聚焦AI驱动的单细胞多组学整合分析，致力于新型抗体偶联药物（ADC）的理性构建与抗肿瘤机制探索，以推动恶性肿瘤的精准诊疗。通过单细胞转录组、蛋白质组及空间组学技术，系统解析恶性肿瘤的高分辨率细胞社群分型与免疫微环境异质性，精准刻画与肿瘤进展、转移和耐药相关的致癌信号通路及免疫逃逸机制，进而鉴定具有高度肿瘤选择性的膜表面新靶点。

2017-10--2021-03   德国海德堡大学   流行病学博士学位
2014-09--2017-06   复旦大学   公共卫生硕士学位
2009-09--2014-06   南京医科大学   医学学士学位

   

2024-07~2027-06,中国科学院杭州医学研究所, 助理研究员
2021-08~2024-06,中国科学院基础医学与肿瘤研究所（筹）, 博士后

   

（ 1 ） 基于深度学习模型的肿瘤Bulk样本RNA-seq测序数据反卷积方法, 发明专利, 2025, 第 3 作者, 专利号: ZL 2025 1 0343511.1

   

（1） Leveraging artificial intelligence in antibody-drug conjugate development: from target identification to clinical translation in oncology, npj Precision Oncology, 2025, 第 1 作者
（2） Single-Cell Transcriptomics Reveals a Multi-Compartmental Cellular Cascade Underlying Elahere-Induced Ocular Toxicity in Rats, Pharmaceuticals , 2025, 第 10 作者  通讯作者
（3） Lysosomal Cathepsin S Escape Facilitates Near Infrared Light-Triggered Pyroptosis Via an Antibody-Indocyanine Green Conjugate, Advanced science, 2025, 第 15 作者  通讯作者
（4） Perivascular niche-resident alveolar macrophages confer interstitial pneumonitis related to trastuzumab deruxtecan, Cancer Research, 2025, 第 10 作者
（5） Eliminating VEGFA+ tumor-associated neutrophils by antibody-drug conjugates boosts antitumor immunity and potentiates PD-1 immunotherapy in preclinical models of cervical cancer, Cell Death & Disease, 2025, 第 3 作者
（6） Identification of CD66c as a potential target in gastroesophageal junction cancer for antibody–drug conjugate development, Gastric Cancer, 2025, 第 5 作者
（7） Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody‐Drug Conjugates in Preclinical Models, Advanced Therapeutics, 2024, 第 11 作者  通讯作者
（8） Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk, Human Genomics, 2024, 第 2 作者
（9） An Aptamer-Based Nanoflow Cytometry Method for the Molecular Detection and Classification of Ovarian Cancers through Profiling of Tumor Markers on Small Extracellular Vesicles, Angewandte Chemie International Edition, 2024, 第 7 作者
（10） Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma, Advanced Science, 2024, 第 3 作者
（11） Use of period analysis to provide a timely assessment of 5-year relative survival for pancreatic cancer patients from Taizhou, eastern China, BMC Cancer, 2023, 第 1 作者
（12） Associations between pancreatic expression quantitative traits and risk of pancreatic ductal adenocarcinoma, Carcinogenesis, 2021, 第 3 作者
（13） Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk, Frontiers in Oncology, 2021, 第 1 作者
（14） Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility, International Journal of Cancer, 2021, 第 12 作者
（15） Genetic Polymorphisms Involved in Mitochondrial Metabolism and Pancreatic Cancer Risk, Cancer Epidemiology Biomarkers & Prevention, 2021, 第 12 作者
（16） Association of genetic variants affecting microRNAs and pancreatic cancer risk., Frontiers in Genetics, 2021, 第 1 作者
（17） Mendelian randomisation study of the effects of known and putative risk factors on pancreatic cancer, Journal of Medical Genetics, 2020, 第 1 作者

   

（ 1 ）  基于单细胞证据的抗体偶联药物Elahere致角膜损伤的体外机制验证及干预探索, 负责人, 地方任务, 2026-01--2027-12
（ 2 ） 陆叶-科研与人才启动经费, 负责人, 地方任务, 2024-07--2027-06