100701-药物化学

类天然产物和类药性骨架合成的新方法技术与高质量多样性小分子库
新型活性化合物的发现与优化及候选药物的开发
小分子探针的设计与合成

1994-09--1997-06   中国科学院上海药物研究所   博士
1991-09--1994-06   兰州大学   硕士

药物化学，博士研究生

-- 博士

   

2005-05~现在, 中国科学院上海药物研究所, 研究员
2001-08~2005-05,美国Vivoquest Inc., 药物化学资深研究员
2001-04~2001-07,美国Rockefeller University, 博士后
2000-08~2001-04,美国Harvard Medical School , 博士后
1998-09~2000-08,美国Georgetown University Medical Center, 博士后
1997-09~1998-07,日本名古屋大学农学院有机室, 博士后

2015-01-01-2019-12-31,上海市药学会药化专业委员会委员, 药化专业委员会委员
2014-01-01-2019-12-31,中国科学院藏药研究重点实验室学术委员会委员, 学术委员会委员

药物化学

   

（1） 类药性与靶向性化合物库及其制备关键技术研究, 二等奖, 其他, 2016
（2） 国家杰出青年, 一等奖, 国家级, 2012
（3） 朱李月华优秀教师奖, 一等奖, 院级, 2011
（4） 中国药学会青年生物药物奖, 一等奖, 国家级, 2010

[1] 胡有洪, 谢欣, 陈泰文, 李鑫, 谢志铖, 郭世猛. 2-胺基嘧啶类衍生物及其制备方法和用途. 202310394367.5, 2023-04-13.

[2] 胡有洪, 楼丽广, 谢志铖, 李琳, 王蕾. 一类含杂芳环炔基化合物及其制备方法和用途. 202310214944.8, 2023-03-08.

[3] 胡有洪, 陈奕, 谢志铖, 丁健, 李欣, 方艳芬, 沈倩倩. 含2-芳杂环取代的脲类化合物、其制备方法和用途. CN115703738A, 2023-02-17.

[4] 胡有洪, 陈奕, 张卓, 方艳芬, 蒋婧升, 沈倩倩, 龙国璋, 丁健, 陈五红. 去唾液酸糖蛋白受体配体与细胞毒素的偶联物及其应用. 202310079838.3, 2023-01-17.

[5] 胡有洪, 耿美玉, 李大强, 沈爱军, 张卓, 李亚磊, 杨华杰, 刘红椿, 钟韩悦, 丁健. 含S构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用. CN114957132A, 2022-08-30.

[6] 胡有洪, 左建平, 韩胜, 童贤崑, 杨莉, 李恒. 十氢异喹啉类化合物及其制备方法和用途. 2022106431848, 2022-06-08.

[7] 胡有洪, 陈奕, 曾艳萍, 丁健, 肖剑. 一种蛋白降解剂及其制备方法和用途. 2022105722297, 2022-05-24.

[8] 胡有洪, 唐炜, 谢志铖, 范晨, 李欣, 向才贵, 马彦杰, 冯春兰. 邻氨基吡啶炔基类化合物在制备抗过敏药物中的用途. CN: CN114246865A, 2022-03-29.

[9] 高召兵, 胡有洪, 魏爱环, 郑月明, 杨春皓, 熊兵, 陈笑艳, 秦慧, 谭村, 许海燕, 周雷. 酰胺类化合物及其制备方法和用途. 202210267217.3, 2022-03-17.

[10] 胡有洪, 耿美玉, 王建荣, 任文明, 艾菁, 杨占坤, 郭凤, 冯磊. 含邻氨基吡啶炔基的化合物的盐及其制备方法和应用. CN: CN114075135A, 2022-02-22.

[11] 胡有洪, 黄锐敏, 任文明, 彭程远, 陈菁菁, 项淮江, 陈五红. 靶向酪氨酸激酶识别的可逆性荧光化合物及其制备方法和应用. CN: CN111848657B, 2021-12-31.

[12] 胡有洪, 黄锐敏, 任文明, 祖里帕力·木沙, 项淮江, 彭程远, 陈五红. EGFR特异识别的荧光化合物，其制备方法和用途. CN: CN112574240A, 2021-03-30.

[13] 胡有洪, 章海燕, 任文明, 张菁菁, 项淮江, 陈菁菁, 谢志铖. 3-噻唑烯基氟化硼络合二吡咯甲川类化合物及其制备方法和用途. CN: CN112574239A, 2021-03-30.

[14] 陈民利, 马全鑫, 白东鲁, 胡有洪, 张冠亚, 金昌明, 吕建东. 硫酸舒欣啶在制备抗心衰产品中的应用. CN: CN112516136A, 2021-03-19.

[15] 胡有洪, 左建平, 陈五红, 杨莉, 赵琪良, 刘菲菲, 曾艳萍, 童贤崑, 曾丽敏, 魏爱环. 4-吡啶取代酞嗪酮类化合物、其制备方法、药物组合物及用途. CN: CN112125881A, 2020-12-25.

[16] 胡有洪, 耿美玉, 陈菁菁, 沈爱军, 谢志铖, 刘红椿, 曾丽敏, 李亚磊, 彭润泽, 张敏敏, 张婕, 丁健. 一种吡咯并吡啶酮类化合物、其制备方法、其组合物和用途. CN: CN112094266A, 2020-12-18.

[17] 胡有洪, 谢欣, 鲁伯埙, 张玉芳, 郭世猛, 王聪聪, 王志龙. 一种不饱和酮类化合物、其制备方法和用途. CN: CN111792990A, 2020-10-20.

[18] 胡有洪, 丁健, 唐炜, 谢华, 谢志铖, 童林江, 任文明, 高远卓. 邻氨基吡啶炔类化合物及其制备方法和用途. CN: CN111662227A, 2020-09-15.

[19] 胡有洪, 耿美玉, 任文明, 丁健, 官晓聪, 艾菁, 王浪, 彭霞, 刘杨, 戴阳, 曾丽敏. 含邻氨基杂芳环炔基的化合物及其制备方法和用途. CN: CN110582483A, 2019-12-17.

[20] 南发俊, 丁健, 耿美玉, 陈奕, 胡有洪, 陈悦婷, 徐济民, 刘桦楠. EZH2抑制剂及其制备和抗肿瘤治疗中的应用. CN: CN110016014A, 2019-07-16.

[21] 谢欣, 鲁伯埙, 胡有洪, 郭世猛, 李贺轩, 张玉芳, 何冰清. 一类环状内酯类化合物在制备用于预防和/或治疗亨廷顿病的药物中的用途. CN: CN109568307A, 2019-04-05.

[22] 胡有洪, 耿美玉, 段文文, 丁健, 万鹏辉, 沈爱军, 陆栋, 刘红椿, 魏爱环, 张敏敏, 曾丽敏, 曹靖晨. 一种哒嗪酮母核结构的组蛋白去乙酰化酶抑制剂及其制备方法和用途. CN: CN109280032A, 2019-01-29.

[23] 胡有洪, 左建平, 陆栋, 杨莉, 曾丽敏, 刘菲菲, 张韫喆, 陈五红, 童贤崑. 酞嗪酮类化合物、其制备方法、药物组合物及用途. CN: CN109134429A, 2019-01-04.

[24] 胡有洪, 耿美玉, 任文明, 丁健, 官晓聪, 艾菁, 彭霞, 刘杨, 戴阳, 王浪, 曾丽敏. 含邻氨基杂芳环炔基的化合物及其制备方法和用途. CN: CN108456163A, 2018-08-28.

[25] 胡有洪, 陈笑艳, 丁健, 任文明, 钟大放, 陈奕, 谢华. 吲哚-1-碳酸酯类化合物、其制备方法和应用. CN: CN108250187A, 2018-07-06.

[26] 胡有洪, 左建平, 陆栋, 唐炜, 邢唯强, 杨莉, 王浪, 王亚娟. 哒嗪酮类化合物、其制备方法、药物组合物及用途. CN: CN107848986A, 2018-03-27.

[27] 胡有洪, 冷颖, 陈五红, 宁萌萌, 王浪, 曾丽敏. 一种含吡嗪环链接的苯丙酸类化合物、其药物组合物、制备方法和用途. CN: CN107556252A, 2018-01-09.

[28] 胡有洪, 冯林音, 程刚, 于雪莉, 王浪, 卢慧, 陈红, 张蕾, 盛佳. 喹唑啉化合物在调控神经干细胞增殖和分化中的应用. CN: CN106632091A, 2017-05-10.

[29] 胡有洪, 左建平, 陆栋, 唐炜, 邢唯强, 杨莉, 王浪, 王亚娟. 哒嗪酮类化合物、其制备方法、药物组合物及用途. CN: CN106467495A, 2017-03-01.

[30] 胡有洪, 章海燕, 任文明, 徐明明. 荧光开关型BODIPY类化合物及其制备方法和应用. CN: CN106349261A, 2017-01-25.

[31] 胡有洪, 冷颖, 陈红, 宁萌萌. 一类山酮串色酮类化合物及其制备方法和用途. CN: CN104945389A, 2015-09-30.

[32] 胡有洪, 楼丽广, 陈红, 全海天, 李德文, 谢成英. 一类芳基杂环小分子化合物、其衍生物及其制备方法和用途. CN: CN104341386A, 2015-02-11.

[33] 胡有洪, 耿美玉, 刘杨, 丁健, 艾菁. 一类炔基杂环类化合物及其应用. CN: CN104211639A, 2014-12-17.

[34] 胡有洪, 冷颖, 李德文, 宁萌萌. 一种含氮杂环链接的苯丙酸类化合物、其药物组合物、制备方法和用途. CN: CN104109115A, 2014-10-22.

[35] 胡有洪, 耿美玉, 邢唯强, 丁健, 艾菁. 哒嗪酮类化合物、其制备方法、药物组合物及其用途. CN: CN103664895A, 2014-03-26.

[36] 胡有洪, 冷颖, 段书冬, 黄素玲. 氮(氧)杂环戊烷-2-酮(硫酮)类化合物、其药物组合物、制备方法和用途. CN: CN103626713A, 2014-03-12.

[37] 楼丽广, 胡有洪, 赵红兵, 林世军, 谢成英, 邢唯强, 全海天, 李德文. 6-(4-(二氟甲氧基)-3-甲氧基苯基)哒嗪-3(2H)-酮在制备抗肿瘤药物中的用途. CN: CN102872017A, 2013-01-16.

[38] 胡有洪, 王贺瑶, 闫建伟, 姬俊, 盛佳, 王婷. 联杂芳基羧酸类化合物、其制备方法,包含该化合物的药物组合物、及用途. CN: CN102757420A, 2012-10-31.

[39] 胡有洪, 耿美玉, 刑唯强, 艾菁, 盛佳, 王英. 一类哒嗪酮类化合物,其药物组合物、制备方法及用途. CN: CN102731409A, 2012-10-17.

[40] 胡有洪, 王贺瑶, 晁博, 闫桂蕊, 任立宁. 一类呋喃香豆素类衍生物及其制备方法和用途. CN: CN102617585A, 2012-08-01.

[41] 左建平, 胡有洪, 唐伟, 晁博, 童贤崑, 李德文, 姬飞虹, 何佩岚. 一类喹唑啉类化合物在制备抗黄病毒科病毒的药物中的用途. CN: CN102552271A, 2012-07-11.

[42] 冷颖, 陶燕铎, 胡有洪, 龚键, 黄淑玲, 于瑞涛. 二氢呋喃-2-酮类化合物在制备抗糖尿病及糖脂代谢药物中的用途. CN: CN102451178A, 2012-05-16.

[43] 丁侃, 胡有洪, 方建平, 刘杨, 李德文. N-(2-甲基呋喃2,3-d嘧啶-4-基)丙烯酰胺、其制备方法及其用途. CN: CN102260270A, 2011-11-30.

[44] 李树坤, 胡有洪, 闫建伟, 白东鲁, 周丽君. 联芳基醇二胺类化合物、其药物组合物、制备方法及应用. CN: CN102190638A, 2011-09-21.

[45] 胡有洪, 楼丽广, 林世军, 赵红兵, 邢唯强, 全海天. 一类以N为桥键的哒嗪酮类化合物在制备抗肿瘤的药物中的用途. CN: CN102133217A, 2011-07-27.

[46] 胡有洪, 楼丽广, 谢福春, 赵红兵. 一类嘧啶类小分子化合物、其制备方法及用途. CN: CN102115470A, 2011-07-06.

[47] 胡有洪, 楼丽广, 刘杨, 吴琼, 黄丽平, 谢成英. 一类多环苯并吡喃酮类化合物及其制备方法和用途. CN: CN102108083A, 2011-06-29.

[48] 胡有洪, 楼丽广, 程刚, 徐永平, 谢福春, 唐卫东, 李佳. 一类新型嘧啶类小分子化合物、其制备方法及其用途. CN: CN101033224B, 2011-04-27.

[49] 胡有洪, 楼丽广, 林世军, 赵红兵, 刘振德, 徐永平, 晁博. 一类哒嗪酮类化合物及其制备方法和制备药物的用途. CN: CN101538245B, 2011-02-16.

[50] 胡有洪, 楼丽广, 林世军, 赵红兵, 刘振德, 徐永平, 晁博. 哒嗪酮类化合物在制备抗肿瘤药物中的用途. CN: CN101537006A, 2009-09-23.

[51] 胡有洪, 刘振德, 李德文, 李树坤, 何煦昌, 白东鲁. 一类新型多取代呋喃并嘧啶化合物及其合成方法. CN: CN101121718A, 2008-02-13.

[52] 何煦昌, 白东鲁, 杨勤刚, 李树坤, 胡有洪. 醇二胺类化合物、及其制备方法和应用、以及包括该化合物的组合物. CN: CN1982298A, 2007-06-20.

   

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[12] Ma, Mengna, Guo, Shimeng, Lin, Xi, Li, Shanshan, Wu, Yiran, Zeng, Yanping, Hu, Youhong, Zhao, Suwen, Xu, Fei, Xie, Xin, Shui, Wenqing. Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52. ACS CHEMICAL BIOLOGY[J]. 2020, 15(12): 3275-3284, https://www.webofscience.com/wos/woscc/full-record/WOS:000608852300023.
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（ 1 ） 抗肿瘤嘧啶先导化合物的发现及作用机理研究, 主持, 国家级, 2009-01--2011-12
（ 2 ） 发育与生殖相关的小分子化合物库及相关技术平台的建立, 参与, 国家级, 2011-09--2013-09
（ 3 ） 新型抗病毒活性化合物的抗病毒作用机制及构效关系的研究, 主持, 市地级, 2010-01--2011-12
（ 4 ） 小分子哒嗪酮类化合物为探针研究肿瘤细胞增殖信号传导机制, 主持, 国家级, 2009-01--2011-12
（ 5 ） 新型抗肿瘤微管蛋白抑制剂嘧啶类化合物的成药性研究, 主持, 省级, 2011-01--2013-01
（ 6 ） 基于含色酮环中间体的串联及多组分反应研究和多样性分子库的合成, 主持, 国家级, 2012-01--2015-12
（ 7 ） 新型抗HCV小分子候选新药的研究开发, 主持, 省级, 2011-01--2013-12
（ 8 ） 基于天然产物D8的抗糖尿病活性的候选新药研究, 主持, 国家级, 2012-01--2015-12
（ 9 ） 药物化学, 主持, 国家级, 2013-01--2016-12
（ 10 ） 新型GPR40激动剂的候选药物发现, 主持, 部委级, 2015-09--2016-08
（ 11 ） 靶向GPR40抗糖尿病候选新药临床前研究和个性化特征研究, 主持, 部委级, 2015-10--2016-09
（ 12 ） 抗糖尿病靶向GPR40个性化先导化合物的发现, 主持, 部委级, 2016-01--2017-12
（ 13 ） 选择性RET抑制剂的抗肿瘤候选药物研究, 主持, 部委级, 2016-09--2017-08
（ 14 ） 治疗糖尿病及其并发症创新药物发现及机理研究, 参与, 市地级, 2016-01--2017-12
（ 15 ） 哒嗪酮类选择性HDAC6抑制剂的个性化抗肿瘤先导化合物的发现, 主持, 部委级, 2018-01--2019-12
（ 16 ） 亨廷顿病新靶标GPR52的验证及先导化合物的发现, 主持, 市地级, 2018-01--2019-12
（ 17 ） 新型哒嗪酮类抗肝癌候选新药研究, 主持, 国家级, 2009-01--2010-12
（ 18 ） 类药性与靶向化合物库及其制备关键技术研究, 参与, 国家级, 2009-01--2010-12
（ 19 ） 高效合成驱动的药物先导化合物的发现, 参与, 市地级, 2018-04--2020-04
（ 20 ） 新型哒嗪酮类抗肝癌新药 YHHU-756 临床前研究, 主持, 国家级, 2013-01--2015-12

已指导学生

程刚  博士研究生  100701-药物化学  

赵立志  博士研究生  100701-药物化学  

谢福春  博士研究生  100701-药物化学  

林世军  博士研究生  100701-药物化学  

刘杨  博士研究生  100701-药物化学  

龚健  硕士研究生  077901-药物化学  

李德文  硕士研究生  077901-药物化学  

闫建伟  博士研究生  100701-药物化学  

晁博  博士研究生  100701-药物化学  

邢唯强  博士研究生  100701-药物化学  

盛佳  硕士研究生  077901-药物化学  

陈红  博士研究生  100701-药物化学  

黄丽平  博士研究生  100701-药物化学  

段书冬  博士研究生  100701-药物化学  

金世玉  硕士研究生  085235-制药工程  

任文明  博士研究生  100701-药物化学  

陆栋  博士研究生  100701-药物化学  

现指导学生

万鹏辉  硕士研究生  105500-药学  

张玉芳  博士研究生  100701-药物化学  

陈菁菁  硕士研究生  078001-药物化学  

彭润泽  博士研究生  100701-药物化学  

谢志铖  硕士研究生  078001-药物化学  

段文迪  硕士研究生  078001-药物化学  

赵琪良  硕士研究生  105500-药学  

2005年获中国科学院“****”资助，回国任上海药物研究所研究员、博士研究生导师。2006年获上海市“浦江人才计划”资助，2012年获“国家杰出青年科学基金”资助。主要进行类天然产物和类药性骨架合成的新方法研究、多样性小分子库的构建，及新型活性化合物的发现与优化及候选药物的开发。针对重大疾病的多种生物模型进行筛选，发现多个具有抗肿瘤、抗病毒、抗糖尿病等新结构类型的创新性活性化合物实体，已获得候选新药和新型药物先导物。相关工作获得2项国家自然科学基金面上项目、2项国家重大新药创制专项候选新药专题资助。