生物医用高分子材料

组织工程支架材料

   

070305-高分子化学与物理

1.组织工程支架材料及其药物释放功能、生物活性研究
2.新型有机无机复合骨缺损修复材料研制
3.生物医用材料表面改性及其表面生物学性能研究

2000年于内蒙古民族大学化学系毕业，获得理学学士学位；
2007年于中科院成都有机化学研究所高分子化学与物理专业毕业， 获得理学博士学位。

-- 研究生

-- 博士

   

2007年7月起在中国科学院成都有机化学研究所工作，2010年1月起聘为副研究员。

“聚乳酸与自然铜的复合物和用途” 中国专利， 申请号200610020485.6

   

[1] Du, Yuhan, Xing, Luyao, Hou, Peijie, Qi, Jin, Liu, Xiliang, Zhang, Yiyi, Chen, Dongliang, Li, Qing, Xiong, Chengdong, Huang, Tianfang, Zhang, Lifang. Dual stimulus response mechanical properties tunable biodegradable and biocompatible PLCL/PPDO based shape memory composites. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2022, 648: [2] Liu, Xiliang, Liu, Song, Li, Kaiqi, Fan, Youkun, Feng, Shaomin, Peng, Lijun, Zhang, Tianyao, Wang, Xin, Chen, Dongliang, Xiong, Chengdong, Bai, Wei, Zhang, Lifang. Preparation and property evaluation of biodegradable elastomeric PTMC/PLCL networks used as ureteral stents. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2021, 630: http://dx.doi.org/10.1016/j.colsurfa.2021.127550.
[3] Liu, Xiliang, Liu, Song, Feng, Shaomin, Li, Kaiqi, Fan, Youkun, Wang, Xin, Xiao, Jianping, Bai, Wei, Chen, Dongliang, Xiong, Chengdong, Zhang, Lifang. Biodegradable cross-linked poly(1,3-trimethylene carbonate) networks formed by gamma irradiation under vacuum. POLYMERS FOR ADVANCED TECHNOLOGIES[J]. 2021, 32(11): 4373-4385, http://dx.doi.org/10.1002/pat.5439.
[4] 张丽芳. Thermal, mechanical and degradation properties of flexible poly(1,3-trimethylene carbonate) / poly(L-lactide-co-ε-caprolactone) blends. Journal of Polymer Research[J]. 2021, [5] 张丽芳. Enhanced bone regeneration using poly(trimethylene carbonate)/vancomycin hydrochloride porous microsphere scaffolds in presence of the silane coupling. Journal of Industrial and Engineering Chemistry[J]. 2021, [6] 张丽芳. Chitosan-coated hydroxyapatite and drug-loaded polytrimethylene carbonate/polylactic acid scaffold for enhancing bone regeneration.. Carbohydrate Polymer[J]. 2021, [7] 张丽芳. Biodegradable cross-linked poly(L-lactide-co-ε-caprolactone) networks for ureteral stent formed by gamma irradiation under vacuum. Journal of Industrial and Engineering Chemistry[J]. 2021, [8] Liu, Xiliang, Liu, Song, Li, Kaiqi, Feng, Shaomin, Fan, Youkun, Peng, Lijun, Wang, Xin, Chen, Dongliang, Xiong, Chengdong, Bai, Wei, Zhang, Lifang. Preparation and degradation characteristics of biodegradable elastic poly (1,3-trimethylene carbonate) network. POLYMER DEGRADATION AND STABILITY[J]. 2021, 193: http://dx.doi.org/10.1016/j.polymdegradstab.2021.109718.
[9] He, Jian, Zhang, Yu, Liu, Xiaoyi, Peng, Lijun, Li, Huiling, Xiong, Chengdong, Zhang, Lifang. Load-bearing PTMC-beta tri-calcium phosphate and dexamethasone biphasic composite microsphere scaffolds for bone tissue engineering. MATERIALS LETTERS[J]. 2020, 260: http://dx.doi.org/10.1016/j.matlet.2019.126939.
[10] 刘锡亮, 冯少敏, 祁金, 张丽芳, 熊成东, 王昕, 白威, 马攀. 聚对二氧环己酮制备及等温退火. 合成化学[J]. 2020, 28(9): 796-800, http://lib.cqvip.com/Qikan/Article/Detail?id=7102773051.
[11] He, Jian, Hu, Xulin, Zhang, Yu, Liu, Xiaoyi, Peng, LiJun, Li, Huiling, Xiong, Chengdong, Zhang, Lifang. A composite polytrimethylene carbonate microsphere-reinforced porous scaffold for osteoblast regeneration. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2020, 587: http://dx.doi.org/10.1016/j.colsurfa.2019.124325.
[12] Zheng, Yanyan, Liu, Lvhua, Xiong, Chengdong, Zhang, Lifang. Enhancement of bioactivity on modified polyetheretherketone surfaces with -COOH, -OH and -PO4H2 functional groups. MATERIALS LETTERS[J]. 2018, 213: 84-87, http://dx.doi.org/10.1016/j.matlet.2017.11.019.
[13] Yanyan Zheng, Chengdong Xiong, Lifang Zhang. Corrigendum to "Formation of bone-like apatite on plasma-carboxylated poly(etheretherketone) surface" Mater. Lett. 126 (2014) 147–150. MATERIALS LETTERS. 2016, 180: 6-6, http://dx.doi.org/10.1016/j.matlet.2016.05.069.
[14] Zheng, Yanyan, Xiong, Chengdong, Zhang, Lifang. Dose-dependent enhancement of osteoblast cell adhesion, spreading and proliferation on plasma-carboxylated poly(etheretherketone) surface. MATERIALS LETTERS[J]. 2016, 164: 60-63, http://dx.doi.org/10.1016/j.matlet.2015.10.124.
[15] Yanyan Zheng, Chengdong Xiong, Shenglan Zhang, Xiaoyu Li, Lifang Zhang. Bone-like apatite coating on functionalized poly(etheretherketone) surface via tailored silanization layers technique. MATERIALS SCIENCE & ENGINEERING C. 2015, 55: 512-523, http://dx.doi.org/10.1016/j.msec.2015.05.070.
[16] Yanyan Zheng, Chengdong Xiong, Lifang Zhang. Fabrication and characterization of PDLLA/pyrite composite bone scaffold for osteoblast culture. INDIAN ACADEMY OF SCIENCES. 2015, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201912010230197ZK.
[17] Zheng, Yanyan, Xiong, Chengdong, Wang, Zhecun, Li, Xiaoyu, Zhang, Lifang. A combination of CO2 laser and plasma surface modification of poly(etheretherketone) to enhance osteoblast response. APPLIED SURFACE SCIENCE[J]. 2015, 344: 79-88, http://dx.doi.org/10.1016/j.apsusc.2015.03.113.
[18] Zheng, Yanyan, Xiong, Chengdong, Wang, Zhecun, Zhang, Lifang. Enhanced osteoblast cells adhesion, spreading, and proliferation to surface-carboxylated poly(etheretherketone). JOURNALOFBIOACTIVEANDCOMPATIBLEPOLYMERS[J]. 2015, 30(3): 302-318, [19] Zheng, Yanyan, Xiong, Chengdong, Zhang, Lifang. Formation of bone-like apatite on plasma-carboxylated poly(etheretherketone) surface. MATERIALS LETTERS[J]. 2014, 126: 147-150, http://dx.doi.org/10.1016/j.matlet.2014.04.021.
[20] Zheng, Yanyan, Xiong, Chengdong, Li, Xiaoyu, Zhang, Lifang. Covalent attachment of cell-adhesive peptide Gly-Arg-Gly-Asp (GRGD) to poly(etheretherketone) surface by tailored silanization layers technique. APPLIED SURFACE SCIENCE[J]. 2014, 320: 93-101, http://dx.doi.org/10.1016/j.apsusc.2014.09.091.
[21] 韩崇涛, 马驰, 蒋立新, 熊成东, 张丽芳. 吸附共沉淀法制备聚醚醚酮/多壁碳纳米管复合材料与性能研究. 合成化学[J]. 2013, 21(1): 26-31, http://lib.cqvip.com/Qikan/Article/Detail?id=44871517.
[22] 张丽芳. High performance PEEK / CNTS / BG biomaterials in mechanical properties and bioactivity. Journal of Polymer Research. 2013, [23] 吴航, 张丽芳, 白威, 马驰, 熊成东. 聚合温度对聚磷酸钙聚合度及结构的影响. 无机材料学报[J]. 2012, 27(2): 174-178, http://lib.cqvip.com/Qikan/Article/Detail?id=40919635.
[24] 吴航, 张丽芳, 熊左春, 马驰, 陈栋梁, 熊成东. 酯交换反应条件对聚（L-丙交酯-co-ε-己内酯）力学性能的影响. 合成化学[J]. 2011, 19(5): 590-594, http://lib.cqvip.com/Qikan/Article/Detail?id=39240119.
[25] 张丽芳. Preparation and Characterization of Biodegradable Poly(D, L-lactide) and Surface Modified Bioactive Glass Composites for Bone Repairing Materials. Journal of Materials Science: Materials in Medicine2009. 2009, [26] Bai Wei, Zhang LiFang, Huang XiaoChuan, Li Qing, Xiong ChengDong. Crystallization behaviour of ppdo/pdlla blends. GAOFENZI CAILIAO KEXUE YU GONGCHENG/POLYMERIC MATERIALS SCIENCE AND ENGINEERING[J]. 2009, Vol.25 no.11: 72-75, http://www.corc.org.cn/handle/1471x/1995220.
[27] Xu, Liang, Xiong, Zuo Chun, Yang, Dejuan, Zhang, Li Fang, Chang, Jiang, Xiong, Cheng Dong. Preparation and In Vitro Degradation of Novel Bioactive Polylactide/Wollastonite Scaffolds. JOURNAL OF APPLIED POLYMER SCIENCE[J]. 2009, 114(6): 3396-3406, https://www.webofscience.com/wos/woscc/full-record/WOS:000270746000007.
[28] 张丽芳. Studies on Poly(D,L-lactic acid)/Wollastonite composites as a biomaterial. Iran Polym J. 2008, [29] 张丽芳. Hydrophilic poly (ethylene glycol) coating on PLA/BCP bone scaffold for drug delivery,. Materials science and engineering C-Biomimetic and supramolecular systems. 2008, [30] 张丽芳, 陈和春, 徐梁, 熊左春, 白威, 赵娜, 熊成东. 聚乳酸／中药自然铜复合多孔膜的制备及其性能研究. 合成化学[J]. 2008, 16(1): 8-11,23, http://lib.cqvip.com/Qikan/Article/Detail?id=26617059.
[31] Zhang, Li Fang, Sun, Rui, Xu, Liang, Du, Jian, Xiong, Zuo Chun, Chen, He Chun, Xiong, Cheng Dong. Hydrophilic poly (ethylene glycol) coating on PDLLA/BCP bone scaffold for drug delivery and cell culture. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS[J]. 2008, 28(1): 141-149, http://www.corc.org.cn/handle/1471x/2392420.
[32] Zhang, Li Fang, Yang, De Juan, Chen, He Chun, Sun, Rui, Xu, Liang, Xiong, Zuo Chun, Govender, Thirumala, Xiong, Cheng Dong. An ionically crosslinked hydrogel containing vancomycin coating on a porous scaffold for drug delivery and cell culture. INTERNATIONAL JOURNAL OF PHARMACEUTICS[J]. 2008, 353(1-2): 74-87, http://dx.doi.org/10.1016/j.ijpharm.2007.11.023.
[33] 张丽芳. 聚乳酸/聚已二醇－聚乳酸新型亲水支架的制备及性能研究. 生物医学工程学杂志. 2007, 

   

中国科学院“西部之光”人才培养计划“西部博士资助项目”: 聚乳酸－乙醇酸/生物活性玻璃三维多孔骨组织工程复合支架研究

现指导学生

韩崇涛  硕士研究生  070305-高分子化学与物理