基本信息
张宏  男  博导  中国科学院生物物理研究所
电子邮件: hongzhang@sun5.ibp.ac.cn
通信地址: 北京朝阳大屯路15号
邮政编码: 100101

研究领域

我们实验室的兴趣主要集中在研究多细胞生物中自噬作用的机理和调控机制。细胞自体吞噬是一种溶酶体介导的降解系统。它通过形成一种叫做自噬小体的双膜结构来包裹细胞质和一些受损的细胞器。自噬小体最终与溶酶体发生融合,以完成对底物的降解。在哺乳动物中,自噬作用参与了许多生理过程,包括抵御饥饿胁迫,清除有毒性倾向的蛋白,对抗外来病原入侵以及决定细胞死亡和组织动态平衡等。自噬作用的紊乱会引起许多病理反应,包括神经退行性疾病,肝功能异常,心肌梗塞,肿瘤发生等严重疾病。秀丽线虫(C. elegans)拥有丰富的发育生物学的背景和便利的遗传实验手段。这使得秀丽线虫成为研究自噬作用过程以及蛋白质聚集体的选择性降解机制的良好模型。

我们实验室的前期工作建立了秀丽线虫作为多细胞生物自体吞噬的模型以研究细胞自噬的作用机理、调控机制以及生理功能。我们发现在线虫胚胎发育的过程中,有许多蛋白聚合体是被自噬作用选择性地降解,包括了特异存在于生殖细胞中的P颗粒。我们克隆了SEPA-1这个介导P颗粒被自噬系统选择性降解的关键因子。通过遗传筛选,我们还发现了多细胞生物特异的参与自噬作用的多个基因,epg-3, epg-4, epg-5和epg-6,丰富了人们对多细胞生物体中自噬作用机理的认识。

实验室以后的工作主要集中在:

1. 新自噬突变体基因的克隆和功能研究。

2.发现在选择性地降解特定蛋白聚集体过程中所必需的基因。

3. 研究自体吞噬的活性在生物体发育过程中的变化关系。

4. 研究自噬作用在生物体发育过程中的生理学功能。

招生信息

细胞生物学,遗传发育学,生物化学与分子生物学
招生专业
071009-细胞生物学
招生方向
多细胞生物自噬作用的机理和调控机制;神经退行性疾病的发生机制
细胞自噬,神经退行性疾病

教育背景

1994-09--2001-03   美国纽约爱因斯坦医学院   分子遗传学博士学位
1991-09--1994-07   北京医科大学   肿瘤学硕士学位
1987-09--1991-07   安徽大学   生物化学学士学位
学历

博士

学位
博士

工作经历

   
工作简历
2012-02~现在, 中国科学院生物物理研究所, 研究员
2004-07~2012-02,北京生命科学研究所, 高级研究员
2001-03~2004-06,哈佛大学医学院、马萨诸塞总医院癌症中心, 博士后
社会兼职
2017-10-31-今,中国生物物理学会, 秘书长
2017-01-01-今,The Journal of Cell Biology, 编委会成员
2017-01-01-今,国际细胞生物学联合体(International Federation for Cell Biology), 副主席
2016-01-01-今,Cell Death and Differentiation, 编委会成员
2016-01-01-今,eLife, 审稿委员会成员
2015-01-01-今,Journal of Cell Science, 编委会成员
2013-01-01-今,EMBO reports, 编委会成员
2012-01-01-今,Autophagy, 副主编
2012-01-01-今,The Journal of Biological Chemistry, 编委会成员

教授课程

普通生物学实验
科研实践I
发现生命奥秘

专利与奖励

   
奖励信息
(1) 第二届全国创新争先奖, 国家级, 2020
(2) 国家自然科学奖, 二等奖, 国家级, 2019
(3) 中国细胞生物学学会“杰出成就”奖, 其他, 2019
(4) 臻溪生命学者, 其他, 2018
(5) 百千万人才工程, 一等奖, 国家级, 2017
(6) 北京市科学技术奖, 二等奖, 省级, 2016
(7) 第二批国家“万人计划”领军人才人, 一等奖, 部委级, 2016
(8) 第六届谈家桢生命科学奖创新奖, 一等奖, 其他, 2014
(9) 中青年科技创新领军人才奖, 一等奖, 部委级, 2013
(10) 国家杰出青年基金奖, 一等奖, 国家级, 2012
(11) 霍华德 休斯医学研究所(HHMI)国际青年科学家奖, 一等奖, 其他, 2012
(12) Lilly亚洲杰出科研成就奖, 一等奖, 其他, 2006
(13) Burroughs Wellcome基金会生物医学成就奖, 一等奖, 其他, 2005
(14) 马萨诸塞总医院医学发现奖, 一等奖, 其他, 2004

出版信息

   
发表论文
[1] Miao, Guangyan, Zhao, Hongyu, Li, Yan, Ji, Mingming, Chen, Yong, Shi, Yi, Bi, Yuhai, Wang, Peihui, Zhang, Hong. ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation. DEVELOPMENTAL CELL[J]. 2021, 56(4): 427-+, http://dx.doi.org/10.1016/j.devcel.2020.12.010.
[2] Hong Zhang. β-propeller proteins WDR45 and WDR45B control autophagosome maturation into autolysosomes in neural cells. Current Biology. 2021, [3] Hong Zhang. The ER membrane proteins Atlastin 2/3 regulate ER targeting of the ULK1 complex and formation of the ER-isolation membrane contact. The Journal of Cell Biology. 2021, [4] Hui Zhang, Hong Zhang. Entry, egress and vertical transmission of SARS-CoV-2. Journal of Molecular Cell Biology. 2021, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108610/.
[5] Di Chen, Qiaoxia Zheng, Long Sun, Mingming Ji, Yan Li, Hongyu Deng, Hong Zhang. ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress. Developmental Cell. 2021, 56(23): 3250-3263.e5, [6] Zhao, Yan G, Codogno, Patrice, Zhang, Hong. Machinery, regulation and pathophysiological implications of autophagosome maturation. NATURE REVIEWS MOLECULAR CELL BIOLOGYnull. 2021, 22(11): 733-750, http://dx.doi.org/10.1038/s41580-021-00392-4.
[7] Zhang, Hong, Ji, Xiong, Li, Pilong, Liu, Cong, Lou, Jizhong, Wang, Zheng, Wen, Wenyu, Xiao, Yue, Zhang, Mingjie, Zhu, Xueliang. Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases. SCIENCE CHINA-LIFE SCIENCESnull. 2020, 63(7): 953-985, http://lib.cqvip.com/Qikan/Article/Detail?id=7102303892.
[8] Ji, Cuicui, Zhao, Hongyu, Li, Dongfang, Sun, Huayu, Hao, Junfeng, Chen, Ruiguo, Wang, Xiaoqun, Zhang, Hong, Zhao, Yan G. Role of Wdr45b in maintaining neural autophagy and cognitive function. AUTOPHAGY[J]. 2020, 16(4): 615-625, https://www.webofscience.com/wos/woscc/full-record/WOS:000475191500001.
[9] Zhao, Yan G, Zhang, Hong. Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates. DEVELOPMENTAL CELLnull. 2020, 55(1): 30-44, http://dx.doi.org/10.1016/j.devcel.2020.06.033.
[10] Zheng, Hui, Yuan, Chongzhen, Zhang, Hui, Chen, Yingyu, Zhang, Hong. The tissue- and developmental stage-specific involvement of autophagy genes in aggrephagy. AUTOPHAGY[J]. 2020, 16(4): 589-599, https://www.webofscience.com/wos/woscc/full-record/WOS:000475172700001.
[11] Chen, Di, Wang, Zheng, Zhao, Yan G, Zheng, Hui, Zhao, Hongyu, Liu, Nan, Zhang, Hong. Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity. DEVELOPMENTAL CELL[J]. 2020, 55(5): 588-+, http://dx.doi.org/10.1016/j.devcel.2020.10.010.
[12] Zheng Wang, Gangming Zhang, Hong Zhang. Protocol for analyzing protein liquid–liquid phase separation. 2019, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=3&recid=&FileName=SSJDF38A27553C91479D80C2666D6FC5B62B&DbName=SSJDLAST&DbCode=SSJD&yx=&pr=&URLID=&bsm=.
[13] Zheng Wang, Hong Zhang. Phase Separation, Transition, and Autophagic Degradation of Proteins in Development and Pathogenesis. Trends in Cell Biology. 2019, 29(5): 417-427, http://dx.doi.org/10.1016/j.tcb.2019.01.008.
[14] Hong Zhang. The ER-localized transmembrane protein TMEM39A/SUSR2 regulates autophagy by controlling the trafficking of the PtdIns(4)P phosphatase SAC1.. Molecular Cell. 2019, [15] Hong Zhang. Role of Wdr45b in maintaining neural autophagy and cognitive function.. Autophagy. 2019, [16] Zhang, Yujie, Qi, Linxiang, Zhang, Hong. TGF beta-like DAF-7 acts as a systemic signal for autophagy regulation in C. elegans. JOURNAL OF CELL BIOLOGY[J]. 2019, 218(12): 3998-4006, [17] Wang, Zheng, Zhang, Hong. Phzse Separation, Transition, and Autophagic Degradation of Proteins in Development and Pathogenesis. TRENDS IN CELL BIOLOGYnull. 2019, 29(5): 417-427, [18] Hong Zhang. The ER-Localized Protein DFCP1 Modulates ERLipid. Cell reports. 2019, [19] Xie, Kang, Zhang, Peng, Na, Huimin, Liu, Yangli, Zhang, Hong, Liu, Pingsheng. MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans. SCIENTIFIC REPORTS[J]. 2019, 9(1): https://doaj.org/article/cc63e54d0e424da7a681226dea2837e1.
[20] Gangming, Zhang, Zheng, Wang, Zhuo, Du, 张宏. mTOR通过调节PGL颗粒的相变来控制它被自噬降解的新机制. 科学新闻. 2019, 46-46, http://lib.cqvip.com/Qikan/Article/Detail?id=75888869504849574850485053.
[21] Wang Zheng, Zhang Gangming, Zhang Hong. Protocol for analyzing protein liquid–liquid phase separation. Biophysics Reports[J]. 2019, 5(1): 1-9, http://lib.cqvip.com/Qikan/Article/Detail?id=7001777561.
[22] Zhao, Yan G, Zhang, Hong. Autophagosome maturation: An epic journey from the ER to lysosomes. JOURNAL OF CELL BIOLOGYnull. 2019, 218(3): 757-770, [23] Zhao, Yan G, Zhang, Hong. Core autophagy genes and human diseases. CURRENT OPINION IN CELL BIOLOGYnull. 2019, 61: 117-125, http://dx.doi.org/10.1016/j.ceb.2019.08.003.
[24] Wang, Zhaoyu, Zhao, Hongyu, Yuan, Chongzhen, Zhao, Dongfeng, Sun, Yanan, Wang, Xiaochen, Zhang, Hong. The RBG-1-RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function in C. elegans. JOURNAL OF CELL SCIENCE[J]. 2019, 132(19): https://www.webofscience.com/wos/woscc/full-record/WOS:000490938000016.
[25] Zhang, Gangming, Wang, Zheng, Du, Zhuo, Zhang, Hong. mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation. CELL[J]. 2018, 174(6): 1492-+, http://dx.doi.org/10.1016/j.cell.2018.08.006.
[26] Wang, Zheng, Zhang, Hong. Mitophagy: Vps13D Couples Mitochondrial Fission and Autophagic Clearance. CURRENT BIOLOGYnull. 2018, 28(2): R66-R68, http://dx.doi.org/10.1016/j.cub.2017.12.017.
[27] Zhu, Yimeng, Zhang, Gangming, Lin, Shaoyu, Shi, Juanming, Zhang, Hong, Hu, Junjie. Sec61 beta facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules. PROTEIN & CELL[J]. 2018, 9(7): 616-628, https://www.webofscience.com/wos/woscc/full-record/WOS:000436455300003.
[28] Zhao, Yan G, Zhang, Hong. Formation and maturation of autophagosomes in higher eukaryotes: a social network. CURRENT OPINION IN CELL BIOLOGYnull. 2018, 53: 29-36, http://dx.doi.org/10.1016/j.ceb.2018.04.003.
[29] Zhao, Yan G, Liu, Nan, Miao, Guangyan, Chen, Yong, Zhao, Hongyu, Zhang, Hong. The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis. CURRENT BIOLOGY[J]. 2018, 28(8): 1234-+, http://dx.doi.org/10.1016/j.cub.2018.03.002.
[30] Zhao, Yan G, Zhang, Hong. The ER-localized autophagy protein EPG-3/VMP1 regulates ER contacts with other organelles by modulating ATP2A/SERCA activity. AUTOPHAGYnull. 2018, 14(2): 362-363, https://www.webofscience.com/wos/woscc/full-record/WOS:000429594000018.
[31] Hong Zhang. Potent and specific atg8-targeting autophagy inhibitory peptides derived from giant ankyrins. Nature Chemical Biology. 2018, [32] Liu, Yangli, Xu, Shimeng, Zhang, Congyan, Zhu, Xiaotong, Hammad, Mirza Ahmed, Zhang, Xuelin, Christian, Mark, Zhang, Hong, Liu, Pingsheng. Hydroxysteroid dehydrogenase family proteins on lipid droplets through bacteria, C-elegans, and mammals. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS[J]. 2018, 1863(8): 881-894, http://dx.doi.org/10.1016/j.bbalip.2018.04.018.
[33] 魏文毅, 孙毅, 曹诚, 常智杰, 陈策实, 陈佺, 程金科, 冯仁田, 高大明, 胡荣贵, 贾立军, 姜天霞, 金建平, 李汇华, 李卫, 刘翠华, 刘萱, 马蕾娜, 缪时英, 饶枫, 商瑜, 宋质银, 万勇, 王恒彬, 王平, 王占新, 吴缅, 吴乔, 谢旗, 谢松波, 谢志平, 徐平, 许执恒, 杨波, 阳成伟, 应美丹, 张宏冰, 张令强, 赵永超, 周军, 朱军, 王琳芳, 张宏, 王琛, 邱小波. 类泛素蛋白及其中文命名. 科学通报[J]. 2018, 63(25): 2564-2569, http://lib.cqvip.com/Qikan/Article/Detail?id=676354836.
[34] Xu, Linan, Gong, Weibin, Cusack, Sarah A, Wu, Huiwen, Loovers, Harriet M, Zhang, Hong, Perrett, Sarah, Jones, Gary W. The beta 6/beta 7 region of the Hsp70 substrate-binding domain mediates heat-shock response and prion propagation. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2018, 75(8): 1445-1459, https://www.webofscience.com/wos/woscc/full-record/WOS:000427583300010.
[35] Yan, G.Zhao, Yong, Chen, Guangyan, Miao, Hongyu, Zhao, Wenyan, Qu, Dongfang, Li, Zheng, Wang, Nan, Liu, Lin, Li, She, Chen, Pingsheng, Liu, Du, Feng, 张宏. 内质网跨膜蛋白EPG-3/VMP1激活钙通道SERCA来调节ER与隔离膜的互作. 科学新闻. 2018, 87-87, http://lib.cqvip.com/Qikan/Article/Detail?id=675303285.
[36] 张明杰. Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins. NATURE CHEMICAL BIOLOGY[J]. 2018, 14(8): 778-787, https://www.webofscience.com/wos/woscc/full-record/WOS:000438970200012.
[37] Xiaotong Zhu, Yangli Liu, Hong Zhang, Pingsheng Liu. Whole-genome RNAi screen identifies methylation-related genes influencing lipid metabolism in Caenorhabditis elegans. 遗传学报:英文版. 2018, 45(5): 259-272, http://lib.cqvip.com/Qikan/Article/Detail?id=675474095.
[38] 陈扬, 刘玉乐, 张宏, 刘伟, 孙启明, 杨崇林, 刘志华, 王一国, 俞立. 细胞自噬中的新蛋白质机器的鉴定和研究. 中国基础科学. 2018, 20(1): 7-12, http://lib.cqvip.com/Qikan/Article/Detail?id=675432586.
[39] 张宏, 张慧. 多细胞生物自噬的分子机制和生理功能. 安徽大学学报:自然科学版. 2018, 42(5): 105-114, http://lib.cqvip.com/Qikan/Article/Detail?id=676268640.
[40] Congyan Zhang, Li Yang, Yunfeng Ding, Yang Wang, Lan Lan, Qin Ma, Xiang Chi, Peng Wei, Yongfang Zhao, Alexander Steinbchel, Hong Zhang, Pingsheng Liu. Bacterial lipid droplets bind to DNA via an intermediary protein that enhances survival under stress. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/a4398771e5734c789040c858443b3bd2.
[41] Zhao, Yan G, Chen, Yong, Miao, Guangyan, Zhao, Hongyu, Qu, Wenyan, Li, Dongfang, Wang, Zheng, Liu, Nan, Li, Lin, Chen, She, Liu, Pingsheng, Feng, Du, Zhang, Hong. The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. MOLECULAR CELL[J]. 2017, 67(6): 974-+, http://dx.doi.org/10.1016/j.molcel.2017.08.005.
[42] 张宏. Vici综合征的致病蛋白EPG5介导自噬小体与晚期内体/溶酶体融合过程. 科学新闻. 2017, 87-87, http://lib.cqvip.com/Qikan/Article/Detail?id=672078075.
[43] Joshi, Amit S, Zhang, Hong, Prinz, William A. Organelle biogenesis in the endoplasmic reticulum. NATURE CELL BIOLOGYnull. 2017, 19(8): 876-882, https://www.webofscience.com/wos/woscc/full-record/WOS:000406500300002.
[44] Zhang, Gangming, Lin, Long, Qi, Di, Zhang, Hong. The composition of a protein aggregate modulates the specificity and efficiency of its autophagic degradation. AUTOPHAGY[J]. 2017, 13(9): 1487-1495, https://www.webofscience.com/wos/woscc/full-record/WOS:000412206800003.
[45] 薛雪, 张宏. 2016年诺奖解读——生理学或医学奖:自噬的前世今生. 科学世界. 2016, 4-6, http://lib.cqvip.com/Qikan/Article/Detail?id=670474851.
[46] 张慧, 张宏. 自噬: 细胞自身物质更新代谢的重要机制. 科学通报[J]. 2016, 61(36): 3903-3906, [47] Zhao, Yan G, Zhang, Hong. ULK1 cycling: The ups and downs of the autophagy response. JOURNAL OF CELL BIOLOGYnull. 2016, 215(6): 757-759, https://www.webofscience.com/wos/woscc/full-record/WOS:000390414900004.
[48] Wu, Fan, Wang, Peng, Shen, Yuxian, Noda, Nobuo N, Zhang, Hong. Small differences make a big impact: Structural insights into the differential function of the 2 Atg8 homologs in C-elegans. AUTOPHAGYnull. 2016, 12(3): 606-607, [49] Wang, Lulan, Wu, Aiping, Wang, Yao E, Quanquin, Natalie, Li, Chunfeng, Wang, Jingfeng, Chen, HsiangWen, Liu, Suyang, Liu, Ping, Zhang, Hong, Qin, F XiaoFeng, Jiang, Taijiao, Cheng, Genhong. Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase. JOURNAL OF VIROLOGY[J]. 2016, 90(6): 2938-2947, https://www.webofscience.com/wos/woscc/full-record/WOS:000374110600020.
[50] Miao, Guangyan, Zhao, Yan G, Zhao, Hongyu, Ji, Cuicui, Sun, Huayu, Chen, Yingyu, Zhang, Hong. Mice deficient in the Vici syndrome gene Epg5 exhibit features of retinitis pigmentosa. AUTOPHAGY[J]. 2016, 12(12): 2263-2270, http://dx.doi.org/10.1080/15548627.2016.1238554.
[51] Zhao, Yan G, Zhang, Hong. The Incredible ULKs: Autophagy and Beyond. MOLECULAR CELLnull. 2016, 62(4): 475-476, http://dx.doi.org/10.1016/j.molcel.2016.05.005.
[52] Yan G.Zhao, Hong Zhang. The Nobel Prize: an appetizer before the feast. 科学通报:英文版. 2016, 1711-1714, http://lib.cqvip.com/Qikan/Article/Detail?id=74888487504849545050484849.
[53] Zhang, Hong, Hu, Junjie. Shaping the Endoplasmic Reticulum into a Social Network. TRENDS IN CELL BIOLOGYnull. 2016, 26(12): 934-943, http://dx.doi.org/10.1016/j.tcb.2016.06.002.
[54] Wang, Zheng, Miao, Guangyan, Xue, Xue, Guo, Xiangyang, Yuan, Chongzhen, Wang, Zhaoyu, Zhang, Gangming, Chen, Yingyu, Feng, Du, Hu, Junjie, Zhang, Hong. The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes. MOLECULAR CELL[J]. 2016, 63(5): 781-795, http://www.corc.org.cn/handle/1471x/2375651.
[55] Lu, Qun, Yokoyama, Christine C, Williams, Jesse W, Baldridge, Megan T, Jin, Xiaohua, DesRochers, Brittany, Bricker, Traci, Wilen, Craig B, Bagaitkar, Juhi, Loginicheva, Ekaterina, Sergushichev, Alexey, Kreamalmeyer, Darren, Keller, Brian C, Zhao, Yan, Kambal, Amal, Green, Douglas R, Martinez, Jennifer, Dinauer, Mary C, Holtzman, Michael J, Crouch, Erika C, Beatty, Wandy, Boon, Adrianus C M, Zhang, Hong, Randolph, Gwendalyn J, Artyomov, Maxim N, Virgin, Herbert W. Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. CELL HOST & MICROBE[J]. 2016, 19(1): 102-113, https://www.webofscience.com/wos/woscc/full-record/WOS:000369839900014.
[56] Wang, Yongqiang, Qu, Jiuxin, Ba, Qi, Dong, Jiuhong, Zhang, Liang, Zhang, Hong, Wu, Aiping, Wang, Dayan, Xia, Zanxian, Peng, Daxin, Shu, Yuelong, Cao, Bin, Jiang, Taijiao. Detection and typing of human-infecting influenza viruses in China by using a multiplex DNA biochip assay. JOURNAL OF VIROLOGICAL METHODS[J]. 2016, 234: 178-185, http://dx.doi.org/10.1016/j.jviromet.2016.04.021.
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[70] Wu, Yanwei, Cheng, Shiya, Zhao, Hongyu, Zou, Wei, Yoshina, Sawako, Mitani, Shohei, Zhang, Hong, Wang, Xiaochen. PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. EMBO REPORTS[J]. 2014, 15(9): 973-981, https://www.webofscience.com/wos/woscc/full-record/WOS:000341711600011.
[71] Cheng, Shiya, Wu, Yanwei, Lu, Qun, Yan, Jiacong, Zhang, Hong, Wang, Xiaochen. Autophagy genes coordinate with the class II PI/PtdIns 3-kinase PIKI-1 to regulate apoptotic cell clearance in C. elegans. AUTOPHAGY[J]. 2013, 9(12): 2022-2032, https://www.webofscience.com/wos/woscc/full-record/WOS:000328299800009.
[72] Li, Sihui, Yang, Peiguo, Tian, E, Zhang, Hong. Arginine Methylation Modulates Autophagic Degradation of PGL Granules in C. elegans. MOLECULAR CELL[J]. 2013, 52(3): 421-433, http://dx.doi.org/10.1016/j.molcel.2013.09.014.
[73] Zhao Hongyu, Zhao Yan G, Wang Xingwei, Xu Lanjun, Miao Lin, Feng Du, Chen Quan, Kovcs Attila L, Fan Dongsheng, Zhang Hong. Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration.. The Journal of cell biology. 2013, [74] Li, Chunfeng, Ba, Qi, Wu, Aiping, Zhang, Hong, Deng, Tao, Jiang, Taijiao. A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly. FEBS JOURNAL[J]. 2013, 280(4): 1139-1149, http://www.irgrid.ac.cn/handle/1471x/756635.
[75] Xu, LiQiong, Wu, Si, Buell, Alexander K, Cohen, Samuel I A, Chen, LiJun, Hu, WanHui, Cusack, Sarah A, Itzhaki, Laura S, Zhang, Hong, Knowles, Tuomas P J, Dobson, Christopher M, Welland, Mark E, Jones, Gary W, Perrett, Sarah. Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES[J]. 2013, 368(1617): http://www.irgrid.ac.cn/handle/1471x/756513.
[76] Wang, Haibin, Lu, Qun, Cheng, Shiya, Wang, Xiaochen, Zhang, Hong. Autophagy activity contributes to programmed cell death in Caenorhabditis elegans. AUTOPHAGY[J]. 2013, 9(12): 1975-1982, https://www.webofscience.com/wos/woscc/full-record/WOS:000328299800005.
[77] Zhao, Hongyu, Zhao, Yan G, Wang, Xingwei, Xu, Lanjun, Miao, Lin, Feng, Du, Chen, Quan, Kovacs, Attila L, Fan, Dongsheng, Zhang, Hong. Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration. JOURNAL OF CELL BIOLOGY[J]. 2013, 200(6): 731-741, http://www.irgrid.ac.cn/handle/1471x/756506.
[78] Lin, Long, Yang, Peiguo, Huang, Xinxin, Zhang, Hui, Lu, Qun, Zhang, Hong. The scaffold protein EPG-7 links cargo receptor complexes with the autophagic assembly machinery. JOURNAL OF CELL BIOLOGY[J]. 2013, 201(1): 113-129, http://www.irgrid.ac.cn/handle/1471x/756573.
[79] Zhang, Hui, Wu, Fan, Wang, Xingwei, Du, Hongwei, Wang, Xiaochen, Zhang, Hong. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. AUTOPHAGY[J]. 2013, 9(12): 1965-1974, https://www.webofscience.com/wos/woscc/full-record/WOS:000209520300002.
[80] Zhao, Yan G, Zhao, Hongyu, Sun, Huayu, Zhang, Hong. Role of Epg5 in selective neurodegeneration and Vici syndrome. AUTOPHAGY[J]. 2013, 9(8): 1258-1262, https://www.webofscience.com/wos/woscc/full-record/WOS:000323314600017.
[81] Zhang, Peipei, Zhang, Hong. Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C-elegans. EMBO REPORTS[J]. 2013, 14(6): 568-576, http://www.irgrid.ac.cn/handle/1471x/756597.
[82] Hong Zhang. Differential function of the two Atg4 homologues in the aggrephagy pathway in C. elegans. The Journal of Biological Chemistry. 2012, [83] Truman, Andrew W, Kristjansdottir, Kolbrun, Wolfgeher, Donald, Hasin, Naushaba, Polier, Sigrun, Zhang, Hong, Perrett, Sarah, Prodromou, Chrisostomos, Jones, Gary W, Kron, Stephen J. CDK-Dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-Cycle Progression. CELL[J]. 2012, 151(6): 1308-1318, http://dx.doi.org/10.1016/j.cell.2012.10.051.
[84] Liang, Qianqian, Yang, Peiguo, Tian, E, Han, Jinghua, Zhang, Hong. The C. elegans ATG101 homolog EPG-9 directly interacts with EPG-1/Atg13 and is essential for autophagy. AUTOPHAGY[J]. 2012, 8(10): 1426-1433, http://www.irgrid.ac.cn/handle/1471x/756956.
[85] Zhao Yan G, Zhao Hongyu, Miao Lin, Wang Li, Sun Fei, Zhang Hong. The p53-induced gene Ei24 is an essential component of the basal autophagy pathway.. The Journal of biological chemistry. 2012, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD13012100910313&DbName=SJPD_04&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[86] Huang, Jie, Wang, Haibin, Chen, Yingyu, Wang, Xiaochen, Zhang, Hong. Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance. DEVELOPMENT[J]. 2012, 139(24): 4613-4622, http://www.irgrid.ac.cn/handle/1471x/756914.
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[88] Yang, Peiguo, Zhang, Hong. The coiled-coil domain protein EPG-8 plays an essential role in the autophagy pathway in C. elegans. AUTOPHAGY[J]. 2011, 7(2): 159-165, https://www.webofscience.com/wos/woscc/full-record/WOS:000286802800003.
[89] Lu, Qun, Yang, Peiguo, Huang, Xinxin, Hu, Wanqiu, Guo, Bin, Wu, Fan, Lin, Long, Kovacs, Attila L, Yu, Li, Zhang, Hong. The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes. DEVELOPMENTAL CELL[J]. 2011, 21(2): 343-357, http://dx.doi.org/10.1016/j.devcel.2011.06.024.
[90] Huang, Xinxin, Zhang, Hui, Zhang, Hong. The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans. DEVELOPMENT[J]. 2011, 138(10): 2059-2068, https://www.webofscience.com/wos/woscc/full-record/WOS:000289886200017.
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科研活动

   
科研项目
( 1 ) 多细胞生物自噬过程中膜的构建与融合, 主持, 国家级, 2015-01--2020-12
( 2 ) 细胞自噬、代谢及相关疾病的研究, 主持, 国家级, 2015-08--2020-07
( 3 ) 多细胞生物发育过程中自噬活性的调控机制, 主持, 国家级, 2017-01--2021-12
( 4 ) 多细胞生物所特有的自噬新蛋白质机器的鉴定、功能 和作用机制, 参与, 国家级, 2017-07--2022-06
( 5 ) 多细胞生物自噬溶酶体形成及再生的调控机制, 主持, 国家级, 2018-01--2022-12
参与会议
(1)Atlastin 2/3 regulate ER targeting of the ULK1 complex to initiate autophagy   2021-06-08
(2)Inositol polyphosphate multikinase inhibits liquid-liquid phase separation of TFEB to regulate autophagy activity   2020-10-05
(3)Role of WDR45 and WDR45B in maintaining neural autophagy and cognitive function   2020-08-27
(4)ER-localized SUSR2 controls trafficking of the PtdIns(4)P phosphatase SAC1 to modulate autophagy activity   2019-12-09
(5)ER-localized SUSR2 controls trafficking of the PtdIns(4)P phosphatase SAC1 to modulate autophagy activity   2019-11-05
(6)ER-localized SUSR2 controls trafficking of the PtdIns(4)P phosphatase SAC1 to modulate autophagy activity   2019-02-17
(7)Phase separation of PGL granules controls their autophagic degradation and heat stress adaptation during C. elegans development   2018-04-22
(8)Phase separation of PGL granules controls their autophagic degradation and heat stress adaptation during C. elegans development   2018-03-18
(9)The function of DFCP1   2017-12-13
(10)Differential Function of the Four WIPIs in Autophagy   2016-06-06
(11)Non-autonomous autophagy regulation during C. elegans larval development   2016-03-21
(12)The cargo, developmental stage and context specific requirement of the C. elegans   张宏   2015-06-19
(13)O-GlcNAc-Modification of SNAP-29 Regulates Autophagosome Maturation   张宏   2015-03-27
(14)Sugar modification regulates autophagosome maturation   张宏   2014-12-19
(15)Autophagy and Neurodegeneration   张宏   2014-10-12
(16)Different autophagy gene knockout mice show distinct neurodegenerative   张宏   2014-06-19
(17)Role of Arginine Methylation in Selective Autophagy   张宏   2014-03-18
(18)C. elegans - a genetic model for discovery of new Autophagy factors in metazoans   张宏   2012-03-15

指导学生

已指导学生

袁崇珍  博士研究生  071009-细胞生物学  

戚迪  博士研究生  071009-细胞生物学  

祁林祥  博士研究生  071009-细胞生物学  

张刚明  博士研究生  071009-细胞生物学  

姬翠翠  博士研究生  071009-细胞生物学  

李东方  博士研究生  071009-细胞生物学  

王赵玉  博士研究生  071009-细胞生物学  

陈迪  博士研究生  071009-细胞生物学  

张玉洁  博士研究生  071009-细胞生物学  

现指导学生

刘楠  博士研究生  071009-细胞生物学  

杜晓燕  博士研究生  071009-细胞生物学  

蔡晓琛  博士研究生  071009-细胞生物学  

赵鑫  博士研究生  071009-细胞生物学  

居辰  硕士研究生  071010-生物化学与分子生物学  

缑晓萌  硕士研究生  071009-细胞生物学  

彭康福  博士研究生  071009-细胞生物学  

杨春  硕士研究生  071006-神经生物学  

钟华健  博士研究生  071009-细胞生物学