YONG Q. ZHANG, PhD, doctoral supervisor, Institute of Genetics and Developmental Biology Chinese Academy of Sciences

Fax: 86 10 6480 7611
Address: No.1 West Beichen Road, Chao Yang District Beijing, China
Postcode: 100101

Research Areas

Study on the molecular and genetic mechanisms of intellectual disability and synapse development and function in Drosophila


1985 - 1991 Beijing Agricultural University. Ph.D. Biochemistry & Molecular Biology

1980 - 1985 Huazhong Agricultural University, Wuhan. B.Sc. Veterinary Medicine


Work Experience
2004 - present: Professor and Deputy Director of the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. 

Study on the molecular and genetic mechanisms of intellectual disability and synapse development and function in Drosophila.

1998 - 2003: with Dr Kendal Broadie, first at the University of Utah, then at Vanderbilt University

Postdoctoral Associate: neurological functions of fragile X protein; genes involved in synaptic development and function in Drosophila.

1995 -  1997: with Professor Michael Ashburner, Fellow of the Royal Society. Department of Genetics, University of Cambridge, England.

Postdoctoral Associate: genome mapping within the European Drosophila Genome Project; molecular and genetic analyses of stress sensitive B, a behavioral mutant gene.

1994: with Prof. Ab van Kammen in the Department of Molecular Biology, Wageningen University, the Netherlands.

Visiting scientist: map-based cloning of disease resistance genes from tomato. 

1992 - 1995: Principle investigator in the Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Molecular characterization of fruit-ripening related genes and manipulating fruit ripening by transgenes
Teaching Experience
Signal Transduction
Molecular Genetics
Editorial duties
1.  Associate editor of Journal of Genetics and Genomics, editor-in-chief of Hereditas (Beijing), and editor of Sccientific Reports.

2. Ad hoc reviewer for

    Human Molecular Genetics

    Developmental Biology

    Journal of Neuroscience

    Journal of Cell Science 

    PLoS Genetics

Honors & Distinctions

1. The chief of the "Reproductive and Development" project in Ministry of Science and Technology of the People’s Republic of China. (2014-2018)

2. State Council Expert for Special Allowance (2012). 

3. A "hundred people plan" researcher of Chinese Academy of Sciences (2005). 

4. The National Science Fund for Distinguished Young Scholars (2005). 

5. Kennedy Center for Research on Human Development at Vanderbilt University (2003). 

6. FRAXA Research Foundation at (2001-2002).


1. Drosophila S6 kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor thickveins. PLoS Genet, 2015. Corresponding author

2. A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling. Cell Reports, 2014. Non corresponding author

3. Drosophila Acyl-CoA synthetase long-chain family member 4 inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling, Journal of Neuroscience, 2014 (Featured article). Corresponding author

4. Microtubule-severing protein katanin regulates neuromuscular junction development and dendritic elaboration in Drosophila. Development, 2014. Corresponding author

5. Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing Mad expression. Journal of Neuroscience, 2013. Corresponding author

6. Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly. PLoS Genet. Corresponding author

7. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. Proc Natl Acad Sci USA, 2013, Corresponding author

8. RIM Promotes Calcium Channel Accumulation at Active Zones of the Drosophila Neuromuscular Junction. Journal of Neuroscience, 2012. Non Corresponding author

9. Drosophila FMRP participates in the DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. Human Molecular Genetics, 2012. Co-corresponding Author

10. Drosophila acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission. Journal of Neuroscience, 2011. Corresponding author

11. Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria. Human Molecular Genetics, 2011. Corresponding author

12. Drosophila CG10527 mutants are resistant to juvenile hormone and its analog methoprene. Biochemical and Biophysical Research Communications, 2010. Corresponding author

13. Distinct pre- and postsynaptic dismantling processes of Drosophila neuromuscular junctions during metamorphosis. Journal of Neuroscience, 2010. Corresponding author

14. Drosophila twinfilin is required for cell migration and synaptic endocytosis. Journal of Cell Science, 2010. Co-corresponding Author


Graduated students

Liu Zhiwei   Doctor    071008 - Developmental biology

Zhang Haiying    Doctor    071008 - Developmental biology

Wang Dan    Doctor    071008 - Developmental biology

Zhi Hui    Doctor    071008 - Developmental biology

Chen Yan    Doctor    071008 - Developmental biology

Jiang Fangfang    Doctor    071008 - Developmental biology

Liu Zhihua    Doctor    071008 - Developmental biology

Liu Wei    Doctor    071008 - Developmental biology

Xiong Ying    Doctor    071008 - Developmental biology

Shi Wenwen    Doctor    071008 - Developmental biology

Zhao Lu    Doctor    071008 - Developmental biology

Zhao Guoli    Doctor    071008 - Developmental biology

Huang Yan    Doctor    071008 - Developmental biology

Huang Sheng    Master    071006 - Neurobiology 

Currently learning students

Wu Song    Doctor    071008 - Developmental biology

Li Wenhua    Doctor    071006 - Neurobiology

Zhao Kai    Doctor    071006 - Neurobiology

Jia Mingyue    Doctor    071006 - Neurobiology

Meng Danqing    Doctor    071006 - Neurobiology

Li Meixiang    Master    071007 - Genetics

Hong Huilin    Master    071006 – Neurobiology

Chen Mo    Doctor    071006 - Neurobiology

Zhao Hui    Doctor    071006 - Neurobiology

Guo Meizhi    Master    071008 - Developmental biology

Li Tingting    Master    071006 – Neurobiology

Wang Qiqi    Master    071006 – Neurobiology

Ding Haitao    Doctor    071006 - Neurobiology

Md. Shafayat Hossain    Doctor    071006 - Neurobiology

Elsayed Metwally mahmoud    Doctor    071006 - Neurobiology