生物相容光化学：有机光化学，光化学生物学

   

070303-有机化学
0703Z1-化学生物学

有机光化学
光化学生物学

2011-11--中国科学院上海有机化学研究所   研究员
2007-09--2011-10   哈佛大学，霍华德休斯医学研究院   化学生物学博士后研究员
2002-09--2007-08   普林斯顿大学   有机化学博士
1998-09--2002-07   北京大学   化学学士

   

2011-11~现在, 中国科学院上海有机化学研究所, 研究员
2007-09~2011-10,哈佛大学，霍华德休斯医学研究院, 化学生物学博士后研究员

生物有机化学
高等有机化学
专业英语（化材）
化学生物学主题研讨课
专业英语（化学）
硕士研讨班（有机化学）
主题研讨课（有机化学）
物理有机化学
化学小分子全合成与化学生物学

（1） Photochemical Boronate Rearrangement Enables the One-Pot Synthesis of 2,4-Difunctionalized 2H-Chromenes, Organic Letters, 2026, 第 3 作者  通讯作者
（2） Quantitative profiling of lipid transport between organelles enabled by subcellular photocatalytic labelling, Nature Chemistry, 2025, 第 6 作者  通讯作者
（3） Miniature Photoenzyme Enables Organelle-Specific Cellular Control via Deboronative Hydroxylation, Angewandte Chemie International Edition, 2025, 第 6 作者  通讯作者
（4） Bioorthogonal Photocatalytic Protein Labeling and Cross-Linking Enabled by Stabilized Ketyl Radicals, Journal of the American Chemical Society, 2025, 第 10 作者  通讯作者
（5） Thiophenol-Catalyzed Radical Hydroformylation of Unactivated Sterically Hindered Alkenes, Journal of the American Chemical Society, 2025, 第 5 作者  通讯作者
（6） Inside Back Cover: Miniature Photoenzyme Enables Organelle-Specific Cellular Control via Deboronative Hydroxylation, Angewandte Chemie International Edition, 2025, 第 6 作者  通讯作者
（7） Photocatalytic Aldehyde Allylation for Site-Specific DNA Functionalization, Chinese Journal of Chemistry, 2025, 第 2 作者  通讯作者
（8） Chemoselective Synthesis of α -Tertiary Hydroxy Oximes via Photochemical 1,3-Boronate Rearrangement, ORGANIC LETTERS, 2024, 第 4 作者  通讯作者
（9） Radical 6- Endo Addition Enables Pyridine Synthesis under Metal-Free Conditions, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2024, 第 6 作者  通讯作者
（10） Photochemical 1,3-boronate rearrangement enables three-component N-alkylation for α-tertiary hydroxybenzylamine synthesis, NATURE COMMUNICATIONS, 2024, 第 6 作者  通讯作者
（11） Photocatalytic Oxyalkynylation of Unactivated Alkenes Enabled by Hypervalent Iodine(III) Reagents, ACS CATALYSIS, 2024, 第 4 作者  通讯作者
（12） Site-specific DNA post-synthetic modification via fast photocatalytic allylation, ORGANIC CHEMISTRY FRONTIERS, 2024, 第 4 作者  通讯作者
（13） Metal-Free 1,3-Boronate Rearrangement to Ketones Driven by Visible Light, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2024, 第 7 作者  通讯作者
（14） Formyl Radical Generation from α-Chloro N -Methoxyphthalimides Enables Selective Aldehyde Synthesis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 第 6 作者  通讯作者
（15） Visible-light-induced protein labeling in live cells with aryl azides, CHEMICAL COMMUNICATIONS, 2023, 第 3 作者  通讯作者
（16） Distal Amidoketone Synthesis Enabled by Dimethyl Benziodoxoles via Dual Copper/Photoredox Catalysis, ACS CATALYSIS, 2023, 第 9 作者  通讯作者
（17） Selective C-H Acyloxylation of Sulfides/Disulfides Enabled by Hypervalent Iodine Reagents, ADVANCED SYNTHESIS & CATALYSIS, 2023, 第 2 作者  通讯作者
（18） Genetically Encoded Photocatalysis Enables Spatially Restricted Optochemical Modulation of Neurons in Live Mice, ACS CENTRAL SCIENCE, 2023, 第 8 作者  通讯作者
（19） Radical C(sp 3 )-H Heck-type Reaction of N -Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols, ORGANIC LETTERS, 2022, 第 3 作者  通讯作者
（20） Hypervalent Iodine Reagents Enable C(sp 2 )-H Amidation of (Hetero)arenes with Iminophenylacetic Acids, ORGANIC LETTERS, 2022, 第 5 作者  通讯作者
（21） Hypervalent Iodine Reagents Enable C-H Alkynylation with Iminophenylacetic Acids via Alkoxyl Radicals, ORGANIC LETTERS, 2022, 第 6 作者  通讯作者
（22） Ligand-Directed Caging Enables the Control of Endogenous DNA Alkyltransferase Activity with Light inside Live Cells, Angewandte Chemie International Edition, 2022, 第 5 作者  通讯作者
（23） Hypervalent Iodine Reagents Enable C(sp(2))-H Amidation of (Hetero)arenes with Iminophenylacetic Acids, ORGANIC LETTERS, 2022, 第 5 作者  通讯作者
（24） Radical C(sp3)-H Heck-type Reaction of N-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols, Organic Letters, 2022, 第 3 作者  通讯作者
（25） Endogenous Proteins Modulation in Live Cells with Small Molecules and Light, CHEMBIOCHEM, 2022, 第 3 作者  通讯作者
（26） Terminal Trifluoromethylation of Ketones via Selective C-C Cleavage of Cycloalkanols Enabled by Hypervalent Iodine Reagents, Organic Letters, 2021, 第 5 作者  通讯作者
（27） Selective Mitochondrial Protein Labeling Enabled by Biocompatible Photocatalytic Reactions inside Live Cells, JACS AU, 2021, 第 9 作者  通讯作者
（28） Selective C(sp(3))-C(sp(3)) Cleavage/Alkynylation of Cycloalkylamides Enables Aminoalkyne Synthesis with Hypervalent Iodine Reagents, ACS CATALYSIS, 2021, 第 3 作者  通讯作者
（29） Investigations on the 1,2-Hydrogen Atom Transfer Reactivity of Alkoxyl Radicals under Visible-Light-Induced Reaction Conditions, SYNLETT, 2021, 第 3 作者  通讯作者
（30） Visible-Light-Induced Alkoxyl Radicals Enable alpha-C(sp(3))-H Bond Allylation, ISCIENCE, 2020, 第 6 作者  通讯作者
（31） Illuminating Biology with Visible-Light-induced Biocompatible Reactions, CHEMPHOTOCHEM, 2020, 第 1 作者  通讯作者
（32） Visible-Light-Induced Alkoxyl Radicals Enable α-C(sp3)-H Bond Allylation, ISCIENCE, 2020, 第 6 作者  通讯作者
（33） Intermolecular Radical Addition to Ketoacids Enabled by Boron Activation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 5 作者  通讯作者
（34） Photocatalysis Enables Visible-Light Uncaging of Bioactive Molecules in Live Cells, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 7 作者  通讯作者
（35） DNA-Encoded Library Chemistry: Amplification of Chemical Reaction Diversity for the Exploration of Chemical Space, ALDRICHIMICA ACTA, 2019, 第 4 作者  通讯作者
（36） Acyl Radical Smiles Rearrangement To Construct Hydroxybenzophenones by Photoredox Catalysis., ORGANIC LETTERS, 2019, 第 4 作者  通讯作者
（37） Visible light-driven organic photochemical synthesis in China, Visible light-driven organic photochemical synthesis in China, SCIENCE CHINA-CHEMISTRY, 2019, 第 1 作者  通讯作者
（38） Visible-Light-Induced Alkoxyl Radical Generation for Inert Chemical Bond Cleavage/Functionalizations, Chem. Commun., 2018, 第 1 作者  通讯作者
（39） Visible-light-induced alkoxyl radical generation for inert chemical bond cleavage/functionalization, CHEMICAL COMMUNICATIONS, 2018, 第 2 作者  通讯作者
（40） Investigations of alkynylbenziodoxole derivatives for radical alkynylations in photoredox catalysis, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2018, 第 4 作者  通讯作者
（41） Cyclic Iodine Reagents Enable Allylic Alcohols for Alkyl Boronate Addition/Rearrangement by Photoredox Catalysis, CHINESE JOURNAL OF CHEMISTRY, 2018, 第 3 作者  通讯作者
（42） Metal-Free C(sp(3))-H Allylation via Aryl Carboxyl Radicals Enabled by Donor-Acceptor Complex, ORGANIC LETTERS, 2018, 第 4 作者  通讯作者
（43） Cyclic Iodine Reagents Enable Allylic Alcohols for Alkyl Boronate Addition/Rearrangement by Photoredox Catalysis, Cyclic Iodine Reagents Enable Allylic Alcohols for Alkyl Boronate Addition/Rearrangement by Photoredox Catalysis, CHINESE JOURNAL OF CHEMISTRY, 2018, 第 3 作者  通讯作者
（44） Selective P-C(sp(3)) Bond Cleavage and Radical Alkynylation of alpha-Phosphorus Alcohols by Photoredox Catalysis, CHEMISTRY-A EUROPEAN JOURNAL, 2018, 第 3 作者  通讯作者
（45） Donor-Acceptor Complex Enables Alkoxyl Radical Generation for Metal-Free C(sp(3))-C(sp(3)) Cleavage and Allylation/Alkenylation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 第 4 作者  通讯作者
（46） Visible-Light-Induced Carboxyl and Alkoxyl Radical Generations and Reactions, ACTA CHIMICA SINICA, 2017, 第 2 作者  通讯作者
（47） Selective carbonyl-c(sp(3)) bond cleavage to construct ynamides, ynoates, and ynones by photoredox catalysis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 第 3 作者  通讯作者
（48） 可见光引发的氧自由基的新型产生方式及反应, 化学学报, 2017, 第 2 作者
（49） Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp(3))-C(sp(3)) Bond Cleavage and Functionalizations, 2016, 
（50） Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp3)−H Functionalization under Mild Reaction Conditions, ANGEWANDTE CHEMIE, 2016, 第 5 作者  通讯作者
（51） Polarity-Reversed Allylations of Aldehydes, Ketones, and Imines Enabled by Hantzsch Ester in Photoredox Catalysis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 第 2 作者  通讯作者
（52） Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp(3))-H Functionalization under Mild Reaction Conditions, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 第 5 作者  通讯作者
（53） Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp(3))-C(sp(3)) Bond Cleavage and Functionalizations, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 第 4 作者  通讯作者
（54） Radical Decarboxylative Functionalizations Enabled by Dual Photoredox Catalysis, ACS CATALYSIS, 2016, 第 3 作者  通讯作者
（55） Biomolecule-compatible chemical bond-formation and bond-cleavage reactions induced by visible light, TETRAHEDRON LETTERS, 2015, 第 2 作者  通讯作者
（56） Visible-light-induced chemoselective reductive decarboxylative alkynylation under biomolecule-compatible conditions, CHEMICAL COMMUNICATIONS, 2015, 第 5 作者  通讯作者
（57） Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 第 3 作者  通讯作者
（58） Chemoselective and fast decarboxylative allylation by photoredox catalysis under mild conditions, ORGANIC CHEMISTRY FRONTIERS, 2015, 第 2 作者
（59） Hypervalent Iodine Reagents Enable Chemoselective Deboronative/Decarboxylative Alkenylation by Photoredox Catalysis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 第 3 作者  通讯作者
（60） Visible-Light-Induced Chemoselective Deboronative Alkynylation under Biomolecule-Compatible Conditions, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 第 5 作者  通讯作者
（61） Discovery and biological characterization of geranylated RNA in bacteria, NATURE CHEMICAL BIOLOGY, 2012, 第 2 作者
（62） Ruthenium-Catalyzed Three-Component Coupling via Hydrative Conjugate Addition of Alkynes to Alkenes: One-Pot Synthesis of 1,4-Dicarbonyl Compounds, CHEMISTRY-AN ASIAN JOURNAL, 2011, 第 1 作者
（63） A Biomolecule-Compatible Visible Light-Induced Azide Reduction from a DNA-Encoded Reaction Discovery System, NATURE CHEMISTRY, 2011, 第 1 作者  通讯作者
（64） Ruthenium-catalyzed hydrative cyclization of 1,5-enynes, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 

（1） Hypervalent iodine reagents in photochemistry, In Science of Synthesis: Hypervalent Halogens in Organic Synthesis, , Thieme: Stuttgart, 2025-12, 第 3 作者
（2） 2-(Chloromethoxy)-1H-isoindole-1,3(2H)-dione, John Wiley & Sons, 2024-01, 第 2 作者
（3） Oxygen-centered radicals, Science of Synthesis Reference Library: Free Radicals: Fundamentals and Applications in Organic Synthesis, Georg Thieme Verlag KG, 2021-07, 第 3 作者
（4） Photochemistry of Hypervalent Iodine Compounds in Patai’s Chemistry of Functional Groups, John Wiley & Sons, 2018-01, 第 2 作者
（5） Tris(acetylacetonato)iron(III), e-EROS Encyclopedia of Reagents for Organic Synthesis, John Wiley and Sons, 2007-01, 第 1 作者