071010-生物化学与分子生物学
071005-微生物学

代谢工程，合成生物学
微生物细胞工厂构建

2012-09--2015-12   武汉大学   博士
2009-09--2012-06   山东大学   硕士
2005-09--2009-07   北方民族大学   本科

   

2022-02~2024-01,丹麦科技大学, 博士后
2016-05~2021-09,查尔姆斯理工大学, 博士后

   

（ 1 ） 一种生产β-胡萝卜素的酵母菌株及其应用, 2018, 第 2 作者, 专利号: CN105087408B

   

[1] Li, Xiaowei, GadarLopez, Adrian E, Chen, Ling, Jayachandran, Sidharth, CruzMorales, Pablo, Keasling, Jay D. Mining natural products for advanced biofuels and sustainable bioproducts. CURRENT OPINION IN BIOTECHNOLOGY. 2023, 第 1 作者84: http://dx.doi.org/10.1016/j.copbio.2023.103003.
[2] Zhan, Chunjun, Li, Xiaowei, Lan, Guangxu, Baidoo, Edward E K, Yang, Yankun, Liu, Yuzhong, Sun, Yang, Wang, Shijie, Wang, Yanyan, Wang, Guokun, Nielsen, Jens, Keasling, Jay D, Chen, Yun, Bai, Zhonghu. Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph. NATURE CATALYSIS[J]. 2023, 第 2 作者6(5): 435-450, http://dx.doi.org/10.1038/s41929-023-00957-w.
[3] Jiwei Mao, Marta Tous Mohedano, Jing Fu, Xiaowei Li, Quanli Liu, Jens Nielsen, Verena Siewers, Yun Chen. Fine-tuning of p-coumaric acid synthesis to increase (2S)-naringenin production in yeast. METABOLIC ENGINEERING. 2023, 第 4 作者79: 192-202, http://dx.doi.org/10.1016/j.ymben.2023.08.003.
[4] Wang, Yanyan, Li, Xiaowei, Chen, Xin, Siewers, Verena. CRISPR/Cas9-mediated point mutations improve alpha-amylase secretion in Saccharomyces cerevisiae. FEMS YEAST RESEARCH[J]. 2022, 第 2 作者22(1): 
[5] Chen, Xin, Li, Xiaowei, Ji, Boyang, Wang, Yanyan, Ishchuk, Olena P, Vorontsov, Egor, Petranovic, Dina, Siewers, Verena, Engqvist, Martin K M. Suppressors of amyloid-? toxicity improve recombinant protein production in yeast by reducing oxidative stress and tuning cellular metabolism. METABOLIC ENGINEERING[J]. 2022, 第 2 作者72: 311-324, http://dx.doi.org/10.1016/j.ymben.2022.04.005.
[6] Li, Xiaowei, Wang, Yanyan, Li, Gang, Liu, Quanli, Pereira, Rui, Chen, Yun, Nielsen, Jens. Metabolic network remodelling enhances yeast's fitness on xylose using aerobic glycolysis. NATURE CATALYSIS[J]. 2021, 第 1 作者4(9): 783-+, http://dx.doi.org/10.1038/s41929-021-00670-6.
[7] Zhan, Chunjun, Li, Xiaowei, Yang, Yankun, Nielsen, Jens, Bai, Zhonghu, Chen, Yun. Strategies and challenges with the microbial conversion of methanol to high-value chemicals. BIOTECHNOLOGY AND BIOENGINEERING. 2021, 第 2 作者118(10): 3655-3668, http://dx.doi.org/10.1002/bit.27862.
[8] Wang, Yanyan, Li, Xiaowei, Chen, Xin, Nielsen, Jens, Petranovic, Dina, Siewers, Verena. Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion. MICROBIAL CELL FACTORIES[J]. 2021, 第 2 作者20(1): http://dx.doi.org/10.1186/s12934-021-01624-0.
[9] Qin, Ning, Li, Lingyun, Ji, Xu, Li, Xiaowei, Zhang, Yiming, Larsson, Christer, Chen, Yun, Nielsen, Jens, Liu, Zihe. Rewiring Central Carbon Metabolism Ensures Increased Provision of Acetyl-CoA and NADPH Required for 3-OH-Propionic Acid Production. ACS SYNTHETIC BIOLOGY[J]. 2020, 第 4 作者9(12): 3236-3244, http://dx.doi.org/10.1021/acssynbio.0c00264.
[10] Xin Chen, Boyang Ji, Xinxin Hao, Xiaowei Li, Frederik Eisele, Thomas Nystrm, Dina Petranovic. FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism. NATURE COMMUNICATIONS[J]. 2020, 第 4 作者11(1): 1-16, 
[11] Dabirian, Yasaman, Li, Xiaowei, Chen, Yun, David, Florian, Nielsen, Jens, Siewers, Verena. Expanding the Dynamic Range of a Transcription Factor-Based Biosensor in Saccharomyces cerevisiae. ACS SYNTHETIC BIOLOGY[J]. 2019, 第 2 作者  通讯作者  8(9): 1968-1975, http://dx.doi.org/10.1021/acssynbio.9b00144.
[12] Ma, Tian, Shi, Bin, Ye, Ziling, Li, Xiaowei, Liu, Min, Chen, Yun, Xia, Jiang, Nielsen, Jens, Deng, Zixin, Liu, Tiangang. Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene. METABOLIC ENGINEERING[J]. 2019, 第 4 作者52: 134-142, http://dx.doi.org/10.1016/j.ymben.2018.11.009.
[13] Liu, Quanli, Yu, Tao, Li, Xiaowei, Chen, Yu, Campbell, Kate, Nielsen, Jens, Chen, Yun. Rewiring carbon metabolism in yeast for high level production of aromatic chemicals. NATURE COMMUNICATIONS[J]. 2019, 第 3 作者10(1): https://doaj.org/article/85b8439535674a50b63d8be156d51506.
[14] Shi, Bin, Ma, Tian, Ye, Ziling, Li, Xiaowei, Huang, Yanglei, Zhou, Zhiyi, Ding, Yunkun, Deng, Zixin, Liu, Tiangang. Systematic metabolic engineering of Saccharomyces cerevisiae for lycopene overproduction. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2019, 第 4 作者67(40): 11148-11157, 
[15] Li, Xiaowei, Chen, Yun, Nielsen, Jens. Harnessing xylose pathways for biofuels production. CURRENT OPINION IN BIOTECHNOLOGY. 2019, 第 1 作者57: 56-65, http://dx.doi.org/10.1016/j.copbio.2019.01.006.
[16] Ma, Tian, Zhou, Yuanjie, Li, Xiaowei, Zhu, Fayin, Cheng, Yongbo, Liu, Yi, Deng, Zixin, Liu, Tiangang. Genome mining of astaxanthin biosynthetic genes from Sphingomonas sp ATCC 55669 for heterologous overproduction in Escherichia coli. BIOTECHNOLOGY JOURNAL[J]. 2016, 第 3 作者11(2): 228-237, https://www.webofscience.com/wos/woscc/full-record/WOS:000370002800007.
[17] Ye, Ziling, Li, Xiaowei, Cheng, Yongbo, Liu, Zhijie, Tan, Gaoyi, Zhu, Fayin, Fu, Shuai, Deng, Zixin, Liu, Tiangang. Evaluation of 3-hydroxypropionate biosynthesis in vitro by partial introduction of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2016, 第 2 作者43(9): 1313-1321, http://dx.doi.org/10.1007/s10295-016-1793-z.
[18] Li, Xiaowei, Guo, Daoyi, Cheng, Yongbo, Zhu, Fayin, Deng, Zixin, Liu, Tiangang. Overproduction of Fatty Acids in Engineered Saccharomyces cerevisiae. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2014, 第 1 作者111(9): 1841-1852, http://dx.doi.org/10.1002/bit.25239.
[19] Hou, Jin, Suo, Fan, Wang, Chengqiang, Li, Xiaowei, Shen, Yu, Bao, Xiaoming. Fine-tuning of NADH oxidase decreases byproduct accumulation in respiration deficient xylose metabolic Saccharomyces cerevisiae. BMC BIOTECHNOLOGY[J]. 2014, 第 4 作者14(1): 13-13, http://dx.doi.org/10.1186/1472-6750-14-13.
[20] Peng, Bingyin, Shen, Yu, Li, Xiaowei, Chen, Xiao, Hou, Jin, Bao, Xiaoming. Improvement of xylose fermentation in respiratory-deficient xylose-fermenting Saccharomyces cerevisiae. METABOLIC ENGINEERING[J]. 2012, 第 3 作者14(1): 9-18, http://dx.doi.org/10.1016/j.ymben.2011.12.001.

（1） 酵母代谢工程, Metabolic Engineering of Yeast, WILEY‐VCH GmbH, 2021-07, 第 3 作者