利用生物信息学和化学信息学，开发和优化药物筛选模型，进而开展现有药物的药效学再评价、毒副作用机制和预警研究，以及现有药物的二次开发研究。曾开发10个基于靶点的药物筛选平台，其中包括首个针对 HCMV terminase 的药物评价筛选平台，获得 NIH资助 300 万美元开发 HCMV terminase 抑制剂。在药物筛选领域发表 SCI 文章 50余篇，i10指数30。作为主要执行人完成了美国NIH项目、香港卫生署项目等多个药物研究项目。回国后主持国家自然科技基金、广东省自然科技基金和高水平医院登峰计划以及深圳市科创委项目。现为国家自然科技基金评审专家，深圳市海外引进高层次人才，深圳南山区领航人才。

   

071010-生物化学与分子生物学

药物筛选

2010-08--2014-12   香港中文大学   博士
2007-09--2010-06   中国药科大学   硕士
2003-09--2007-06   南京中医药大学   学士

博士 香港中文大学

   

2018-09~现在, 中国科学院深圳先进技术研究院, 副研究员
2015-11~2018-08,美国明尼苏达大学, 博士后研究员
2013-12~2015-10,香港中文大学, 助理研究员

2023-07-01-今,香港中文大学深圳研究院创业导师,
2022-07-01-今,Chinese Medicine青年编委,

深圳市海外高层次人才“孔雀计划”C类引进人才，2019年

（ 1 ） Discovery of FDA-approved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening, 发明, 2018, 第 2 作者, 专利号: US9968616B2

   

[1] Yan Wang, Yongchao Ma, Qiuling Zhong, Bing Song, Qian Liu. Transcriptomic analysis of rat brain response to alternating current electrical stimulation: unveiling insights via single-nucleus RNA sequencing. MedComm[J]. 2024, 第 1 作者  通讯作者  15(4): e514, https://onlinelibrary.wiley.com/doi/10.1002/mco2.514.
[2] Yanni Shen, Qian Xie, Yiling Wang, Jianhui Liang, Cuilu Jiang, Xiaoping Liu, Yan Wang, Chun Hu. Design, synthesis and anti-osteosarcoma activity study of novel pyrido2,3-dpyrimidine derivatives by inhibiting DKK1-Wnt/β-catenin pathway. BIOORGANIC CHEMISTRY. 2023, 第 7 作者  通讯作者  141: http://dx.doi.org/10.1016/j.bioorg.2023.106848.
[3] Kuangyang Yang, Qian Xie, Jiaxin Liao, Na Zhao, Jianhui Liang, Ben Liu, Jianhai Chen, Wenxiang Cheng, Xueling Bai, Peng Zhang, Qian Liu, Bing Song, Junyi Danny Wang, Fanghao Zheng, Chun Hu, Lichu Liu, Lei Chen, Yan Wang. Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2023, 第 18 作者  通讯作者  311: http://dx.doi.org/10.1016/j.jep.2023.116476.
[4] He, MingFeng, Liang, JianHui, Shen, YanNi, Zhang, ChaoWei, Yang, KuangYang, Liu, LiChu, Xie, Qian, Hu, Chun, Song, Xun, Wang, Yan. Coptisine Inhibits Influenza Virus Replication by Upregulating p21. MOLECULES[J]. 2023, 第 10 作者  通讯作者  28(14): http://dx.doi.org/10.3390/molecules28145398.
[5] Yang, Kuangyang, Xie, Qian, Tang, Tingting, Zhao, Na, Liang, Jianhui, Shen, Yanni, Li, Ziqi, Liu, Ben, Chen, Jianhai, Cheng, Wenxiang, Bai, Xueling, Zhang, Peng, Liu, Qian, Song, Bing, Hu, Chun, Liu, Lichu, Wang, Yan. Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. PHYTOMEDICINE[J]. 2023, 第 17 作者  通讯作者  108: http://dx.doi.org/10.1016/j.phymed.2022.154506.
[6] Lei Chen, Xia Qiu, Abigail Dupre, Oscar PellonCardenas, Xiaojiao Fan, Xiaoting Xu, Prateeksha Rout, Katherine D Walton, Joseph Burclaff, Ruolan Zhang, Wenxin Fang, Rachel Ofer, Alexandra Logerfo, Kiranmayi Vemuri, Sheila Bandyopadhyay, Jianming Wang, Gaetan Barbet, Yan Wang, Nan Gao, Ansu O Perekatt, Wenwei Hu, Scott T Magness, Jason R Spence, Michael P Verzi. TGFB1 induces fetal reprogramming and enhances intestinal regeneration. CELL STEM CELL. 2023, 第 18 作者30(11): 1520-1537.e8, http://dx.doi.org/10.1016/j.stem.2023.09.015.
[7] Xie, Qian, Yang, Kuangyang, Liang, Jianhui, Shen, Yanni, Liu, Lichu, Wang, Yan. Spheroid culture of chondrocytes exhibits elevated levels of inflammation: A better approach for investigating the mechanisms of osteoarthritis?. PHARMACOLOGICAL RESEARCH[J]. 2023, 第 6 作者  通讯作者  191: http://dx.doi.org/10.1016/j.phrs.2023.106762.
[8] Qian Liu, Vsevolod Telezhkin, Wenkai Jiang, Yu Gu, Yan Wang, Wei Hong, Weiming Tian, Polina Yarova, Gaofeng Zhang, Simon Mingyuen Lee, Peng Zhang, Min Zhao, Nicholas D Allen, Emilio Hirsch, Josef Penninger, Bing Song. Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation. CELL & BIOSCIENCE[J]. 2023, 第 5 作者13(1): 1-17, https://doaj.org/article/797ccd32264d468c927a159ef5755817.
[9] Yang, Kuangyang, Xie, Qian, Liang, Jianhui, Shen, Yanni, Li, Ziqi, Zhao, Na, Wu, Yuanyan, Liu, Lichu, Zhang, Peng, Hu, Chun, Chen, Lei, Wang, Yan. Identification of Andrographolide as a novel FABP4 inhibitor for osteoarthritis treatment. PHYTOMEDICINE[J]. 2023, 第 12 作者  通讯作者  118: http://dx.doi.org/10.1016/j.phymed.2023.154939.
[10] Wenxin Fang, Ruolan Zhang, Jianhui Liang, Wanrong Xie, Youtao Zhang, Lei Chen, Yan Wang. Cereblon: A promising E3 ligase for broad-spectrum anticancer PROTAC drug development?. PHARMACOLOGICAL RESEARCH[J]. 2023, 第 7 作者  通讯作者  196: 106901, http://dx.doi.org/10.1016/j.phrs.2023.106901.
[11] Qian Xie, Yanni Shen, Yanli Meng, Jianhui Liang, Jing Xu, Shishao Liang, Xiaoping Liu, Yan Wang, Chun Hu. Pyrido2,3-dpyrimidine-2,4(1H,3H)-dione derivatives as RAF-MEK-ERK pathway signaling pathway blockers: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 第 8 作者  通讯作者  240: http://dx.doi.org/10.1016/j.ejmech.2022.114579.
[12] Senaweera, Sameera, Edwards, Tiffany C, Kankanala, Jayakanth, Wang, Yan, Sahani, Rajkumar Lalji, Xie, Jiashu, Geraghty, Robert J, Wang, Zhengqiang. Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV). ACTA PHARMACEUTICA SINICA B[J]. 2022, 第 4 作者12(4): 1671-1684, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7222772&detailType=1.
[13] Zhang, Jinwen, He, Mingfeng, Xie, Qian, Su, Ailing, Yang, Kuangyang, Liu, Lichu, Liang, Jianhui, Li, Ziqi, Huang, Xiuxin, Hu, Jianshu, Liu, Qian, Song, Bing, Hu, Chun, Chen, Lei, Wang, Yan. Predicting In Vitro and In Vivo Anti-SARS-CoV-2 Activities of Antivirals by Intracellular Bioavailability and Biochemical Activity. ACS OMEGA[J]. 2022, 第 15 作者  通讯作者  7(49): 45023-45035, http://dx.doi.org/10.1021/acsomega.2c05376.
[14] Wan, Jiangfan, Wang, Gang, Qin, Fuying, Huang, Danling, Wang, Yan, Su, Ailing, Zhang, Haiping, Liu, Yang, Zeng, Shaoyin, Wei, Chaoliang, Cheng, Yongxian, Liu, Jie. Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia. ACTA PHARMACOLOGICA SINICA[J]. 2022, 第 5 作者43(9): 2340-2350, http://dx.doi.org/10.1038/s41401-022-00870-1.
[15] Hu, Ziwei, Hu, Hao, Hu, Zhili, Zhong, Xiaojun, Guan, Yifu, Zhao, Yunshi, Wang, Lu, Ye, Liang, Ming, Liliang, Rajoka, Muhammad Shahid Riaz, He, Zhendan, Wang, Yan, Song, Xun. Sanguinarine, Isolated From Macleaya cordata, Exhibits Potent Antifungal Efficacy Against Candida albicans Through Inhibiting Ergosterol Synthesis. FRONTIERS IN MICROBIOLOGY[J]. 2022, 第 12 作者  通讯作者  13: https://doaj.org/article/190cd5e3daea45a288a63c83b4d36302.
[16] He, MingFeng, Liang, JianHui, Shen, YanNi, Zhang, JinWen, Liu, Ying, Yang, KuangYang, Liu, LiChu, Wang, Junyi, Xie, Qian, Hu, Chun, Song, Xun, Wang, Yan. Glycyrrhizin Inhibits SARS-CoV-2 Entry into Cells by Targeting ACE2. LIFE-BASEL[J]. 2022, 第 12 作者  通讯作者  12(11): http://dx.doi.org/10.3390/life12111706.
[17] Wang, Yan, SotoAcosta, Ruben, Ding, Rui, Chen, Liqiang, Geraghty, Robert J. Anti-HCMV activity by an irreversible p97 inhibitor LC-1310. MEDICINAL CHEMISTRY RESEARCH[J]. 2021, 第 1 作者30(2): 440-448, http://dx.doi.org/10.1007/s00044-020-02679-1.
[18] 陈建海, 张鹏. Notch-1 and Notch-3 Mediates Hypoxia-Induced Synovial Fibroblasts Activation in Rheumatoid Arthritis. Arthritis & Rheumatology[J]. 2021, 
[19] Wang, Yan, Chen, Lei. Lung tissue distribution of drugs as a key factor for COVID-19 treatment. BRITISH JOURNAL OF PHARMACOLOGY. 2020, 第 1 作者  通讯作者  177(21): 4995-4996, https://www.doi.org/10.1111/bph.15102.
[20] Hu, Yiping, Zhang, Tiantian, Chen, Jingqin, Cheng, WenXiang, Chen, Jianhai, Zheng, Zhengtan, Lin, Jietao, Zhu, Guoyuan, Zhang, Yong, Bai, Xueling, Wang, Yan, Song, Bing, Wang, Qingwen, Qin, Ling, Zhang, Peng. Downregulation of Hypoxia-Inducible Factor-1 alpha by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2020, 第 11 作者19: 1330-1342, https://www.webofscience.com/wos/woscc/full-record/WOS:000519557700109.
[21] Qin, FuYing, Zhang, HaoXing, Di, QianQian, Wang, Yan, Yan, YongMing, Chen, WeiLin, Cheng, YongXian. Ganoderma cochlear Metabolites as Probes to Identify a COX-2 Active Site and as in Vitro and in Vivo Anti-Inflammatory Agents. ORGANIC LETTERS[J]. 2020, 第 4 作者22(7): 2574-2578, https://www.webofscience.com/wos/woscc/full-record/WOS:000526335800015.
[22] Wang, Yan, Chen, Lei. Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2020, 第 1 作者  通讯作者  889: http://dx.doi.org/10.1016/j.ejphar.2020.173634.
[23] Wang, Yan, Xiao, ChuYing, Lin, HuangQuan, Hu, JianShu, Ip, TszMing, Wan, David ChiCheong. Development of an enzyme-linked immunosorbent assay for Keap1-Nrf2 interaction inhibitors identification. REDOX BIOLOGY[J]. 2020, 第 1 作者  通讯作者  34: http://dx.doi.org/10.1016/j.redox.2020.101573.
[24] Cheng, WenXiang, Huang, Huan, Chen, JianHai, Zhang, TianTian, Zhu, GuoYuan, Zheng, ZhengTan, Lin, JieTao, Hu, YiPing, Zhang, Yong, Bai, XueLing, Wang, Yan, Xu, ZhanWang, Song, Bing, Mao, YiYing, Yang, Fei, Zhang, Peng. Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2020, 第 11 作者22: 92-100, http://dx.doi.org/10.1016/j.jot.2019.07.007.
[25] Yan, YongMing, Zhang, HaoXing, Liu, Huan, Wang, Yan, Wu, JingBo, Li, YanPeng, Cheng, YongXian. (+/-)-Lucidumone, a COX-2 InhibitoryCaged Fungal Meroterpenoid from Ganoderma lucidum. ORGANIC LETTERS[J]. 2019, 第 4 作者21(21): 8523-8527, https://www.webofscience.com/wos/woscc/full-record/WOS:000494553300004.
[26] Wang, Yan, Geraghty, Robert J. FRET-based assay using a three-way junction DNA substrate to identify inhibitors of human cytomegalovirus pUL89 endonuclease activity. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES[J]. 2019, 第 1 作者127: 29-37, http://dx.doi.org/10.1016/j.ejps.2018.10.016.
[27] Yan YongMing, Zhang HaoXing, Liu Huan, Wang Yan, Wu JingBo, Li YanPeng, Cheng YongXian. ( plus /-)-Lucidumone, a COX-2 Inhibitory Caged Fungal Meroterpenoid from Ganoderma lucidum. ORGANIC LETTERS[J]. 2019, 第 4 作者21(21): 8523-8527, 
[28] Wen Liang Pan, Yan Wang, Yuan Hao, Jack Ho Wong, Wing Cheong Chan, David ChiCheong Wan, Tzi Bun Ng. Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells. BBA - MOLECULAR BASIS OF DISEASE. 2018, 第 2 作者1864(11): 3837-3846, http://dx.doi.org/10.1016/j.bbadis.2018.09.008.
[29] Kankanala, Jayakanth, Wang, Yan, Geraghty, Robert J, Wang, Zhengqiang. Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. CHEMMEDCHEM[J]. 2018, 第 2 作者13(16): 1658-1663, https://www.webofscience.com/wos/woscc/full-record/WOS:000442341900006.
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[31] Wang Yan. Synthesis, β-catenin Translocation Capability and ALP Activation Activity of 7H-thiazolo [3, 2-b]-1, 2, 4-triazin-7-one Derivatives. Medicinal Chemistry. 2018, 第 1 作者
[32] Wang, Yan, Tang, Jing, Wang, Zhengqiang, Geraghty, Robert J. Metal-chelating 3-hydroxypyrimidine-2,4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication. ANTIVIRAL RESEARCH[J]. 2018, 第 1 作者152: 10-17, http://dx.doi.org/10.1016/j.antiviral.2018.01.015.
[33] Zhou, Wenbo, Wang, Yan, Xie, Jiashu, Geraghty, Robert J. A fluorescence-based high-throughput assay to identify inhibitors of tyrosylprotein sulfotransferase activity. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2017, 第 2 作者482(4): 1207-1212, http://dx.doi.org/10.1016/j.bbrc.2016.12.013.
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[49] Wang, Yan, Pan, WenLiang, Liang, WeiCheng, Law, WaiKit, Ip, Denis TszMing, Ng, TziBun, Waye, Mary MiuYee, Wan, David ChiCheong. Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE[J]. 2013, 第 1 作者2013: https://doaj.org/article/9f19b4bf1d62436989b8e651b91785ff.
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佛山市中医院

沈阳药科大学

东南大学

深圳大学

深圳技术大学