新一代DNA测序与低成本DNA合成技术提供了海量基因资源与快速廉价的基因获取手段，为设计和创制工程细胞提供了近乎无限的可能性。我们实验室开发基于CRISPR相关系统的微生物基因组编辑工具和定向进化方法，加速细胞构建以理解相关遗传与生化机制，据此迭代设计工程微生物，用于能源、农业和医药领域。

实验室设计的基因组编辑工具质粒分发四千余次，数十种生物催化酶与化学品高产菌株在国内商用，纤维素乙醇酵母在中国、美国与巴西应用于二代乙醇生产。杨晟研究员获DuPont Young Professor Award, Novozymes Innovation Award, 国务院政府特殊津贴及国家杰出青年科学基金。多位毕业生创办或联合创办各自的合成生物学公司。

本组现有助理6人，博后1人，博士生3人，硕士生2人及一批客座研发人员。

1. 硕博连读生（微生物学）：每年两名含博士生。

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建议大三暑期前早联系早实习早了解早决定早选择。‍‍‍‍‍‍‍‍‍‍

2. 外招博士生：每位导师最多推荐3名学生参加笔试，笔试通过后，最多推荐1名学生参加面试，最后根据总分从高到低排序，待硕士研究生4月中旬完成转博后，再根据剩余博士名额及华理和同济联培名额进行录取。 

博士研究生为申请-考核制，《基础生物学》由我单位统一组织考试，满分100分，考试时间1小时，业务课二由课题组组织考核（形式不限，面试、实验操作等）并打分（共三档：A-90分，B-80分，C-70分）。 

3. 专业硕士生（生物工程）：每年一名，没想好是否读博的可以考虑。往年基本没啥竞争，推免生或上线统考生先到先得。

4. 特别研究助理/博士后：职责为完成高水平论文和/或开展企业合作项目。享受上海市落户绿色通道政策，年薪按单位标准，就高不就低。

5. 中国科技大学"所系结合”联合培养硕博连读生

  1）中国科技大学依托学院负责组织基地研究生招生，将基地介绍和招生专业纳入本学院招生简章和专业目录，统筹安排招生计划，组织复试录取工作，邀请基地专家参与招生选拔工作。
  2）基地研究生纳入中科大学籍管理。基地研究生第一学年在校本部完成基础课程学习，第二学年开始进入研究所开展科研训练。
  3）基地硕士研究生可申请转博，淘汰率约50%。 
  4）基地研究生学位申请和授予按照中国科大相关学科研究生学位授予标准执行。（博士毕业要求：a，科大为第一署名单位；b 独立一作或并列一作的前两位。独立一作文章的水平大概在3-5分的杂志，并列作者文章大概 Plant Cell及以上，硕士毕业要求：一篇第一作者文章（杂志不限）或专利）
  5）基地研究生在所系结合研究生导师指导下取得的科研成果，其知识产权原则上由我校和基地所在科研院所共享， 发表学术论文(著作)、申请专利、申报奖项等成果可署名双方 单位，用以申请学位的科研成果必须以“中国科学技术大学”为 第一署名(完成)单位。 
  6）所系结合研究生导师负责提供基地研究生在学期间的助研津贴，在基地学习期间的资助标准不低于基地所在科研院所研究生助研津贴标准。

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1.  https://www.researchgate.net/profile/Sheng_Yang10
2. 1、Jiao Zhu, Jiao Zhang, Feng Dong, Rongsheng Tao, Junjie Yang, Yingmiao Liu, Ying Zhang, Yu Jiang*, Sheng Yang*(2025) Reverse Metabolic Engineering of L‑Arginine Biosynthesis in Corynebacterium glutamicum. ACS Sustainable Chemistry & Engineering. 22(1):71. doi:10.1021/acssuschemeng.5c03737
3. 2、Xiaoyu Wang, Siqi Yang, Fenghui Qian, Feng Dong, Xiaojie Zhou, Mingyu Yin, Ying Zhang, Zhiwei Huang, Yu Jiang, Sheng Yang* (2025) RAGATH-Associated DNA Nuclease Assisted DNA Insertion in Corynebacterium glutamicum. ACS Synthetic Biology. 14(5): 1861-1867
4. 3、Lian Wu, Junbin He, Wanqing Wei, Haixue Pan, Xin Wang, Sheng Yang*, Yong Liang*, Gongli Tang*, Jiahai Zhou* (2025) Three distinct strategies lead to programmable aliphatic C−H oxidation in bicyclomycin biosynthesis. Nature Communications. 16(1): 4651
5. 4、Xiaojie Zhou,  Siqi Yang, Bingbing Sun, Feng Dong, Mingyu Yin, Yu Jiang, Zhiwei Huang, Sheng Yang*(2025) Implementation of RAGATH RNA-associated DNA Endonucleases as Genome Editing Tool in Escherichia coli. Biotechnol J. doi: 10.1002/biot.70005
6. 5、Kaiqi Zhi, Zhiguo An, Mingyang Zhang, Kehan Liu, Yafan Cai, Zhenyu Wang, Di Zhang, Jinle Liu, Zhi Wang, Chenjie Zhu, Dong Liu*, Sheng Yang*，Hanjie Ying (2025) Biofflm-Based Immobilization Fermentation for Continuous hEGF Production in Saccharomyces cerevisiae. Fermentation. 10(12): 661
7. 6、Yiwen Zhang#, Junjie Yang#, Fenghui Qian, Kate Brandon Sutton, Carsten Hjort, Wenping Wu, Yu Jiang, Sheng Yang* (2024) Engineering a xylose fermenting yeast for lignocellulosic ethanol production. Nature Chemical Biology. doi: 10.1038/s41589-024-01771-6
8. 7、Xinyun Jing, Niubing Zhang, Xiaojuan Zhou, Ping Chen, Jie Gong, Kaixiang Zhang, Xueting Wu, Wenjuan Cai, Bangce Ye, Pei Hao, Guoping Zhao, Sheng Yang，Xuan Li* (2024) Creating a bacterium that forms eukaryotic nucleosome core particles. Nature communications, 2024, 15 (1): 8283.
9. 8、Yuguo Niu, Xiaoming Hu, Yali Song, Cunchuan Wang, Peixiang Luo, Shihong Ni, Fuxin Jiao, Ju Qiu, Weihong Jiang, Sheng Yang, Jun Chen, Rui Huang, Haizhou Jiang, Shanghai Chen, Qiwei Zhai, Jia Xiao*, Feifan Guo*（2024）Blautia Coccoides is a Newly Identified Bacterium Increased by Leucine Deprivation and has a Novel Function in Improving Metabolic Disorders. Advanced Science. doi：10.1002/advs.202309255
10. 9、Jiaqi Xu, Yijie Sun, Jianping Wu, Sheng Yang*, Lirong Yang* (2023) Chromosome Recombination and Modification by LoxP -mediated Evolution in Vibrio natriegens using CRISPR-associated Transposases. Biotechnology and Bioengineering. 121(3):1163-1172
11. 10、Jinzhong Tian†*, Wangshuying Deng†, Ziwen Zhang, Jiaqi Xu, Guiling Yang, Guoping Zhao, Sheng Yang, Weihong Jiang*, Yang Gu*(2023) Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery. Nature Communications. doi:10.1038/s41467-023-43631-2
12. 11、Ping Yang, Junjie Yang, Ting Lin, Qi Liu, Yu Yin, Daijie Chen, Sheng Yang* (2023) Efficient Genome Editing in Most Staphylococcus aureus by Using the Restriction-Modification Systems Silent CRISPR-Cas9 Toolkit. ACS Synthetic Biology .DOI: 10.1021/acssynbio.3c00339
13. 12、Jinle Liu, Junjie Yang, Lihua Yuan, Chunhua Wu, Yu Jiang, Wei Zhuang, Hanjie Ying, Sheng Yang* (2023) Modulated Arabinose Uptake and cAMP Signaling Synergistically Improve Glucose and Arabinose Consumption in Recombinant Yeast. J Agric Food Chem. DIO: 10.1021/acs.jafc.3c04386
14. 13、 Junbin He, Lian Wu, Wanqing Wei , Song Meng , Zhengtao Liu , Xuan Wu , Haixue Pan , Sheng Yang , Yong Liang*, Jiahai Zhou*, Gongli Tang* (2023)  Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis. Nature Catalysis. DOI: 10.1038/s41929-023-00987-4
15. 14、Siqi Yang, Jiao Zhu, Xiaojie Zhou, Jiao Zhang, Qi Li, Furong Bian, Jidong Zhu, Ting Yan, Xiaoyu Wang, Ying Zhang, Junjie Yang, Yu Jiang, Sheng Yang* (2023) RNA-guided DNA transposition in Corynebacterium glutamicum and Bacillus subtilis. ACS Synthetic Biology. DOI:10.1021/acssynbio.3c00193
16. 15、Yu Jiang#, Xiyuan Li#, Fenghui Qian, Bingbing Sun, Xiyuan Wang, Yan Zhang, Deqiang Zhang, Meiyu Geng, Zuoquan Xie*, Sheng Yang* (2023) Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway. Research . 6: 0102
17. 16、Ziyu Yang, Juanxiu Qin, Lina Zhao, Tianchi Chen, Qian Huang, Ying Jian, Qi Zhao, Sheng Yang, Qi Li, Qian Liu, Michael Otto*, Min Li* (2023) Host sorbitol and bacterial sorbitol utilization promote C. difficile infection in inflammatory bowel disease. Gastroenterology, doi: https://doi.org/10.1053/j.gastro.2023.02.046.
18. 17、Qi Li, Mingjun Sun, Lu Lv, Yong Zuo, Suyi Zhang, Ying Zhang, and Sheng Yang* (2023) Improving the Editing Efficiency of CRISPR-Cas9 by Reducing the Generation of Escapers Based on the Surviving Mechanism. ACS Synthetic Biology. DOI: https://doi.org/10.1021/acssynbio.2c00619
19. 18、Zhiqiang Wen, Jun Chen, Yunliu Yang, Ying Zhang, Yu Jiang*, Sheng Yang* (2022) Pilot-scale fermentation of 300 t/a total solvents from sweet sorghum stalk juice. Chemical Engineering Journal. DOI:https://doi.org/10.1016/j.cej.2022.140534
20. 19、Yu Jiang#*, Bingbing Sun#, Fenghui Qian , Feng Dong, Chongmao Xu , Wuling Zhong, Rui Huang , Qiwei Zhai , Sheng Yang* (2022) Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a living therapeutic for phenylketonuria. SCIENCE CHINA Life Sciences. DOI: 10.1007/s11427-021-2137-3
21. 20、Wuling Zhong, Hui Wang, Yale Yang, Yali Zhang, Hejin Lai, Yalan Cheng, Huimin Yu, Ning Feng , Rui Huang, Shen Liu, Sheng Yang, Tongyang Hao, Baoyu Zhang, Hao Ying, Fang Zhang, Feifan Guo, Qiwei Zhai* (2022) High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption. Nature Metabolism. 4:1713–1731
22. 21、Qingzhuo Wang#, Huabao Zheng#, Rongsheng Tao, Qi Li, Yu Jiang*, Sheng Yang* (2022) Vitreoscilla hemoglobin enhances the catalytic performance of industrial oxidases in vitro. Applied Microbiology and Biotechnology. DOI: 10.1007/s00253-022-11974-3
23. 22、Junjie Yang*#, Jiawei Yang#, Yiwen Zhang, Siqi Yang, Jieze Zhang, Yu Jiang, Sheng Yang* (2021) CRISPR-associated transposase system can insert multiple copies of donor DNA into the same target locus. The CRISPR Journal. 4(6):789-798
24. 23、Jiaqi Xu, Sheng Yang*, Lirong Yang* (2021) Vibrio natriegens as a host for rapid biotechnology. Trends in Biotechnology. DOI:10.1016/j.tibtech.2021.10.007
25. 24、Qi Li, Jieze Zhang, Junjie Yang, Yu Jiang, Sheng Yang* (2021) Recent progress on n-butanol production by lactic acid bacteria. World Journal of Microbiology and Biotechnology . 37:205
26. 25、Siqi Yang#, Yiwen Zhang#, Jiaqi Xu, Jiao Zhang, Jieze Zhang, Junjie Yang, Yu Jiang, Sheng Yang* (2021) Orthogonal CRISPR-associated transposases for parallel and multiplexed chromosomal integration. Nucleic Acids Research. DOI: 10.1093/nar/gkab752
27. 26、Yiwen Zhang, Jiawei Yang, Siqi Yang, Jieze Zhang, Jun Chen, Rongsheng Tao, Yu Jiang, Junjie Yang and Sheng Yang* (2021) Programming cells by multicopy chromosomal integration using CRISPR-associated transposases. The CRISPR Journal. 4(3):350-359
28. 27、Jiaqi Xu, Junjie Yang, Yu Jiang, Mianbin Wu*, Sheng Yang*, Lirong Yang (2021) A novel global transcriptional perturbation target identified by forward genetics reprograms Vibrio natriegens for improving recombinant protein production. Acta Biochim Biophys Sin. 53(9):1124–1130
29. 28、Tianqiong Shi, Yawen Li, Li Zhu, Yangyang Tong, Junjie Yang, Yunming Fang, Meng Wang, Jieze Zhang, Yu Jiang, Sheng Yang*(2021) Engineering the oleaginous yeast Yarrowia lipolytica for β-farnesene overproduction. Biotechnology journal. DOI: 10.1002/biot.202100097
30. 29、Li Zhu, Jieze Zhang, Jiawei Yang, Yu Jiang, Sheng Yang*(2021) Strategies for optimizing acetyl-CoA formation from glucose in bacteria. Trends in Biotechnology. doi: 10.1016/j.tibtech.2021.04.004.
31. 30、Qi Li, Bingbing Sun, Jun Chen, Yiwen Zhang, Yu Jiang, Sheng Yang*(2021) A modified pCas/pTargetF system for CRISPR-Cas9-assisted genome editing in Escherichia coli. Acta Biochim Biophys Sin. 53(5):620-627.
32. 31、Xin Wang, Bei Liao, Zhijun Li, Guangxin Liu, Liuyang Diao, Fenghui Qian, Junjie Yang, Yu Jiang, Shumiao Zhao, Youguo Li, Sheng Yang*(2021) Reducing glucoamylase usage for commercial-scale ethanol production from starch using glucoamylase expressing Saccharomyces cerevisiae. Bioresources and Bioprocessing.8:20
33. 32、Jiaqi Xu, Feng Dong, Meixian Wu, Rongsheng Tao, Junjie Yang, Mianbin Wu, Yu Jiang*, Sheng Yang*, Lirong Yang*(2021) Vibrio natriegens as a pET compatible expression host complementary to Escherichia coli. Frontiers in Microbiology. doi:10.3389/fmicb.2021.627181.
34. 33、Bingbing Sun, Haiyan Liu , Yu Jiang, Lei Shao, Sheng Yang*, Daijie Chen*(2020) New Mutations Involved in Colistin Resistance in Acinetobacter baumannii. mSphere. 5(2):e00895-19
35. 34、Qi Li, Meixian Wu, Zhiqiang Wen, Yuan Jiang, Xin Wang, Yawei Zhao, Jinle Liu, Junjie Yang, Yu Jiang, Sheng Yang*(2020) Optimization of n‑butanol synthesis in Lactobacillus brevis via the functional expression of thl, hbd, crt and te.Journal of Industrial Microbiology & Biotechnology. doi:10.1007/s10295-020-02331-2
36. 35、Xiaoman Sun, Zixu Zhang, Lingru Wang, Jinggang Wang, Yan Liang, Haifeng Yang, Rongsheng Tao, Yu Jiang, Junjie Yang, Sheng Yang* (2020) Downregulation of T7 RNA polymerase transcription enhances pET‐based recombinant protein production in Escherichia coli BL21 (DE3) by suppressing autolysis. Biotechnology and Bioengineering. doi: 10.1002/bit.27558
37. 36、Jiao Zhang, Fenghui Qian, Feng Dong, Qingzhuo Wang, Junjie Yang, Yu Jiang*, Sheng Yang* (2020) De Novo Engineering of Corynebacterium glutamicum for l-Proline Production. ACS Synth Biol. doi: 10.1021/acssynbio.0c00249
38. 37、Yiwen Zhang, Xiaoman Sun, Qingzhuo Wang, Jiaqi Xu, Feng Dong, Siqi Yang, Jiawei Yang, Zixu Zhang, Yuan Qian, Jun Chen, Jiao Zhang, Yingmiao Liu, Rongsheng Tao, Yu Jiang, Junjie Yang*, Sheng Yang* (2020) Multicopy chromosomal integration using CRISPR-associated transposases. ACS Synth Biol. doi: 10.1021/acssynbio.0c00073
39. 38、Jinle Liu, Yu Jiang, Jun Chen, Junjie Yang, Weihong Jiang, Wei Zhuang, Hanjie Ying, Sheng Yang* (2020) Metabolic engineering and adaptive evolution of Clostridium beijerinckii to increase solvents production from corn stover hydrolysate. J Agric Food Chem. doi: 10.1021/acs.jafc.0c03048
40. 39、Zhiqiang Wen, Qi Li, Jinle Liu, Mingjie Jin*, Sheng Yang* (2020) Consolidated bioprocessing for butanol production of cellulolytic Clostridia: development and optimization. Microb Biotechnol. 13(2):410-422
41. 40、Zhiqiang Wen, Minrui Lu, Rodrigo Ledesma-Amaro, Qi Li, Mingjie Jin*, Sheng Yang* (2020) TargeTron Technology Applicable in Solventogenic Clostridia: Revisiting 12 Years' Advances. Biotechnology journal. 15(1):e1900284
42. 41、Zhiqiang Wen, Rodrigo Ledesma-Amaro, Minrui Lu, Yu Jiang, Shuliang Gao, Mingjie Jin*, Sheng Yang* (2020) Combined evolutionary engineering and genetic manipulation improve low pH tolerance and butanol production in a synthetic microbial Clostridium community. Biotechnology and Bioengineering. Doi: 10.1002/bit.27333
43. 42、Zhiqiang Wen, Rodrigo Ledesma-Amaro, Minrui Lu, Mingjie Jin*, Sheng Yang* (2020) Metabolic Engineering of Clostridium cellulovorans to Improve Butanol Production by Consolidated Bioprocessing. ACS synthetic biology.Doi: 10.1021/acssynbio.9b00331
44. 43、Qi Li, Francois M. Seys, Nigel P. Minton, Junjie Yang, Yu Jiang, Weihong Jiang, Sheng Yang*（2019）CRISPR-Cas9(D10A) nickase-assisted base editing in solvent producer Clostridium beijerinckii. Biotechnol Bioeng. Doi: 10.1002/bit.26949
45. 44、He Huang, Xin Song, Sheng Yang*（2019） Development of a RecE/T-Assisted CRISPR-Cas9 Toolbox for Lactobacillus. Biotechnology journal. doi: 10.1002/biot.201800690.
46. 45、Zhiqiang Wen, Ledesma-Amaro, Rodrigo; Jianping Lin*, Yu Jiang, Sheng Yang*（2019）Improved n-butanol production from Clostridium cellulovorans by integrated metabolic and evolutionary engineering. Appl Environ Microbiol. Doi: 10.1128/AEM.02560-18
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48. 46、杨萍 ，刘蔷，蒋宇，孙兵兵，杨俊杰，李琦，杨晟*，陈代杰*，（2019）耐甲氧西林金黄色葡萄球菌MRSA252辅酶A二硫化物还原酶缺失延缓苯唑西林的次级损伤效应，微生物学报，59（12）：2296-2305
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50. 47、杨萍，孙兵兵，杨俊杰，杨晟*， 蒋宇*，（2018）CRISPR-Cas系统的抗耐药菌应用，中国抗生素杂志， 43（8）:927-931
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52. 48、李琦，武美贤，郭清华，邵悠然，杨俊杰，蒋宇*，杨晟*，（2018）细菌基因组编辑技术进展，生命科学，10.13376/j.cbls/2019201
53. 
    
54. 49、Xinyun Jing, Bingran Xie, Longxian Chen, Niubing Zhang, Yiyi Jiang, Hang Qin, Hongbing Wang, Pei Hao*, Sheng Yang* , Xuan Li*（2018）Implementation of the CRISPR-Cas13a system in fission yeast and its repurposing for precise RNA editing. Nucleic Acids Res. Doi :10.1093/nar/gky433
55. 
    
56. 50、Bingbing Sun, Junjie Yang, Sheng Yang*, Richard D. Ye*, Daijie Chen,*; Yu Jiang*（2018）A CRISPR-Cpf1-Assisted Non-Homologous End Joining Genome Editing System of Mycobacterium smegmatis. Biotechnology journal . 13 (9) ：1700588
57. 
    
58. 51、Xin Wang, Junjie Yang, Sheng Yang*, Yu Jiang*（2018）Unraveling the genetic basis of fast L-arabinose consumption on top of recombinant xylose-fermenting Saccharomyces cerevisiae. Biotechnol Bioeng. Doi:10.1002/bit.26827
59. 52、Jun Sun, Qingzhuo Wang, Yu Jiang, Zhiqiang Wen, Lirong Yang, Jianping Wu* and Sheng Yang*（2018）Genome editing and transcriptional repression in Pseudomonas putida KT2440 via the type II CRISPR system. Microb Cell Fact. 17:41
60. 53、Xin Song, He Huang, Zhi-Qiang Xiong, Lianzhong Ai*, Sheng Yang* (2017) CRISPR-Cas9D10A Nickase-Assisted Genome Editing in Lactobacillus casei. Appl. Environ. Microbiol. doi: 10.1128/AEM.01259-17
61. 54、Qi Liu, Yu Jiang, Lei Shao, Ping Yang, Bingbing Sun,Sheng Yang*, and Daijie Chen* (2017) CRISPR/Cas9-based efficient genome editing in Staphylococcus aureus. Acta Biochim Biophys Sin. doi: 10.1093/abbs/gmx074
62. 55、Xiaoshu Xu, Chao Wang, Jun Chen, and Sheng Yang* （2017）Streptomyces virginiae PPDC is a new type of phenylpyruvate decarboxylase composed of two subunits. ACS Chemical Biology 2017; doi:10.1021/acschembio.7b00307
63. 56、Yu Jiang, Fenghui Qian, Junjie Yang, Yingmiao Liu, Feng Dong, Chongmao Xu, Bingbing Sun, Biao Chen, Xiaoshu Xu, Yan Li, Renxiao Wang, Sheng Yang* (2017) CRISPR-Cpf1 -assisted genome editing of Corynebacterium glutamicum. Nature Communications.doi:10.1038/ncomms15179 ESI高被引
64. 57、Shuliang Gao, Yangyang Tong, Li Zhu, Ge Mei, Zhang Yian, Daijie Chen, Yu Jiang, Sheng Yang* (2017) Iterative integration of multiple-copy pathway genes in Yarrowia lipolytica for heterologous β-carotene production. Metabolic Engineering. 41:192-201
65. 58、Zhiqiang Wen, Nigel P. Minton, Ying Zhang, Qi Li, Jinle Liu, Yu Jiang, Sheng Yang*（2017）Enhanced solvent production by metabolic engineering of a twin-clostridial consortium. Metabolic Engineering.39：38-48
66. 59、Qingzhuo Wang, ShuangYan Tang*, Sheng Yang* (2017) Genetic biosensors for small-molecule products: Design and applications in high-throughput screening. Frontiers of Chemical Science and Engineering. 11 (1), 15-26.
67. 60、Junjie Yang and Sheng Yang* (2016)Comparative analysis of Corynebacterium glutamicum genomes: a new perspective for the industrial production of amino acids. BMC Genomics . 18(1):940
68. 61、Yu Jiang, Rongsheng Tao, Zhengquan Shen, Liangdong Sun, Fuyun Zhu, Sheng Yang*(2016)Enzymatic Production of Glutathione by Bifunctional γ-Glutamylcysteine Synthetase/Glutathione Synthetase Coupled with In Vitro Acetate Kinase-Based ATP Generation. Appl Biochem Biotechnol.180（7） 1446-1455
69. 62、Shuliang Gao, Yangyang Tong, Zhiqiang Wen, Li Zhu, Mei Ge, Daijie Chen*, Yu Jiang*, Sheng Yang* (2016) Multiplex gene editing of the Yarrowia lipolytica genome using the CRISPR-Cas9 system. Journal of Industrial Microbiology & Biotechnology . 43（8）1085–1093
70. 63、Yu Jiang Rongsheng Tao , Sheng Yang* (2016) Tailor-made biocatalysts enzymes for the fine chemical industry in China. Biotechnol Journal. 11,1121–1123
71. 64、Qi Li, Jun Chen, Nigel P. Minton, Ying Zhang, Zhiqiang Wen, Jinle Liu, Haifeng Yang, Zhe Zeng, Xiaodan Ren, Junjie Yang, Yang Gu, Weihong Jiang, Yu Jiang, Sheng Yang* (2016) CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii. Biotechnology Journal. 11(7):961-72
72. 65、Chen Yang, Xiang Gao, Yu Jiang, Bingbing Sun, Fang Gao, Sheng Yang*（2016）Synergy between methylerythritol phosphate pathway and mevalonate pathway for isoprene production in Escherichia coli. Metabolic Engineering, 2016, 37:79–91
73. 66、Xiaoshu Xu, Jun Chen, Qingzhuo Wang, Chunlan Duan, Yan Li, Renxiao Wang,Sheng Yang*(2016) Mutagenesis of Key Residues in the Binding Center of l-Aspartate-b-Semialdehyde Dehydrogenase from Escherichia coli Enhances Utilization of the Cofactor NAD(H), ChemBioChem.17:56-64
74. 67、Yu Jiang, Biao Chen, Chunlan Duan, Bingbing Sun, Junjie Yang, and Sheng Yang* (2015)Multigene Editing in the Escherichia coli Genome via the CRISPR-Cas9 System. Appl. Environ. Microbiol. 81:2506-14  ESI高被引
75. 68、Ning Zhang, Lijun Shao, Yu Jiang, Yang Gu, Qi Li, Jinle Liu, Weihong Jiang, Sheng Yang* (2015) I-SceI-mediated scarless gene modification via allelic exchange in Clostridium. Journal Microbial Methods. 108:49-60
76. 69、Yu Jiang, Jinle Liu, Yunliu Yang, Weihong Jiang, Sheng Yang* (2014) Current status and prospects of industrial bio-production of n-butanol in China, Biotechnology Advances. 33：1493-1501
77. 70、Junjie Yang, Bingbing Sun, He Huang, Yu Jiang, Liuyang Diao, Biao Chen, Chongmao Xua,Xin Wang, Jinle Liu, Weihong Jiang, Sheng Yang* (2014) High-efficiency Scarless Genetic Modification in Escherichia coli Using lambda-Red Recombination and I-SceI Cleavage. Appl. Environ. Microbiol. 80(13):3826-34
78. 71、Rongsheng Tao, Yu Jiang, Fuyun Zhu, Sheng Yang* (2014) A one-pot system for production ofL-2-aminobutyric acid from L-threonine by L-threonine deaminase and a NADH regeneration system based on L-leucine dehydrogenase and formate dehydrogenase. Biotechnology Letters 36(4):835-41
79. 72、Liuyang Diao, Yingmiao Liu, Fenghui Qian, Junjie Yang, Yu Jiang, Sheng Yang* (2013）Construction of fast xylose-fermenting yeast based on industrial ethanol-producing diploid Saccharomyces cerevisiaeby rational design and adaptive evolution. BMC Biotechnology 13:110
80. 73、Zhilin Li, Han Xiao, Weihong Jiang, Yu Jiang*, Sheng Yang* (2013) Improvement of butanol production from xylose mother liquor by engineering xylose metabolic pathway in Clostridium acetobutylicum EA 2018. Applied Biochemistry and Biotechnology. 171(3):555-68
81. 74、Han Xiao, Zhilin Li, Yu Jiang, Yunliu Yang, Weihong Jiang, Yang Gu*, Sheng Yang* (2012) Metabolic engineering of D-xylose pathway in Clostridium beijerinckii to optimize solvent production from xylose mother liquid. Metabolic Engineering 14: 565-578
82. 75、Han Xiao, Yang Gu, Yuanyuan Ning, Yunliu Yang, W.J. Mitchell, Weihong Jiang*, Sheng Yang* (2011) Confirmation and elimination of xylose-metabolic bottlenecks in glucose-PTS-deficient Clostridium acetobutylicum to realize simultaneous utilization of glucose, xylose and arabinose. Appl. Environ. Microbiol 77:7886-7895
83. 76、Zhoutong Sun, Yuanyuan Ning, Lixia Liu, Yingmiao Liu, Bingbing Sun, Weihong Jiang, Chen Yang and Sheng Yang* (2011) Metabolic engineering of the L-phenylalanine pathway in Escherichia coli for the production of S- or R-mandelic acid. Microbial Cell Factories. 10:71 Highly Accessed
84. 77、Li Zhu, Rongsheng Tao, Yi Wang, Yu Jiang, Xin Lin, Yunliu Yang, Huabao Zheng, Weihong Jiang, Sheng Yang* (2011) Removal of L-alanine from the production of L-2-aminobutyric acid by introduction of alanine racemase and D-amino acid oxidase. Appl Microbiol Biotechnol. 90:903-910
85. 78、Jian LI, Jingbo Zhao, Meng Zhao, Yunliu Yang, Weihong Jiang, Sheng Yang* (2010)Screening and Characterization of Butanol Tolerant Microorganisms. Letters in Applied Microbiology 50: 373-9
86. 79、Yu Jiang, Chongmao Xu, Feng Dong, Yunliu Yang, Weihong Jiang*, Sheng Yang* (2009) Disruption of the acetoacetate decarboxylase gene in solvent-producing Clostridium acetobutylicum increases the butanol ratio. Metabolic Engineering 11: 284-91
87. 80、Junjie Yang, Weihong Jiang, Sheng Yang* (2009). mazF as a counter-selectable marker for unmarked genetic modification of Pichia pastoris. FEMS Yeast Research. 9(4): 600-9
88. 81、Hong Yu, Jian Li, Dalong Zhang, Yunliu Yang, Weihong Jiang, Sheng Yang* (2009). Improving the thermostability of N-carbamyl-D-amino acid amidohydrolase by error-prone PCR. Appl. Microbiol. Biotechnol. 82(2): 279-85
89. 82、Lijun Shao, Shiyuan Hu, Yi Yang, Yang Gu, Jun Chen, Yunliu Yang, Weihong Jiang*, Sheng Yang* (2007) Targeted gene disruption by use of a group II intron (targetron) vector in Clostridium acetobutylicum. Cell Research. 17: 963-5

​杨晟研究组揭示了高效利用秸秆糖酵母背后的机制

杨晟研究员获上海市2015年度科技进步奖一等奖

文汇报：真正的科研人员应该有点阿Q精神

杨晟研究员被北京化工大学聘任为兼职教授

杨晟研究员荣获“诺维信创新奖”

文汇报：依托基础研究、转化平台、体制保障“三板斧”接通科研与产业

人民日报：让经济与科技不再两张皮

解放日报：没啥论文为企业创收却上亿

经济日报：打通创新价值链

光明日报:“湖州中心”成为 成果转化重要平台

科技日报：湖州显现“中科院平台效应”

浙江日报：借力国家队搭建新平台-湖州着力推进院地合作

钱江晚报：湖州生物医药产业渐成气候

湖州日报：中央媒体集中采访 中科院湖州应用技术 研究与产业化中心 自主创新平台建设

长春大成集团与中科院上海生科院工业生物中心产学研结合成果斐然

杨晟研究组建立高效的谷氨酸棒杆菌CRISPR-Cpf1基因组编辑系统

杨晟研究组建立偏利共生人工双梭菌系统用于转化玉米芯产溶剂

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