晁彦杰  男  博导  中国科学院上海巴斯德研究所
电子邮件: yjchao@ips.ac.cn
通信地址: 岳阳路320号新生命科学大楼B座711室
邮政编码: 200031

研究领域

高毒力超级细菌,呼吸道病原体,肠道病原体,微生物致病机理,非编码RNA,基因表达调控,疫苗

招生信息

招生专业
071005-微生物学
071009-细胞生物学
100103-病原生物学
招生方向
细菌致病机理
非编码RNA
基因表达调控

教育背景

2008-12--2014-09   Max-Planck Institute & Humboldt University of Berlin, Germany   PhD

教授课程

高级微生物学

专利与奖励

   
专利成果
( 1 ) 检测牛结核抗体的免疫胶体金试纸条及制备方法, 发明专利, 2009, 第 5 作者, 专利号: CN100494352

( 2 ) 一种适用于牛结核抗体检测的试剂盒及应用, 发明专利, 2007, 第 3 作者, 专利号: CN1982439

( 3 ) 一种肺炎克雷伯菌的新型减毒策略及其在疫苗中的应用, 发明专利, 2024, 第 1 作者, 专利号: 202410792429.2

出版信息

   
发表论文
(1) RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence, Nature Communications, 2024, 第 10 作者  通讯作者
(2) A widely conserved protein Rof inhibits transcription termination factor Rho and promotes Salmonella virulence program, Nature Communications, 2024, 第 14 作者  通讯作者
(3) CpxR promotes the carbapenem antibiotic resistance of Klebsiella pneumoniae by directly regulating the expression and the dissemination of blaKPC on the IncFII conjugative plasmid, EMERGING MICROBES AND INFECTIONS, 2023, 第 6 作者  通讯作者
(4) In vivo RNA interactome profiling reveals 3'UTR-processed small RNA targeting a central regulatory hub, NATURE COMMUNICATIONS, 2023, 第 7 作者  通讯作者
(5) Decoding the microbiome: advances in genetic manipulation for gut bacteria, TRENDS IN MICROBIOLOGY, 2023, 第 4 作者  通讯作者
(6) Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection, NATURE COMMUNICATIONS, 2023, 第 10 作者
(7) Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?, MICROBIAL CELL, 2023, 第 4 作者  通讯作者
(8) RNase III-CLASH brings bacterial RNA networks into focus, TRENDS IN MICROBIOLOGY, 2022, 第 2 作者  通讯作者
(9) Impact of pseudouridylation, substrate fold, and degradosome organization on the endonuclease activity of RNase E, RNA, 2021, 第 3 作者
(10) The global emergence of a novel Streptococcus suis clade associated with human infections, EMBO MOLECULAR MEDICINE, 2021, 第 2 作者
(11) The conserved 3'UTR-derived small RNA NarS mediates mRNA crossregulation during nitrate respiration, NUCLEIC ACIDS RESEARCH, 2020, 第 2 作者
(12) InVivo Cleavage Map Illuminates the Central Role of RNase E in Coding and Non-coding RNA Pathways, MOLECULAR CELL, 2017, 第 1 作者
(13) A 3'UTR-Derived Small RNA Provides the Regulatory Noncoding Arm of the Inner Membrane Stress Response, MOLECULAR CELL, 2016, 第 1 作者
(14) Transcriptome-Wide Identification of Hfq-Associated RNAs in Brucella suis by Deep Sequencing, JOURNAL OF BACTERIOLOGY, 2016, 第 3 作者
(15) Dual RNA-seq unveils noncoding RNA functions in host-pathogen interactions, NATURE, 2016, 第 5 作者
(16) dRNA-Seq Reveals Genomewide TSSs and Noncoding RNAs of Plant Beneficial Rhizobacterium Bacillus amyloliquefaciens FZB42, PLOS ONE, 2015, 第 3 作者
(17) Cross talk between ABC transporter mRNAs via a target mRNA-derived sponge of the GcvB small RNA, EMBO JOURNAL, 2015, 第 2 作者
(18) Regulatory small RNAs from the 3' regions of bacterial mRNAs, CURRENT OPINION IN MICROBIOLOGY, 2015, 第 2 作者
(19) RNA-Mediated Regulation in Pathogenic Bacteria, COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2013, 第 2 作者
(20) An atlas of Hfq-bound transcripts reveals 3'UTRs as a genomic reservoir of regulatory small RNAs, EMBO JOURNAL, 2012, 第 1 作者
(21) The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 7 作者
(22) CRISPR RNA maturation by trans -encoded small RNA and host factor RNase III, NATURE, 2011, 第 5 作者
(23) The role of Hfq in bacterial pathogens, CURRENT OPINION IN MICROBIOLOGY, 2010, 第 1 作者
(24) Potential challenges to the Stop TB Plan for humans in China; cattle maintain M.bovis and M. tuberculosis, TUBERCULOSIS, 2009, 第 2 作者
(25) Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates in China (vol 46, pg 4075, 2008), JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 第 2 作者
(26) Serological survey of bovine herpesvirus type 1 infection in China, VETERINARY MICROBIOLOGY, 2008, 
(27) Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates in China, JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 第 2 作者
(28) Utility of mycobacterial interspersed repetitive unit typing for differentiating Mycobacterium tuberculosis isolates in Wuhan, China, JOURNAL OF MEDICAL MICROBIOLOGY, 2007, 第 5 作者

科研活动

   
科研项目
( 1 ) 病原细菌小RNA调控功能的系统研究, 主持, 国家级, 2022-07--2025-06
( 2 ) 原核非编码RNA研究, 主持, 国家级, 2022-05--2025-04

指导学生

已指导学生

金思卉  硕士研究生  086000-生物与医药  

现指导学生

陆雨洁  硕士研究生  086000-生物与医药  

林星宇  博士研究生  100103-病原生物学  

王皓宇  博士研究生  071005-微生物学  

姜宏年  硕士研究生  086002-制药工程  

张硕  博士研究生  071005-微生物学  

王茂淋  博士研究生  071005-微生物学  

程帅  博士研究生  071005-微生物学