基本信息

于寅 男 博导 中国科学院深圳先进技术研究院
电子邮件: yin.yu@siat.ac.cn
通信地址: 中国科学院深圳先进技术研究院F1204 深圳市南山区西丽大学城学苑大道1068号 邮编 518055
邮政编码:
电子邮件: yin.yu@siat.ac.cn
通信地址: 中国科学院深圳先进技术研究院F1204 深圳市南山区西丽大学城学苑大道1068号 邮编 518055
邮政编码:
研究领域
生物材料,药物递送,合成生物学,再生医学,细胞与基因治疗
招生信息
招生专业
071009-细胞生物学
招生方向
合成生物学,再生医学,生物材料,组织工程
教育背景
2010-08--2015-05 美国爱荷华大学 博士
2005-09--2010-07 南通大学医学院 学士
2005-09--2010-07 南通大学医学院 学士
学历
工作经历
工作简历
2015-09~2017-12,哈佛大学医学院, 博士后研究员
专利与奖励
奖励信息
(1) 深圳市自然科学奖, 二等奖, 市地级, 2023
(2) Young Investigator Award, OARSI (Osteoarthritis Research Society International) World Congress, 一等奖, 其他, 2015
(2) Young Investigator Award, OARSI (Osteoarthritis Research Society International) World Congress, 一等奖, 其他, 2015
专利成果
( 1 ) 载药微凝胶球、载药支架及其制备方法, 发明专利, 2022, 第 1 作者, 专利号: ZL 2022 1 0640868.2
( 2 ) 一种有限自我复制mRNA分子系统、制备方法及应用, 发明专利, 2021, 第 2 作者, 专利号: ZL202111080355. 2
( 3 ) 一种钙通道抑制剂氧海罂粟碱在骨关节炎中的应用, 发明专利, 2020, 第 2 作者, 专利号: ZL202010664513. 8
( 4 ) 转基因猪的培育方法和应用, 发明专利, 2018, 第 2 作者, 专利号: ZL201810150399.X
( 5 ) 生物凝胶制剂、其制备方法及应用, 发明专利, 2022, 第 1 作者, 专利号: 202210395313.6
( 6 ) 重编程因子抗衰老mRNA组合物、制备方法及应用, 发明专利, 2023, 第 2 作者, 专利号: 202310344412.6
( 7 ) 重编程因子抗衰老表达系统、生物材料及用途, 发明专利, 2023, 第 2 作者, 专利号: 202310401321.1
( 8 ) 一种编码表皮生长因子的化学修饰mRNA及其构建方法和应用, 发明专利, 2023, 第 2 作者, 专利号: 202310828267.9
( 9 ) 过继性免疫细胞、其制备方法及应用, 发明专利, 2023, 第 2 作者, 专利号: 202311027930.1
( 10 ) 皮肤重编程因子制剂在制备促皮肤伤口愈合药物中的用途, 发明专利, 2023, 第 2 作者, 专利号: 202311027063.1
( 11 ) 重编程因子制剂、生物材料及用途, 发明专利, 2023, 第 2 作者, 专利号: 202311178612.5
( 12 ) 一种嵌合抗原受体纳米复合物及其制备方法和在制备抗衰老药物中的应用, 发明专利, 2024, 第 2 作者, 专利号: 202410297300.4
( 13 ) 双硫仑药物在治疗骨关节炎中的应用, 发明专利, 2022, 第 1 作者, 专利号: 202210640855.5
( 14 ) Bioprinter and Methods of using Same, 发明专利, 2024, 第 3 作者, 专利号: US11903612B2
( 15 ) Methods for the regeneration of articular cartilage in vivo, 发明专利, 2018, 第 2 作者, 专利号: US20180000736A1
( 2 ) 一种有限自我复制mRNA分子系统、制备方法及应用, 发明专利, 2021, 第 2 作者, 专利号: ZL202111080355. 2
( 3 ) 一种钙通道抑制剂氧海罂粟碱在骨关节炎中的应用, 发明专利, 2020, 第 2 作者, 专利号: ZL202010664513. 8
( 4 ) 转基因猪的培育方法和应用, 发明专利, 2018, 第 2 作者, 专利号: ZL201810150399.X
( 5 ) 生物凝胶制剂、其制备方法及应用, 发明专利, 2022, 第 1 作者, 专利号: 202210395313.6
( 6 ) 重编程因子抗衰老mRNA组合物、制备方法及应用, 发明专利, 2023, 第 2 作者, 专利号: 202310344412.6
( 7 ) 重编程因子抗衰老表达系统、生物材料及用途, 发明专利, 2023, 第 2 作者, 专利号: 202310401321.1
( 8 ) 一种编码表皮生长因子的化学修饰mRNA及其构建方法和应用, 发明专利, 2023, 第 2 作者, 专利号: 202310828267.9
( 9 ) 过继性免疫细胞、其制备方法及应用, 发明专利, 2023, 第 2 作者, 专利号: 202311027930.1
( 10 ) 皮肤重编程因子制剂在制备促皮肤伤口愈合药物中的用途, 发明专利, 2023, 第 2 作者, 专利号: 202311027063.1
( 11 ) 重编程因子制剂、生物材料及用途, 发明专利, 2023, 第 2 作者, 专利号: 202311178612.5
( 12 ) 一种嵌合抗原受体纳米复合物及其制备方法和在制备抗衰老药物中的应用, 发明专利, 2024, 第 2 作者, 专利号: 202410297300.4
( 13 ) 双硫仑药物在治疗骨关节炎中的应用, 发明专利, 2022, 第 1 作者, 专利号: 202210640855.5
( 14 ) Bioprinter and Methods of using Same, 发明专利, 2024, 第 3 作者, 专利号: US11903612B2
( 15 ) Methods for the regeneration of articular cartilage in vivo, 发明专利, 2018, 第 2 作者, 专利号: US20180000736A1
出版信息
发表论文
[1] Bioactive Materials. 2023, 通讯作者
[2] Molecular Pharmaceutics. 2023, 通讯作者
[3] Macromolecular Bioscience. 2023, 通讯作者
[4] Macromolecular Bioscience. 2022, 通讯作者
[5] Biomaterials. 2022, 通讯作者
[6] Wu, Yang, Kennedy, Patrick, Bonazza, Nicholas, Yu, Yin, Dhawan, Aman, Ozbolat, Ibrahim. Three-Dimensional Bioprinting of Articular Cartilage: A Systematic Review. CARTILAGE. 2021, 第 4 作者12(1): 76-92, http://dx.doi.org/10.1177/1947603518809410.
[7] Zhong, Gang, Long, Huiping, Chen, Fei, Yu, Yin. Oxoglaucine mediates Ca2+ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/calmodulin/CAMK-II pathway. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2021, 第 4 作者 通讯作者 178(15): 2931-2947, http://dx.doi.org/10.1111/bph.15466.
[8] Zhong, Gang, Yao, Jun, Huang, Xing, Luo, Yixuan, Wang, Meng, Han, Jinyu, Chen, Fei, Yu, Yin. Injectable ECM hydrogel for delivery of BMSCs enabled full-thickness meniscus repair in an orthotopic rat model. BIOACTIVE MATERIALS[J]. 2020, 第 8 作者 通讯作者 5(4): 871-879, http://lib.cqvip.com/Qikan/Article/Detail?id=7103847767.
[9] Meng Wang, Yixuan Luo, Yin Yu, Fei Chen. Bioengineering Approaches to Accelerate Clinical Translation of Stem Cell Therapies Treating Osteochondral Diseases. STEMCELLSINTERNATIONAL[J]. 2020, 第 3 作者 通讯作者 2020: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775142/.
[10] 陈飞, 钟超, 孙飞, 于寅. 合成生物学在生物材料科学中的应用及展望. 生物产业技术[J]. 2019, 第 4 作者5-12, http://lib.cqvip.com/Qikan/Article/Detail?id=7001298258.
[11] Huang, Haishui, Yu, Yin, Hu, Yong, He, Xiaoming, Usta, O Berk, Yarmush, Martin L. Generation and manipulation of hydrogel microcapsules by droplet-based microfluidics for mammalian cell culture. LAB ON A CHIP. 2017, 第 2 作者17(11): 1913-1932, http://dx.doi.org/10.1039/c7lc00262a.
[12] Yu, Yin, Moncal, Kazim K, Li, Jianqiang, Peng, Weijie, Rivero, Iris, Martin, James A, Ozbolat, Ibrahim T. Three-dimensional bioprinting using self-assembling scalable scaffold-free "tissue strands" as a new bioink. SCIENTIFIC REPORTS[J]. 2016, 第 1 作者6: https://www.webofscience.com/wos/woscc/full-record/WOS:000378502400001.
[13] Akkouch, Adil, Yu, Yin, Ozbolat, Ibrahim T. Microfabrication of scaffold-free tissue strands for three-dimensional tissue engineering. BIOFABRICATION[J]. 2015, 第 2 作者7(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000366460800002.
[14] Yu, Y, Seol, D, Marc, B, Zheng, H, Buckwalter, J, Martin, J. RECRUITMENT OF ENDOGENOUS CHONDROGENIC PROGENITOR CELLS FOR ARTICULAR CARTILAGE REPAIR. OSTEOARTHRITIS AND CARTILAGE. 2015, 23: A40-A41, http://dx.doi.org/10.1016/j.joca.2015.02.092.
[15] 于寅. Functional full-thickness articular cartilage repair by rhSDF-1alpha loaded fibrin/ha hydrogel network via chondrogenic progenitor cells homing. Arthritis Rheumatology. 2015, 第 1 作者
[16] Zhang, Yahui, Yu, Yin, Akkouch, Adil, Dababneh, Amer, Dolati, Farzaneh, Ozbolat, Ibrahim T. In vitro study of directly bioprinted perfusable vasculature conduits. BIOMATERIALS SCIENCE[J]. 2015, 第 2 作者3(1): 134-143, https://www.webofscience.com/wos/woscc/full-record/WOS:000345908400014.
[17] Seol, Dongrim, Yu, Yin, Choe, Hyeonghun, Jang, Keewoong, Brouillette, Marc J, Zheng, Hongjun, Lim, TaeHong, Buckwalter, Joseph A, Martin, James A. Effect of Short-Term Enzymatic Treatment on Cell Migration and Cartilage Regeneration: In Vitro Organ Culture of Bovine Articular Cartilage. TISSUE ENGINEERING PART A[J]. 2014, 第 2 作者20(13-14): 1807-1814, https://www.webofscience.com/wos/woscc/full-record/WOS:000339171900004.
[18] Dolati, Farzaneh, Yu, Yin, Zhang, Yahui, De Jesus, Aribet M, Sander, Edward A, Ozbolat, Ibrahim T. In vitro evaluation of carbon-nanotube-reinforced bioprintable vascular conduits. NANOTECHNOLOGY[J]. 2014, 第 2 作者25(14): 145101-145101, https://www.webofscience.com/wos/woscc/full-record/WOS:000332942800001.
[19] Yu, Y, Zheng, H, Buckwalter, J A, Martin, J A. Single cell sorting identifies progenitor cell population from full thickness bovine articular cartilage. OSTEOARTHRITIS AND CARTILAGE[J]. 2014, 22(9): 1318-1326, http://dx.doi.org/10.1016/j.joca.2014.07.002.
[20] Zhang, Yahui, Yu, Yin, Dolati, Farzaneh, Ozbolat, Ibrahim T. Effect of multiwall carbon nanotube reinforcement on coaxially extruded cellular vascular conduits. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS[J]. 2014, 第 2 作者39: 126-133, http://dx.doi.org/10.1016/j.msec.2014.02.036.
[21] Ozbolat, Ibrahim T, Yu, Yin. Bioprinting Toward Organ Fabrication: Challenges and Future Trends. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING[J]. 2013, 第 2 作者60(3): 691-699, http://dx.doi.org/10.1109/TBME.2013.2243912.
[22] Zhang, Yahui, Yu, Yin, Chen, Howard, Ozbolat, Ibrahim T. Characterization of printable cellular micro-fluidic channels for tissue engineering. BIOFABRICATION[J]. 2013, 第 2 作者5(2): 025004-025004, https://www.webofscience.com/wos/woscc/full-record/WOS:000318149900005.
[2] Molecular Pharmaceutics. 2023, 通讯作者
[3] Macromolecular Bioscience. 2023, 通讯作者
[4] Macromolecular Bioscience. 2022, 通讯作者
[5] Biomaterials. 2022, 通讯作者
[6] Wu, Yang, Kennedy, Patrick, Bonazza, Nicholas, Yu, Yin, Dhawan, Aman, Ozbolat, Ibrahim. Three-Dimensional Bioprinting of Articular Cartilage: A Systematic Review. CARTILAGE. 2021, 第 4 作者12(1): 76-92, http://dx.doi.org/10.1177/1947603518809410.
[7] Zhong, Gang, Long, Huiping, Chen, Fei, Yu, Yin. Oxoglaucine mediates Ca2+ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/calmodulin/CAMK-II pathway. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2021, 第 4 作者 通讯作者 178(15): 2931-2947, http://dx.doi.org/10.1111/bph.15466.
[8] Zhong, Gang, Yao, Jun, Huang, Xing, Luo, Yixuan, Wang, Meng, Han, Jinyu, Chen, Fei, Yu, Yin. Injectable ECM hydrogel for delivery of BMSCs enabled full-thickness meniscus repair in an orthotopic rat model. BIOACTIVE MATERIALS[J]. 2020, 第 8 作者 通讯作者 5(4): 871-879, http://lib.cqvip.com/Qikan/Article/Detail?id=7103847767.
[9] Meng Wang, Yixuan Luo, Yin Yu, Fei Chen. Bioengineering Approaches to Accelerate Clinical Translation of Stem Cell Therapies Treating Osteochondral Diseases. STEMCELLSINTERNATIONAL[J]. 2020, 第 3 作者 通讯作者 2020: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775142/.
[10] 陈飞, 钟超, 孙飞, 于寅. 合成生物学在生物材料科学中的应用及展望. 生物产业技术[J]. 2019, 第 4 作者5-12, http://lib.cqvip.com/Qikan/Article/Detail?id=7001298258.
[11] Huang, Haishui, Yu, Yin, Hu, Yong, He, Xiaoming, Usta, O Berk, Yarmush, Martin L. Generation and manipulation of hydrogel microcapsules by droplet-based microfluidics for mammalian cell culture. LAB ON A CHIP. 2017, 第 2 作者17(11): 1913-1932, http://dx.doi.org/10.1039/c7lc00262a.
[12] Yu, Yin, Moncal, Kazim K, Li, Jianqiang, Peng, Weijie, Rivero, Iris, Martin, James A, Ozbolat, Ibrahim T. Three-dimensional bioprinting using self-assembling scalable scaffold-free "tissue strands" as a new bioink. SCIENTIFIC REPORTS[J]. 2016, 第 1 作者6: https://www.webofscience.com/wos/woscc/full-record/WOS:000378502400001.
[13] Akkouch, Adil, Yu, Yin, Ozbolat, Ibrahim T. Microfabrication of scaffold-free tissue strands for three-dimensional tissue engineering. BIOFABRICATION[J]. 2015, 第 2 作者7(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000366460800002.
[14] Yu, Y, Seol, D, Marc, B, Zheng, H, Buckwalter, J, Martin, J. RECRUITMENT OF ENDOGENOUS CHONDROGENIC PROGENITOR CELLS FOR ARTICULAR CARTILAGE REPAIR. OSTEOARTHRITIS AND CARTILAGE. 2015, 23: A40-A41, http://dx.doi.org/10.1016/j.joca.2015.02.092.
[15] 于寅. Functional full-thickness articular cartilage repair by rhSDF-1alpha loaded fibrin/ha hydrogel network via chondrogenic progenitor cells homing. Arthritis Rheumatology. 2015, 第 1 作者
[16] Zhang, Yahui, Yu, Yin, Akkouch, Adil, Dababneh, Amer, Dolati, Farzaneh, Ozbolat, Ibrahim T. In vitro study of directly bioprinted perfusable vasculature conduits. BIOMATERIALS SCIENCE[J]. 2015, 第 2 作者3(1): 134-143, https://www.webofscience.com/wos/woscc/full-record/WOS:000345908400014.
[17] Seol, Dongrim, Yu, Yin, Choe, Hyeonghun, Jang, Keewoong, Brouillette, Marc J, Zheng, Hongjun, Lim, TaeHong, Buckwalter, Joseph A, Martin, James A. Effect of Short-Term Enzymatic Treatment on Cell Migration and Cartilage Regeneration: In Vitro Organ Culture of Bovine Articular Cartilage. TISSUE ENGINEERING PART A[J]. 2014, 第 2 作者20(13-14): 1807-1814, https://www.webofscience.com/wos/woscc/full-record/WOS:000339171900004.
[18] Dolati, Farzaneh, Yu, Yin, Zhang, Yahui, De Jesus, Aribet M, Sander, Edward A, Ozbolat, Ibrahim T. In vitro evaluation of carbon-nanotube-reinforced bioprintable vascular conduits. NANOTECHNOLOGY[J]. 2014, 第 2 作者25(14): 145101-145101, https://www.webofscience.com/wos/woscc/full-record/WOS:000332942800001.
[19] Yu, Y, Zheng, H, Buckwalter, J A, Martin, J A. Single cell sorting identifies progenitor cell population from full thickness bovine articular cartilage. OSTEOARTHRITIS AND CARTILAGE[J]. 2014, 22(9): 1318-1326, http://dx.doi.org/10.1016/j.joca.2014.07.002.
[20] Zhang, Yahui, Yu, Yin, Dolati, Farzaneh, Ozbolat, Ibrahim T. Effect of multiwall carbon nanotube reinforcement on coaxially extruded cellular vascular conduits. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS[J]. 2014, 第 2 作者39: 126-133, http://dx.doi.org/10.1016/j.msec.2014.02.036.
[21] Ozbolat, Ibrahim T, Yu, Yin. Bioprinting Toward Organ Fabrication: Challenges and Future Trends. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING[J]. 2013, 第 2 作者60(3): 691-699, http://dx.doi.org/10.1109/TBME.2013.2243912.
[22] Zhang, Yahui, Yu, Yin, Chen, Howard, Ozbolat, Ibrahim T. Characterization of printable cellular micro-fluidic channels for tissue engineering. BIOFABRICATION[J]. 2013, 第 2 作者5(2): 025004-025004, https://www.webofscience.com/wos/woscc/full-record/WOS:000318149900005.
科研活动
科研项目
( 1 ) 骨科智能生物材料及个性化植入物三维生物制造系统, 负责人, 地方任务, 2018-03--2022-08
( 2 ) 自复制RNA增强间充质干细胞软骨修复潜能的机制研究, 负责人, 国家任务, 2024-01--2026-12
( 3 ) 再生医学材料联合实验室, 负责人, 其他, 2023-11--2025-11
( 4 ) 深圳市材料合成生物学重点实验室, 参与, 地方任务, 2023-01--2025-12
( 5 ) 基于细胞工厂的3D打印外泌体原料关键技术研发, 参与, 地方任务, 2024-01--2025-12
( 2 ) 自复制RNA增强间充质干细胞软骨修复潜能的机制研究, 负责人, 国家任务, 2024-01--2026-12
( 3 ) 再生医学材料联合实验室, 负责人, 其他, 2023-11--2025-11
( 4 ) 深圳市材料合成生物学重点实验室, 参与, 地方任务, 2023-01--2025-12
( 5 ) 基于细胞工厂的3D打印外泌体原料关键技术研发, 参与, 地方任务, 2024-01--2025-12
指导学生
已指导学生
王瑶敏 硕士研究生 086000-生物与医药