Chinese medicinal plants genetics and gemonics

2002  Ph. D. Clemson University, Clemson, SC, US

1997       M.S. China Agricultural University, Beijing, China

1994        B. S. Shandong Agricultural University, Shandong, China

Work Experience

2015/09 － now   Professor of Medicinal Plant Genetics and Genomics, South China Botanical Garden, Chinese Academy of Sciences

2005/03 － 2015/08   Professor of Plant Genetics and Genomics, Wuhan Botanical Garden, Chinese Academy of Sciences

2009/07 － 2014/12       Guest Professor, South China Botanical Garden, Chinese Academy of Sciences

2002/05 – 2005/06  Postdoc Research Associate, Cornell University, US. Advisor: Dr. Steve Tanksley

1997/08 － 2002/05 Research Assistant, Clemson University, US. Advisor: Dr. Greg Reighard and Dr. Albert Abbott

Selected Publications: (* corresponding author)

1.        Zeng SH, Ouyang P, Mo S, Wang Y*: Comparative characterization of phenylalanine ammonia lyase and chalcone synthase genes among four Pogostemon cablin (Blanco) Benth cultivars. Biologia Plantarum 2015, 59:298-304.

2.        Khaldun ABM, Huang W, Liao S, Lv H, Wang Y*: Identification of microRNAs and target genes in the fruit and shoot tip of Lycium chinense: a traditional Chinese medicinal plant. PLoS ONE 2015, 10(1): e0116334.

3.        Zhang YJ, Yang LL, Chen JJ, Sun W, Wang Y*: Taxonomic and phylogenetic analysis of Epimedium L. based on amplified fragment length polymorphisms. Scientia Horticulturae 2014, 170:284-292.

4.        Zhang YJ, Dang HS, Li JQ, Wang Y*: The Epimedium wushanense (Berberidaceae) species complex, with one new species from Sichuan, China. Phytotaxa 2014, 172(1):39-45.

5.        Zeng SH, Wu M, Zou CY, Liu XM, Shen XF, Hayward A, Liu CZ, Wang Y*: Comparative analysis of anthocyanin biosynthesis during fruit development in two Lycium species. Physiologia Plantarum 2014, 150(4):505-516.

6.        Zeng SH, Liu YL, Wu M, Liu XM, Shen XF, Liu CZ, Wang Y*: Identification and validation of reference genes for quantitative real-time PCR normalization and its applications in Lycium. PLoS ONE 2014, 9(5).

7.        Yousaf Z*, Hu W, Zhang Y, Zeng S, Wang Y: Exploration of genetic diversity among medicinally important genus Epimedium species based on genomic and EST-SSR marker. Natural Product Research 2014:1-6.

8.        Wang W, Feng B, Xiao J, Xia Z, Zhou X, Li P, Zhang W, Wang Y, Moller BL, Zhang P et al: Cassava genome from a wild ancestor to cultivated varieties. Nature Communications 2014, 5.

9.        Sun W, Huang WJ, Li ZN, Song C, Liu D, Liu YL, Hayward A, Liu YF, Huang HW, Wang Y*: Functional and evolutionary analysis of the AP1/SEP/AGL6 superclade of MADS-box genes in the basal eudicot Epimedium sagittatum. Annals of Botany 2014, 113(4):653-668.

10.    Shen X, Zeng S, Wu M, Liu C, Wang Y*: Characterization of proanthocyaninrelated leucoanthocyanidin reductase and anthocyanidin reductase genes in Lycium ruthenicum Murr. Journal of Chinese Pharmaceutical Sciences 2014, 23(6):369-377.

11.    Liu YL, Sun W, Zeng SH, Huang WJ, Di Liu D, Hu WM, Shen XF, Wang Y*: Virus-induced gene silencing in two novel functional plants, Lycium barbarum L. and Lycium ruthenicum Murr. Scientia Horticulturae 2014, 170:267-274.

12.           Liu Y, Zeng S, Sun W, Wu M, Hu W, Shen X, Wang Y*: Comparative analysis of carotenoid accumulation in two Goji (Lycium barbarum L. and L. ruthenicum Murr.) BMC Plant Biology 2014, 14:269.

13.    Liu D, Sun W, Yuan YW, Zhang N, Hayward A, Liu YL, Wang Y*: Phylogenetic analyses provide the first insights into the evolution of OVATE family proteins in land plants. Annals of Botany 2014, 113(7):1219-1233.

14.    Lei C, Ma Q, Tang QY, Ai XR, Zhou Z, Yao L, Wang Y, Wang Q*, Dong JZ*: Sodium selenite regulates phenolics accumulation and tuber development of purple potatoes. Scientia Horticulturae 2014, 165:142-147.

15.    Wei Sun, Wenjun Huang, Lifei Liu, Zhineng Li, Chi Song, Alice Hayward, Di Liu, Yongliang Liu, Hongwen Huang*, Ying Wang*. 2014. Functional and evolutionary analysis of the AP1/SEP/AGL6 superclade of MADs-box genes in the basal eudicot Epimedium sagittatum. Annals of Botany, 113(4):653-668.

16.    Shaohua Zeng, Min Wu, Caiyun Zou, Xiaomin Liu, Xiaofei Shen, Ying Wang*. 2013 Molecular cloning and expression analysis of genes involved in anthocyanin biosynthesis during fruit development in two Lycium species. Physiologia Plantarum 150:505-516.

17.    Dong, J., Ding, J., Yu, P., Lei, C., Zheng, X., Wang Y.* Composition and distribution of the main active components in selenium-enriched fruit bodies of Cordyceps militaris link. Food Chemistry, 2013, 137: 164-167.

18.    Shaohua Zeng, Yilan Liu, Ying Wang*. 2013 Light stress suppresses the accumulation of epimedins A, B, C, and icariin in Epimedium, a traditional medicinal plant. Acta Physiologiae Plantarum. 35(11):3271-3275

19.    Shaohua Zeng, Yilan Liu, Weiming Hu, Yongliang Liu, Xiaofei Shen, Ying Wang*. 2013 Integrated transcriptional and phytochemical analyses of the flavonoid biosynthesis pathway in Epimedium. Plant Cell, Tissue and Organ Culture. 115(3): 355-365.

20.    Xu, YQ, Z Li, L Yuan, X Zhang, D Lu, *H Huang, *Y Wang. 2013. Variation of epimedin A, B, C and icariin in ten representative populations of Epimedium brevicornu Maxim. and implication for utilization. Chemistry and Biodiversity. 4:711-721

21.    Liu, D, Zeng Shao-hua, Chen Jian-jun, Zhang Yan-jun, Xiao Gong, Jiang Yue and Wang Ying*. 2013 The first view on the huge genome of Epimedium sagittatum (Sieb. et Zucc) Maxim, a Chinese traditional medicinal plant. International Journal of Molecular Sciences 14:13559-13576

22.    Wei Sun, Wenjun Huang, Zhineng Li, Haiyan Lv, Hongwen Huang and Ying Wang*.  Characterization of a Crabs Claw Gene in basal eudicot species Epimedium sagittatum (Berberidaceae). International Journal of Molecular Sciences. 2013, 14(1), 1119-1131.

23.    Chen, JJ, X Liu, LY Zhu, Y Wang* 2013 Nuclear genome size estimation and karyotype analysis of Lycium species (Solanaceae), Scientia Horticulturae, 151: 46-50.

24.    The Tomato Genome Consortium (Sato, S, …Y Wang (Principal Investigator)¹⁴… G Gianese) (2012) The tomato genome sequence provides insights into fleshy fruit evolution. Nature. 485: 635-641

25.    Zhou, Y, YY Yau, DW Ow*, Y Wang*. 2012 Site-specific deletion in tomato by the CinH-RS2 and ParA-MRS site-specific recombination systems. Plant Biotechnology Reports 6:225-232   

26.    Guo, J., Y. Liu, Y. Wang, J. Chen, Y. Li, H. Huang, L. Qiu, Y. Wang* (2012) Population structure of the wild soybean (Glycine soja) in China: implications from microsatellite analyses. Annals of Botany 110, 777-785.

27.    Song, C., J. Guo, W. Sun, Y. Wang*. 2012 Whole genome duplication of intra- and inter-chromosomes in the tomato genome. J Genet Genomics 39, 361-368.

28.    Yousaf Z, Umer A, Younas A, Khan F, Wang Y 2012 Allelopathic Plants: 24. Gunus Allium L. Allelopathy Journal 29, 1-12.

29.    Zhang, Hua-Feng, Yang, Xiao-Hua, Wang, Ying*. 2011 Microwave assisted extraction of secondary metabolites from plants: Current status and future directions. Trends in Food Science & Technology 22(12): 672 - 688

30.    Zeng, Shaohua, Yanqin Xu，Ying Wang*. 2011. Isolation and characterization of two MADS-box 1 genes from Lycium barbarum L. Biologia Plantarum  55 (3): 567-571

31.    Dong, Jingzhou，Wensheng Gao, Dayan Lu, Ying Wang* 2011a Simultaneous extraction and analysis of four polyphenols from leaves of Lycium barbarum L. Journal of Food Biochemistry. 35:914-931.

32.    Dong, Jing-zhou, Zhicheng Wang, Ying Wang*. 2011b Rapid extraction of polysaccharides from fruits of Lycium barbarum L. Journal of Food Biochemistry. 35:1047-1057.

33.    Guo Juan †, Yunsheng Wang †, Chi Song, Jianfeng Zhou, Lijuan Qiu, Hongwen Huang*, Ying Wang*. 2010. A single origin and moderate bottleneck during domestication of soybean (Glycine max): implications from microsatellites and nucleotide sequences. Annals of Botany 106:505-514.

34.    Zeng Shaohua, Gong Xiao, Juan Guo, Zhangjun Fei, Yanqin Xu, Bruce Roe, Ying Wang*, 2010 Development of 454-EST dataset and EST-SSRs in a traditional Chinese medicinal plant, Epimedium sagittatum (Sieb. Et Zucc.) Maxim. BMC Genomics 11:94

35.     Zhang, Huafeng, Xiao-hua Yang, Lidong Zhao, and Ying Wang*. 2009 Ultrasonic-assisted extraction of epimedin C from fresh leaves of Epimedium and extraction mechanism. Innovative Food Science & Emerging Technologies, 10(1):54-60.

36.    Wang, Ying, Adam Diehl, Adam Siepel, Feinan Wu, Jim Giovannani, Julia Vrebalov, Steve Tanksley*. 2008 Sequencing and comparative analysis of a conserved syntenic segment in the Solanaceae. Genetics, 180:391-408  

37.  Xu, Yanqin, Zuozhou Li, Ying Wang*. 2008 Fourteen microsatellite loci for the important Chinese medicinal plant Epimedium sagittatum and cross-species application in other medicinal species. Molecular Ecology Notes, 8:640-642

38.    Zhang, Huafeng, Tianshun Yang, Zuozhou Li, Ying Wang*. 2008 Simultaneous extraction of epimedin A, B, C and icariin from Herba Epimedii by ultrasonic technique.  Ultrasonics Sonochemistry, 15:376-385

39.    Wang, Y., X. Tang, Z. Cheng, L. Mueller, J. Giovannoni, S. Tanksley* 2006 Euchromatin and paricentromeric heterochromatin: comparative composition in the tomato genome, Genetics 172:2529-2540

40.    Wang, Y., R. van der Hoeven, R. Nielsen, Z. Cheng, L. Mueller, S. Tanksley*. 2005 Characteristics of the tomato nuclear genome as determined by sequencing unmethylated DNA. Theoretical and Applied Genetics, 112:72-84

41.  Mueller, L., T. H. Solow, N. Taylor, B. Skwarecki, R. Buels, J. Binns, C. Lin, M. H. Wright, R. Ahrens, Y. Wang, E. V. Herbst, E. R. Keyder, N. Menda, D. Zamir, and S. D. Tanksley* 2005 The SOL genomics network. A comparative resource for Solanaceae biology and beyond. Plant Physiology 138: 1310-1317 

      Released Cultivars and Issued Patents：

     2013  Ying Wang, Wenjun Huang, Wei Sun, Haiyan Lv, A transcription factor gene controlling the biosynthesis of flavonoids in   Epimedium. Patent number: 201310062733.3

   2012  Ying Wang, Jingzhou Dong, Qing Wang, Chunzhao Liu, Xinlan Xu, Xunru Ai, Xiaojiang Zheng,  An air-lift light, sound, magnetic bioreactor. Patent number: ZL2012 2 0686462.X

    2011  Ying Wang, Tianshun Yang, Jianlin Yue, Jingzhou Dong, National Goji Cultivar ‘Zhongke Lvchuan 1’ (Lycium barbarum)  S-SC-AV-022-2011

    2007  Huafeng Zhnag, Ying Wang, Huaqiang Zhang, A Microwave and ultrasonic coupling extraction device with thermostat  Patent number: ZL 200720086099.7

    2008  Ying Wang, Jingzou Dong, Huafeng Zhang, Tianshun Yang, A functional oral liquid and its preparation method. Patent number: 200810197013.7

      1)      Secondary metabolism in Chinese Medicinal Plants, Epimedium and Lycium

2)      Evolutionary genomics and comparative functional genomics of Solanaceae and Berberidaceae species

3)      Molecular Breeding of Chinese Medicinal Plants

4)      Sustainable utilization of Chinese Medicinal Plants

Invited Talks:

2014.08.17-22 Invited session talk, 29th International Horticultural Congress 2014, “Biosynthesis of major carotenoid in traditional Chinese Medicinal Plant Lycium barbarum ” , Brisbane, Australia.

2014.7.2-7.5 The 3rd International Conference on Plant Metabolism “Comparative Analysis of Secondary Metabolite Biosynthesis in Medicinal Species”,Xiamen,China

2013.10.13-17  Chairman for “Medicinal Plants” Session and Invited talk  “Biosynthesis of major carotenoid in traditional Chinese Medicinal Plant Lycium barbarum” SOL 2013, Beijing, China

2012.11.13-15  Invited talk at The 13th Conference of International Association of Botanical Garden, “New Technology Used for Discovery and Utilization of Epimedium Plants ”

2012.10.13-15  2012 Chinese Annual Conference of Plant Biology, “Transcriptional Factors Related to Flavonoid Biosynthesis in the Medicinal Plant Epimedium sagittatum”

2012.10.25  Invited talk at the Korea Annual Meeting for Medicinal Plants, “Secondary metabolism in medicinal plant Epimedium sagittatum with huge genome size”

2012.10.4  Invited talk at Horticulture Department, Michigan State University,  “Biosynthesis of Major Bioactive Compounds in the Medicinal Plant Epimedium sagittatum”

2011.11.28-12.1 Comparative analysis of Lycium barbarum genome with tomato and potato genome based on 454-EST sequences, SOL & ICuGI 2011, 8^th Solanaceae and 2^nd Cucurbaticeae Joint Conference

2011.9.25-28 Biosynthesis and regulation of bioactive compounds in medicinal plant—Epimedium. Invited talk in Colloquium “Research Highlights and Commercial Application of Medicinal Plants”, 108 Annual Conference of the American Society for Horticultural Science,  Hawaii,USA

2011.6.30-7.3 Biosynthesis and regulation of flavonoids in medicinal plant -- Epimedium sagittatum , The 2^nd International Conference on Plant Metabolism, Qingdao, China

2010.11.17-19 Biosynthesis and Regulation of Bioactive Compounds in Epimedium L. Genetics. International Conference of Genomics, Shenzhen, China

2010.08.1-6 107^th ASHS meeting, Genetics and Genomics of Chinese Medicinal Plants, Epimedium L.  Palm Desert, California, USA

2007.4.16-20  Genetic Diversity and Sustainable Utilization of Chinese Medicinal Plants, Lycium and Epimedium. 3rd Global Botanic Gardens Congress，Wuhan， China

2006.1.14-18  Landscape of the Tomato Genome: Characteristics of the tomato nuclear genome as determined by BACs and undermethylated DNA. Plant and Animal Genome COnference XIV, San Diego, CA, USA.

2006.7.23-26  Genetic Diversity and Sustainable Utilization of Chinese Medicinal Plants, Lycium and Epimedium. The SOL Genome Workshop 2006， Madison，Wisconsin， USA

​

已指导学生

陈建军  博士研究生  071001-植物学  

桂蓓  硕士研究生  071001-植物学  

葛静  硕士研究生  071001-植物学  

张华峰  博士研究生  071001-植物学  

徐艳琴  博士研究生  071001-植物学  

曾少华  博士研究生  071001-植物学  

高翔  硕士研究生  071001-植物学  

罗艳  硕士研究生  071001-植物学  

郭娟  博士研究生  071001-植物学  

董静洲  博士研究生  071001-植物学  

黄文俊  博士研究生  071001-植物学  

宋驰  博士研究生  071001-植物学  

李植  硕士研究生  071001-植物学  

肖贡  博士研究生  071001-植物学  

周银  博士研究生  071001-植物学  

闫秀梅  硕士研究生  071001-植物学  

曾丽萍  硕士研究生  071001-植物学  

刘谊兰  硕士研究生  071001-植物学  

向巧彦  博士研究生  071001-植物学  

魏国燕  硕士研究生  071001-植物学  

刘迪  博士研究生  071001-植物学  

胡伟明  博士研究生  071001-植物学  

廖思红  硕士研究生  071001-植物学  

王应丽  硕士研究生  071001-植物学  

杨路路  博士研究生  071001-植物学  

刘永亮  博士研究生  071001-植物学  

薛定磊  硕士研究生  071001-植物学  

杜刘稳  硕士研究生  071001-植物学  

沈笑飞  硕士研究生  071001-植物学  

现指导学生

杨小满  博士研究生  071010-生物化学与分子生物学  

郭品品  硕士研究生  085238-生物工程  

杨美珍  硕士研究生  071010-生物化学与分子生物学  

龚海光  博士研究生  071010-生物化学与分子生物学  

彭思敏  硕士研究生  085238-生物工程  

林爽  博士研究生  071010-生物化学与分子生物学  

魏瑾瑢  硕士研究生  071010-生物化学与分子生物学  

艾培炎  博士研究生  071010-生物化学与分子生物学  

包宇飞  硕士研究生  085238-生物工程