生物相容光化学：有机光化学，光化学生物学

   

070303-有机化学
0703Z1-化学生物学

有机光化学
光化学生物学

2002-09--2007-08   普林斯顿大学   有机化学博士
1998-09--2002-07   北京大学   化学学士

   

2011-11~现在, 中国科学院上海有机化学研究所, 研究员
2007-09~2011-10,哈佛大学，霍华德休斯医学研究院, 化学生物学博士后研究员

生物有机化学
化学生物学主题研讨课
高等有机化学
专业英语（化材）
专业英语（化学）
主题研讨课（有机化学）
硕士研讨班（有机化学）
物理有机化学
化学小分子全合成与化学生物学

   

（1） 中国科学院大学院级优秀授课教师, 院级, 2022
（2） 拜耳研究奖, 其他, 2021
（3） 药明康德生命化学研究奖, 国家级, 2021
（4） 上海市优秀学术/技术带头人, , 省级, 2021
（5） Thieme Chemistry Journal Award, 其他, 2018
（6） 上海市科技系统青年五四奖章, 省级, 2018
（7） 中国光化学泊菲莱优秀青年科学家奖, 部委级, 2017
（8） 国家自然科学基金委员会优秀青年科学基金, 部委级, 2016
（9） ****（青年项目）, , 国家级, 2012
（10） 上海浦江人才计划, 省级, 2012
（11） 普林斯顿大学Bristol-Myers Squibb研究生合成化学奖, , 其他, 2005
（12） 北京大学明德奖学金, , 研究所（学校）, 2002
（13） 第30届国际化学奥林匹克竞赛银牌, , 其他, 1998

[1] 陈以昀, 李齐, 刘丹, 李德芳. 一种流式光化学反应装置. CN: CN208599707U, 2019-03-15.

[2] 陈以昀, 李齐, 刘丹, 李德芳. 一种流式光化学反应装置. CN: CN208599707U, 2019-03-15.

[3] 陈以昀, 李齐, 刘丹, 李德芳. 一种流式光化学反应装置. CN: CN110694566B, 2024-06-28.

[1] 陈以昀. Photocatalytic Aldehyde Allylation for Site-Specific DNA Functionalization. Chinese Journal of Chemistry[J]. 2025, 第 1 作者  通讯作者  43(null): 97-103, 
[2] Huang, Ying, Zhang, Yixin, Hu, Chenchen, Chen, Yiyun. Site-specific DNA post-synthetic modification via fast photocatalytic allylation. ORGANIC CHEMISTRY FRONTIERS[J]. 2024, 第 4 作者  通讯作者  11(16): 4408-4415, http://dx.doi.org/10.1039/d4qo00752b.
[3] Hao, Kejia, Li, Defang, Fu, Dongmin, Zou, Peng, Xie, Shasha, Lan, Yu, Chen, Yiyun. Metal-Free 1,3-Boronate Rearrangement to Ketones Driven by Visible Light. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2024, 第 7 作者  通讯作者  null(null): http://dx.doi.org/10.1002/anie.202316481.
[4] Kaixing Zeng, ZhiHan Jiao, Qin Jiang, Ru He, Yixin Zhang, WeiGuang Li, TianLe Xu, Yiyun Chen. Genetically EncodedPhotocatalysis Enables SpatiallyRestricted Optochemical Modulation of Neurons in Live Mice. ACS CENTRAL SCIENCE[J]. 2024, 第 8 作者  通讯作者  10(1): 163-175, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10823520/.
[5] 陈以昀. Chemoselective Synthesis of α-Tertiary Hydroxy Oximes via Photochemical 1,3-Boronate Rearrangement. Org. Lett.[J]. 2024, 第 1 作者  通讯作者  26(null): 7795-7799, 
[6] 陈以昀. Radical 6-Endo Addition Enables Pyridine Synthesis under Metal-Free Conditions. Angewandte Chemie[J]. 2024, 第 1 作者  通讯作者  63(null): e202410297, 
[7] 陈以昀. Photochemical 1,3-Boronate Rearrangement Enables Three-Component N-Alkylation for α-Tertiary Hydroxybenzylamine Synthesis. Nat. Commun.[J]. 2024, 第 1 作者  通讯作者  15(null): 10234, 
[8] 陈以昀. Photocatalytic Oxyalkynylation of Unactivated Alkenes Enabled by Hypervalent Iodine (III) Reagents. ACS Catal.[J]. 2024, 第 1 作者  通讯作者  14(null): 13202-13208, 
[9] Liu, Dan, Yang, Kai, Fang, Di, Lan, Yu, Chen，Yiyun. Formyl Radical Generation from α-Chloro N-Methoxyphthalimides Enables Selective Aldehyde Synthesis. Angewandte Chemie International Edition[J]. 2023, 第 5 作者  通讯作者  62: e202213686, 
[10] Zhang, Yixin, Tan, Jiawei, Chen, Yiyun. Visible-light-induced protein labeling in live cells with aryl azides. CHEMICAL COMMUNICATIONS. 2023, 第 3 作者  通讯作者  59(17): 2413-2420, http://dx.doi.org/10.1039/d2cc06987c.
[11] 张议丹, 韩丽丽, 陈以昀. Photo-Modulation of Gene-Editing Enzymes CRISPR/Cas9 with Bifunctional Small-Molecule Ligands. Chinese Journal of Chemistry[J]. 2023, 第 3 作者  通讯作者  
[12] Ge, Yuanyuan, Shao, Yingbo, Wu, Shuang, Liu, Pan, Li, Junzhao, Qin, Hanzhang, Zhang, Yanxia, Xue, Xiaosong, Chen, Yiyun. Distal Amidoketone Synthesis Enabled by Dimethyl Benziodoxoles via Dual Copper/Photoredox Catalysis. ACS CATALYSIS[J]. 2023, 第 9 作者  通讯作者  3749-3756, http://dx.doi.org/10.1021/acscatal.3c00230.
[13] Wu, Shuang, Chen, Yiyun. Selective C-H Acyloxylation of Sulfides/Disulfides Enabled by Hypervalent Iodine Reagents. ADVANCED SYNTHESIS & CATALYSIS[J]. 2023, 第 2 作者  通讯作者  365(16): 2690-2696, http://dx.doi.org/10.1002/adsc.202300360.
[14] Liu, Zhengyi, Pan, Yue, Zou, Peng, Huang, Hanchu, Chen, Yali, Chen, Yiyun. Hypervalent Iodine Reagents Enable C-H Alkynylation with Iminophenylacetic Acids via Alkoxyl Radicals. ORGANIC LETTERS[J]. 2022, 第 6 作者  通讯作者  24(32): 5951-5956, http://dx.doi.org/10.1021/acs.orglett.2c02210.
[15] Zhang，Yixin, Han， Lili, Tian，Xiaoxu, Peng， Chao, Chen，Yiyun. Ligand-Directed Caging Enables the Control of Endogenous DNA Alkyltransferase Activity with Light inside Live Cells. Angewandte Chemie International Edition[J]. 2022, 第 5 作者  通讯作者  61: e202115472, https://onlinelibrary.wiley.com/doi/10.1002/anie.202115472.
[16] Pan, Yue, Liu, Zhengyi, Zou, Peng, Chen, Yali, Chen, Yiyun. Hypervalent Iodine Reagents Enable C(sp(2))-H Amidation of (Hetero)arenes with Iminophenylacetic Acids. ORGANIC LETTERS[J]. 2022, 第 5 作者  通讯作者  24(36): 6681-6685, http://dx.doi.org/10.1021/acs.orglett.2c02751.
[17] Fang, Di, Zhang, Yidan, Chen, Yiyun. Radical C(sp3)-H Heck-type Reaction of N-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols. Organic Letters[J]. 2022, 第 3 作者  通讯作者  24: 2050-2054, 
[18] Zeng, Kaixing, Han, Lili, Chen, Yiyun. Endogenous Proteins Modulation in Live Cells with Small Molecules and Light. CHEMBIOCHEM[J]. 2022, 第 3 作者  通讯作者  23(21): http://dx.doi.org/10.1002/cbic.202200244.
[19] Wu, Shuang, Li, Junzhao, He, Ru, Jia, Kunfang, Chen，Yiyun. Terminal Trifluoromethylation of Ketones via Selective C-C Cleavage of Cycloalkanols Enabled by Hypervalent Iodine Reagents. Organic Letters[J]. 2021, 第 5 作者  通讯作者  23: 9204-9209, 
[20] Haoyan Wang, Yixin Zhang, Kaixing Zeng, Jiali Qiang, Ye Cao, Yunxia Li, Yanshan Fang, Yaoyang Zhang, Yiyun Chen. Selective Mitochondrial Protein Labeling Enabled by Biocompatible Photocatalytic Reactions inside Live Cells. JACS AU[J]. 2021, 第 9 作者  通讯作者  1(7): https://doaj.org/article/12928db9b863482b89181164074a7a32.
[21] Liu, Zhengyi, Wu, Shuang, Chen, Yiyun. Selective C(sp(3))-C(sp(3)) Cleavage/Alkynylation of Cycloalkylamides Enables Aminoalkyne Synthesis with Hypervalent Iodine Reagents. ACS CATALYSIS[J]. 2021, 第 3 作者  通讯作者  11(16): 10565-10573, http://dx.doi.org/10.1021/acscatal.1c02981.
[22] Liu, Dan, Zhang, Jing, Chen, Yiyun. Investigations on the 1,2-Hydrogen Atom Transfer Reactivity of Alkoxyl Radicals under Visible-Light-Induced Reaction Conditions. SYNLETT[J]. 2021, 第 3 作者  通讯作者  32(4): 356-361, https://www.webofscience.com/wos/woscc/full-record/WOS:000595085700001.
[23] Zhang, Jing, Liu, Dan, Liu, Song, Ge, Yuanyuan, Lan, Yu, Chen, Yiyun. Visible-Light-Induced Alkoxyl Radicals Enable alpha-C(sp(3))-H Bond Allylation. ISCIENCE[J]. 2020, 第 6 作者  通讯作者  23(1): http://dx.doi.org/10.1016/j.isci.2019.100755.
[24] Chen, Yiyun. Illuminating Biology with Visible-Light-induced Biocompatible Reactions. CHEMPHOTOCHEM. 2020, 第 1 作者  通讯作者  4(5): 319-320, http://dx.doi.org/10.1002/cptc.202000033.
[25] Jing Zhang, Dan Liu, Song Liu, Yuanyuan Ge, Yu Lan, Yiyun Chen. Visible-Light-Induced Alkoxyl Radicals Enable α-C(sp3)-H Bond Allylation. ISCIENCE[J]. 2020, 第 6 作者  通讯作者  23(1): 
[26] Xie, Shasha, Li, Defang, Huang, Hanchu, Zhang, Fuyuan, Chen, Yiyun. Intermolecular Radical Addition to Ketoacids Enabled by Boron Activation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 第 5 作者  通讯作者  141(41): 16237-16242, https://www.webofscience.com/wos/woscc/full-record/WOS:000491220300010.
[27] Wang, Haoyan, Li, WeiGuang, Zeng, Kaixing, Wu, YanJiao, Zhang, Yixin, Xu, TianLe, Chen, Yiyun. Photocatalysis Enables Visible-Light Uncaging of Bioactive Molecules in Live Cells. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 第 7 作者  通讯作者  58(2): 561-565, 
[28] Huang, Ying, Savych, Olena, Moroz, Yuii, Chen, Yiyun, Goodnow, Robert A, Jr. DNA-Encoded Library Chemistry: Amplification of Chemical Reaction Diversity for the Exploration of Chemical Space. ALDRICHIMICA ACTA[J]. 2019, 第 4 作者  通讯作者  52(3): 75-87, 
[29] Li, Junzhao, Liu, Zhengyi, Wu, Shuang, Chen, Yiyun. Acyl Radical Smiles Rearrangement To Construct Hydroxybenzophenones by Photoredox Catalysis. ORGANIC LETTERS[J]. 2019, 第 4 作者  通讯作者  21(7): 2077-2080, http://dx.doi.org/10.1021/acs.orglett.9b00353.
[30] Chen, Yiyun, Lu, LiangQiu, Yu, DaGang, Zhu, ChengJian, Xiao, WenJing. Visible light-driven organic photochemical synthesis in China. SCIENCE CHINA-CHEMISTRY[J]. 2019, 第 1 作者  通讯作者  62(1): 24-57, http://lib.cqvip.com/Qikan/Article/Detail?id=6100204794.
[31] 陈以昀. Visible-Light-Induced Alkoxyl Radical Generation for Inert Chemical Bond Cleavage/Functionalizations. Chem. Commun.. 2018, 第 1 作者  通讯作者  
[32] Jia, Kunfang, Chen, Yiyun. Visible-light-induced alkoxyl radical generation for inert chemical bond cleavage/functionalization. CHEMICAL COMMUNICATIONS. 2018, 第 2 作者  通讯作者  54(48): 6105-6112, http://dx.doi.org/10.1039/c8cc02642d.
[33] Pan, Yue, Jia, Kunfang, Chen, Yali, Chen, Yiyun. Investigations of alkynylbenziodoxole derivatives for radical alkynylations in photoredox catalysis. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 第 4 作者  通讯作者  14(1): 1215-1221, http://www.corc.org.cn/handle/1471x/2178357.
[34] Mingshang Liu, Hanchu Huang, Yiyun Chen. Cyclic Iodine Reagents Enable Allylic Alcohols for Alkyl Boronate Addition/Rearrangement by Photoredox Catalysis. CHINESE JOURNAL OF CHEMISTRY[J]. 2018, 第 3 作者  通讯作者  1209-1212, https://www.webofscience.com/wos/woscc/full-record/WOS:000450017200019.
[35] Li, Yang, Zhang, Jing, Li, Defang, Chen, Yiyun. Metal-Free C(sp(3))-H Allylation via Aryl Carboxyl Radicals Enabled by Donor-Acceptor Complex. ORGANIC LETTERS[J]. 2018, 第 4 作者  通讯作者  20(11): 3296-3299, http://dx.doi.org/10.1021/acs.orglett.8b01172.
[36] Liu, Mingshang, Huang, Hanchu, Chen, Yiyun. Cyclic Iodine Reagents Enable Allylic Alcohols for Alkyl Boronate Addition/Rearrangement by Photoredox Catalysis. CHINESE JOURNAL OF CHEMISTRY[J]. 2018, 第 3 作者  通讯作者  36(12): 1209-1212, http://lib.cqvip.com/Qikan/Article/Detail?id=6100154730.
[37] Jia, Kunfang, Li, Junzhao, Chen, Yiyun. Selective P-C(sp(3)) Bond Cleavage and Radical Alkynylation of alpha-Phosphorus Alcohols by Photoredox Catalysis. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2018, 第 3 作者  通讯作者  24(13): 3174-3177, https://www.webofscience.com/wos/woscc/full-record/WOS:000426495100017.
[38] Zhang, Jing, Li, Yang, Xu, Ruoyu, Chen, Yiyun. Donor-Acceptor Complex Enables Alkoxyl Radical Generation for Metal-Free C(sp(3))-C(sp(3)) Cleavage and Allylation/Alkenylation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 第 4 作者  通讯作者  56(41): 12619-12623, http://dx.doi.org/10.1002/anie.201707171.
[39] Zhang Jing, Chen Yiyun. Visible-Light-Induced Carboxyl and Alkoxyl Radical Generations and Reactions. ACTA CHIMICA SINICA. 2017, 第 2 作者  通讯作者  75(1): 41-48, http://dx.doi.org/10.6023/A16080416.
[40] Jia, Kunfang, Pan, Yue, Chen, Yiyun. Selective Carbonyl-C(sp(3)) Bond Cleavage To Construct Ynamides, Ynoates, and Ynones by Photoredox Catalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 第 3 作者  通讯作者  56(9): 2478-2481, http://www.corc.org.cn/handle/1471x/2193408.
[41] 张晶, 陈以昀. 可见光引发的氧自由基的新型产生方式及反应. 化学学报[J]. 2017, 第 2 作者41-48, 
[42] Jia Kunfang Zhang Fuyuan Huang Hanchu Chen Yiyun. Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp(3))-C(sp(3)) Bond Cleavage and Functionalizations. 2016, 138(5): 1514-1517, 
[43] Zhang Jing, Li Yang, Zhang Fuyuan, Hu Chenchen, Chen Yiyun. Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp3)−H Functionalization under Mild Reaction Conditions. ANGEWANDTE CHEMIE[J]. 2016, 第 5 作者  通讯作者  55: 1872-1875, http://dx.doi.org/10.1002/ange.201510014.
[44] Qi, Li, Chen, Yiyun. Polarity-Reversed Allylations of Aldehydes, Ketones, and Imines Enabled by Hantzsch Ester in Photoredox Catalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 第 2 作者  通讯作者  55(42): 13312-13315, 
[45] Zhang, Jing, Li, Yang, Zhang, Fuyuan, Hu, Chenchen, Chen, Yiyun. Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp(3))-H Functionalization under Mild Reaction Conditions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 第 5 作者  通讯作者  55(5): 1872-1875, https://www.webofscience.com/wos/woscc/full-record/WOS:000369854000052.
[46] Jia, Kunfang, Zhang, Fuyuan, Huang, Hanchu, Chen, Yiyun. Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp(3))-C(sp(3)) Bond Cleavage and Functionalizations. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 第 4 作者  通讯作者  138(5): 1514-1517, http://dx.doi.org/10.1021/jacs.5b13066.
[47] Huang, Hanchu, Jia, Kunfang, Chen, Yiyun. Radical Decarboxylative Functionalizations Enabled by Dual Photoredox Catalysis. ACS CATALYSIS[J]. 2016, 第 3 作者  通讯作者  6(8): 4983-4988, https://www.webofscience.com/wos/woscc/full-record/WOS:000381236700016.
[48] Hu, Chenchen, Chen, Yiyun. Biomolecule-compatible chemical bond-formation and bond-cleavage reactions induced by visible light. TETRAHEDRON LETTERS[J]. 2015, 第 2 作者  通讯作者  56(7): 884-888, http://dx.doi.org/10.1016/j.tetlet.2014.12.034.
[49] Yang, Jie, Zhang, Jing, Qi, Li, Hu, Chenchen, Chen, Yiyun. Visible-light-induced chemoselective reductive decarboxylative alkynylation under biomolecule-compatible conditions. CHEMICAL COMMUNICATIONS[J]. 2015, 第 5 作者  通讯作者  51(25): 5275-5278, https://www.webofscience.com/wos/woscc/full-record/WOS:000351393600016.
[50] Huang, Hanchu, Zhang, Guojin, Chen, Yiyun. Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 第 3 作者  通讯作者  54(27): 7872-7876, https://www.webofscience.com/wos/woscc/full-record/WOS:000356886600024.
[51] Hu, Chenchen, Chen, Yiyun. Chemoselective and fast decarboxylative allylation by photoredox catalysis under mild conditions. ORGANIC CHEMISTRY FRONTIERS[J]. 2015, 第 2 作者2(10): 1352-1355, http://dx.doi.org/10.1039/c5qo00187k.
[52] Huang, Hanchu, Jia, Kunfang, Chen, Yiyun. Hypervalent Iodine Reagents Enable Chemoselective Deboronative/Decarboxylative Alkenylation by Photoredox Catalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 第 3 作者  通讯作者  54(6): 1881-1884, https://www.webofscience.com/wos/woscc/full-record/WOS:000349209200037.
[53] Huang, Hanchu, Zhang, Guojin, Gong, Li, Zhang, Shuaiyan, Chen, Yiyun. Visible-Light-Induced Chemoselective Deboronative Alkynylation under Biomolecule-Compatible Conditions. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2014, 第 5 作者  通讯作者  136(6): 2280-2283, https://www.webofscience.com/wos/woscc/full-record/WOS:000331343300024.
[54] Dumelin, Christoph E, Chen, Yiyun, Leconte, Aaron M, Chen, Y Grace, Liu, David R. Discovery and biological characterization of geranylated RNA in bacteria. NATURE CHEMICAL BIOLOGY[J]. 2012, 第 2 作者8(11): 913-919, https://www.webofscience.com/wos/woscc/full-record/WOS:000310052100010.
[55] Chen, Yiyun, Park, Sung Hwan, Lee, Chung Whan, Lee, Chulbom. Ruthenium-Catalyzed Three-Component Coupling via Hydrative Conjugate Addition of Alkynes to Alkenes: One-Pot Synthesis of 1,4-Dicarbonyl Compounds. CHEMISTRY-AN ASIAN JOURNAL[J]. 2011, 第 1 作者6(8): 2000-2004, http://dx.doi.org/10.1002/asia.201100266.
[56] Chen, Yiyun, Kamlet, Adam S, Steinman, Jonathan B, Liu, David R. A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system. NATURE CHEMISTRY[J]. 2011, 第 1 作者  通讯作者  3(2): 146-153, http://dx.doi.org/10.1038/NCHEM.932.
[57] Chen, YY, Ho, DM, Lee, C. Ruthenium-catalyzed hydrative cyclization of 1,5-enynes. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2005, 127(35): 12184-12185, https://www.webofscience.com/wos/woscc/full-record/WOS:000231637100018.

（1） Tris(acetylacetonato)iron(III), e-EROS Encyclopedia of Reagents for Organic Synthesis, John Wiley and Sons, 2007-01, 第 1 作者
（2） Photochemistry of Hypervalent Iodine Compounds in Patai’s Chemistry of Functional Groups, John Wiley & Sons, 2018-01, 第 2 作者
（3） Oxygen-centered radicals, Science of Synthesis Reference Library: Free Radicals: Fundamentals and Applications in Organic Synthesis, Georg Thieme Verlag KG, 2021-07, 第 3 作者
（4） 2-(Chloromethoxy)-1H-isoindole-1,3(2H)-dione, John Wiley & Sons, 2024-01, 第 2 作者