基本信息
张建国 男 硕导 其他
电子邮件： zhangjg@genomics.cn
通信地址： 广东省深圳市盐田区洪安三街21号华大综合园7栋
邮政编码： 518083
电子邮件： zhangjg@genomics.cn
通信地址： 广东省深圳市盐田区洪安三街21号华大综合园7栋
邮政编码： 518083
研究领域
2001年至今一直从事基因组学和生物信息学相关研究工作。
早期主要从事动植物、微生物的基因组学研究。作为生物信息骨干参加了中国杂交水稻基因组计划，并荣获2003年度中国科学院杰出科技成就集体奖（11/18）(2003-02-02-208)。先后参与了家蚕、家鸡、第一个亚洲人、玉米、家猪等大型基因组研究计划，主持了西瓜基因组的组装和生物信息分析工作。
2010年研究重点转到疾病基因组研究。基于遗传病临床样本和表型信息，以多组学平台和生物信息技术为主，致力于揭示遗传病的分子基础和生物标志物，促进遗传病的临床筛查、诊断、干预和治疗。开展的研究主要集中在出生缺陷、罕见病、脑病、孕期疾病以及生物信息分析工具与方法的开发。
2023年至今，团队研究聚焦在大人群基因组研究和基于多组学技术的全生命周期复杂疾病防控研究。研究项目包括百万人基因组研究，母婴队列多组学研究，心血管疾病多组学研究，复杂脑病多组学研究等。
招生信息
招生专业
0710Z1-基因组学
0710J3-生物信息学
085400-电子信息
0710J3-生物信息学
085400-电子信息
招生方向
大人群基因组研究
复杂疾病多组学研究
教育背景
2005-09--2011-06 复旦大学 博士研究生
1997-09--2001-06 南开大学 本科
1997-09--2001-06 南开大学 本科
工作经历
工作经历
2011-07~现在, 深圳华大生命科学研究院, 实验室负责人/临床科研高级总监/主任科学家
2001-07~2005-08,北京华大基因研究中心, 项目负责人/部门副主管
社会兼职
2023-11-27～至今，河北医科大学，硕士生导师
2021-08-05～至今，中国科学院大学，硕士生导师
2020-03-20～2022-12-31, 安徽医科大学特聘副教授, 特聘副教授
2018-09-13～2023-09-13, 中国微循环学会-神经变性病专委会-阿尔茨海默病生物标志物学组副主任委员, 副主任委员
2018-07-20～2023-07-20, 西北大学兼职教授, 兼职教授
专利与奖励
奖励信息
（1） 深圳市高层次专业人才, 一等奖, 市地级, 2009
（2） 中国科学院杰出科技成就奖, 部委级, 2004
（2） 中国科学院杰出科技成就奖, 部委级, 2004
专利成果
[1] 刘汉奎, 张振馨, 张建国, 田长耕, 黄小燕. CARS基因突变体及其应用. CN: CN114591980A, 2022-06-07.
[2] 高雪, 袁永一, 戴朴, 林琼芬, 管李萍, 张建国, 谌于蓝. 基因突变体及其应用. CN: CN110878307A, 2020-03-13.
[3] 高雪, 戴朴, 袁永一, 林琼芬, 管李萍, 张建国, 党孝. 分离的编码IFNLR1突变体的核酸及其应用. CN: CN109943569A, 2019-06-28.
[4] 张浩, 李振宇, 马升升, 李红玉, 李建康, 黄慧强, 申丹, 蒋慧, 张建国. 设计目标区域特异性液相探针的方法和系统. CN: CN107292125B, 2021-03-05.
[5] 布娟, 何思捷, 张建国, 方明艳, 王乐今, 刘敬. EPHA2基因突变型及其应用. CN: CN106167800B, 2019-07-19.
[6] 高雪, 戴朴, 张建国, 谌于蓝, 管李萍, 徐讯. PTPRQ基因突变体及其应用. CN: CN105838720B, 2019-04-30.
[7] 张建国, 亚历山大·费利利, 方明艳, 蒋慧, 徐讯, 王俊. 分离的编码POPDC1突变体的核酸及其应用. CN: CN105821047B, 2020-08-07.
[8] 刘少君, 戴兰兰, 刘勇, 谌于蓝, 陈玉剑, 张建国, 阙海萍. AMSH基因突变体及其应用. CN: CN105821062B, 2019-07-12.
[9] 廖卫平, 周青, 石奕武, 管李萍, 秦兵, 何娜, 张建国. 遗传性癫痫伴热性惊厥附加症SCN1A基因新突变. CN: CN104774841A, 2015-07-15.
[10] 方明艳, 安德烈·马索蒂, 张建国, 江宠颐, 徐讯. 分离的编码KCNJ6突变体的核酸及其应用. CN: CN105779462B, 2019-10-22.
[11] 戴兰兰, 杨勇, 张建国, 林志淼, 刘汉奎, 冯程, 谌于蓝, 汪慧君, 汪建. KLHL24基因突变体及其应用. CN: CN107974436B, 2019-11-08.
[12] 何思捷, 张建国, 刘轩竹, 李建康, 徐讯. VPS13B基因突变体及其应用. CN: CN105779463B, 2019-08-09.
[2] 高雪, 袁永一, 戴朴, 林琼芬, 管李萍, 张建国, 谌于蓝. 基因突变体及其应用. CN: CN110878307A, 2020-03-13.
[3] 高雪, 戴朴, 袁永一, 林琼芬, 管李萍, 张建国, 党孝. 分离的编码IFNLR1突变体的核酸及其应用. CN: CN109943569A, 2019-06-28.
[4] 张浩, 李振宇, 马升升, 李红玉, 李建康, 黄慧强, 申丹, 蒋慧, 张建国. 设计目标区域特异性液相探针的方法和系统. CN: CN107292125B, 2021-03-05.
[5] 布娟, 何思捷, 张建国, 方明艳, 王乐今, 刘敬. EPHA2基因突变型及其应用. CN: CN106167800B, 2019-07-19.
[6] 高雪, 戴朴, 张建国, 谌于蓝, 管李萍, 徐讯. PTPRQ基因突变体及其应用. CN: CN105838720B, 2019-04-30.
[7] 张建国, 亚历山大·费利利, 方明艳, 蒋慧, 徐讯, 王俊. 分离的编码POPDC1突变体的核酸及其应用. CN: CN105821047B, 2020-08-07.
[8] 刘少君, 戴兰兰, 刘勇, 谌于蓝, 陈玉剑, 张建国, 阙海萍. AMSH基因突变体及其应用. CN: CN105821062B, 2019-07-12.
[9] 廖卫平, 周青, 石奕武, 管李萍, 秦兵, 何娜, 张建国. 遗传性癫痫伴热性惊厥附加症SCN1A基因新突变. CN: CN104774841A, 2015-07-15.
[10] 方明艳, 安德烈·马索蒂, 张建国, 江宠颐, 徐讯. 分离的编码KCNJ6突变体的核酸及其应用. CN: CN105779462B, 2019-10-22.
[11] 戴兰兰, 杨勇, 张建国, 林志淼, 刘汉奎, 冯程, 谌于蓝, 汪慧君, 汪建. KLHL24基因突变体及其应用. CN: CN107974436B, 2019-11-08.
[12] 何思捷, 张建国, 刘轩竹, 李建康, 徐讯. VPS13B基因突变体及其应用. CN: CN105779463B, 2019-08-09.
出版信息
发表论文
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科研活动
科研项目
（ 1 ） 基于多组学方法的帕金森病发病机制研究, 负责人, 地方任务, 2019-03--2022-03
（ 2 ） 遗传和环境因素交互作用下神经环路的沉默与早期AD发病, 参与, 国家任务, 2016-07--2021-06
（ 3 ） 阿尔茨海默病遗传机制及生物标记技术的研发, 负责人, 地方任务, 2015-08--2017-08
（ 4 ） 眼科出生缺陷及遗传性疾病家系收集与珍惜资源复制, 负责人, 国家任务, 2014-05--2017-04
（ 5 ） HBV感染相关疾病基因组医学标记物研究, 参与, 国家任务, 2014-04--2017-04
（ 6 ） 眼科单基因病致病基因发现研究及检测技术开发, 负责人, 地方任务, 2013-08--2015-07
（ 7 ） 西瓜基因组测序及生物信息学分析, 负责人, 国家任务, 2010-01--2011-12
（ 8 ） 罕见病基因变异库与智能分析工具研发与验证, 参与, 国家任务, 2022-12--2025-11
（ 9 ） 建立基于多组学的无创性孕期疾病预测的算法和技术体系, 负责人, 其他国际合作项目, 2021-11--2024-12
（ 2 ） 遗传和环境因素交互作用下神经环路的沉默与早期AD发病, 参与, 国家任务, 2016-07--2021-06
（ 3 ） 阿尔茨海默病遗传机制及生物标记技术的研发, 负责人, 地方任务, 2015-08--2017-08
（ 4 ） 眼科出生缺陷及遗传性疾病家系收集与珍惜资源复制, 负责人, 国家任务, 2014-05--2017-04
（ 5 ） HBV感染相关疾病基因组医学标记物研究, 参与, 国家任务, 2014-04--2017-04
（ 6 ） 眼科单基因病致病基因发现研究及检测技术开发, 负责人, 地方任务, 2013-08--2015-07
（ 7 ） 西瓜基因组测序及生物信息学分析, 负责人, 国家任务, 2010-01--2011-12
（ 8 ） 罕见病基因变异库与智能分析工具研发与验证, 参与, 国家任务, 2022-12--2025-11
（ 9 ） 建立基于多组学的无创性孕期疾病预测的算法和技术体系, 负责人, 其他国际合作项目, 2021-11--2024-12
参与会议
（1）基因组时代的眼科临床与科研 中国研究型医院学会眼科学会与视觉科学专委会2019学术年会 2019-03-22