail?id=668965611.
[25] Huang, Juan, Yang, Meiling, Lu, Lu, Zhang, Xiaoming. Diverse Functions of Small RNAs in Different Plant-Pathogen Communications. FRONTIERS IN MICROBIOLOGY[J]. 2016, 第 4 作者  通讯作者  7: https://doaj.org/article/5ffd8e80abbe46ef9dc3a0e46f118191.
[26] Zhang, Xiaoming, Niu, DongDong, Carbonell, Alberto, Wang, Airong, Lee, Angel, Tun, Vinnary, Wang, Zonghua, Carrington, James C, Chang, Chiaen A, Jin, Hailing. ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis. NATURE COMMUNICATIONS[J]. 2014, 第 1 作者5: https://www.webofscience.com/wos/woscc/full-record/WOS:000345647200001.
[27] Zhang, Xiaoming, Lii, Yifan, Wu, Zhigang, Polishko, Anton, Zhang, Huiming, Chinnusamy, Viswanathan, Lonardi, Stefano, Zhu, JianKang, Liu, Renyi, Jin, Hailing. Mechanisms of Small RNA Generation from Cis-NATs in Response to Environmental and Developmental Cues. MOLECULAR PLANT[J]. 2013, 第 1 作者6(3): 704-715, http://dx.doi.org/10.1093/mp/sst051.
[28] 张晓明. Genome-wide analysis of plant nat-siRNAs reveals novel insights into their distribution, biogenesis and function. Genome Biol. 2012, 第 1 作者
[29] Zhang, Xiaoming, Zhao, Hongwei, Gao, Shang, Wang, WeiChi, KatiyarAgarwal, Surekha, Huang, HsienDa, Raikhel, Natasha, Jin, Hailing. Arabidopsis Argonaute 2 Regulates Innate Immunity via miRNA393*-Mediated Silencing of a Golgi-Localized SNARE Gene, MEMB12. MOLECULAR CELL[J]. 2011, 第 1 作者42(3): 356-366, http://dx.doi.org/10.1016/j.molcel.2011.04.010.
[30] Padmanabhan, Chellappan, Zhang, Xiaoming, Jin, Hailing. Host small RNAs are big contributors to plant innate immunity. CURRENT OPINION IN PLANT BIOLOGY. 2009, 第 2 作者12(4): 465-472, http://dx.doi.org/10.1016/j.pbi.2009.06.005.
[31] Zhang, Xiaoming, Du, Peng, Lu, Lu, Xiao, Qi, Wang, Wenjuan, Cao, Xuesong, Ren, Bo, Wei, Chunhong, Li, Yi. Contrasting effects of HC-Pro and 2b viral suppressors from Sugarcane mosaic virus and Tomato aspermy cucumovirus on the accumulation of siRNAs. VIROLOGY[J]. 2008, 第 1 作者374(2): 351-360, http://www.corc.org.cn/handle/1471x/2389126.

（1） 生态基因组学, 科学出版社, 2019-09, 第 其他 作者

   

（ 1 ） 植物病毒病害, 负责人, 国家任务, 2024-01--2028-12
（ 2 ） 生物互作的非编码RNA调控机制与精准控制新靶点研发, 负责人, 研究所自主部署, 2024-01--2026-12
（ 3 ） 重大病虫害成灾致害机理研究, 负责人, 国家任务, 2022-09--2025-12
（ 4 ） 重大入侵种与微生物的共生入侵机制, 负责人, 国家任务, 2021-01--2024-12
（ 5 ） 内质网叶绿体互作及其在植物抗病毒过程中作用, 负责人, 国家任务, 2020-01--2020-05
（ 6 ） 水稻-媒介-病毒互作机制研究, 负责人, 地方任务, 2020-01--2020-12
（ 7 ） 植物病毒病害, 负责人, 国家任务, 2017-01--2019-12
（ 8 ） 表观遗传修饰稳定传代技术的开发与建立, 负责人, 国家任务, 2017-01--2020-12
（ 9 ） 植物保护, 负责人, 国家任务, 2016-01--2018-12
（ 10 ） 基因信息传递过程中非编码RNA的调控作用机制, 负责人, 国家任务, 2016-01--2018-12
（ 11 ） 生物间表观遗传抗性信息流的识别解码, 负责人, 中国科学院计划, 2015-09--2019-06
（ 12 ） 跨界RNA沉默信息流的抗虫作用机制及功能, 负责人, 国家任务, 2015-01--2018-12

已指导学生

杜娟  博士研究生  0710Z1-基因组学  

刘艳  博士研究生  0710Z1-基因组学  

刘洋  博士研究生  0710Z1-基因组学  

李琼  博士研究生  0710Z1-基因组学  

刘青  博士研究生  0710Z1-基因组学  

徐彦卓  博士研究生  0710Z1-基因组学  

王乾  硕士研究生  0710Z1-基因组学  

刘宁坤  博士研究生  0710Z1-基因组学  

刘倩倩  硕士研究生  086000-生物与医药  

史健飞  硕士研究生  0710Z1-基因组学  

现指导学生

宋双伟  博士研究生  0710Z1-基因组学  

王乾  博士研究生  0710Z1-基因组学  

刘莎莎  博士研究生  0710Z1-基因组学  

赵一鸣  硕士研究生  0710Z1-基因组学  

谢立强  硕士研究生  086000-生物与医药  

周文玲  博士研究生  0710Z1-基因组学  

蔡志豪  硕士研究生  0710Z1-基因组学  

朱孟杰  博士研究生  0710Z1-基因组学  

周永亮  硕士研究生  0710Z1-基因组学  

苗淮奇  博士研究生  0710Z1-基因组学  

丁晨曦  博士研究生  0710Z1-基因组学