基本信息
张国芳      中国科学院深圳先进技术研究院
电子邮件: gf.zhang@siat.ac.cn
通信地址: 广东省深圳市南山区学苑大道1068号
邮政编码:

研究领域

纳米生物学,纳米医学

招生信息

   
招生专业
071010-生物化学与分子生物学
0703Z1-化学生物学
071009-细胞生物学
招生方向
纳米生物学,纳米医学
纳米医学,纳米免疫安全性
肿瘤免疫学,免疫检查点肿瘤治疗

教育背景

2010-09--2018-12   河北师范大学   博士

工作经历

   
工作简历
2023-01~现在, 中国科学院深圳先进技术研究院, 副研究员
2021-06~2022-12,中国科学院深圳先进技术研究院, 助理研究员
2019-01~2021-06,中国科学院深圳先进技术研究院, 博士后

发表论文

(1) A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination, Nature Nanotechnology, 2022, 第 1 作者

(2) Trojan Horse Effect of Biologically Aged Microplastics-An Intracellular Carrier of LPS for Licensing Noncanonical Inflammasome Activation. , Environmental Science & Technology, 2026, 共同通讯作者

(3) Amino Acid Residue-Driven Nanoparticle Targeting of Protein Cavities: Surface Chemistry Dictates Binding Specificity beyond Size Complementarity. , Journal of the American Chemical Society, 2026, 第 2 作者。共同一作

(4)Target Binding of Black Phosphorus Nanomaterial to Polo‐Like Kinase 1 for Cancer Chemotherapy: A Mutual Selection of Nanomaterial and Protein. Exploration, 2025, 20240143。共同通讯

(5) Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2, NANO TODAY, 2024, 第 1 作者

(6) ZIF-67-Derived Antivirus Cobalt Hydroxide LDH Nanosheets Produced through High-Concentration Cobalt Ion-Assisted Hydration, ADVANCED FUNCTIONAL MATERIALS, 2024, 第 2 作者。共同一作

(7)Nano-assemblies overcome cancer multidrug resistance for effectively synergistic chemo-immuno-oncotherapy. Chemical Engineering Journal, 2024 490(20):151437. 共同一作

(8) The importance of the IL-1 family of cytokines in nanoimmunosafety and nanotoxicology, WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2022, 第 1 作者

(9) Formation of a β -Endorphin Corona Mitigates Alzheimer's Amyloidogenesis, SMALL, 2025, 第 3 作者,共同一作

(10)Microplastics interact with SARS-CoV-2 and facilitate host cell infection, ENVIRONMENTAL SCIENCE-NANO, 2022, 第 1 作者

(11) Reinforce the Combinational Immuno-Oncotherapy of Switching "Cold" Tumor to "Hot" by Responsive Penetrating Nanogels, ACS Applied Materials and Interfaces, 2021, 第 2 作者 共同一作

(12)Tea Polyphenol Coordinated with Nanoparticles of ZIF-8 and Coated with Polydopamine and PEG for Immuno-Oncotherapy, ACS Applied Nano Materials, 2023, 第 10 作者 共同通讯作者

(13) Biocorona modulates the inflammatory response induced by gold nanoparticles in human epidermal keratinocytes, TOXICOLOGY LETTERS, 第 3 作者 共同通讯作者

(14)The Synergistic Strategies for the Immuno-Oncotherapy with Photothermal Nanoagents. WIREs Nanomedicine & Nanobiotechnology. 2021, e1717。 共同一作

(15)Designing Nanoparticles to Minimize Unintended Inflammatory Responses: A Step toward Safer and More Effective Precision Nanomedicine. Nanomedicine, 2025,20 (11), 1213-1217.。共同通讯

(16) Modulation of the inflammatory tumor microenvironment: a new approach for photothermal-synergized cancer immunotherapy, NANOMEDICINE, 2019, 第 2 作者

(17) AFM-Based Deep Learning Decodes Human Macrophage Mechanophenotypes, SMALL METHODS, 2025, 第 14 作者

(18) Strengthening the Combinational Immunotherapy from Modulating the Tumor Inflammatory Environment via Hypoxia-Responsive Nanogels, ADVANCED HEALTHCARE MATERIALS, 2024, 第 10 作者

(19) Antisenescence ZIF-8/Resveratrol Nanoformulation with Potential for Enhancement of Bone Fracture Healing in the Elderly, ACS BIOMATERIALS SCIENCE & ENGINEERING, 2023, 第 4 作者

(20) Tailoring multivalent nanomedicines for monkeypox, NANO TODAY, 2023, 第 2 作者

(21) The synergistic strategies for the immuno-oncotherapy with photothermal nanoagents, WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2021, 第 2 作者

科研项目

1. 国家重点研发计划政府间重点专项项目,诱导天然免疫记忆用于治疗和预防感染性疾病的纳米药物研究,200万,2026.03-2028.02,主持。

2. 国家自然科学基金,青年科学基金项目,金属有机框架纳米材料ZIF-8的免疫毒理学效应与机制研究,32201154,30万,2023-2025,主持,结题。

3. 广东省自然科学基金,面上项目,新型纳米佐剂研发及其抗肿瘤应用,15万,2024-2026,主持,在研。