081703-生物化工
071005-微生物学

生物化工，微生物代谢工程

2005-07--2010-07   山东大学微生物技术国家重点实验室   硕博士研究生
2000-09--2004-07   山东大学   学士

   

2020-08~现在, 中国科学院青岛生物能源与过程研究所, 系统微生物工程研究组组长
2017-07~2020-08,中国科学院青岛生物能源与过程研究所, 生物基材料组群-精细化学品研究组组长
2016-11~2017-07,中国科学院青岛生物能源与过程研究所, 创新组组长
2016-10~2016-11,美国麻省理工学院, 访问学者
2010-07~2016-10,中国科学院青岛生物能源与过程研究所, 助研/副研
2000-09~2004-07,山东大学国家糖工程中心, 研究助理

2022-02-01-2024-01-30,The Innovation, Youth Editor
2021-02-28-今,Frionter in Microbiology副主编,
2014-06-18-2016-06-18,《微生物前沿》编委,

   

（1） 中国科学院青年创新促进会优秀会员, 院级, 2021
（2） 闵恩泽能源化工青年进步奖, 一等奖, 部委级, 2017

[1] 张海波, 门潇, 刘红双, 王磊, 廖韦红. 一种编码大根香叶烯A合成酶的基因的应用. CN116121230A, 2023-05-16.
[2] 张海波, 王磊, 陈雪冬, 门潇, 廖韦红. 一种基于法尼烯发酵液原位合成维生素A的方法及其应用. CN: CN116375622A, 2023-07-04.
[3] 张海波, 陈国强, 赵晓琦, 刘丽娟. 一种基于开放式发酵的微生物耐盐多糖的制备工艺. 202210276843.9, 2022-03-15.
[4] 张海波, 陈国强, 门潇, 赵晓琦. 一种纳米银辅助开放式发酵生产细菌纤维素膜的方法. 202210263860.9, 2022-03-15.
[5] 张海波, 张鸽, 刘好宝, 邓帅军. 一株高地芽孢杆菌及其在产高稳定性碱性 果胶酶中的应用. CN114317364A, 2022-04-12.
[6] 张海波, 王帆, 张瑶, 金永明, 韩菊. 一种烟叶培养基及其制备以及直接发酵生产生物基化学品的方法. CN: CN115678919A, 2023-02-03.
[7] 张海波, 王帆, 金永明, 张瑶, 韩菊. 一种烟叶生物质直接液态发酵生产生物基化学品的方法. 202110845667.1, 2021-07-26.
[8] 张海波, 刘丽娟, 陈国强, 包文智, 曹小贺. 一种来源于肠杆菌的双向启动子及其应用. 202110843870.5, 2021-07-23.
[9] 张海波, 刘丽娟, 陈国强, 包文智, 赵晓琦. 一种同时生产生长素和2-苯乙醇的方法及其应用. 202110840917.2, 2021-07-23.
[10] 张海波, 刘丽娟, 陈国强, 包文智, 曹小贺. 一种来源于肠杆菌的双向启动子及其应用. CN: CN115678899A, 2023-02-03.
[11] 张海波, 刘丽娟, 陈国强, 包文智, 赵晓琦. 一种同时生产生长素和2-苯乙醇的方法及其应用. CN: CN115678921A, 2023-02-03.
[12] 张海波, 王纪明, 咸漠, 门潇, 刘丽娟, 王帆, 张鸽, 陈国强. 一种泰乐菌素降解菌及其筛选方法与应用. CN: CN111893059B, 2021-12-21.
[13] 张海波, 门潇, 咸漠, 刘晋锋. 一种高产法尼烯的基因工程菌及其构建方法与应用. CN: CN111607546A, 2020-09-01.
[14] 张海波, 门潇, 咸漠, 刘晋锋. 一种高产法尼烯的重组菌及其构建方法与应用. CN: CN111607545A, 2020-09-01.
[15] 张海波, 张鸽, 咸漠, 王帆, 陈国强, 门潇, 刘丽娟, 王纪明, 李兴, 李志豪. 一种利用特基拉芽孢杆菌固态发酵烟草废弃物产碱性果胶酶的方法. CN: CN113046341A, 2021-06-29.
[16] 张海波, 陈国强, 咸漠, 张鸽, 王帆, 门潇, 刘丽娟, 李兴, 王纪明, 徐镇祥. 一种利用烟草水解液生产2-苯乙醇的方法. CN: CN113046396A, 2021-06-29.
[17] 张海波, 刘好宝, 张鸽, 梁开朝, 李方友, 蔡斌, 向小华, 沈忠, 王娟, 李志豪, 陈国强. 一种雪茄外包皮烟叶保湿的方法. CN113040410A, 2021-06-29.
[18] 张海波, 刘好宝, 咸漠, 梁开朝, 辛玉华, 张鸽, 王帆, 陈国强, 沈忠, 王娟, 向小华. 一种雪茄茄芯烟叶的四段式发酵方法. CN: CN110693075A, 2020-01-17.
[19] 刘好宝, 张海波, 梁开朝, 张鸽, 咸漠, 辛玉华, 沈忠, 王娟, 向小华, 陈国强, 王帆. 一种降低雪茄烟叶堆垛过程中烧堆风险的两段式发酵方法. CN: CN110638087A, 2020-01-03.
[20] 咸漠, 刘丽娟, 张海波, 齐畅, 曹小贺. 一种转化纤维素水解液合成法尼烯的基因工程菌及其应用. CN: CN111378588A, 2020-07-07.
[21] 张海波, 刘丽娟, 咸漠, 齐畅, 曹小贺. 一种合成β-法尼烯的基因工程菌及其应用. CN: CN111378587A, 2020-07-07.
[22] 咸漠, 齐畅, 张海波, 刘丽娟, 曹小贺. 一种发酵生产β-法尼烯的玉米水解液培养基及其应用. CN: CN111378691A, 2020-07-07.
[23] 张海波, 咸漠, 刘长青, 门潇, 李美洁. 一种提高异戊二烯产量的基因工程菌及其构建方法与应用. CN: CN111363709A, 2020-07-03.
[24] 咸漠, 吴桐, 张海波, 张鸽, 李兴, 王帆. 一种具有桧烯高耐受能力的大肠杆菌基因工程菌及其构建方法与应用. CN: CN111321098A, 2020-06-23.
[25] 张海波, 王帆, 咸漠, 门潇, 张鸽, 陈国强, 石东祥. 一种烟叶醇化过程中微生物群落演替的分析方法. CN: CN111187850A, 2020-05-22.
[26] 张海波, 王帆, 咸漠, 石东祥, 门潇, 刘丽娟, 张鸽, 陈国强. 一种烟草废弃物的处理方法及其应用. CN: CN111185458A, 2020-05-22.
[27] 咸漠, 张海波, 陈国强. 一种产黑色素短梗霉在联产普鲁兰多糖和苯乙醇中的应用. CN: CN109321608A, 2019-02-12.
[28] 咸漠, 门潇, 张海波, 许子燕. 一种合成法尼烯的基因工程菌及其构建方法与应用. CN: CN110964678A, 2020-04-07.
[29] 咸漠, 门潇, 张海波, 许子燕. 一种二硝基甲苯磺酸钠降解菌及其筛选方法与应用. CN: CN110964652A, 2020-04-07.
[30] 张海波, 李美洁, 咸漠, 吴桐. 一种通过改变非限速酶的核糖体结合位点提高异戊二烯工程菌产量的方法. CN: CN109097384B, 2021-08-13.
[31] 咸漠, 李美洁, 张海波, 吴桐. 一种异戊二烯合酶和其编码基因、表达载体、工程菌以及生产异戊二烯的方法及应用. CN: CN109097378B, 2021-08-03.
[32] 咸漠, 张海波, 高铭鸿, 李娟, 郑家欢. 一种功能性细菌纤维素的制备方法. CN: CN108607607A, 2018-10-02.
[33] 咸漠, 王纪明, 张海波, 王帆, 刘会洲. 一种细胞表面展示有豆壳过氧化物酶的重组酵母菌及其构建方法与应用. CN: CN108085332A, 2018-05-29.
[34] 张海波, 咸漠, 张鸽, 王帆. 一株特基拉芽孢杆菌CAS-MEI-2-33及其应用. CN: CN109957522A, 2019-07-02.
[35] 咸漠, 王帆, 张海波, 门潇. 一种微球菌及其在生产2,3-丁二醇中的应用. CN: CN109797114A, 2019-05-24.
[36] 咸漠, 刘丽娟, 张海波, 黄世永. 一种合成桧烯的基因工程菌及其构建方法与应用. CN: CN109777745A, 2019-05-21.
[37] 张海波, 赵宏伟, 咸漠, 齐畅. 一种具有γ‑松油烯合成能力的基因工程菌及其构建方法与应用. CN: CN107354118A, 2017-11-17.
[38] 张海波, 王纪明, 咸漠, 赵宏伟, 高玉新, 刘会洲. 耐热β‑淀粉酶‑海藻糖合成酶融合酶、其表达基因以及分泌该融合酶的工程菌与应用. CN: CN107254459A, 2017-10-17.
[39] 咸漠, 张海波, 刘长青, 刘会洲, 刘炜, 徐鑫. 一种以生物质水解液为原料合成苯乙烯的基因工程菌及其构建方法与应用. CN: CN109136158A, 2019-01-04.
[40] 张海波, 王帆, 咸漠, 赵宏伟, 刘会洲. 一种利用宏基因组测序辅助筛选烟草发酵过程中微生物的方法. CN: CN109112067A, 2019-01-01.
[41] 咸漠, 张海波, 陈国强, 王纪明, 赵宏伟, 刘会洲, 徐鑫. 一种适宜在碱性条件下生产高分子、无色素普鲁兰多糖的菌株及其应用. CN: CN107760609A, 2018-03-06.
[42] 张海波, 咸漠, 陈国强, 王纪明, 赵宏伟, 刘会洲, 刘炜. 一种高效生产低分子普鲁兰多糖的诱变菌株及其应用. 中国: CN107760608A, 2018-03-06.
[43] 咸漠, 赵宏伟, 王纪明, 张海波. 一种纳米级细菌纤维素膜的制备方法及应用. CN: CN105821094A, 2016-08-03.
[44] 咸漠, 刘辉, 张海波, 邹慧斌. 一种采用细胞融合技术生产异戊二烯的方法及其构建的融合子. CN: CN103571820A, 2014-02-12.
[45] 咸漠, 张海波, 赵国明, 刘玉华. 一种采用高纤维素水解液耐受性大肠杆菌生产生物基化学品的方法. CN: CN103571773A, 2014-02-12.
[46] 咸漠, 张海波, 冯德鑫, 冯璐. 一种利用纤维素水解液合成生物基化学品的恶臭假单胞菌及其应用. CN: CN103571774A, 2014-02-12.
[47] 咸漠, 杨建明, 冯红茹, 张海波, 刘炜. 一种生物法合成α-或β-蒎烯的方法. CN: CN104120148A, 2014-10-29.
[48] 咸漠, 张海波, 刘炜, 周凤丽. 一种高性能类蛛丝蛋白材料及其生物合成方法. CN: CN103833838A, 2014-06-04.
[49] 咸漠, 张海波, 刘炜, 徐鑫. 筛选生产底物广泛性的腈水解酶的菌株的方法. CN: CN102690766A, 2012-09-26.
[50] 咸漠, 张海波, 刘炜. 一株以葡萄糖为碳源合成2-苯乙醇的肠杆菌. CN: CN103131645A, 2013-06-05.
[51] 咸漠, 曹玉锦, 赵国明, 张海波. 一种提高工程大肠杆菌间苯三酚合成能力的方法. CN: CN102787135A, 2012-11-21.
[52] 咸漠, 张英伟, 李良智, 孙长江, 赵国明, 高毅, 张海波. 一种生物催化1,3-二噁烷转化制备1,3-丙二醇的方法. CN: CN102586341A, 2012-07-18.
[53] 咸漠, 杨路, 杨建明, 张英伟, 张海波, 高毅. 一种制备异戊二烯的重组细胞及其制备方法. CN: CN102559769A, 2012-07-11.
[54] 咸漠, 张英伟, 张海波, 孙长江, 刘炜, 尹祖建. 一种可降解材料及制备方法和应用. CN: CN102336300A, 2012-02-01.

   

[1] The Innovation Life. 2023,   通讯作者  
[2] ACS Applied Materials & Interfaces. 2023,   通讯作者  
[3] Hongshuang Liu, Senbiao Fang, Lin Zhao, Xiao Men, Haibo Zhang. A Single Active-Site Mutagenesis Confers Enhanced Activity and/or Changed Product Distribution to a Pentalenene Synthase from Streptomyces sp. PSKA01. BIOENGINEERING[J]. 2023, 第 5 作者  通讯作者  10(392): https://doaj.org/article/2d7583e03fca4090989ad1c6b5c7b084.
[4] Zhang, Ge, Wang, Fan, Deng, Shuaijun, Chen, Guoqiang, Liu, Haobao, Zhang, Haibo. A pH-stable alkaline pectate lyase produced by the newly identified strain Bacillus altitudinis CAS-WZS-08. JOURNAL OF KING SAUD UNIVERSITY SCIENCE[J]. 2023, 第 6 作者  通讯作者  35(4): http://dx.doi.org/10.1016/j.jksus.2023.102649.
[5] Yang, Yajing, Chen, Guoqiang, Zhao, Xiaoqi, Cao, Xiaohe, Wang, Lei, Mu, Jingjiu, Qi, Fenghui, Liu, Lijuan, Zhang, Haibo. Structural Characterization, Antioxidant and Antitumor Activities of the Two Novel Exopolysaccharides Produced by Debaryomyces hansenii DH-1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, 第 9 作者24(1): http://dx.doi.org/10.3390/ijms24010335.
[6] Chen, Guoqiang, Liang, Xin, Men, Xiao, Liu, Lijuan, Wang, Fan, Bao, Xichang, Zhang, Haibo. Enhancing thermal conductivity and chemical protection of bacterial cellulose/silver nanowires thin-film for high flexible electronic skin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2023, 第 7 作者  通讯作者  229: 422-431, http://dx.doi.org/10.1016/j.ijbiomac.2022.12.325.
[7] 吴丽君, 张鸽, 陈晓娜, 张瑶, 金永明, 段如敏, 邓帅军, 白晓莉, 王帆, 张海波. 云南雪茄烟叶人工发酵过程中化学成分与细菌群落变化及其相关性分析. 中国烟草学报[J]. 2023, 第 10 作者29(4): 124-134, http://lib.cqvip.com/Qikan/Article/Detail?id=7110261719.
[8] International Journal of Biological Macromolecules. 2022,   通讯作者  
[9] Wenzhi Bao, Xing Li, Jinfeng Liu, Rong Zheng, Lijuan Liu, Haibo Zhang. The Characterization of an Efficient Phenylpyruvate Decarboxylase KDC4427, Involved in 2-Phenylethanol and IAA Production from Bacterial Enterobacter sp. CGMCC 5087. Microbiology Spectrum[J]. 2022, 第 6 作者  通讯作者  https://journals.asm.org/doi/epub/10.1128/spectrum.02660-21.
[10] Lijuan Liu, Wenzhi Bao, Xiao Men, Haibo Zhang. Engineering for life in toxicity: key to industrializing microbial synthesis of high energy density fuels. Engineering Microbiology[J]. 2022, 第 4 作者  通讯作者  2(2): 
[11] Wang, Fan, Jin, Yongming, Chen, Xiaona, Zhang, Yao, Jiang, Xinglin, Zhang, Ge, Chen, Guoqiang, Yang, Mingjun, Leng, Feifan, Li, Hongtao, Wu, Lijun, Zhang, Haibo. The diversity, structure and function of microbial communities changes across aging process of tobacco leaves. ENVIRONMENTAL RESEARCH COMMUNICATIONS[J]. 2022, 第 12 作者  通讯作者  4(9): http://dx.doi.org/10.1088/2515-7620/ac9352.
[12] Shuaijun Deng, Ge Zhang, OluwaseunOlayemi Aluko, Zhijie Mo, Jingjing Mao, Haibo Zhang, Xiaohui Liu, Ming Ma, Qian Wang, Haobao Liu. Bitter and astringent substances in green tea: composition, human perception mechanisms, evaluation methods and factors influencing their formation. Food Research International[J]. 2022, 第 6 作者  通讯作者  https://www.sciencedirect.com/science/article/pii/S0963996922003192.
[13] 李志豪, 张鸽, 貊志杰, 邓帅军, 李佳轶, 张海波, 刘晓晖, 刘好宝. 一株产木聚糖酶的蜡样芽孢杆菌对雪茄烟叶成分及发酵产物的影响. 生物技术通报[J]. 2022, 第 6 作者38(2): 105-112, http://lib.cqvip.com/Qikan/Article/Detail?id=7106696612.
[14] Xiaoqi Zhao, Guoqiang Chen, Fan Wang, Han Zhao, Yuxi Wei, Lijuan Liu, Haibo Zhang. Extraction, characterization, antioxidant activity and rheological behavior of a polysaccharide produced by the extremely salt tolerant Bacillus subtilis LR-1. LWT- Food Science and Technology[J]. 2022, 第 7 作者  通讯作者  https://www.sciencedirect.com/science/article/pii/S0023643822003486.
[15] Han, Ju, Wang, Fan, Li, Zhihao, Liu, Lijuan, Zhang, Ge, Chen, Guoqiang, Liu, Jing, Zhang, Haibo. Isolation and identification of an osmotolerant Bacillus amyloliquefaciens strain T4 for 2, 3-butanediol production with tobacco waste. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2021, 第 8 作者  通讯作者  http://dx.doi.org/10.1080/10826068.2021.1925912.
[16] 张鸽, 张海波, 李志豪, 邓帅军, 李东亮, 张良, 蔡斌, 王娟, 王帆, 陈国强, 张海波, 刘好宝. 海南H382雪茄烟叶不同发酵周期细菌群落多样性表征及演替分析. 中国烟草学报[J]. 2021, 第 2 作者
[17] 包文智, 李兴, 张海波, 峥嵘, 刘丽娟. rpoS基因在肠杆菌CGMCC 5087响应环境胁迫中的功能. 微生物学通报[J]. 2021, 第 3 作者48(1): 104-112, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb21010104?st=article_issue.
[18] Wang, Jiming, Wang, Chaoming, Men, Xiao, Yue, Tongqin, Madzak, Catherine, Xiang, Xiaohua, Xiang, Haiying, Zhang, Haibo. Construction of arming Yarrowia lipolytica surface-displaying soybean seed coat peroxidase for use as whole-cell biocatalyst. ENZYME AND MICROBIAL TECHNOLOGY[J]. 2020, 第 8 作者  通讯作者  135: http://dx.doi.org/10.1016/j.enzmictec.2019.109498.
[19] 徐镇祥, 李美洁, 门潇, 陈国强, 王纪明, 咸漠, 张海波. 甲羟戊酸途径的代谢支路调控策略的研究进展. 生物加工过程[J]. 2020, 第 7 作者18(1): 44-51, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C44YLTlOAiTRKibYlV5Vjs7i8oRR1PAr7RxjuAJk4dHXos_Ux283gQgLh0v1wOSGO9PtNOgOeBkGljO_jHHs3jDG&uniplatform=NZKPT.
[20] Fan Wang, Dongxiang Shi, Ju Han, Ge Zhang, Xinglin Jiang, Mingjun Yang, Zhenying Wu, Chunxiang Fu, Zhihao Li, Mo Xian, Haibo Zhang. Comparative Study on Pretreatment Processes for Different Utilization Purposes of Switchgrass. ACS OMEGA[J]. 2020, 第 11 作者  通讯作者  5(35): 21999-22007, https://www.webofscience.com/wos/woscc/full-record/WOS:000570009400003.
[21] Li, Meijie, Hou, Feifei, Wu, Tong, Jiang, Xinglin, Li, Fuli, Liu, Haobao, Xian, Mo, Zhang, Haibo. Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories. NATURAL PRODUCT REPORTS. 2020, 第 8 作者  通讯作者  37(1): 80-99, http://dx.doi.org/10.1039/c9np00016j.
[22] Jiang, Xinglin, Palazzotto, Emilia, Wybraniec, Ewa, Munro, Lachlan Jake, Zhang, Haibo, Kell, Douglas B, Weber, Tilmann, Lee, Sang Yup. Automating Cloning by Natural Transformation. ACS SYNTHETIC BIOLOGY[J]. 2020, 第 5 作者9(12): 3228-3235, http://dx.doi.org/10.1021/acssynbio.0c00240.
[23] Wu, Tong, Liu, Jinfeng, Li, Meijie, Zhang, Ge, Liu, Lijuan, Li, Xing, Men, Xiao, Xian, Mo, Zhang, Haibo. Improvement of sabinene tolerance of Escherichia coli using adaptive laboratory evolution and omics technologies. BIOTECHNOLOGY FOR BIOFUELS[J]. 2020, 第 9 作者  通讯作者  13(1): http://dx.doi.org/10.1186/s13068-020-01715-x.
[24] 霍明月, 张鸽, 苏玉龙, 李兴, 张海波, 峥嵘, 刘好宝. 一株耐受高浓度葡萄糖且产乙偶姻菌株的筛选及产物鉴定. 生物技术通报[J]. 2020, 第 5 作者36(8): 53-60, http://lib.cqvip.com/Qikan/Article/Detail?id=7102585427.
[25] 曹小贺, 张海波, 包文智, 刘丽娟, 夏海锋. 提高酿酒酵母异戊二烯产量的代谢途径的挖掘. 食品与发酵工业[J]. 2020, 第 2 作者46(12): 1-7, http://lib.cqvip.com/Qikan/Article/Detail?id=7102084068.
[26] Li, Meijie, Liu, Changqing, Yang, Jianming, Nian, Rui, Xian, Mo, Li, Fuli, Zhang, Haibo. Common problems associated with the microbial productions of aromatic compounds and corresponding metabolic engineering strategies. BIOTECHNOLOGY ADVANCES. 2020, 第 7 作者  通讯作者  41: http://dx.doi.org/10.1016/j.biotechadv.2020.107548.
[27] Li, Meijie, Xia, Qingqing, Zhang, Haibo, Zhang, Rubing, Yang, Jianming. Metabolic Engineering of Different Microbial Hosts for Lycopene Production. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2020, 第 3 作者68(48): 14104-14122, https://www.webofscience.com/wos/woscc/full-record/WOS:000596914400002.
[28] Chen, Hailin, Li, Meijie, Liu, Changqing, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Enhancement of the catalytic activity of Isopentenyl diphosphate isomerase (IDI) from Saccharomyces cerevisiae through random and site-directed mutagenesis (vol 17, 65, 2018). MICROBIAL CELL FACTORIES. 2020, 第 4 作者  通讯作者  19(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000513891500002.
[29] Zhang, Ge, Li, Shugui, Xu, Yingbo, Wang, Juan, Wang, Fan, Xin, Yuhua, Shen, Zhong, Zhang, Haibo, Ma, Ming, Liu, Haobao. Production of alkaline pectinase: a case study investigating the use of tobacco stalk with the newly isolated strain Bacillus tequilensis CAS-MEI-2-33. BMC BIOTECHNOLOGY[J]. 2019, 第 8 作者19(1): http://dx.doi.org/10.1186/s12896-019-0526-6.
[30] Chen, Guoqiang, Zhu, Youshuang, Zhang, Ge, Liu, Haobao, Wei, Yuxi, Wang, Pinggui, Wang, Fan, Xian, Mo, Xiang, Haiying, Zhang, Haibo. Optimization and characterization of pullulan production by a newly isolated high-yielding strain Aureobasidium melanogenum. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2019, 第 10 作者  通讯作者  49(6): 557-566, http://dx.doi.org/10.1080/10826068.2019.1591988.
[31] Li, Meijie, Chen, Hailin, Liu, Changqing, Guo, Jing, Xu, Xin, Zhang, Haibo, Nian, Rui, Xian, Mo. Improvement of isoprene production in Escherichia coli by rational optimization of RBSs and key enzymes screening. MICROBIAL CELL FACTORIES[J]. 2019, 第 6 作者  通讯作者  18(1): https://doaj.org/article/4f969fc6f48c41c1bbf7471931db4726.
[32] Xu, Zhenxiang, Chen, Guoqiang, Xue, Le, Zhang, Haibo, Wang, Jiming, Xiang, Haiying, Li, Jinglong, Zheng, Kai. Isolation, structural characterizations and bioactivities of exopolysaccharides produced by Bacillus licheniformis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 第 4 作者141: 298-306, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000506713000031.
[33] Chen, Hailin, Liu, Changqing, Li, Meijie, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Directed evolution of mevalonate kinase in Escherichia coli by random mutagenesis for improved lycopene (vol 8, pg 15021, 2018). RSC ADVANCES. 2019, 第 4 作者  通讯作者  9(16): 8934-8934, 
[34] 王娟, 王帆, 张鸽, 辛玉华, 张海波, 刘好宝. 烤烟烟叶淀粉含量5种测定方法的比较. 分子植物育种[J]. 2019, 第 5 作者1673-1678, http://lib.cqvip.com/Qikan/Article/Detail?id=70909087504849574853485157.
[35] Li, Meijie, Liu, Changqing, Chen, Hailin, Deng, Li, Zhang, Haibo, Nian, Rui, Xian, Mo. Biochemical characterization of isoprene synthase from Ipomoea batatas. JOURNAL OF BIOSCIENCE AND BIOENGINEERING[J]. 2019, 第 5 作者127(2): 138-144, http://dx.doi.org/10.1016/j.jbiosc.2018.07.022.
[36] Minghong Gao, Juan Li, Zixian Bao, Moudong Hu, Rui Nian, Dexin Feng, Dong An, Xing Li, Mo Xian, Haibo Zhang. A natural in situ fabrication method of functional bacterial cellulose using a microorganism. NATURE COMMUNICATIONS[J]. 2019, 第 10 作者  通讯作者  10(1): 1-10, https://doaj.org/article/dbc7ea057c2c457da85dd2bdb225985e.
[37] 张鸽, 梁开朝, 辛玉华, 王娟, 李书贵, 李爱军, 王帆, 张海波, 刘好宝. 基于高通量测序和传统分离研究雪茄外包皮表面细菌多样性及演替. 应用与环境生物学报[J]. 2018, 第 8 作者24(4): 783-788, http://lib.cqvip.com/Qikan/Article/Detail?id=676217420.
[38] Wang, Fan, Zhao, Hongwei, Xiang, Haiying, Wu, Lijun, Men, Xiao, Qi, Chang, Chen, Guoqiang, Zhang, Haibo, Wang, Yi, Xian, Mo. Species Diversity and Functional Prediction of Surface Bacterial Communities on Aging Flue-Cured Tobaccos. CURRENT MICROBIOLOGY[J]. 2018, 第 8 作者  通讯作者  75(10): 1306-1315, http://ir.qibebt.ac.cn/handle/337004/12208.
[39] Chen, Hailin, Liu, Changqing, Li, Meijie, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Directed evolution of mevalonate kinase in Escherichia coli by random mutagenesis for improved lycopene. RSC ADVANCES[J]. 2018, 第 4 作者  通讯作者  8(27): 15021-15028, http://www.irgrid.ac.cn/handle/1471x/1782359.
[40] Xiao Men, Fan Wang, GuoQiang Chen, HaiBo Zhang, Mo Xian. Biosynthesis of Natural Rubber: Current State and Perspectives. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2018, 第 4 作者20(1): https://doaj.org/article/ca1489dc6ecd461da1b19c7de85001e1.
[41] Liu, Changqing, Men, Xiao, Chen, Hailin, Li, Meijie, Ding, Zhaorui, Chen, Guoqiang, Wang, Fan, Liu, Haobao, Wang, Qian, Zhu, Youshuang, Zhang, Haibo, Xian, Mo. A systematic optimization of styrene biosynthesis in Escherichia coli BL21(DE3). BIOTECHNOLOGY FOR BIOFUELS[J]. 2018, 第 11 作者  通讯作者  11(1): https://doaj.org/article/7f539cc8ae6643f685ce446674b963ae.
[42] Chen, Hailin, Li, Meijie, Liu, Changqing, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Enhancement of the catalytic activity of Isopentenyl diphosphate isomerase (IDI) from Saccharomyces cerevisiae through random and site-directed mutagenesis. MICROBIAL CELL FACTORIES[J]. 2018, 第 4 作者  通讯作者  17(1): http://www.irgrid.ac.cn/handle/1471x/1782354.
[43] Zhao, Hongwei, Xia, Jian, Wang, Jiming, Yan, Xiaofei, Wang, Cong, Lei, Tingzhou, Xian, Mo, Zhang, Haibo. Production of bacterial cellulose using polysaccharide fermentation wastewater as inexpensive nutrient sources. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT[J]. 2018, 第 8 作者  通讯作者  32(2): 350-356, http://www.irgrid.ac.cn/handle/1471x/1755519.
[44] Qi, Chang, Zhao, Hongwei, Li, Wenyang, Li, Xing, Xiang, Haiying, Zhang, Ge, Liu, Haobao, Wang, Qian, Wang, Yi, Xian, Mo, Zhang, Haibo. Production of gamma-terpinene by metabolically engineered Escherichia coli using glycerol as feedstock. RSC ADVANCES[J]. 2018, 第 11 作者  通讯作者  8(54): 30851-30859, https://www.webofscience.com/wos/woscc/full-record/WOS:000444700500026.
[45] Li, Meijie, Nian, Rui, Xian, Mo, Zhang, Haibo. Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 第 4 作者  通讯作者  102(18): 7725-7738, http://ir.qibebt.ac.cn/handle/337004/11890.
[46] 张鸽, 梁开朝, 辛玉华, 王娟, 李书贵, 王帆, 张海波, 刘好宝. 四个国家雪茄外包皮烟叶表面细菌分离与活性测定. 中国烟草科学[J]. 2018, 第 7 作者39(2): 82-88, http://lib.cqvip.com/Qikan/Article/Detail?id=7000645625.
[47] Liu, Changqing, Zhang, Kai, Cao, Wenyan, Zhang, Ge, Chen, Guoqiang, Yang, Haiyan, Wang, Qian, Liu, Haobao, Xian, Mo, Zhang, Haibo. Genome mining of 2-phenylethanol biosynthetic genes from Enterobacter sp CGMCC 5087 and heterologous overproduction in Escherichia coli. BIOTECHNOLOGY FOR BIOFUELS[J]. 2018, 第 10 作者  通讯作者  11(1): http://ir.qibebt.ac.cn/handle/337004/10998.
[48] Wang, Fan, Men, Xiao, Zhang, Ge, Liang, Kaichao, Xin, Yuhua, Wang, Juan, Li, Aijun, Zhang, Haibo, Liu, Haobao, Wu, Lijun. Assessment of 16S rRNA gene primers for studying bacterial community structure and function of aging flue-cured tobaccos. AMB EXPRESS[J]. 2018, 第 8 作者  通讯作者  8(1): http://ir.qibebt.ac.cn/handle/337004/11013.
[49] 吴丽君, 梁开朝, 王帆, 高锐, 王毅, 段如敏, 刘好宝, 张海波, 白晓莉. 增香细菌HD-7的鉴定及香气成分分析. 天然产物研究与开发[J]. 2018, 第 8 作者30(2): 246-250, http://lib.cqvip.com/Qikan/Article/Detail?id=7000474822.
[50] Cao, Yujin, Zhang, Haibo, Liu, Hui, Liu, Wei, Zhang, Rubing, Xian, Mo, Liu, Huizhou. Biosynthesis and production of sabinene: current state and perspectives. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 第 2 作者102(4): 1535-1544, 
[51] Liu, Changqing, Zheng, Kai, Xu, Ying, Stephen, Lacmata Tamekou, Wang, Jiming, Zhao, Hongwei, Yue, Tongqing, Nian, Rui, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Expression and characterization of soybean seed coat peroxidase in Escherichia coli BL21(DE3). PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2017, 第 9 作者  通讯作者  47(8): 768-775, http://www.irgrid.ac.cn/handle/1471x/1755786.
[52] Liu, Hui, Cheng, Tao, Zou, Huibin, Zhang, Haibo, Xu, Xin, Sun, Chao, Aboulnaga, Elhussiny, Cheng, Zhongkai, Zhao, Guang, Xian, Mo. High titer mevalonate fermentation and its feeding as a building block for isoprenoids (isoprene and sabinene) production in engineered Escherichia coli. PROCESS BIOCHEMISTRY[J]. 2017, 第 4 作者62: 1-9, http://dx.doi.org/10.1016/j.procbio.2017.07.021.
[53] Chen, Guoqiang, Wang, Jiming, Su, Yulong, Zhu, Youshuang, Zhang, Ge, Zhao, Hongwei, Liu, Haobao, Yang, Ying, Nian, Rui, Zhang, Haibo, Wei, Yuxi, Xian, Mo. Pullulan production from synthetic medium by a new mutant of Aureobasidium pullulans. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2017, 第 10 作者  通讯作者  47(10): 963-969, https://www.webofscience.com/wos/woscc/full-record/WOS:000418064000003.
[54] Zhao, Hongwei, Li, Jingyuan, Wang, Jiming, Xu, Xin, Xian, Mo, Liu, Huizhou, Zhang, Haibo. Calcium Supplementation Abates the Inhibition Effects of Acetic Acid on Saccharomyces cerevisiae. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY[J]. 2017, 第 7 作者  通讯作者  181(4): 1573-1589, http://ir.qibebt.ac.cn/handle/337004/9290.
[55] Zhao Hongwei, Li Jingyuan, Wang Jiming, Xu Xin, Xian Mo, Liu Huizhou, Zhang Haibo. Calcium Supplementation Abates the Inhibition Effects of Acetic Acid on Saccharomyces cerevisiae. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY[J]. 2017, 第 7 作者
[56] 陈泉, 卓燕玲, 许爱娜, 咸漠, 彭馨莹, 杨元生, 张海波, 年锐, 张巍, , , , , , , , , , . 蛋白A亲和层析法纯化单克隆抗体工艺的优化. 生物工程学报[J]. 2016, 第 7 作者32(6): 1−12, https://cjb.ijournals.cn/cjbcn/article/abstract/gc16060807?st=article_issue.
[57] Li, QianZhu, Jiang, XingLin, Feng, XinJun, Wang, JiMing, Sun, Chao, Zhang, HaiBo, Xian, Mo, Liu, HuiZhou. Recovery Processes of Organic Acids from Fermentation Broths in the Biomass-Based Industry. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 第 6 作者  通讯作者  26(1): 1-8, http://dx.doi.org/10.4014/jmb.1505.05049.
[58] Chen, Quan, Toh, Phyllicia, Sun, Yue, Latiff, Sarah Maria Abdul, Hoi, Aina, Xian, Mo, Zhang, Haibo, Nian, Rui, Zhang, Wei, Gagnon, Pete. Histone-dependent IgG conservation in octanoic acid precipitation and its mechanism. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 第 7 作者100(23): 9933-9941, http://dx.doi.org/10.1007/s00253-016-7719-x.
[59] Zheng, Yanning, Li, Lingling, Liu, Qiang, Zhang, Haibo, Cao, Yujin, Xian, Mo, Liu, Huizhou. High-specificity synthesis of novel monomers by remodeled alcohol hydroxylase. BMC BIOTECHNOLOGY[J]. 2016, 第 4 作者16(1): http://ir.qibebt.ac.cn/handle/337004/8498.
[60] Zhang, Haibo, Zhou, Fengli, Jiang, Xinglin, Cao, Mingle, Wang, Shilu, Zou, Huibin, Cao, Yujin, Xian, Mo, Liu, Huizhou. Microbial production of amino acid-modified spider dragline silk protein with intensively improved mechanical properties. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2016, 第 1 作者46(6): 552-558, http://www.irgrid.ac.cn/handle/1471x/1110004.
[61] Chen, Dawei, Liang, Fengbing, Feng, Dexin, Xian, Mo, Zhang, Haibo, Liu, Huizhou, Du, Fanglin. An efficient route from reproducible glucose to 5-hydroxymethylfurfural catalyzed by porous coordination polymer heterogeneous catalysts. CHEMICAL ENGINEERING JOURNAL[J]. 2016, 第 5 作者300: 177-184, http://dx.doi.org/10.1016/j.cej.2016.04.039.
[62] Chen, Quan, Latiff, Sarah Maria Abdul, Toh, Phyllicia, Peng, Xinying, Hoi, Aina, Xian, Mo, Zhang, Haibo, Nian, Rui, Zhang, Wei, Gagnon, Pete. A simple and efficient purification platform for monoclonal antibody production based on chromatin-directed cell culture clarification integrated with precipitation and void-exclusion anion exchange chromatography. JOURNAL OF BIOTECHNOLOGY[J]. 2016, 第 7 作者236: 128-140, http://dx.doi.org/10.1016/j.jbiotec.2016.08.014.
[63] Sun, Weizhi, Liu, Yaojie, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Biomimetic Nitration of Phenols Using Metalloporphyrins/H2O2/NO2 (-). CATALYSIS LETTERS[J]. 2015, 第 3 作者145(11): 1991-1999, http://www.irgrid.ac.cn/handle/1471x/1001164.
[64] Feng, Xinjun, Xian, Mo, Liu, Wei, Xu, Chao, Zhang, Haibo, Zhao, Guang. Biosynthesis of poly(3-hydroxypropionate) from glycerol using engineered Klebsiella pneumoniae strain without vitamin B-12. BIOENGINEERED[J]. 2015, 第 5 作者6(2): 77-81, http://ir.qibebt.ac.cn/handle/337004/8603.
[65] Zhang, H., Liu, Q., Cao, Y., Feng, X., Zheng, Y., Zou, H., Xian, M.. Microbial production of sabinene--a new terpene-based precursor of advanced biofuel. MICROB CELL FACT[J]. 2014, 13(20): 1, http://ir.qibebt.ac.cn/handle/337004/8754.
[66] 张海波. Non-mediated oxidation of non-phenol dye methyl red with purified laccase from Trametes hirsuta lg-9. Journal of Pure and Applied Microbiology. 2014, 第 1 作者
[67] Zhang, Haibo, Cao, Mingle, Jiang, Xinglin, Zou, Huibin, Wang, Cong, Xu, Xin, Xian, Mo. De-novo synthesis of 2-phenylethanol by Enterobacter sp CGMCC 5087. BMC BIOTECHNOLOGY[J]. 2014, 第 1 作者14(1): http://ir.qibebt.ac.cn/handle/337004/12561.
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[69] Cao, Yujin, Liu, Wei, Xu, Xin, Zhang, Haibo, Wang, Jiming, Xian, Mo. Production of free monounsaturated fatty acids by metabolically engineered Escherichia coli. BIOTECHNOLOGY FOR BIOFUELS[J]. 2014, 第 4 作者7(1): http://ir.qibebt.ac.cn/handle/337004/6298.
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[73] Yang, Jianming, Nie, Qingjuan, Ren, Meng, Feng, Hongru, Jiang, Xinglin, Zheng, Yanning, Liu, Min, Zhang, Haibo, Xian, Mo. Metabolic engineering of Escherichia coli for the biosynthesis of alpha-pinene. BIOTECHNOLOGY FOR BIOFUELS[J]. 2013, 第 8 作者  通讯作者  6(1): 60-60, http://www.irgrid.ac.cn/handle/1471x/830135.
[74] 王纪明, 刘炜, 徐鑫, 张海波, 咸漠, , , , , , . 工程大肠杆菌生产高附加值有机酸、醇研究进展. 生物工程学报[J]. 2013, 第 4 作者29(10): 1, https://cjb.ijournals.cn/cjbcn/article/abstract/gc13001363?st=article_issue.
[75] Cao, Yujin, Xian, Mo, Zou, Huibin, Zhang, Haibo. Metabolic Engineering of Escherichia coli for the Production of Xylonate. PLOS ONE[J]. 2013, 第 4 作者8(7): http://www.irgrid.ac.cn/handle/1471x/830128.
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（ 1 ） 海南雪茄特色发酵, 负责人, 地方任务, 2017-06--2020-12
（ 2 ） 泰山学者青年专家, 负责人, 地方任务, 2020-01--2024-12
（ 3 ） 微生物合成技术, 负责人, 地方任务, 2021-01--2023-12
（ 4 ） Enterobacter sp. CGMCC 5087时序合成苯乙醇与吲哚乙酸调控因子的挖掘与调控机制解析, 负责人, 国家任务, 2022-01--2025-12
（ 5 ） 青促会优秀, 负责人, 中国科学院计划, 2022-01--2024-12

已指导学生

韩雪萍  硕士研究生  085238-生物工程  

吴桐  硕士研究生  085238-生物工程  

刘长青  硕士研究生  085238-生物工程  

韩菊  硕士研究生  081703-生物化工  

张鸽  博士研究生  081703-生物化工  

王帆  博士研究生  081703-生物化工  

陈国强  博士研究生  081703-生物化工  

现指导学生

严逸海  硕士研究生  086000-生物与医药  

戴海玲  硕士研究生  086000-生物与医药  

张晓  硕士研究生  086000-生物与医药  

张睿敏  硕士研究生  071005-微生物学  

邓帅军  博士研究生  071005-微生物学