基本信息
陈以昀 男 博导 上海有机化学研究所
电子邮件:yiyunchen@sioc.ac.cn
通信地址:上海市零陵路345号
邮政编码:200032
课题组网页:http://yiyunchen.sioc.ac.cn/

招生信息

   
招生专业
070303-有机化学
070321-化学生物学
招生方向
生物相容反应;小分子调控蛋白功能
小分子调控蛋白功能;光治疗新方法

教育背景

2002-09--2007-08 普林斯顿大学 有机化学博士
1998-09--2002-07 北京大学 化学学士

工作经历

   
工作简历
2011-11--今 中国科学院上海有机化学研究所 研究员
2007-09--2011-10 哈佛大学,霍华德休斯医学研究院 化学生物学博士后研究员

教授课程

化学小分子全合成与化学生物学、 生物有机化学

专利与奖励

   
奖励信息
(1) ****(青年项目),国家级,2012
(2) 普林斯顿大学Bristol-Myers Squibb研究生合成化学奖,其他级,2005
(3) 北京大学明德奖学金,研究所(学校)级,2002
(4) 第30届国际化学奥林匹克竞赛银牌,其他级,1998
专利成果
[1] 陈以昀, 李齐, 刘丹, 李德芳. 一种流式光化学反应装置. CN: CN110694566A, 2020-01-17.

[2] 陈以昀, 李齐, 刘丹, 李德芳. 一种流式光化学反应装置. CN: CN208599707U, 2019-03-15.

出版信息

发表论文
[1] Zhang,Yixin, Han, Lili, Tian,Xiaoxu, Peng, Chao, Chen,Yiyun. Ligand-Directed Caging Enables the Control of Endogenous DNA Alkyltransferase Activity with Light inside Live Cells. Angewandte Chemie International Edition[J]. 2022, 61: e202115472-, https://onlinelibrary.wiley.com/doi/10.1002/anie.202115472.
[2] Fang, Di, Zhang, Yidan, Chen, Yiyun. Radical C(sp3)-H Heck-type Reaction of N-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols. Organic Letters[J]. 2022, 24: 2050-2054, [3] Wu, Shuang, Li, Junzhao, He, Ru, Jia, Kunfang, Chen,Yiyun. Terminal Trifluoromethylation of Ketones via Selective C-C Cleavage of Cycloalkanols Enabled by Hypervalent Iodine Reagents. Organic Letters[J]. 2021, 23: 9204-9209, [4] 陈以昀. Selective Mitochondrial Proteins Labeling Enabled by Biocompatible Photocatalytic Reactions inside Live Cells. JACS Au[J]. 2021, 1(7): 1066-1075, [5] Liu, Dan, Zhang, Jing, Chen, Yiyun. Investigations on the 1,2-Hydrogen Atom Transfer Reactivity of Alkoxyl Radicals under Visible-Light-Induced Reaction Conditions. SYNLETT[J]. 2021, 32(4): 356-361, https://www.webofscience.com/wos/woscc/full-record/WOS:000595085700001.
[6] 陈以昀. Selective C(sp3)-C(sp3) Cleavage/Alkynylation of Cycloalkylamides Enables Aminoalkyne Synthesis with Hypervalent Iodine Reagent. ACS Catalysis[J]. 2021, 11(16): 10565-10573, [7] Chen, Yiyun. Illuminating Biology with Visible-Light-induced Biocompatible Reactions. CHEMPHOTOCHEMnull. 2020, 4(5): 319-320, http://dx.doi.org/10.1002/cptc.202000033.
[8] Jing Zhang, Dan Liu, Song Liu, Yuanyuan Ge, Yu Lan, Yiyun Chen. Visible-Light-Induced Alkoxyl Radicals Enable α-C(sp3)-H Bond Allylation. iScience. 2020, 23(1): [9] Xie, Shasha, Li, Defang, Huang, Hanchu, Zhang, Fuyuan, Chen, Yiyun. Intermolecular Radical Addition to Ketoacids Enabled by Boron Activation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(41): 16237-16242, https://www.webofscience.com/wos/woscc/full-record/WOS:000491220300010.
[10] Wang, Haoyan, Li, WeiGuang, Zeng, Kaixing, Wu, YanJiao, Zhang, Yixin, Xu, TianLe, Chen, Yiyun. Photocatalysis Enables Visible-Light Uncaging of Bioactive Molecules in Live Cells. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(2): 561-565, [11] Huang, Ying, Savych, Olena, Moroz, Yuii, Chen, Yiyun, Goodnow, Robert A, Jr. DNA-Encoded Library Chemistry: Amplification of Chemical Reaction Diversity for the Exploration of Chemical Space. ALDRICHIMICA ACTA[J]. 2019, 52(3): 75-87, [12] Li, Junzhao, Liu, Zhengyi, Wu, Shuang, Chen, Yiyun. Acyl Radical Smiles Rearrangement To Construct Hydroxybenzophenones by Photoredox Catalysis. ORGANIC LETTERS[J]. 2019, 21(7): 2077-2080, https://www.webofscience.com/wos/woscc/full-record/WOS:000464247500030.
[13] Chen, Yiyun, Lu, LiangQiu, Yu, DaGang, Zhu, ChengJian, Xiao, WenJing. Visible light-driven organic photochemical synthesis in China. SCIENCE CHINA-CHEMISTRYnull. 2019, 62(1): 24-57, http://lib.cqvip.com/Qikan/Article/Detail?id=6100204794.
[14] 陈以昀. Selective P-C(sp3) Bond Cleavage and Radical Alkynylation of α-Phosphorus Alcohols by Photoredox Catalysis. Chem. Eur. J.. 2018, [15] 陈以昀. Visible-Light-Induced Alkoxyl Radical Generation for Inert Chemical Bond Cleavage/Functionalizations. Chem. Commun.. 2018, [16] Pan, Yue, Jia, Kunfang, Chen, Yali, Chen, Yiyun. Investigations of alkynylbenziodoxole derivatives for radical alkynylations in photoredox catalysis. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 14(1): 1215-1221, http://www.corc.org.cn/handle/1471x/2178357.
[17] Mingshang Liu, Hanchu Huang, Yiyun Chen. Cyclic Iodine Reagents Enable Allylic Alcohols for Alkyl Boronate Addition/Rearrangement by Photoredox Catalysis. Chinese Journal of Chemistry[J]. 2018, 1209-1212, https://www.webofscience.com/wos/woscc/full-record/WOS:000450017200019.
[18] Li, Yang, Zhang, Jing, Li, Defang, Chen, Yiyun. Metal-Free C(sp(3))-H Allylation via Aryl Carboxyl Radicals Enabled by Donor-Acceptor Complex. ORGANIC LETTERS[J]. 2018, 20(11): 3296-3299, https://www.webofscience.com/wos/woscc/full-record/WOS:000434367500033.
[19] Zhang Jing, Chen Yiyun. Visible-Light-Induced Carboxyl and Alkoxyl Radical Generations and Reactions. ACTA CHIMICA SINICAnull. 2017, 75(1): 41-48, https://www.webofscience.com/wos/woscc/full-record/WOS:000395965800005.
[20] Zhang, Jing, Li, Yang, Xu, Ruoyu, Chen, Yiyun. Donor-Acceptor Complex Enables Alkoxyl Radical Generation for Metal-Free C(sp(3))-C(sp(3)) Cleavage and Allylation/Alkenylation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(41): 12619-12623, https://www.webofscience.com/wos/woscc/full-record/WOS:000411810600036.
[21] Jia, Kunfang, Pan, Yue, Chen, Yiyun. Selective Carbonyl-C(sp(3)) Bond Cleavage To Construct Ynamides, Ynoates, and Ynones by Photoredox Catalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(9): 2478-2481, http://www.corc.org.cn/handle/1471x/2193408.
[22] 张晶, 陈以昀. 可见光引发的氧自由基的新型产生方式及反应. 化学学报. 2017, [23] Huang, Hanchu, Jia, Kunfang, Chen, Yiyun. Radical Decarboxylative Functionalizations Enabled by Dual Photoredox Catalysis. ACS CATALYSIS[J]. 2016, 6(8): 4983-4988, https://www.webofscience.com/wos/woscc/full-record/WOS:000381236700016.
[24] Qi, Li, Chen, Yiyun. Polarity-Reversed Allylations of Aldehydes, Ketones, and Imines Enabled by Hantzsch Ester in Photoredox Catalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(42): 13312-13315, [25] Zhang, Jing, Li, Yang, Zhang, Fuyuan, Hu, Chenchen, Chen, Yiyun. Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp(3))-H Functionalization under Mild Reaction Conditions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(5): 1872-1875, https://www.webofscience.com/wos/woscc/full-record/WOS:000369854000052.
[26] Jia, Kunfang, Zhang, Fuyuan, Huang, Hanchu, Chen, Yiyun. Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp(3))-C(sp(3)) Bond Cleavage and Functionalizations. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 138(5): 1514-1517, https://www.webofscience.com/wos/woscc/full-record/WOS:000370215400011.
[27] Hu, Chenchen, Chen, Yiyun. Biomolecule-compatible chemical bond-formation and bond-cleavage reactions induced by visible light. TETRAHEDRON LETTERS[J]. 2015, 56(7): 884-888, http://dx.doi.org/10.1016/j.tetlet.2014.12.034.
[28] Yang, Jie, Zhang, Jing, Qi, Li, Hu, Chenchen, Chen, Yiyun. Visible-light-induced chemoselective reductive decarboxylative alkynylation under biomolecule-compatible conditions. CHEMICAL COMMUNICATIONS[J]. 2015, 51(25): 5275-5278, https://www.webofscience.com/wos/woscc/full-record/WOS:000351393600016.
[29] Huang, Hanchu, Zhang, Guojin, Chen, Yiyun. Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(27): 7872-7876, https://www.webofscience.com/wos/woscc/full-record/WOS:000356886600024.
[30] Hu, Chenchen, Chen, Yiyun. Chemoselective and fast decarboxylative allylation by photoredox catalysis under mild conditions. ORGANIC CHEMISTRY FRONTIERS[J]. 2015, 2(10): 1352-1355, http://dx.doi.org/10.1039/c5qo00187k.
[31] Huang, Hanchu, Jia, Kunfang, Chen, Yiyun. Hypervalent Iodine Reagents Enable Chemoselective Deboronative/Decarboxylative Alkenylation by Photoredox Catalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(6): 1881-1884, https://www.webofscience.com/wos/woscc/full-record/WOS:000349209200037.
[32] Huang, Hanchu, Zhang, Guojin, Gong, Li, Zhang, Shuaiyan, Chen, Yiyun. Visible-Light-Induced Chemoselective Deboronative Alkynylation under Biomolecule-Compatible Conditions. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2014, 136(6): 2280-2283, https://www.webofscience.com/wos/woscc/full-record/WOS:000331343300024.
[33] Dumelin, Christoph E, Chen, Yiyun, Leconte, Aaron M, Chen, Y Grace, Liu, David R. Discovery and biological characterization of geranylated RNA in bacteria. NATURE CHEMICAL BIOLOGY[J]. 2012, 8(11): 913-919, https://www.webofscience.com/wos/woscc/full-record/WOS:000310052100010.
[34] Chen, Yiyun, Kamlet, Adam S, Steinman, Jonathan B, Liu, David R. A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system. NATURE CHEMISTRY[J]. 2011, 3(2): 146-153, http://dx.doi.org/10.1038/NCHEM.932.
[35] Chen, Yiyun, Park, Sung Hwan, Lee, Chung Whan, Lee, Chulbom. Ruthenium-Catalyzed Three-Component Coupling via Hydrative Conjugate Addition of Alkynes to Alkenes: One-Pot Synthesis of 1,4-Dicarbonyl Compounds. CHEMISTRY-AN ASIAN JOURNAL[J]. 2011, 6(8): 2000-2004, https://www.webofscience.com/wos/woscc/full-record/WOS:000294112200020.
[36] Chen, YY, Ho, DM, Lee, C. Ruthenium-catalyzed hydrative cyclization of 1,5-enynes. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2005, 127(35): 12184-12185, https://www.webofscience.com/wos/woscc/full-record/WOS:000231637100018.
发表著作
(1) 三(乙酰丙酮基)铁(III), e-EROS有机合成试剂百科全书,Tris(acetylacetonato)iron(III), e-EROS Encyclopedia of Reagents for Organic Synthesis,John Wiley and Sons,2007-01,第1作者

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