基本信息

俞初一 男 汉族 博导 化学研究所

电子邮件:yucy@iccas.ac.cn
联系电话: 010 62610366
通信地址:北京市海淀区中关村北一街2号,中国科学院化学研究所
邮政编码:100190

课题组主页:

研究领域

天然产物化学
糖化学生物学
杂环化学

招生信息

   
招生专业
070303-有机化学
070321-化学生物学
招生方向
糖化学生物学,药物化学
天然产物全合成

教育背景

1992-07--1995-06   中国科学院化学研究所   理学博士学位
1989-09--1992-06   中国科学院化学研究所   理学硕士学位
1981-09--1985-06   江西师范大学   理学学士学位
出国学习工作

1996年-1999年英国桑德兰大学生命学院博士后;
1999年-2001年英国牛津大学有机化学系(Dyson Perrins Laboratory)博士后

工作经历

1985年-1989年上饶师专化学系助教 

​1995年-1996年中国科学院化学所助理研究员 

1996年1999年英国Sunderland大学生命学院, 博士后

1999年2001年,英国牛津大学, 博士后

2001年7月中国科学院“****”,中科院分子识别与功能重点实验室,研究员,博士生导师 

社会兼职
2012-01-01-今,国家单糖化学合成工程技术研究中心, 中心副主任,技术委员会委员

教授课程

药物化学

专利与奖励

   
专利成果
[1] 俞初一, 杨林丰, 贾月梅, 李意羡, 加藤敦. 化合物及其制备方法与应用、糖苷酶抑制剂. CN: CN110128315A, 2019-08-16.

[2] 俞初一, 程宾, 贾月梅, 李意羡, 加藤敦. C4枝化的多羟基吡咯烷类化合物及其制备方法和应用. CN: CN106966943A, 2017-07-21.

[3] 俞初一, 郭斯阳, 贾月梅, 李意羡. 一种蓖麻油酸甲酯的制备方法. CN: CN106906051A, 2017-06-30.

[4] 俞初一, 宋营营, 贾月梅, 李意羡, 加藤敦. 多羟基吡咯烷类化合物及其制备方法和应用. CN: CN106349141A, 2017-01-25.

[5] 俞初一, 吴庆昆, 李意羡, 加藤敦. 一种小构树碱类似物及其制备方法和糖苷酶抑制剂与应用. CN: CN106117101A, 2016-11-16.

[6] 俞初一, 贾月梅, 李意羡, 郭斯阳. 偶氮苯甲酸类化合物及其制备方法和应用. CN: CN105985259A, 2016-10-05.

[7] 俞初一, 钱宝琛, 胡祥国. 吲哚里西啶亚氨基糖及其前体化合物和它们的制备方法与应用. CN: CN105732620A, 2016-07-06.

[8] 俞初一, 王洪耀, 贾月梅, 李意羡. 一种制备打碗花精及其中间体的方法. CN: CN105622459A, 2016-06-01.

[9] 俞初一, 钱宝琛, 宋营营, 贾月梅, 李意羡, 加藤敦. 苦马豆素及其中间体的制备方法和苦马豆素衍生物及其制备方法和应用. CN: CN105541854A, 2016-05-04.

[10] 俞初一, 宋营营, 贾月梅, 李意羡, 加藤敦. 小构树碱类化合物及其制备方法和应用. CN: CN105085357A, 2015-11-25.

[11] 俞初一, 宋营营, 贾月梅, 李意羡, 加藤敦. 小构树碱类化合物及其制备方法和应用. CN: CN105085356A, 2015-11-25.

[12] 俞初一, 赵辉, 贾月梅, 陈伟, 李意羡. 一种柠檬酸三酯类化合物及其制备方法和派立辛的制备方法. CN: CN104876980A, 2015-09-02.

[13] 俞初一, 李意羡, 加藤敦, 赵萱. 单氟代Radicamine化合物及其应用与制备方法. CN: CN104557654A, 2015-04-29.

[14] 俞初一, 徐文远, 贾月梅, 张威, 孙喆. 并环亚氨基糖化合物及其中间体和药物及其制备方法和应用. CN: CN103467470A, 2013-12-25.

[15] 俞初一, 朱建设, 贾月梅, 陈伟, 李意羡. 一种Pochonicine类似物或其药学上可接受的盐及其应用. CN: CN103435619A, 2013-12-11.

[16] 俞初一, 胡祥国, 贾月梅, 江新涛, 余官能, 章晓炜, 杨锦飞, 邱曾烨, 赵文博. 氮杂糖季铵盐化合物及其制备方法与应用. CN: CN103265476A, 2013-08-28.

[17] 俞初一, 胡祥国, 贾月梅, 江新涛, 余官能, 章晓炜, 杨锦飞, 邱曾烨, 赵文博. 一种螺环氮杂糖季铵盐化合物及其制备方法与应用. CN: CN103254120A, 2013-08-21.

[18] 俞初一, 余官能, 贾月梅, 胡祥国, 李意羡. 2,3-二脱氧核糖和2,3-二脱氧-2,3-二脱氢核糖及其前体化合物的制备方法. CN: CN103242277A, 2013-08-14.

[19] 俞初一, 余官能, 贾月梅, 胡祥国, 李意羡. 1-O-烷基-2,3-二脱氧-2,3-二脱氢-5-O-(烷基硅基)-呋喃糖的制备方法和应用. CN: CN103242405A, 2013-08-14.

[20] 俞初一, 赵文博, 贾月梅, 胡祥国. 七元环多羟基硝酮及其制备方法和应用. CN: CN102993095A, 2013-03-27.

[21] 俞初一, 赵辉, 贾月梅, 加藤敦. 小钩树碱I和J类似物及其制备方法与应用. CN: CN102775384A, 2012-11-14.

[22] 俞初一, 李意羡, 贾月梅. 氟代多羟基吡咯里西啶及其制备方法与应用. CN: CN102659787A, 2012-09-12.

[23] 俞初一, 李意羡, 贾月梅, 胡祥国. 一种以催化氢化法还原酮糖制备L-核糖的方法. CN: CN102276661A, 2011-12-14.

[24] 俞初一, 李意羡, 贾月梅, 胡祥国. 一种以催化氢化法还原酮糖制备D-阿洛糖的方法. CN: CN102268048A, 2011-12-07.

[25] 俞初一, 张朝兰, 贾月梅, 胡祥国, 加藤敦. 一种多羟基去甲基托品烷类化合物及其制备方法与应用. CN: CN102267993A, 2011-12-07.

[26] 俞初一, 李意羡, 贾月梅. 氟代亚氨基糖化合物及其制备方法与应用. CN: CN102199116A, 2011-09-28.

[27] 俞初一, 穆罕默德雅库, 贾月梅. 一类多环杂环化合物及其制备方法与应用. CN: CN101220030B, 2010-09-15.

[28] 黄志镗, 彭涛, 廖江鹏, 俞初一. 一种合成烯酮缩胺衍生物的方法. CN: CN101041635B, 2010-07-21.

[29] 俞初一, 王武宝, 贾月梅, 李意羡, 芮培欣, 张威. 一种制备六元环多羟基环状硝酮的方法. CN: CN101693686A, 2010-04-14.

[30] 俞初一, 苏加坤, 贾月梅, 李意羡, 芮培欣. 一种含芳基氮杂糖化合物及其制备方法与应用. CN: CN101693708A, 2010-04-14.

[31] 俞初一, 高红云. 一种合成多羟基吡咯啉士啶类生物碱的方法. CN: CN100567298C, 2009-12-09.

[32] 俞初一, 傅 颖, 黄木华, 高红云. 枝化多羟基吡咯烷衍生物及其制备方法与应用. CN: CN100537584C, 2009-09-09.

[33] 俞初一, 乔 岩. 一种3-羟基烯酸衍生物及其制备方法与应用. CN: CN100491326C, 2009-05-27.

[34] 俞初一, 张提, 廖江鹏, 黄志镗. 并环碳苷类化合物、碳苷中间体化合物以及它们的制备方法与应用. CN: CN101200470A, 2008-06-18.

[35] 俞初一, 原学宁, 赵梅欣, 黄志镗. 1,2,3-三唑并1,3-二氮杂环化合物及其制备方法与应用. CN: CN101153041A, 2008-04-02.

[36] 俞初一, 苏青云. 一种双羟基高脯氨酸衍生物及其制备方法与应用. CN: CN101070301A, 2007-11-14.

[37] 俞初一, 杨鹏辉, 赵梅欣, 黄志镗. 四氢吡啶酮并1,3-二氮杂环化合物及其制备方法. CN: CN101070321A, 2007-11-14.

[38] 俞初一, 杨鹏辉, 赵梅欣, 黄志镗. 一种含硝基的并环杂环烯酮缩胺及其制备方法. CN: CN101070320A, 2007-11-14.

[39] 俞初一, 廖江鹏, 张提, 黄志镗. 多羟基杂环烯酮缩胺核苷类似物及其制备方法. CN: CN101070336A, 2007-11-14.

[40] 俞初一, 廖江鹏, 张提, 黄志镗. 1,4-二氢吡啶类化合物及其制备方法. CN: CN101058577A, 2007-10-24.

[41] 俞初一, 黄木华, 胡素琴, 胡祥国, 侯研博, 黄志镗. 一种制备多羟基环状硝酮的方法. CN: CN101058557A, 2007-10-24.

[42] 俞初一, 严胜骄, 张提, 黄志镗. 1,2-二氢吡啶衍生物、碳苷中间体及其制备方法与应用. CN: CN101041660A, 2007-09-26.

[43] 黄志镗, 彭涛, 廖江鹏, 俞初一. 一种合成杂环烯酮缩胺衍生物的方法. CN: CN101041636A, 2007-09-26.

[44] 俞初一, 严胜骄, 黄志镗, 虞爱加. 一种环状氟硼酸内盐衍生物及其制备方法与应用. CN: CN101029053A, 2007-09-05.

出版信息

   
发表论文
[1] Li, YiXian, Wang, JunZhe, Kato, Atsushi, Shimadate, Yuna, Kise, Maki, Jia, YueMei, Fleet, George W J, Yu, ChuYi. Stereocomplementary synthesis of casuarine and its 6-epi-, 7-epi-, and 6,7-diepi-stereoisomers. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 19(43): 9410-9420, http://dx.doi.org/10.1039/d1ob01725j.
[2] Lu, TianTian, Shimadate, Yuna, Cheng, Bin, Kanekiyo, Uta, Kato, Atsushi, Wang, JunZhe, Li, YiXian, Jia, YueMei, Fleet, George W J, Yu, ChuYi. Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-L-ido-DNJ derivatives. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 224: http://dx.doi.org/10.1016/j.ejmech.2021.113716.
[3] Yan, Xin, Shimadate, Yuna, Kato, Atsushi, Li, YiXian, Jia, YueMei, Fleet, George W J, Yu, ChuYi. Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit of Simplified Structures and Potent beta-N-Acetylhexosaminidase Inhibition. MOLECULES[J]. 2020, 25(7): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000531833400023.
[4] Yang, LinFeng, Shimadate, Yuna, Kato, Atsushi, Li, YiXian, Jia, YueMei, Fleet, George W J, Yu, ChuYi. Synthesis and glycosidase inhibition of N-substituted derivatives of 1,4-dideoxy-1,4-imino-d-mannitol (DIM). ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2020, 18(5): 999-1011, https://www.webofscience.com/wos/woscc/full-record/WOS:000512061200022.
[5] Zou, Liangjing, Ruan, Yao, Jiang, Wei, Yan, Nan, Liu, DeYong, Yu, ChuYi, Hu, XiangGuo. Switchable Regioselectivity in the Opening of Aziridine by Fluoride: DFT Calculation and Synthesis of Fluorinated Piperidines. CHEMISTRYSELECT[J]. 2019, 4(43): 12683-12688, https://www.webofscience.com/wos/woscc/full-record/WOS:000498799200034.
[6] Wu, QingKun, Kinami, Kyoko, Kato, Atsushi, Li, YiXian, Fleet, George W J, Yu, ChuYi, Jia, YueMei. Synthesis and Glycosidase Inhibition of Broussonetine M and Its Analogues. Molecules[J]. 2019, 24(20): https://doaj.org/article/55ffc8a9900e4cb3a75fe0e9beb990ea.
[7] Yan, Xin, Li, YiXian, Jia, YueMei, Yu, ChuYi. Glycosylated Iminosugars: Isolation, Synthesis and Biological Activities. PROGRESS IN CHEMISTRY[J]. 2019, 31(11): 1472-1508, [8] 闫新, 李意羡, 贾月梅, 俞初一. 糖苷化的亚氨基糖:分离、合成与生物活性. 化学进展[J]. 2019, 31(11): 1472-1508, http://lib.cqvip.com/Qikan/Article/Detail?id=7100632366.
[9] Yang, Kunhao, Li, Zhongqiu, Lv, Yueguang, Yu, Chuyi, Wang, Peilong, Su, Xiaoou, Wu, Li, He, Yujian. Graphene and AuNPs based electrochemical aptasensor for ultrasensitive detection of hydroxylated polychlorinated biphenyl. ANALYTICA CHIMICA ACTA[J]. 2018, 1041: 94-101, http://dx.doi.org/10.1016/j.aca.2018.08.047.
[10] Li, Yixian, Jia, Yuemei, Yu, Chuyi. Synthesis and Glycosidase Inhibitory Activities of Fluorinated Iminosugars. PROGRESS IN CHEMISTRYnull. 2018, 30(5): 586-600, https://www.webofscience.com/wos/woscc/full-record/WOS:000439521900012.
[11] 李意羡, 贾月梅, 俞初一. 氟代亚氨基糖的合成与糖苷酶抑制活性. 化学进展[J]. 2018, 30(5): 586-600, http://lib.cqvip.com/Qikan/Article/Detail?id=675387087.
[12] Cheng, Bin, Li, YiXian, Jia, YueMei, Yu, ChuYi. Concise synthesis of 1-epi-castanospermine. CHINESE CHEMICAL LETTERS[J]. 2017, 28(8): 1688-1692, http://dx.doi.org/10.1016/j.cclet.2017.05.013.
[13] Hu, Ludan, Xu, Huifen, Yang, Qin, Deng, Zhihong, Yu, ChuYi, Peng, Yiyuan. Quinazoline-directed selective ortho-iodination for the synthesis of 2-(2-iodoaryl)-4-arylquinazolines. JOURNAL OF ORGANOMETALLIC CHEMISTRY[J]. 2017, 843: 20-25, http://dx.doi.org/10.1016/j.jorganchem.2017.05.025.
[14] Fang, Zheng, Hu, WenLi, Liu, DeYong, Yu, ChuYi, Hu, XiangGuo. Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature. GREEN CHEMISTRY[J]. 2017, 19(5): 1299-1302, https://www.webofscience.com/wos/woscc/full-record/WOS:000396144200016.
[15] Liu, Qingju, Zhao, Chuanfang, Huang, Jincheng, Chen, Li, Yang, Kunhao, Gong, Lingling, Du, Yuguo, Yu, Chuyi, Wu, Li, Li, Xiangjun, He, Yujian. Enantioselectivity of D-amino acid oxidase in the presence of ionic liquids. RSC ADVANCES[J]. 2017, 7(54): 34110-34117, https://www.webofscience.com/wos/woscc/full-record/WOS:000405279100052.
[16] Cheng, Bin, Hirokami, Yuki, Li, YiXian, Kato, Atsushi, Jia, YueMei, Yu, ChuYi. Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives. CHINESE CHEMICAL LETTERS[J]. 2017, 28(8): 1701-1704, http://dx.doi.org/10.1016/j.cclet.2017.06.016.
[17] Wu, QingKun, Li, YiXian, Jia, YueMei, Yu, ChuYi. Synthesis of a novel C-branched polyhydroxylated cyclic nitrone. CHINESE CHEMICAL LETTERS[J]. 2017, 28(4): 909-912, http://dx.doi.org/10.1016/j.cclet.2016.12.033.
[18] Li, YiXian, Iwaki, Ren, Kato, Atsushi, Jia, YueMei, Fleet, George W J, Zhao, Xuan, Xiao, Min, Yu, ChuYi. Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2016, 2016(7): 1429-1438, [19] Li, YiXian, Kinami, Kyoko, Hirokami, Yuki, Kato, Atsushi, Su, JiaKun, Jia, YueMei, Fleet, George W J, Yu, ChuYi. Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars: synthesis and glycosidase inhibition. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(7): 2249-2263, https://www.webofscience.com/wos/woscc/full-record/WOS:000370878800015.
[20] Song, YingYing, Kinami, Kyoko, Kato, Atsushi, Jia, YueMei, Li, YiXian, Fleet, George W J, Yu, ChuYi. First total synthesis of (+)-broussonetine W: glycosidase inhibition of natural product & analogs. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(22): 5157-5174, [21] Wang, HongYao, Kato, Atsushi, Kinami, Kyoko, Li, YiXian, Fleet, George W J, Yu, ChuYi. Concise synthesis of calystegines B-2 and B-3 via intramolecular Nozaki-Hiyama-Kishi reaction. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(21): 4885-4896, http://dx.doi.org/10.1039/c6ob00697c.
[22] Liu, Zilei, Jenkinson, Sarah F, Kato, Atsushi, Nakagawa, Shinpei, Wormald, Mark R, Yu, ChuYi, Fleet, George W J. 3-Azidoazetidines as the first scaffolds for beta-amino azetidine carboxylic acid peptidomimetics: azetidine iminosugars containing an acetamido group do not inhibit beta-N-acetylhexosaminidases. TETRAHEDRON-ASYMMETRY[J]. 2016, 27(17-18): 872-881, http://ir.iccas.ac.cn/handle/121111/35282.
[23] Jiang, Xin, Yang, Qin, Yuan, Jianjun, Deng, Zhihong, Mao, Xuechun, Peng, Yiyuan, Yu, Chuyi. Rhodium-catalyzed tandem C-H activation and aza-Michael addition of 2-arylquinazolin-4-ones with acrylates for the synthesis of pyrrolo2,1-bquinazolin-9(1H)-one derivatives. TETRAHEDRON[J]. 2016, 72(9): 1238-1243, http://dx.doi.org/10.1016/j.tet.2016.01.020.
[24] Qian, BaoChen, Kamori, Akiko, Kinami, Kyoko, Kato, Atsushi, Li, YiXian, Fleet, George W J, Yu, ChuYi. Epimerization of C5 of an N-hydroxypyrrolidine in the synthesis of swainsonine related iminosugars. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(19): 4488-4498, http://dx.doi.org/10.1039/c6ob00531d.
[25] Li, YiXian, Shimada, Yousuke, Sato, Kasumi, Kato, Atsushi, Zhang, Wei, Jia, YueMei, Fleet, George W J, Xiao, Min, Yu, ChuYi. Synthesis and Glycosidase Inhibition of Australine and Its Fluorinated Derivatives. ORGANIC LETTERS[J]. 2015, 17(3): 716-719, https://www.webofscience.com/wos/woscc/full-record/WOS:000349274200082.
[26] Kato, Atsushi, Zhang, ZhaoLan, Wang, HongYao, Jia, YueMei, Yu, ChuYi, Kinami, Kyoko, Hirokami, Yuki, Tsuji, Yutaro, Adachi, Isao, Nash, Robert J, Fleet, George W J, Koseki, Jun, Nakagome, Izumi, Hirono, Shuichi. Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal alpha-Glucosidases: Binding Conformation and Interaction for ntSI. JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 80(9): 4501-4515, http://ir.iccas.ac.cn/handle/121111/28074.
[27] Li, YiXian, Shimada, Yousuke, Adachi, Isao, Kato, Atsushi, Jia, YueMei, Fleet, George W J, Xiao, Min, Yu, ChuYi. Fluorinated and Conformationally Fixed Derivatives of L-HomoDMDP: Synthesis and Glycosidase Inhibition. JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 80(10): 5151-5158, http://ir.iccas.ac.cn/handle/121111/28138.
[28] YiXian Li Yousuke Shimada Kasumi Sato Atsushi Kato Wei Zhang YueMei Jia George W J Fleet Min Xiao and ChuYi Yu. Synthesis and Glycosidase Inhibition of Australine and Its Fluorinated Derivatives. Org. Lett.[J]. 2015, 17(3): 716-719, http://ir.iccas.ac.cn/handle/121111/28699.
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科研活动

   
科研项目
( 1 ) 与DMDP结构相关的天然亚氨基糖的合成及其生物活性研究, 主持, 国家级, 2013-01--2016-12
( 2 ) 基于中草药中氮杂糖类化合物的创新药物研究——以GPCRb1/b2AR为靶标的中药活性筛选及创新中药发现, 参与, 国家级, 2013-01--2015-12
( 3 ) 海上大位移井钻井液关键技术研究, 参与, 国家级, 2012-01--2015-12
( 4 ) 药物关键中间体的产业化, 主持, 部委级, 2014-01--2015-12
( 5 ) 单糖药物及其中间体的合成技术研究, 主持, 研究所(学校), 2013-01--2015-12
( 6 ) 肿瘤的糖化学生物学前沿研究, 参与, 国家级, 2012-01--2016-12
( 7 ) 核苷和糖类化合物系列产品的绿色制备, 主持, 院级, 2017-12--2020-11
( 8 ) 糖化学品合成工艺研究及技术服务, 主持, 院级, 2018-01--2020-12

指导学生

已指导学生

高红云  博士研究生  070303-有机化学  

苏青云  博士研究生  070303-有机化学  

乔岩  博士研究生  070303-有机化学  

严胜骄  博士研究生  070303-有机化学  

傅颖  博士研究生  070303-有机化学  

黄木华  博士研究生  070303-有机化学  

杨鹏辉  博士研究生  070303-有机化学  

王武宝  博士研究生  070303-有机化学  

苏加坤  博士研究生  070303-有机化学  

胡祥国  博士研究生  070303-有机化学  

张威  博士研究生  070303-有机化学  

李意羡  博士研究生  070303-有机化学  

张朝兰  博士研究生  070303-有机化学  

赵文博  博士研究生  070303-有机化学  

徐文远  博士研究生  070303-有机化学  

朱建设  博士研究生  070303-有机化学  

赵辉  博士研究生  070303-有机化学  

王洪耀  博士研究生  070303-有机化学  

钱宝琛  博士研究生  070303-有机化学  

吴庆昆  博士研究生  070303-有机化学  

宋营营  博士研究生  070303-有机化学  

程宾  博士研究生  070303-有机化学  

现指导学生

闫新  博士研究生  070303-有机化学  

杨林丰  博士研究生  070303-有机化学  

王俊哲  硕士研究生  070303-有机化学  

訾冬  博士研究生  070303-有机化学  

陆甜甜  硕士研究生  070303-有机化学  

王绪昆  博士研究生  070303-有机化学