金属药物生物无机化学

生物分析化学

二次离子质谱分析

   

070302-分析化学
070301-无机化学

质谱成像分析
多靶点金属抗肿瘤药物

2008-09--2012-06   英国华威大学（University of Warwick）   博士
2005-09--2008-06   南京大学   硕士
2001-09--2005-06   南京大学   学士

2012-12~2015-02   中国科学院化学研究所 助理研究员

2015-03~2023.03   中国科学院化学研究所 活体分析化学实验室 副研究员

2017.05~2017.06 美国西北太平洋国家实验室 (PNNL) 访问学者

2023.03 - 现在         中国科学院化学研究所 怀柔研究中心 副研究员

2023.09 - 现在         中国科学院大学 岗位教师

2024年 中国科学院化学研究所 “突出贡献奖”

2024年 中国科学院化学研究所 第四届仪器管理交流会议论文评选“一等奖”

2022年 中国科学院北京物质科学与纳米技术大型仪器区域中心 “突出贡献奖”

2020年、2013年“中国科学院化学研究所优秀职工”

2019年 中国科学院化学研究所“优秀共产党员”

2017年  入选“中国科学院青年创新促进会会员”

2016年 “中国化学会第30届学术年会优秀墙报奖”

2013年 中国科学院化学研究所 “青年科学奖优秀奖”

 1.            L. Xiang, Z. He, C. Yan, Y. Zhao, Z. Li, L. Jia, Z. Jiang, X. Dai, V. Lemaur, Y. Ma, L. Liu, Q. Meng, Y. Zou, D. Beljonne, F. Zhang, D. Zhang, C.-a. Di and D. Zhu, Nanoscale doping of polymeric semiconductors with confined electrochemical ion implantation, Nat. Nanotechnol., 2024, 19, 1122-1129.
2.            D. Wang, J. Ding, Y. Ma, C. Xu, Z. Li, X. Zhang, Y. Zhao, Y. Zhao, Y. Di, L. Liu, X. Dai, Y. Zou, B. Kim, F. Zhang, Z. Liu, I. McCulloch, M. Lee, C. Chang, X. Yang, D. Wang, D. Zhang, L.-D. Zhao, C.-a. Di and D. Zhu, Multi-heterojunctioned plastics with high thermoelectric figure of merit, Nature, 2024, 632, 528-535.
3.            S. Liu, B. He, W. Yang, X. Zhou, X. Xue, M. Liu, Y. Zhao, X. Wang, J. Si, F. Wang, Z. Zhang, L. Peng and G. Yu, In Situ Growth of High-Quality Single-Crystal Twisted Bilayer Graphene on Liquid Copper, Adv. Mater., 2024, 36, 2312125.
4.            X.-T. Li, Y. Zhao, Y.-H. Zhu, W.-P. Wang, Y. Zhang, F. Wang, Y.-G. Guo, S. Xin and C. Bai, The electrochemistry of stable sulfur isotopes versus lithium, Proc. Natl. Acad. Sci. USA, 2024, 121, e2316564121.
5.            Y. Zhang, W.-P. Wang, Y. Zhao, X. Zhang, H. Guo, H. Gao, D.-X. Xu, Y.-M. Zhao, G. Li, J.-Y. Liang, S. Xin and Y.-G. Guo, Exacerbated High-Temperature Calendar Aging of SiOx-Graphite Electrode Induced by Interparticle Lithium Crosstalk, Adv. Funct. Mater., 2024, 34, 2310309.
6.            贾菲菲, 赵耀 and 汪福意, 质谱技术在微塑料分析领域的发展及应用, 质谱学报, 2023, 44, 131-145.
7.            Y.-Y. Zhang, C.-H. Zhang, Y.-J. Guo, M. Fan, Y. Zhao, H. Guo, W.-P. Wang, S.-J. Tan, Y.-X. Yin, F. Wang, S. Xin, Y.-G. Guo and L.-J. Wan, Refined Electrolyte and Interfacial Chemistry toward Realization of High-Energy Anode-Free Rechargeable Sodium Batteries, J. Am. Chem. Soc., 2023, 145, 25643-25652.
8.            Y. Zhang, J. Jin, Y. Xue, Y. Zhao, Q. Luo, L. Mao and F. Wang, Molecular unravelling of the mechanism of overpotential change at the carbon nanotubes-modified gold electrode surface, Chem. Commun., 2023, 59, 8412-8415.
9.            Y.-F. Tian, S.-J. Tan, C. Yang, Y.-M. Zhao, D.-X. Xu, Z.-Y. Lu, G. Li, J.-Y. Li, X.-S. Zhang, C.-H. Zhang, J. Tang, Y. Zhao, F. Wang, R. Wen, Q. Xu and Y.-G. Guo, Tailoring chemical composition of solid electrolyte interphase by selective dissolution for long-life micron-sized silicon anode, Nature Communications, 2023, 14, 7247.
10.          Q. Meng, M. Fan, X. Chang, H. Li, W.-P. Wang, Y.-H. Zhu, J. Wan, Y. Zhao, F. Wang, R. Wen, S. Xin and Y.-G. Guo, A Functional Prelithiation Separator Promises Sustainable High-Energy Lithium-Ion Batteries, Advanced Energy Materials, 2023, 13, 2300507.
11.          Z. Ma, J. Zhang, J. Lin, W. Li, X. Wu, F. Wang, Y. Zhao and K. Wu, Differentiated oxidation modes of guanine between CpG and ^5mCpG by a photoactivatable Pt(IV) anticancer prodrug, Dalton Trans., 2023, 52, 2786-2798.
12.          J. Lin, J. Zhang, Z. Ma, X. Wu, F. Wang, Y. Zhao, K. Wu and Y. Liu, Reaction of human telomeric unit TTAGGG and a photoactivatable Pt(IV) anticancer prodrug, Dalton Trans., 2023, 52, 12057-12066.
13.          Y. Kang, Y. Zhao, Y. Wei, Y. Zhang, Z. Wang, Q. Luo, J. Du and F. Wang, Ruthenium(II) polypyridyl complexes with visible light-enhanced anticancer activity and multimodal cell imaging, Dalton Trans., 2023, 52, 12478-12489.
14.          F. Jia, X. Zhao and Y. Zhao, Advancements in ToF-SIMS imaging for life sciences, Front. Chem., 2023, 11, 1237408.
15.          J. He, G. Hu, Y. Jiang, S. Zeng, G. Niu, G. Feng, Z. Liu, K. Yang, C. Shao, Y. Zhao, F. Wang, Y. Li and J. Wang, Dual-Interface Engineering in Perovskite Solar Cells with 2D Carbides, Angew. Chem. Int. Ed., 2023, 62, e202311865.
16.          J.-C. Guo, S.-J. Tan, C.-H. Zhang, W.-P. Wang, Y. Zhao, F. Wang, X.-S. Zhang, R. Wen, Y. Zhang, M. Fan, S. Xin, J. Zhang and Y.-G. Guo, A Self-Reconfigured, Dual-Layered Artificial Interphase Toward High-Current-Density Quasi-Solid-State Lithium Metal Batteries, Adv. Mater., 2023, 35, 2300350.
17.          X. Cui, W. Lai, Y. Zhao and C. Chen, The Exosome-Mediated Cascade Reactions for the Transfer and Inflammatory Responses of Fine Atmospheric Particulate Matter in Macrophages, Environ. Sci. Technol., 2023, 57, 7891-7901.
18.          F. Bennet, R. Opitz, N. Ghoreishi, K. Plate, J.-P. Barnes, A. Bellew, A. Belu, G. Ceccone, E. de Vito, A. Delcorte, A. Franquet, F. Fumagalli, D. Gilliland, H. Jungnickel, T. G. Lee, C. Poleunis, D. Rading, H. K. Shon, V. Spampinato, J. G. Son, F. Wang, Y.-C. A. Wang, Y. Zhao, A. Roloff, J. Tentschert and J. Radnik, VAMAS TWA2 interlaboratory comparison: Surface analysis of TiO2 nanoparticles using ToF-SIMS, J. Vac. Sci. Technol., A, 2023, 41, 053210.
19.          Y. Zhan, Q. Cheng, J. Peng, Y. Zhao, F. Vogelbacher, X. Lai, F. Wang, Y. Song and M. Li, Nacre inspired robust self-encapsulating flexible perovskite photodetector, Nano Energy, 2022, 98, 107254.
20.          G. Zhai, L. Yang, Q. Luo, K. Wu, Y. Zhao and F. Wang, Serum phosphopeptide profiling for colorectal cancer diagnosis using liquid chromatography–mass spectrometry, Rapid Commun. Mass Spectrom., 2022, 36, e9316.
21.          J. Tang, Z. Ni, Y. Zhang, Y. Zhao, Q. Luo and F. Wang, ToF-SIMS characterization of surface chemical evolution on electrode surfaces educed by electrochemical activation, J. Anal. At. Spectrom., 2022, 37, 890-897.
22.          S.-J. Tan, Y.-F. Tian, Y. Zhao, X.-X. Feng, J. Zhang, C.-H. Zhang, M. Fan, J.-C. Guo, Y.-X. Yin, F. Wang, S. Xin and Y.-G. Guo, Noncoordinating Flame-Retardant Functional Electrolyte Solvents for Rechargeable Lithium-Ion Batteries, J. Am. Chem. Soc., 2022, 144, 18240-18245.
23.          G.-X. Liu, J.-X. Tian, J. Wan, Y. Li, Z.-Z. Shen, W.-P. Chen, Y. Zhao, F. Wang, B. Liu, S. Xin, Y.-G. Guo and R. Wen, Revealing the High Salt Concentration Manipulated Evolution Mechanism on the Lithium Anode in Quasi-Solid-State Lithium-Sulfur Batteries, Angew. Chem. Int. Ed., 2022, 61, e202212744.
24.          G.-Q. Jin, D.-e. Sun, X. Xia, Z.-F. Jiang, B. Cheng, Y. Ning, F. Wang, Y. Zhao, X. Chen and J.-L. Zhang, Bioorthogonal Lanthanide Molecular Probes for Near-Infrared Fluorescence and Mass Spectrometry Imaging, Angew. Chem. Int. Ed., 2022, 61, e202208707.
25.          Y. Hou, T. Gan, T. Fang, Y. Zhao, Q. Luo, X. Liu, L. Qi, Y. Zhang, F. Jia, J. Han, S. Li, S. Wang and F. Wang, G-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex, Nucleic Acids Res., 2022, 50, 3070–3082.
26.          T. Fang, W. Chen, Y. Cheng, Y. Zhang, Q. Luo, K. Wu, F. Wang, H. Lei and Y. Zhao, LA-ICP-MS bioimaging demonstrated disturbance of metal ions in the brain of Parkinson’s disease model mouse undergoing manganese-enhanced MRI, Anal. Bioanal. Chem., 2022, 414, 5561–5571.
27.          J. Chou, Y. Zhao, X.-T. Li, W.-P. Wang, S.-J. Tan, Y.-H. Wang, J. Zhang, Y.-X. Yin, F. Wang, S. Xin and Y.-G. Guo, Hydrogen Isotope Effects on Aqueous Electrolyte for Electrochemical Lithium-Ion Storage, Angew. Chem. Int. Ed., 2022, 61, e202203137.
28.          Y. Zhang, J. Tang, Z. Ni, Y. Zhao, F. Jia, Q. Luo, L. Mao, Z. Zhu and F. Wang, Real-Time Characterization of the Fine Structure and Dynamics of an Electrical Double Layer at Electrode–Electrolyte Interfaces, J. Phys. Chem. Lett., 2021, 12, 5279-5285.
29.          D. Wei, Y. Yu, Y. Huang, Y. Jiang, Y. Zhao, Z. Nie, F. Wang, W. Ma, Z. Yu, Y. Huang, X.-D. Zhang, Z.-Q. Liu, X. Zhang and H. Xiao, A Near-Infrared-II Polymer with Tandem Fluorophores Demonstrates Superior Biodegradability for Simultaneous Drug Tracking and Treatment Efficacy Feedback, ACS Nano, 2021, 15, 5428-5438.
30.          D. Wei, Y. Chen, Y. Huang, P. Li, Y. Zhao, X. Zhang, J. Wan, X. Yin, T. Liu, J. Yin, Z. Liu, Q. Zhang, J. Wang and H. Xiao, NIR-light triggered dual-cascade targeting core-shell nanoparticles enhanced photodynamic therapy and immunotherapy, Nano Today, 2021, 41, 101288.
31.          Y. Wang, Y. Jiang, D. Wei, P. Singh, Y. Yu, T. Lee, L. Zhang, H. K. Mandl, A. S. Piotrowski-Daspit, X. Chen, F. Li, X. Li, Y. Cheng, A. Josowitz, F. Yang, Y. Zhao, F. Wang, Z. Zhao, A. Huttner, R. S. Bindra, H. Xiao and W. Mark Saltzman, Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance, Nat. Biomed. Eng., 2021, 5, 1048-1058.
32.          S. Qi, Z. Jin, Y. Jian, Y. Hou, C. Li, Y. Zhao, X. Wang and Q. Zhou, Photo-induced mitochondrial DNA damage and NADH depletion by –NO₂ modified Ru(II) complexes, Chem. Commun., 2021, 57, 4162-4165.
33.          Y. Lin, K. Wu, F. Jia, L. Chen, Z. Wang, Y. Zhang, Q. Luo, S. Liu, L. Qi, N. Li, P. Dong, F. Gao, W. Zheng, X. Fang, Y. Zhao and F. Wang, Single cell imaging reveals cisplatin regulating interactions between transcription (co)factors and DNA, Chem. Sci., 2021, 12, 5419-5429.
34.          W. Li, G. Dan, M. Chen, Y. Chen, Z. Wang, Y. Zhao, F. Wang, F. Li, S. Tong and M. Ge, The gas-phase reaction kinetics of different structure of unsaturated alcohols and ketones with O3, Atmos. Environ., 2021, 254, 118394.
35.          T. Li, H. Yang, X. Li, Y. Hou, Y. Zhao, W. Wu, L. Zhao, F. Wang and Z. Zhao, Open-flow microperfusion combined with mass spectrometry for in vivo liver lipidomic analysis, Analyst, 2021, 146, 1915-1923.
36.          F. Jia, Q. Luo, Y. Zhang, Y. Zhao, K. Wu and F. Wang, The Disturbance of Anticancer Drug Cisplatin to Cellular Homeostasis of Trace Elements Revealed by ICP-MS and ToF-SIMS, At. Spectrosc., 2021, 42, 166-174.
37.          G. Chen, P. Li, T. Xue, M. Su, J. Ma, Y. Zhang, T. Wu, L. Han, M. Aldamasy, M. Li, Z. Li, J. Ma, S. Chen, Y. Zhao, F. Wang and Y. Song, Design of Low Bandgap CsPb1−xSnxI2Br Perovskite Solar Cells with Excellent Phase Stability, Small, 2021, 17, 2101380.
38.          Q. Chang, F. Wang, Z. Zuo, F. He, Y. Zhao, F. Wang and Y. Li, High Voltage-Stabilized Graphdiyne Cathode Interface, Small, 2021, 17, 2102066.
39.          Y. Zhao, Y. Kang, F. Xu, W. Zheng, Q. Luo, Y. Zhang, F. Jia and F. Wang, in Adv. Inorg. Chem., eds. P. J. Sadler and R. van Eldik, Academic Press, 2020, vol. 75, pp. 257-285.
40.          Y. Zhao, H. Huang, Y. Zhang, K. Wu, F. Zeng, J. Wang, X. Yu, Z. Zhu, X.-Y. Yu and F. Wang, Atmospheric particulate characterization by ToF-SIMS in an urban site in Beijing, Atmos. Environ., 2020, 220, 117090.
41.          Y. Zhang, W. Zeng, F. Jia, J. Ye, Y. Zhao, Q. Luo, Z. Zhu and F. Wang, Cisplatin-induced alteration on membrane composition of A549 cells revealed by ToF-SIMS, Surf. Interface Anal., 2020, 52, 256-263.
42.          J. Zhang, B. Zhao, S. Chen, Y. Wang, Y. Zhang, Y. Wang, D. Wei, L. Zhang, G. Rong, Y. Weng, J. Hao, B. Li, X.-Q. Hou, X. Kang, Y. Zhao, F. Wang, Y. Zhao, Y. Yu, Q.-P. Wu, X.-J. Liang and H. Xiao, Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy, ACS Nano, 2020, 14, 14831-14845.
43.          J. Zhang, W. Zeng, K. Wu, J. Ye, Y. Cheng, Y. Cheng, T. Zou, N. Peng, X. Wu, Y. Zhao and F. Wang, Unexpected Thymine Oxidation and Collision-Induced Thymine-Pt-guanine Cross-Linking on 5′-TpG and 5′-GpT by a Photoactivatable Diazido Pt(IV) Anticancer Complex, Inorg. Chem., 2020, 59, 8468-8480.
44.          Y. Xie, S. Zhang, X. Ge, W. Ma, X. He, Y. Zhao, J. Ye, H. Zhang, A. Wang and Z. Liu, Lysosomal-targeted anticancer half-sandwich iridium(III) complexes modified with lonidamine amide derivatives, Appl. Organomet. Chem., 2020, 34, e5589.
45.          D. Wei, Y. Yu, X. Zhang, Y. Wang, H. Chen, Y. Zhao, F. Wang, G. Rong, W. Wang, X. Kang, J. Cai, Z. Wang, J.-Y. Yin, M. Hanif, Y. Sun, G. Zha, L. Li, G. Nie and H. Xiao, Breaking the Intracellular Redox Balance with Diselenium Nanoparticles for Maximizing Chemotherapy Efficacy on Patient-Derived Xenograft Models, ACS Nano, 2020, 14, 16984-16996.
46.          Z. Liang, J. Lin, X. Gong, Y. Cheng, C. Huang, J. Zhang, X. Wu, F. Wang, Y. Zhao and K. Wu, Reactions of a photoactivatable diazido Pt(iv) anticancer complex with a single-stranded oligodeoxynucleotide, Dalton Trans., 2020, 49, 11249-11259.
47.        C. Li, F. Xu, Y. Zhao, W. Zheng, W. Zeng, Q. Luo, Z. Wang, K. Wu, J. Du and F. Wang, Platinum(II) Terpyridine Anticancer Complexes Possessing Multiple Mode of DNA Interaction and EGFR Inhibiting Activity, Front. Chem., 2020, 8, 210.
48.          F. Jia, J. Wang, Y. Zhao, Y. Zhang, Q. Luo, L. Qi, Y. Hou, J. Du and F. Wang, In Situ Visualization of Proteins in Single Cells by Time-of-Flight–Secondary Ion Mass Spectrometry Coupled with Genetically Encoded Chemical Tags, Anal. Chem., 2020, 92, 15517-15525.
49.          C. Huang, Z. Ma, J. Lin, X. Gong, F. Zhang, X. Wu, F. Wang, W. Zheng, Y. Zhao and K. Wu, Tandem Mass Spectrometry Reveals Preferential Ruthenation of Thymines in Human Telomeric G-Quadruplex DNA by an Organometallic Ruthenium Anticancer Complex, Organomet., 2020, 39, 3315-3322.
50.          Y. Cheng, J. Zhang, K. Wu, F. Gao, Y. Cheng, T. Zou, X. Wu, Y. Zhao and F. Wang, Photoactivatable diazido Pt(IV) anticancer complex can bind to and oxidize all four nucleosides, Dalton Trans., 2020, 49, 17157-17163.
51.          X.-F. Cheng, Y. Zhao, W. Ye, C. Yu, J.-H. He, F.-Y. Wang and J.-M. Lu, Scaled conductance quantization unravels the switching mechanism in organic ternary resistive memories, J. Mat. Chem. C, 2020, 8, 2964-2969.
52.          Y. Zhang, W. Zeng, L. Huang, W. Liu, E. Jia, Y. Zhao, F. Wang and Z. Zhu, In Situ Liquid Secondary Ion Mass Spectrometry: A Surprisingly Soft Ionization Process for Investigation of Halide Ion Hydration, Anal. Chem., 2019, 91, 7039-7046.
53.          Y. Zhang, J.-G. Wang, X. Yu, D. R. Baer, Y. Zhao, L. Mao, F. Wang and Z. Zhu, Potential-Dynamic Surface Chemistry Controls the Electrocatalytic Processes of Ethanol Oxidation on Gold Surfaces, ACS Energy Letters, 2019, 4, 215-221.
54.          W. Zeng, Y. Zhang, W. Zheng, Q. Luo, J. Han, J. a. Liu, Y. Zhao, F. Jia, K. Wu and F. Wang, Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-Stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry, Molecules, 2019, 24, 1852.
55.          W. Zeng, Z. Du, Q. Luo, Y. Zhao, Y. Wang, K. Wu, F. Jia, Y. Zhang and F. Wang, Proteomic Strategy for Identification of Proteins Responding to Cisplatin-Damaged DNA, Anal. Chem., 2019, 91, 6035-6042.
56.          Q. Yang, W. Shan, L. Hu, Y. Zhao, Y. Hou, Y. Yin, Y. Liang, F. Wang, Y. Cai, J. Liu and G. Jiang, Uptake and Transformation of Silver Nanoparticles and Ions by Rice Plants Revealed by Dual Stable Isotope Tracing, Environ. Sci. Technol., 2019, 53, 625-633.
57.          T. Wu, J. Liu, M. Liu, S. Liu, S. Zhao, R. Tian, D. Wei, Y. Liu, Y. Zhao, H. Xiao and B. Ding, A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery, Angew. Chem. Int. Ed., 2019, 58, 14224-14228.
58.          N. Wang, B. Guan, Y. Zhao, Y. Zou, G. Geng, P. Chen, F. Wang and M. Liu, Sub-10 nm Ag Nanoparticles/Graphene Oxide: Controllable Synthesis, Size-Dependent and Extremely Ultrahigh Catalytic Activity, Small, 2019, 15, 1901701.
59.          L. Qi, Q. Luo, Y. Zhang, F. Jia, Y. Zhao and F. Wang, Advances in Toxicological Research of the Anticancer Drug Cisplatin, Chem. Res. Toxicol., 2019, 32, 1469-1486.
60.          Z. Liu, J. Li, D. Kong, M. Tian, Y. Zhao, Z. Xu, W. Gao and Y. Zhou, Dual Functional Half-Sandwich Ru(II) Complexes: Lysosome-Targeting Probes and Anticancer Agents, Eur. J. Inorg. Chem., 2019, 2019, 287-294.
61.          Y. Lin, J. Wang, W. Zheng, Q. Luo, K. Wu, J. Du, Y. Zhao and F. Wang, Organometallic ruthenium anticancer complexes inhibit human peroxiredoxin I activity by binding to and inducing oxidation of its catalytic cysteine residue, Metallomics, 2019, 11, 546-555.
62.          X. Kang, Y. Yu, Z. Chen, Y. Wu, D. Wei, Y. Zhao, F. Wang and H. Xiao, A negatively charged Pt(iv) prodrug for electrostatic complexation with polymers to overcome cisplatin resistance, J. Mat. Chem. B, 2019, 7, 3346-3350.
63.          H. Hao, X. Liu, X. Ge, Y. Zhao, X. Tian, T. Ren, Y. Wang, C. Zhao and Z. Liu, Half-sandwich iridium(III) complexes with α-picolinic acid frameworks and antitumor applications, J. Inorg. Biochem., 2019, 192, 52-61.
64.          Y. Han, W. Guo, W. Zheng, Q. Luo, K. Wu, Y. Zhao and F. Wang, Mass spectrometric quantification of the binding ratio of metal-based anticancer complexes with protein thiols, Rapid Commun. Mass Spectrom., 2019, 33, 951-958.
65.          梁祖青, 罗群, 郑伟, 赵耀 and 汪福意, 生物质谱鉴定中药活性成分靶标蛋白质的研究进展, 中国科学:生命科学, 2018, 48, 140-150.
66.          Y. Zhang, Q. Luo, W. Zheng, Z. Wang, Y. Lin, E. Zhang, S. Lu, J. Xiang, Y. Zhao and F. Wang, Luminescent cyclometallated platinum(ii) complexes: highly promising EGFR/DNA probes and dual-targeting anticancer agents, Inorg. Chem. Front., 2018, 5, 413-424.
67.          H. Yang, W.-L. Lu, T. Huang, Q.-Y. Chen, J. Gao and Y. Zhao, An aptamer-Fe3+ modified nanoparticle for lactate oxidation and tumor photodynamic therapy, Colloids and Surfaces B: Biointerfaces, 2018, 164, 192-200.
68.          K. Xia, S. Tong, Y. Zhang, F. Tan, Y. Chen, W. Zhang, Y. Guo, B. Jing, M. Ge, Y. Zhao, K. A. Alamry, H. M. Marwani and S. Wang, Heterogeneous Reaction of HCOOH on NaCl Particles at Different Relative Humidities, J. Phys. Chem. A, 2018, 122, 7218-7226.
69.          H. Sun, X. Yu, X. Yang, X. Ma, M. Lin, C. Shao, Y. Zhao, F. Wang and M. Ge, Au/Rod-like MnO2 catalyst via thermal decomposition of manganite precursor for the catalytic oxidation of toluene, Catal. Today, 2018.
70.          C.-F. Shao, Y. Zhao, K. Wu, F.-F. Jia, Q. Luo, Z. Liu and F.-Y. Wang, Correlated Secondary Ion Mass Spectrometry-Laser Scanning Confocal Microscopy Imaging for Single Cell-Principles and Applications, Chin. J. Anal. Chem., 2018, 46, 1005-1016.
71.          Z. Liang, Q. Luo, W. Zheng, Y. Zhao and F. Wang, Progress in identifying target proteins of active ingredients in traditional Chinese medicine by biological mass spectrometry, Science China Biology, 2018, 48, 140-150.
72.          X. He, F. Xu, P. Yu, Y. Wu, F. Wang, Y. Zhao and J. Wang, Solvent-dependent structural dynamics of an azido-platinum complex revealed by linear and nonlinear infrared spectroscopy, Phys. Chem. Chem. Phys., 2018, 20, 9984-9996.
73.          J. Du, Y. Wei, Y. Zhao, F. Xu, Y. Wang, W. Zheng, Q. Luo, M. Wang and F. Wang, A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin–Thioredoxin Reductase System Activity by Induced Oxidization of the Protein, Inorg. Chem., 2018, 57, 5575-5584.
74.          吴魁, 罗群, 赵耀, 郑伟 and 汪福意, 质谱在金属抗肿瘤化合物分子作用机理研究中的应用, 中国科学:化学, 2017, 47, 233-248.
75.          W. Zheng, Y. Zhao, Q. Luo, Y. Zhang, K. Wu and F. Wang, Multi-Targeted Anticancer Agents, Curr. Top. Med. Chem., 2017, 17, 3084-3098.
76.          G. Zhai, L. Yang, Q. Luo, K. Wu, Y. Zhao, J. Liu, S. Xiong and F. Wang, Evaluation of serum phosphopeptides as potential biomarkers of gastric cancer, RSC Advances, 2017, 7, 21630-21637.
77.          X. Yang, X. Yu, M. Lin, M. Ge, Y. Zhao and F. Wang, Interface effect of mixed phase Pt/ZrO2 catalysts for HCHO oxidation at ambient temperature, J. Mat. Chem. A, 2017, 5, 13799-13806.
78.          K. Wu, F. Jia, W. Zheng, Q. Luo, Y. Zhao and F. Wang, Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging, J. Biol. Inorg. Chem., 2017, 22, 653-661.
79.          Y. Wang, Z. Du, W. Zheng, K. Wu, D. Xu, Q. Luo, Y. Zhao, J. Han, Y. Liu and F. Wang, Deciphering of interactions between platinated DNA and HMGB1 by hydrogen/deuterium exchange mass spectrometry, Dalton Trans., 2017, 46, 6187-6195.
80.          W.-L. Lu, Y.-Q. Lan, K.-J. Xiao, Q.-M. Xu, L.-L. Qu, Q.-Y. Chen, T. Huang, J. Gao and Y. Zhao, BODIPY-Mn nanoassemblies for accurate MRI and phototherapy of hypoxic cancer, J. Mat. Chem. B, 2017, 5, 1275-1283.
81.          S. Liu, W. Zheng, K. Wu, Y. Lin, F. Jia, Y. Zhang, Z. Wang, Q. Luo, Y. Zhao and F. Wang, Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex, Chem. Commun., 2017, 53, 4136-4139.
82.          W. Zheng, Y. Zhao, Q. Luo, Y. Zhang, K. Wu and F. Wang, Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes, Sci. China Chem., 2016, 59, 1240-1249.
83.          L. Li, W. Guo, K. Wu, Y. Zhao, Q. Luo, Q. Zhang, J. Liu, S. Xiong and F. Wang, Identification of binding sites of cisplatin to human copper chaperone protein Cox17 by high-resolution FT-ICR-MS, Rapid Commun. Mass Spectrom., 2016, 30, 168-172.
84.          L. Li, W. Guo, K. Wu, X. Wu, L. Zhao, Y. Zhao, Q. Luo, Y. Wang, Y. Liu, Q. Zhang and F. Wang, A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry, J. Inorg. Biochem., 2016, 161, 99-106.
85.          J. Du, Y. Kang, Y. Zhao, W. Zheng, Y. Zhang, Y. Lin, Z. Wang, Y. Wang, Q. Luo, K. Wu and F. Wang, Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines, Inorg. Chem., 2016, 55, 4595-4605.
86.          D. Boison, W.-L. Lu, Q.-M. Xu, H. Yang, T. Huang, Q.-Y. Chen, J. Gao and Y. Zhao, A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer, Colloids and Surfaces B: Biointerfaces, 2016, 147, 387-396.
87.          J. Zhou, C. Fang, Y. Liu, Y. Zhao, N. Zhang, X. Liu, F. Wang and D. Shangguan, Visible-light-induced cleavage of 4-α-amino acid substituted naphthalimides and its application in DNA photocleavage, Org. Biomol. Chem., 2015, 13, 3931-3935.
88.          Y. Zhang, W. Zheng, Q. Luo, Y. Zhao, E. Zhang, S. Liu and F. Wang, Dual-targeting organometallic ruthenium(II) anticancer complexes bearing EGFR-inhibiting 4-anilinoquinazoline ligands, Dalton Trans., 2015, 44, 13100-13111.
89.          J. Qin, Q. Liu, J. Zhang, J. Chen, S. Chen, Y. Zhao and J. Du, Rationally Separating the Corona and Membrane Functions of Polymer Vesicles for Enhanced T2 MRI and Drug Delivery, ACS Appl. Mater. Inter., 2015, 7, 14043-14052.
90.          Y. Lin, Y. Huang, W. Zheng, K. Wu, Q. Luo, Y. Zhao, S. Xiong and F. Wang, Quantification of bindings of organometallic ruthenium complexes to GSTπ by mass spectrometry, J. Inorg. Biochem., 2015, 146, 44-51.
91.          Q. Jiang, Z. Guo, Y. Zhao, F. Wang and L. Mao, In vivo fluorescence sensing of the salicylate-induced change of zinc ion concentration in the auditory cortex of rat brain, Analyst, 2015, 140, 197-203.
92.          J. Du, E. Zhang, Y. Zhao, W. Zheng, Y. Zhang, Y. Lin, Z. Wang, Q. Luo, K. Wu and F. Wang, Discovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells, Metallomics, 2015, 7, 1573-1583.
93.          G. Zhai, X. Wu, Q. Luo, K. Wu, Y. Zhao, J. Liu, S. Xiong, Y.-Q. Feng, L. Yang and F. Wang, Evaluation of serum phosphopeptides as potential cancer biomarkers by mass spectrometric absolute quantification, Talanta, 2014, 125, 411-417.
94.          A. M. Pizarro, R. J. McQuitty, F. S. Mackay, Y. Zhao, J. A. Woods and P. J. Sadler, Cellular Accumulation, Lipophilicity and Photocytotoxicity of Diazido Platinum(IV) Anticancer Complexes, ChemMedChem, 2014, 9, 1169-1175.
95.          S. Liu, K. Wu, W. Zheng, Y. Zhao, Q. Luo, S. Xiong and F. Wang, Identification and discrimination of binding sites of an organoruthenium anticancer complex to single-stranded oligonucleotides by mass spectrometry, Analyst, 2014, 139, 4491-4496.
96.          Z. Du, Q. Luo, L. Yang, T. Bing, X. Li, W. Guo, K. Wu, Y. Zhao, S. Xiong, D. Shangguan and F. Wang, Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex, J. Am. Chem. Soc., 2014, 136, 2948-2951.
97.          W. Zheng, Q. Luo, Y. Lin, Y. Zhao, X. Wang, Z. Du, X. Hao, Y. Yu, S. Lu, L. Ji, X. Li, L. Yang and F. Wang, Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis, Chem. Commun., 2013, 49, 10224-10226.
98.          Y. Zhao, J. A. Woods, N. J. Farrer, K. S. Robinson, J. Pracharova, J. Kasparkova, O. Novakova, H. Li, L. Salassa, A. M. Pizarro, G. J. Clarkson, L. Song, V. Brabec and P. J. Sadler, Diazido Mixed-Amine Platinum(IV) Anticancer Complexes Activatable by Visible-Light Form Novel DNA Adducts, Chem. Eur. J., 2013, 19, 9578-9591.
99.          Y. Zhao, N. J. Farrer, H. Li, J. S. Butler, R. J. McQuitty, A. Habtemariam, F. Wang and P. J. Sadler, De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex, Angew. Chem. Int. Ed., 2013, 52, 13633-13637.
100.       W. Guo, W. Zheng, Q. Luo, X. Li, Y. Zhao, S. Xiong and F. Wang, Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells, Inorg. Chem., 2013, 52, 5328-5338.
101.       Y. Zhao, G. M. Roberts, S. E. Greenough, N. J. Farrer, M. J. Paterson, W. H. Powell, V. G. Stavros and P. J. Sadler, Two-Photon-Activated Ligand Exchange in Platinum(II) Complexes, Angew. Chem. Int. Ed., 2012, 51, 11263-11266.
102.       H.-C. Tai, Y. Zhao, N. J. Farrer, A. E. Anastasi, G. Clarkson, P. J. Sadler and R. J. Deeth, A Computational Approach to Tuning the Photochemistry of Platinum(IV) Anticancer Agents, Chem. Eur. J., 2012, 18, 10630-10642.
103.       H. Li, S. A. Wells, J. E. Jimenez-Roldan, R. A. Römer, Y. Zhao, P. J. Sadler and P. B. O'Connor, Protein flexibility is key to cisplatin crosslinking in calmodulin, Protein Sci., 2012, 21, 1269-1279.
104.       H. Li, Y. Zhao, H. I. A. Phillips, Y. Qi, T.-Y. Lin, P. J. Sadler and P. B. O’Connor, Mass Spectrometry Evidence for Cisplatin As a Protein Cross-Linking Reagent, Anal. Chem., 2011, 83, 5369-5376.
105.       H. Li, T.-Y. Lin, S. L. Van Orden, Y. Zhao, M. P. Barrow, A. M. Pizarro, Y. Qi, P. J. Sadler and P. B. O’Connor, Use of Top-Down and Bottom-Up Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Mapping Calmodulin Sites Modified by Platinum Anticancer Drugs, Anal. Chem., 2011, 83, 9507-9515.
106.       N. J. Farrer, J. A. Woods, L. Salassa, Y. Zhao, K. S. Robinson, G. Clarkson, F. S. Mackay and P. J. Sadler, A Potent Trans-Diimine Platinum Anticancer Complex Photoactivated by Visible Light, Angew. Chem. Int. Ed., 2010, 49, 8905-8908.
107.       X. Kan, Z. Geng, Y. Zhao, Z. Wang and J.-J. Zhu, Magnetic molecularly imprinted polymer for aspirin recognition and controlled release, Nanotechnology, 2009, 20, 165601.
108.       Z. Zhang, Y. Zhao, Z. R. Geng and Z. L. Wang, Dichloridobis[2-(2-chloroethyl)-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole-kappa N]cobalt(II), Acta Crystallogr. E, 2008, 64, M942-U785.
109.       X. W. Kan, Y. Zhao, Z. R. Geng, J. J. Zhu and Z. L. Wang, Composites of multiwalled carbon nanotubes and molecularly imprinted polymers for dopamine recognition, J. Phys. Chem. C, 2008, 112, 4849-4854.

已指导学生

张燕燕  博士研究生  070302-分析化学  

侯垠竹  博士研究生  070302-分析化学  

现指导学生

周阳  博士研究生  070302-分析化学  

李梦瑶  硕士研究生  070302-分析化学  

现任中国计量测试学会离子与原子探针专业委员会创始委员。 

现任Chin. Chem. Let., The Innovation, J. Anal. Test等SCI学术期刊青年编委。