晁彦杰 男 博导 中国科学院上海巴斯德研究所
电子邮件: yjchao@ips.ac.cn
通信地址: 岳阳路320号新生命科学大楼B座711室
邮政编码: 200031
电子邮件: yjchao@ips.ac.cn
通信地址: 岳阳路320号新生命科学大楼B座711室
邮政编码: 200031
研究领域
高毒力超级细菌,呼吸道病原体,肠道病原体,微生物致病机理,非编码RNA,基因表达调控,疫苗
招生信息
招生专业
071005-微生物学071009-细胞生物学100103-病原生物学
招生方向
细菌致病机理非编码RNA基因表达调控
教育背景
2008-12--2014-09 Max-Planck Institute & Humboldt University of Berlin, Germany PhD
教授课程
高级微生物学
专利与奖励
专利成果
( 1 ) 检测牛结核抗体的免疫胶体金试纸条及制备方法, 发明专利, 2009, 第 5 作者, 专利号: CN100494352( 2 ) 一种适用于牛结核抗体检测的试剂盒及应用, 发明专利, 2007, 第 3 作者, 专利号: CN1982439( 3 ) 一种肺炎克雷伯菌的新型减毒策略及其在疫苗中的应用, 发明专利, 2024, 第 1 作者, 专利号: 202410792429.2
出版信息
发表论文
(1) RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence, Nature Communications, 2024, 第 10 作者 通讯作者(2) A widely conserved protein Rof inhibits transcription termination factor Rho and promotes Salmonella virulence program, Nature Communications, 2024, 第 14 作者 通讯作者(3) CpxR promotes the carbapenem antibiotic resistance of Klebsiella pneumoniae by directly regulating the expression and the dissemination of blaKPC on the IncFII conjugative plasmid, EMERGING MICROBES AND INFECTIONS, 2023, 第 6 作者 通讯作者(4) In vivo RNA interactome profiling reveals 3'UTR-processed small RNA targeting a central regulatory hub, NATURE COMMUNICATIONS, 2023, 第 7 作者 通讯作者(5) Decoding the microbiome: advances in genetic manipulation for gut bacteria, TRENDS IN MICROBIOLOGY, 2023, 第 4 作者 通讯作者(6) Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection, NATURE COMMUNICATIONS, 2023, 第 10 作者(7) Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?, MICROBIAL CELL, 2023, 第 4 作者 通讯作者(8) RNase III-CLASH brings bacterial RNA networks into focus, TRENDS IN MICROBIOLOGY, 2022, 第 2 作者 通讯作者(9) Impact of pseudouridylation, substrate fold, and degradosome organization on the endonuclease activity of RNase E, RNA, 2021, 第 3 作者(10) The global emergence of a novel Streptococcus suis clade associated with human infections, EMBO MOLECULAR MEDICINE, 2021, 第 2 作者(11) The conserved 3'UTR-derived small RNA NarS mediates mRNA crossregulation during nitrate respiration, NUCLEIC ACIDS RESEARCH, 2020, 第 2 作者(12) InVivo Cleavage Map Illuminates the Central Role of RNase E in Coding and Non-coding RNA Pathways, MOLECULAR CELL, 2017, 第 1 作者(13) A 3'UTR-Derived Small RNA Provides the Regulatory Noncoding Arm of the Inner Membrane Stress Response, MOLECULAR CELL, 2016, 第 1 作者(14) Transcriptome-Wide Identification of Hfq-Associated RNAs in Brucella suis by Deep Sequencing, JOURNAL OF BACTERIOLOGY, 2016, 第 3 作者(15) Dual RNA-seq unveils noncoding RNA functions in host-pathogen interactions, NATURE, 2016, 第 5 作者(16) dRNA-Seq Reveals Genomewide TSSs and Noncoding RNAs of Plant Beneficial Rhizobacterium Bacillus amyloliquefaciens FZB42, PLOS ONE, 2015, 第 3 作者(17) Cross talk between ABC transporter mRNAs via a target mRNA-derived sponge of the GcvB small RNA, EMBO JOURNAL, 2015, 第 2 作者(18) Regulatory small RNAs from the 3' regions of bacterial mRNAs, CURRENT OPINION IN MICROBIOLOGY, 2015, 第 2 作者(19) RNA-Mediated Regulation in Pathogenic Bacteria, COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2013, 第 2 作者(20) An atlas of Hfq-bound transcripts reveals 3'UTRs as a genomic reservoir of regulatory small RNAs, EMBO JOURNAL, 2012, 第 1 作者(21) The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 7 作者(22) CRISPR RNA maturation by trans -encoded small RNA and host factor RNase III, NATURE, 2011, 第 5 作者(23) The role of Hfq in bacterial pathogens, CURRENT OPINION IN MICROBIOLOGY, 2010, 第 1 作者(24) Potential challenges to the Stop TB Plan for humans in China; cattle maintain M.bovis and M. tuberculosis, TUBERCULOSIS, 2009, 第 2 作者(25) Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates in China (vol 46, pg 4075, 2008), JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 第 2 作者(26) Serological survey of bovine herpesvirus type 1 infection in China, VETERINARY MICROBIOLOGY, 2008, (27) Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates in China, JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 第 2 作者(28) Utility of mycobacterial interspersed repetitive unit typing for differentiating Mycobacterium tuberculosis isolates in Wuhan, China, JOURNAL OF MEDICAL MICROBIOLOGY, 2007, 第 5 作者
科研活动
科研项目
( 1 ) 病原细菌小RNA调控功能的系统研究, 主持, 国家级, 2022-07--2025-06( 2 ) 原核非编码RNA研究, 主持, 国家级, 2022-05--2025-04
指导学生
已指导学生
金思卉 硕士研究生 086000-生物与医药
现指导学生
陆雨洁 硕士研究生 086000-生物与医药
林星宇 博士研究生 100103-病原生物学
王皓宇 博士研究生 071005-微生物学
姜宏年 硕士研究生 086002-制药工程
张硕 博士研究生 071005-微生物学
王茂淋 博士研究生 071005-微生物学
程帅 博士研究生 071005-微生物学