​1. Vaccine adjuvant: Rational design of the physiochemical properties of the vehicles, such as lipid nanoparticle, Pickering emulsion or the hybrid new delivery systems; Unravelling the underlying mechanisms and improving the delivery efficacy by strengthening on the multi-scale delivery process, including tissue targeting, trans-membrane delivery and intracellular fate of the delivered cargos;

2. Mucosal vaccines: Designing delivery systems for intranasal, oral, and nebulization vaccines. 

3. Targeted delivery systems for mRNA: Tuning the ionizable lipid and formulation of lipid nanoparticle (LNP) and non-LNP delivery systems for extrahepatic targeting and posterior ocular delivery. 

4. Process and reactor for large-scale production of nanoparticle：Impinging-reactor design and process optimizations for the large-scale production of lipid nanoparticle (LNP)

2012    B.E.,     Department of Chemistry and Chemical Engineering, Central South University, China

2018    Ph.D.,   Institute of Process Engineering, Chinese Academy of Sciences, China

2022.10-present Professor

                       Institute of Process Engineering, Chinese Academy of Sciences

2019.8-2022.10  Associate Professor  

                       Institute of Process Engineering, Chinese Academy of Sciences

2018.8-2019.8   Assistant Professor

                       Institute of Process Engineering, Chinese Academy of Sciences

1. Yufei Xia^#, Jie Wu^#, Wei Wei, Yiqun Du, Tao Wan, Xiaowei Ma, Wenqi An, Aiying Guo, Chunyu Miao, Hua Yue, Shuoguo Li, Xuetao Cao, Zhiguo Su*, Guanghui Ma*, Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination, Nature Materials, 2018, 17(2): 187-194   

2. Yufei Xia^#, Jie Wu^#, Yiqun Du, Chunyu Miao, Zhiguo Su*, Guanghui Ma*, Bridging systemic immunity with gastrointestinal immune responses via oil-in-polymer capsules, Advanced Materials, 2018, 30(31): 1801067 (Inside Cover) 

3. Yufei Xia^#, Xiangming Na^#, Jie Wu, Guanghui Ma*, The horizon of the emulsion particulate strategy: engineering hollow particles for biomedical applications, Advanced Materials, 2019, 31, 1801159 (Back Cover) 

4. Yiqun Du^#, Yufei Xia^#, Yongjuan Zou, Yuning Hu, Jiaqi Fu, Jie Wu*, Xiao-Dong Gao*, Guanghui Ma*, Exploiting the lymph-node-amplifying effect for potent systemic and gastrointestinal immune responses via polymer/lipid nanoparticles, ACS Nano, 2019, 13(12): 13809-13817 (Cover)  

5. Sha Peng^#, Fengqiang Cao^#, Yufei Xia,* Xiaodong Gao, Lianpan Dai, Jinghua Yan, and Guanghui Ma*, Particulate alum via Pickering emulsion for the enhanced covid-19 vaccine adjuvant, Advanced Materials, 2020, 32, 2004210 (Back Cover) 

6. Yufei Xia^#, Tiantian Song^#, Guanghui Ma*, Synthetic particles for cancer vaccines: Connecting the inherent supply chain, Accounts of Chemical Research, 2020, 53, 10, 2068–2080 (Cover) 

7. Yufei Xia, Qingze Fan, Dongxia Hao, Guanghui Ma*, Zhiguo Su, Chitosan-based mucosal adjuvants: sunrise on the ocean, Vaccine, 2015, 33: 5997-6010，

8. Tiantian Song, Yufei Xia*, Yiqun Du, Michael W. Chen, Hong Qing*, Guanghui Ma*, Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery, Advanced Materials, 2021, 33, 2100106. 

9. Yiqun Du#, Tiantian Song#, Jie Wu, Xiaodong Gao, Guanghui Ma, Yuchen Liu*, Yufei Xia*, Engineering mannosylated Pickering emulsions for the targeted delivery of multicomponent vaccines, Biomaterials, 2022, 280, 121313. 

10. Sihua Wu^#, Yufei Xia^#, Yuning Hu, Guanghui Ma*, Bio-mimic particles for the enhanced vaccinations: Lessons learnt from the natural traits and pathogenic invasion, Advanced Drug Delivery Reviews, 2021, 113871 

1.    Outstanding Young Scholar of National Natural Science Foundation of China (2022).

2.    Young Scholar Award from Chinese Society of Particuology (2022)

3.    CAS Project for Young Scientists in Basic Research (2021, YSBR-010)

4.    National Key Research and Development Program of China (2021YFE020527, 2021YFC2300142)

5.    1st prize of Basic Research Achievement Award of Science and Technology Award of Chemical Society of China (2020)

6.    Beijing Nova Program (2020, Z201100006820139)

7.    “From 0 to 1” Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences (2019, ZDBS-LY-SLH040)

8.    National Natural Science Foundation of China (2019, 21908229)

9.    Special Present Award of Chinese Academy of Sciences (2018)

10. Ray Wu Prize (2018)

11. ISV Annual Congress Award, The International Society for Vaccines (2017)