1、结构新颖的活性天然产物的发现

2、中草药传统功效的药效物质基础研究

3、天然先导结构的发现、结构改造与优化研究

   

100701-药物化学
100800-中药学

天然药物化学
中药化学

2005-09--2008-07   中国科学院上海药物研究所   获理学博士学位
2002-09--2005-07   中国药科大学 中药学院   理学硕士
1998-09--2002-07   武汉大学药学院   获医学硕士

理学博士，药物化学专业

   

2022-07~现在, 中国科学院上海药物研究所, 研究员，课题组长，博士生导师
2017-10~2022-07,中国科学院上海药物研究所, 研究员
2012-10~2017-09,中国科学院上海药物研究所, 副研究员
2008-11~2011-01,德国Wuppertal University, 博士后
2008-08~2012-09,中国科学院上海药物研究所, 助理研究员

2020-08-28-今,上海市药学会中药学专业委员会, 委员

   

[1] 叶阳, 许叶春, 姚胜, 苏海霞, 张磊砢, 肖庚富, 柯昌强, 赵文峰, 冯璐, 谢航. 杨梅素和二氢杨梅素磷酸酯类化合物在防治新冠肺炎药物中的应用. PCT/CN2022/078851, 2022-03-02.
[2] 叶阳, 许叶春, 姚胜, 苏海霞, 张磊砢, 肖庚富, 柯昌强, 赵文峰, 冯璐, 谢航. 杨梅素和二氢杨梅素磷酸酯类化合物在防治新冠肺炎药物中的应用. CN: CN114983993A, 2022-09-02.
[3] 宫丽崑, 叶阳, 吴守燕, 王雯婕, 姚胜, 柯昌强, 孙建华, 冯璐. 甘草次酸和芍药苷的组合在治疗肝损伤、肝纤维化中的应用. CN: CN114272254A, 2022-04-05.
[4] 许叶春, 叶阳, 姚胜, 苏海霞, 唐春萍, 赵文峰, 柯昌强, 谢航, 蒋华良. 邻苯三酚及其衍生物作为共价配体反应弹头的用途. CN: CN113679701A, 2021-11-23.
[5] 叶阳, 许叶春, 姚胜, 赵文峰, 柯昌强, 苏海霞. 苯乙醇苷类化合物及其组合物在制备防治新冠肺炎药物中的应用. CN: CN113491703A, 2021-10-12.
[6] 姚胜, 蒋翔锐, 许叶春, 王震, 谢元超, 沈敬山, 叶阳. 杨梅素类化合物在制备防治新冠肺炎药物中的应用. CN: CN113350330A, 2021-09-07.
[7] 姚胜, 蒋翔锐, 许叶春, 王震, 谢元超, 沈敬山, 叶阳. 杨梅素类化合物在制备防治新冠肺炎药物中的应用. CN: CN113350330B, 2023-04-14.
[8] 许叶春, 叶阳, 谢航, 姚胜, 赵文峰, 柯昌强, 苏海霞, 豆会霞, 蒋华良. 茶叶提取物及其组合物在抗冠状病毒中的应用. CN: CN113332363A, 2021-09-03.
[9] 许叶春, 叶阳, 肖庚富, 沈敬山, 柳红, 苏海霞, 姚胜, 张磊砢, 赵文峰, 柯昌强, 谢航, 唐炜, 左建平, 蒋华良. 黄芩主要成分黄芩素、黄芩苷及其组合物在抗冠状病毒中的应用. CN: CN113244211A, 2021-08-13.
[10] 许叶春, 叶阳, 肖庚富, 沈敬山, 柳红, 苏海霞, 姚胜, 张磊砢, 赵文峰, 柯昌强, 谢航, 唐炜, 左建平, 蒋华良. 黄芩素、黄芩苷用于制备冠状病毒SARS-CoV-2的3CL蛋白酶的抑制剂的用途. CN: CN113244211B, 2023-04-07.
[11] 叶阳, 潘国宇, 姚胜, 薛亚茹, 邓强强, 唐春萍, 彭兆亮, 柯昌强. 9,10-二氢菲类化合物及其用于肝损伤治疗的用途. CN: CN113244203A, 2021-08-13.
[12] 许叶春, 叶阳, 苏海霞, 姚胜, 赵文峰, 柯昌强, 谢航, 沈敬山, 柳红, 唐炜, 左建平, 蒋华良. 黄芩、连翘、金银花主要成分及其组合物在抗冠状病毒中的应用. CN: CN113209164B, 2023-01-20.
[13] 许叶春, 叶阳, 苏海霞, 姚胜, 赵文峰, 柯昌强, 谢航, 沈敬山, 柳红, 唐炜, 左建平, 蒋华良. 黄芩、连翘、金银花主要成分及其组合物在抗冠状病毒中的应用. CN: CN113209164A, 2021-08-06.
[14] 俞强, 叶阳, 单慧, 姚胜. 赤麻木脂素的新用途. CN: CN111743889A, 2020-10-09.
[15] 吴晔明, 叶阳, 武志祥, 姚胜, 蔡翊鸿, 谭敏佳. 丹参酮类化合物及其用于治疗血管瘤的用途. CN: CN109485691B, 2023-04-11.
[16] 吴晔明, 叶阳, 武志祥, 姚胜, 蔡翊鸿, 谭敏佳. 丹参酮类化合物及其用于治疗血管瘤的用途. CN: CN109485691A, 2019-03-19.
[17] 叶阳, 王逸平, 姚胜, 马艳玲, 唐春萍, 赵晶, 柯昌强, 徐文伟. 具有降血脂活性的竹柏內酯类化合物，其制备方法及用途. CN: CN107405330A, 2017-11-28.
[18] 叶阳, 王逸平, 姚胜, 马艳玲, 唐春萍, 赵晶, 柯昌强, 徐文伟. 具有降血脂活性的竹柏內酯类化合物，其制备方法及用途. CN: CN107089993A, 2017-08-25.
[19] 叶阳, 王逸平, 姚胜, 马艳玲, 唐春萍, 赵晶, 柯昌强, 徐文伟. 具有降血脂活性的竹柏內酯类化合物，其制备方法及用途. CN: CN107405330B, 2023-08-01.
[20] 叶阳, 王逸平, 姚胜, 赵晶, 唐春萍, 徐文伟, 柯昌强, 席聪. 具有降血脂活性的松香烷型二萜类化合物，其制备方法及用途. CN: CN106279200A, 2017-01-04.
[21] 叶阳, 唐希灿, 章海燕, 姚胜, 王维, 季萍. 一种高活性柏子提取物及其用途. CN: CN104367603A, 2015-02-25.
[22] 叶阳, 唐希灿, 章海燕, 姚胜, 王维, 季萍. 一种柏子或柏子提取物及其用途. CN: CN113599402A, 2021-11-05.
[23] 叶阳, 林革, 杜健华, 姚胜, 蔡若涓, 马良, 银春, 唐春萍, 柯昌强. 多氧孕甾烷皂苷前药化合物或其组合物及其用途. CN: CN104224818A, 2014-12-24.
[24] 叶阳, 林革, 姚胜, 杜健华, 马良, 蔡若涓, 唐春萍, 银春, 柯昌强, 王亚周. 一类多氧孕甾烷化合物及用途. CN: CN104395318A, 2015-03-04.
[25] 张旭, 李帅, 鲍岚, 叶阳, 姚胜. 治疗或缓解疼痛的物质. CN: CN103239720A, 2013-08-14.
[26] 叶阳, 林鸽, 姚胜, 杜健华, 马良, 蔡若涓, 唐春萍, 柯昌强, 王亚周. 一类多氧孕甾烷化合物及用途. CN: CN103483413A, 2014-01-01.
[27] 叶阳, 冯林音, 葛凡, 蔡欣, 唐春萍, 李希强, 廖苍松, 柯昌强, 姚胜, 季新泉. 一种具有环氧化酶-2异常表达抑制活性的芍药苷类化合物,其制备方法及其用途. CN: CN102731522A, 2012-10-17.

   

[1] Wang Qiaoqiao, Wang Long, Zhang Wenbo, Tang Chunping, Chen Xueqin, Zheng Yueming, Yao Sheng, Gao Zhaobing, Ye Yang. Naphthylisoquinoline alkaloids,a new structural template inhibitor of Navl.7 sodium channel. ACTA PHARMACOLOGICA SINICA[J]. 2023, 第 7 作者44(9): 1768-1776, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7551187&detailType=1.
[2] zhenyu lv, Jiao Meng, Sheng Yao, Fu Xiao, Shilong Li, Haoyang Shi, Chen Cui,, Kaixian Chen, Xiaoming Luo, Yang Ye, Chang Chen. Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis. Cell Reports[J]. 2023, 第 3 作者42: 113288, https://pubmed.ncbi.nlm.nih.gov/37874675/.
[3] Qing Wang, Sheng Yao, Ze-xian Yang, Chen Zhou, Yu Zhang, Ye Zhang, Lei Zhang, Jin-Tian Li, Zhi-Jian Xu, Wei-Liang Zhu, Nai-Xia Zhang, Yang Ye, Lin-Yin Feng. Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment. Acta Pharmacologica Sinica[J]. 2023, 第 2 作者44(6): 1122-1134, https://www.nature.com/articles/s41401-022-01039-6.
[4] Zhuo LI, Hang XIE, Chunping TANG, Lu FENG, Changqiang KE, Yechun XU, Haixia SU, Sheng YAO, Yang YE. Flavonoids from the roots and rhizomes of Sophoratonkinensis and their in vitro anti-SARS-CoV-2 activity. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2023, 第 8 作者  通讯作者  21(1): 65-80, http://dx.doi.org/10.1016/S1875-5364(23)60386-3.
[5] Wang, Qiaoqiao, Wang, Long, Zhang, Wenbo, Tang, Chunping, Chen, Xueqin, Zheng, Yueming, Yao, Sheng, Gao, Zhaobing, Ye, Yang. Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel. ACTA PHARMACOLOGICA SINICA[J]. 2023, 第 7 作者  通讯作者  http://dx.doi.org/10.1038/s41401-023-01084-9.
[6] Hu, Bintao, Li, Han, Tang, Chunping, Ke, ChangQiang, Geng, Meiyu, Yao, Sheng, Xie, Zuoquan, Ye, Yang. Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2022, 第 6 作者  通讯作者  70(18): 5595-5609, http://dx.doi.org/10.1021/acs.jafc.2c01519.
[7] Yingle Mao, Jiaomeng Li, Chunping Tang, Biao Ma, Zhijian Xu, Changqiang Ke, Lu Feng, Haiyan Zhang, Sheng Yao, HuiXiong Dai, Yang Ye. Fused-ring α-pyrones from intramolecular C–H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 第 9 作者  通讯作者  244: 114866, http://dx.doi.org/10.1016/j.ejmech.2022.114866.
[8] Wang, Lin, Wu, Yan, Yao, Sheng, Ge, Huan, Zhu, Ya, Chen, Kun, Chen, Wenzhang, Zhang, Yi, Zhu, Wei, Wang, Hongyang, Guo, Yu, Ma, Peixiang, Ren, Pengxuan, Zhang, Xianglei, Li, Huiqiong, Ali, Mohammad A, Xu, Wenqing, Jiang, Hualiang, Zhang, Leike, Zhu, Lili, Ye, Yang, Shang, Weijuan, Bai, Fang. Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein. ACTA PHARMACOLOGICA SINICA[J]. 2022, 第 3 作者43(4): 788-796, http://lib.cqvip.com/Qikan/Article/Detail?id=7107734707.
[9] Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Zhang, Yumin, Liu, Jia, Shao, Qiang, Wang, Qingxing, Li, Minjun, Xie, Hang, Shang, Weijuan, Ke, Changqiang, Feng, Lu, Jiang, Xiangrui, Shen, Jingshan, Xiao, Gengfu, Jiang, Hualiang, Zhang, Leike, Ye, Yang, Xu, Yechun. Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. NATURE COMMUNICATIONS[J]. 2021, 第 2 作者12(1): 3623, https://doaj.org/article/ff68234682c746f3aa209aef3785fbf8.
[10] Wang, Xing, Peng, Xia, Tang, Chunping, Zhou, Shuaizhen, Ke, ChangQiang, Liu, Yueling, Yao, Sheng, Ai, Jing, Ye, Yang. Anti-inflammatory Eudesmane Sesquiterpenoids from Artemisia hedinii. JOURNAL OF NATURAL PRODUCTS[J]. 2021, 第 7 作者  通讯作者  84(5): 1626-1637, http://dx.doi.org/10.1021/acs.jnatprod.1c00177.
[11] Yaru Xue, Sheng Yao, Qian Liu, Zhaoliang Peng, Qiangqiang DengBo Liu, Zhenghua Ma, Le Wangf Hu Zhou, Yang Ye, Guoyu Pan. Dihydro-stilbene gigantol relieves CCl4-induced hepatic oxidative stress and inflammation in mice via inhibiting C5b-9 formation in the liver. 中国药理学报：英文版[J]. 2020, 第 2 作者41(11): 14, http://lib.cqvip.com/Qikan/Article/Detail?id=7103556607.
[12] Wang, Qiaoqiao, Zhang, Tian, Ke, ChangQiang, Tang, Chunping, Yao, Sheng, Lin, Ligen, Ye, Yang. Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy. BIOORGANIC CHEMISTRY[J]. 2020, 第 5 作者105: https://www.webofscience.com/wos/woscc/full-record/WOS:000603573500009.
[13] Yaru Xue, Qiangqiang Deng, Qingli Zhang, Zhenghua Ma, Binfan Chen, Xiaolu Yu, Huige Peng, Sheng Yao, Jia Liu, Yang Ye, Guoyu Pan. Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway. SCIENTIFIC REPORTS[J]. 2020, 第 8 作者10(1): https://doaj.org/article/5422c27e8d144a1294213cea143e9bfe.
[14] Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Li, Minjun, Liu, Jia, Shang, Weijuan, Xie, Hang, Ke, Changqiang, Hu, Hangchen, Gao, Meina, Yu, Kunqian, Liu, Hong, Shen, Jingshan, Tang, Wei, Zhang, Leike, Xiao, Gengfu, Ni, Li, Wang, Daowen, Zuo, Jianping, Jiang, Hualiang, Bai, Fang, Wu, Yan, Ye, Yang, Xu, Yechun. Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. ACTA PHARMACOLOGICA SINICA[J]. 2020, 第 2 作者41(9): 1167-1177, http://lib.cqvip.com/Qikan/Article/Detail?id=7103065052.
[15] Yang, Yue, Gong, Qi, Wang, Wei, Mao, YingLe, Wang, XiaoRong, Yao, Sheng, Zhang, HaiYan, Tang, Chunping, Ye, Yang. Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 第 6 作者83(12): 3681-3688, https://www.webofscience.com/wos/woscc/full-record/WOS:000603402900022.
[16] Ren, YongMei, Zhou, ShuaiZhen, Zhang, Tian, Qian, Meijia, Zhang, Rui, Yao, Sheng, Zhu, Hong, Tang, Chunping, Lin, Ligen, Ye, Yang. Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy. ORGANIC CHEMISTRY FRONTIERS[J]. 2020, 第 6 作者7(12): 1481-1489, https://www.webofscience.com/wos/woscc/full-record/WOS:000542743600007.
[17] Yuan, Jie, Wen, Xuelan, Ke, ChangQiang, Zhang, Tian, Lin, Ligen, Yao, Sheng, Goodpaster, Jason D, Tang, Chunping, Ye, Yang. Tricarabrols A-C, three anti-inflammatory sesquiterpene lactone trimers featuring a methylene-tethered linkage from Carpesium faberi. ORGANIC CHEMISTRY FRONTIERS[J]. 2020, 第 6 作者7(11): 1374-1382, https://www.webofscience.com/wos/woscc/full-record/WOS:000538168500008.
[18] Pan, Lijia, Nie, Litong, Yao, Sheng, Bi, Aiwei, Ye, Yang, Wu, Yeming, Tan, Zhen, Wu, Zhixiang. Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE[J]. 2020, 第 3 作者46(6): 2137-2149, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595673/.
[19] Qiaoqiao Wang, Tian Zhang, ChangQiang Ke, Chunping Tang, Sheng Yao, Ligen Lin, Yang Ye. Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1β production in macrophages through activating autophagy. BIOORGANIC CHEMISTRY. 2020, 第 5 作者105: http://dx.doi.org/10.1016/j.bioorg.2020.104451.
[20] Guo Wei, Yao Sheng, Sun Pu, Yang Tianbiao, Tang Chunping, Zheng Mingyue, Ye Yang, Meng Linghua. Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening. ACTA PHARMACOLOGICA SINICA[J]. 2020, 第 2 作者41(3): 423-431, http://lib.cqvip.com/Qikan/Article/Detail?id=7101290528.
[21] Hui Shan, Sheng Yao, Yang Ye, Qiang Yu. 3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/ STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells. 中国药理学报:英文版[J]. 2019, 第 2 作者40(12): 1578, http://lib.cqvip.com/Qikan/Article/Detail?id=7100635223.
[22] Liu Meng, Yuan Jie, Hu Wenjuan, Ke Changqiang, Zhang Yifan, Ye Yang, Zhong Dafang, Zhao Guangrong, Yao Sheng, Liu Jia. Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration. ACTA PHARMACOLOGICA SINICA[J]. 2019, 第 9 作者  通讯作者  40(2): 288-296, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6464686&detailType=1.
[23] Wang, Yumeng, Huang, Haixia, Yao, Sheng, Li, Guiling, Xu, Congjian, Ye, Yang, Gui, Suiqi. A lipid-soluble extract of Pinellia pedatisecta Schott enhances antitumor T cell responses by restoring tumor-associated dendritic cell activation and maturation. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2019, 第 3 作者241: 111980, http://dx.doi.org/10.1016/j.jep.2019.111980.
[24] Ma, Jiang, Ruan, Jianqing, Chen, Xinmeng, Li, Dongping, Yao, Sheng, Fu, Peter P, Ye, Yang, Gao, Hong, Wang, Jiyao, Lin, Ge. Pyrrole-Hemoglobin Adducts, a More Feasible Potential Biomarker of Pyrrolizidine Alkaloid Exposure. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2019, 第 5 作者32(6): 1027-1039, https://www.webofscience.com/wos/woscc/full-record/WOS:000472241800014.
[25] Shan, Hui, Yao, Sheng, Ye, Yang, Yu, Qiang. 3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells. ACTA PHARMACOLOGICA SINICA[J]. 2019, 第 2 作者40(12): 1578-1586, https://www.webofscience.com/wos/woscc/full-record/WOS:000500546400008.
[26] Zhu, NanLin, Tang, Chunping, Xu, Chenghui, Ke, ChangQiang, Lin, Ge, Jenis, Janar, Yao, Sheng, Liu, Hongchun, Ye, Yang. Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 第 7 作者82(4): 919-927, https://www.webofscience.com/wos/woscc/full-record/WOS:000466442100027.
[27] Feng, Zheling, Chen, Shixin, Wang, Wei, Feng, Lu, Dong, Yanyan, Zou, Yiping, Ke, Changqiang, Tang, Chunping, Yao, Sheng, Zhang, Haiyan, Gan, Lishe, Ye, Yang, Lin, Ligen. Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity. FITOTERAPIA[J]. 2019, 第 9 作者139: 7, http://dx.doi.org/10.1016/j.fitote.2019.104378.
[28] Wang Yuwei, Tang Chunping, Yao Sheng, Lai Huanling, Li Runze, Xu Jiahui, Wang Qianqian, Fan Xing Xing, Wu Qi Biao, LaiHan, Leung Elaine, Ye Yang, Yao Xiaojun. Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer. PHYTOMEDICINE[J]. 2019, 第 3 作者65: http://dx.doi.org/10.1016/j.phymed.2019.153100.
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（ 1 ） 中药竹柏中具有抗多发性骨髓瘤作用的天然小分子化合物的发现与构效关系研究, 负责人, 国家任务, 2017-01--2020-12
（ 2 ） 杉科植物中松香烷型二萜抗动脉粥样硬化活性的发现及构效关系研究, 负责人, 国家任务, 2015-01--2018-12
（ 3 ） 罗汉松植物中具有降血脂活性的降二萜内酯类化合物的结构改造与初步构效关系研究, 负责人, 国家任务, 2014-01--2016-12
（ 4 ） 天然异喹啉生物碱类抗阿尔茨海默症先导化合物的发现研究, 负责人, 中国科学院计划, 2016-09--2018-06
（ 5 ） 个性化药物核心化学资源系统研究, 负责人, 中国科学院计划, 2016-01--2018-12

现指导学生

王敏  硕士研究生  078100-中药学  

穆佳星  硕士研究生  078100-中药学