1. 纳米生物学

2. 纳米免疫毒理学

3. 纳米医学

4. 免疫学

5. 肿瘤免疫治疗

1.  免疫学, 生物学
2.  纳米医学，纳米生物学
3.  化学生物学

071010-生物化学与分子生物学
0703Z1-化学生物学
071009-细胞生物学

纳米医学，纳米免疫安全性
肿瘤免疫学，免疫检查点肿瘤治疗
免疫学，天然免疫记忆

2011-11--2014-10   萨尔斯堡大学   博士

   

2022-12~现在, 中国科学院深圳先进技术研究院, 研究员
2017-12~2022-12,中国科学院深圳先进技术研究院, 副研究员
2016-09~2018-06,科罗拉多大学, 博士后
2015-07~2016-08,堪萨斯纳米技术研发中心, 博士后
2014-10~2014-12,意大利国家研究院, 博士后
2011-10~2014-10,意大利国家研究院, 玛丽居里研究员/博士

化学生物学进展

   

（1） 河北省自然科学奖, 一等奖, 省级, 2019
（2） 国际纳米毒理学大会旅行奖, 一等奖, 专项, 2016
（3） 国家优秀自费留学生奖学金, 一等奖, 国家级, 2013
（4） 玛丽居里基金, 一等奖, 其他, 2011

（ 1 ） 茶多酚在作为免疫检查点抑制剂及制备用于抗肿瘤的药物中的应用, 发明专利, 2018, 第 1 作者, 专利号: 201811478060.9

   

[1] Guofang Zhang, Xiaofeng Wang, Guocheng Wang, Xiaoman Suo, Yu Qiu, RongHua Luo, Yingnan Liu, Qi Li, Wenhe Luo, Zhenzhen Shi, Fangfang Liu, Zhongda Li, Jing Qu, Liang Li, Neus G Basts, Martin Himly, Liming Wang, FengLiang Liu, YongTang Zheng, Victor Puntes, Yang Li. Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2. NANO TODAY. 2024, 第 21 作者  通讯作者  55: http://dx.doi.org/10.1016/j.nantod.2024.102183.
[2] Advanced Functional Materials. 2023,   通讯作者  
[3] Nahar Jannatun, Yuqian Zhang, Ben Wu, Qingle Song, Guoli Cao, Wenhe Luo, Feng Yuan, Qi Li, Yanqiao Zeng, Guofang Zhang, Guocheng Wang, Yang Li. Tea Polyphenol Coordinated with Nanoparticles of ZIF-8 and Coated with Polydopamine and PEG for Immuno-Oncotherapy. ACS Applied Nano Materials[J]. 2023, 第 12 作者  通讯作者  
[4] Yang, Wenjie, Yang Li, Boraschi, Diana. Association between Microorganisms and Microplastics: How Does It Change the Host-Pathogen Interaction and Subsequent Immune Response?. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, 第 2 作者
[5] Zhengjiang Xu, Yuan Zhang, Danping Lu, Guofang Zhang, Yang Li, Zufu Lu, Fei Wang, Guocheng Wang. Antisenescence ZIF-8/Resveratrol Nanoformulation with Potential for Enhancement of Bone Fracture Healing in the Elderly. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2023, 第 5 作者
[6] Advanced Healthcare Materials. 2023,   通讯作者  
[7] Yichuan Zhang, Quan Gao, Weishuo Li, Rongkun He, Liwei Zhu, Qianjin Lian, Liang Wang, Yang Li, Mark Bradley, Jin Geng. Controlled Intracellular Polymerization for CancerTreatment. JACS AU[J]. 2022, 第 8 作者2(3): 579-589, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970002/.
[8] Zhang, Guofang, Cao, Guoli, Luo, RongHua, Song, Qingle, Zeng, Yanqiao, Liu, Ke, Qu, Jing, Lin, Xian, Liu, FengLiang, Wang, Guocheng, Li, Hongchang, Li, Liang, Zheng, YongTang, Boraschi, Diana, Wu, Lidong, Chang, YanZhong, Li, Yang. Microplastics interact with SARS-CoV-2 and facilitate host cell infection. ENVIRONMENTAL SCIENCE-NANO[J]. 2022, 第 17 作者  通讯作者  9(8): 2653-2664, http://dx.doi.org/10.1039/d2en00019a.
[9] Wenjie Yang, Nahar Jannatun, Yanqiao Zeng, Tinghao Liu, Guofang Zhang, Chunying Chen, Yang Li. Impacts of microplastics on immunity. FRONTIERS IN TOXICOLOGY[J]. 2022, 第 7 作者  通讯作者  4: https://doaj.org/article/f8964d5ff6d0491b8254acf2b6e0dd3a.
[10] Wenjie Yang, Nahar Jannatun, Yanqiao Zeng, Tinghao Liu, Guofang Zhang, Chunying Chen, Yang Li. Impacts of microplastics on immunity. FRONTIERS IN TOXICOLOGY[J]. 2022, 第 7 作者  通讯作者  4: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552327/.
[11] Della Camera, Giacomo, Liu, Tinghao, Yang, Wenjie, Li, Yang, Puntes, Victor F, Gioria, Sabrina, Italiani, Paola, Boraschi, Diana. Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 第 4 作者
[12] Xuejin Li, Dongjie Li, Guofang Zhang, Yanqiao Zeng, Nancy A MonteiroRiviere, YanZhong Chang, Yang Li. Biocorona modulates the inflammatory response induced by gold nanoparticles in human epidermal keratinocytes. TOXICOLOGY LETTERS. 2022, 第 7 作者  通讯作者  369: 34-42, http://dx.doi.org/10.1016/j.toxlet.2022.08.009.
[13] Chen, Yuange, Ouyang, Longling, Liu, Na, Li, Fang, Li, Peiyi, Sun, Mengmeng, Qin, Haiyang, Li, Yang, Xiang, Xueping, Wu, Lidong. pH-responsive magnetic artificial melanin with tunable aggregation-induced stronger magnetism for rapid remediation of plastic fragments. JOURNAL OF HAZARDOUS MATERIALS[J]. 2022, 第 8 作者435: http://dx.doi.org/10.1016/j.jhazmat.2022.128962.
[14] Environmental Science: Nano. 2022,   通讯作者  
[15] Nature Nanotechnology. 2022,   通讯作者  
[16] Shi Qiu, Jiawen Ji, Wei Sun, Jia Pei, Jian He, Yang Li, Jiao Jiao Li, Guocheng Wang. Recent advances in surface manipulation using micro-contact printing for biomedical applications. SMART MATERIALS IN MEDICINE[J]. 2021, 第 6 作者2: 65-73, http://dx.doi.org/10.1016/j.smaim.2020.12.002.
[17] Guofang Zhang, Yalin Cong, Guoli Cao, Liang Li, Peng Yu, Qingle Song, Ke Liu, Jing Qu, Jing Wang, Wei Xu, Shumin Liao, Yunping Fan, Yufeng Li, Guocheng Wang, Lijing Fang, Yanzhong Chang, Yuliang Zhao, Diana Boraschi, Hongchang Li, Chunying Chen, Liming Wang, Yang Li. Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination. bioRxiv[J]. 2021, 第 22 作者  通讯作者  
[18] Boraschi, Diana, Li, Dongjie, Li, Yang, Italiani, Paola. In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH[J]. 2021, 第 3 作者18(22): http://dx.doi.org/10.3390/ijerph182211769.
[19] Ravindran Menon, Dinoop, Li, Yang, Yamauchi, Takeshi, Osborne, Douglas Grant, Vaddi, Prasanna Kumar, Wempe, Michael F, Zhai, Zili, Fujita, Mayumi. EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses. PHARMACEUTICALS[J]. 2021, 第 2 作者14(11): http://dx.doi.org/10.3390/ph14111081.
[20] Shao, Ximing, Ding, Zhihao, Zhou, Wenhua, Li, Yanyan, Li, Zhibin, Cui, Haodong, Lin, Xian, Cao, Guoli, Cheng, Binghua, Sun, Haiyan, Li, Meiqing, Liu, Ke, Lu, Danyi, Geng, Shengyong, Shi, Wenli, Zhang, Guofang, Song, Qingle, Chen, Liang, Wang, Guocheng, Su, Wu, Cai, Lintao, Fang, Lijing, Leong, David Tai, Li, Yang, Yu, XueFeng, Li, Hongchang. Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase. NATURE NANOTECHNOLOGY[J]. 2021, 第 24 作者  通讯作者  16(10): 1150-+, http://dx.doi.org/10.1038/s41565-021-00952-x.
[21] Qingle Song, Guofang Zhang, Bo Wang, Guoli Cao, Dongjie Li, Yu Wang, Yuqian Zhang, Jin Geng, Hongchang Li, Yang Li. Reinforce the Combinational Immuno-Oncotherapy of Switching "Cold" Tumor to "Hot" by Responsive Penetrating Nanogels. ACS Applied Materials and Interfaces[J]. 2021, 第 10 作者  通讯作者  
[22] Qingle Song, Amaneh Javid, Guofang Zhang, Yang Li. Applications of Magnetite Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future Perspectives. FRONTIERS IN IMMUNOLOGY,12,(2021-10-04)[J]. 2021, 第 4 作者  通讯作者  
[23] Cao, Qiang, Liu, Na, Xiao, Yushi, Huang, Rong, Li, Yang, Wu, Lidong. Hybrid Magnetic Hydrogels Used as Artificial Marine Animals for Noncontact Cleaning. ACS APPLIED POLYMER MATERIALS[J]. 2021, 第 5 作者  通讯作者  3(2): 1182-1189, http://dx.doi.org/10.1021/acsapm.1c00019.
[24] Della Camera, Giacomo, Madej, Mariusz, Ferretti, Anna Maria, La Spina, Rita, Li, Yang, Corteggio, Annunziata, Heinzl, Tommaso, Swartzwelter, Benjamin J, Sipos, Gergo, Gioria, Sabrina, Ponti, Alessandro, Boraschi, Diana, Italiani, Paola. Personalised Profiling of Innate Immune Memory Induced by Nano-Imaging Particles in Human Monocytes. FRONTIERS IN IMMUNOLOGY[J]. 2021, 第 5 作者12: http://dx.doi.org/10.3389/fimmu.2021.692165.
[25] Zhang, Yuqian, Zhang, Guofang, Wang, Guocheng, Wu, Lidong, MonteiroRiviere, Nancy A, Li, Yang. The synergistic strategies for the immuno-oncotherapy with photothermal nanoagents. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY. 2021, 第 6 作者  通讯作者  13(5): http://dx.doi.org/10.1002/wnan.1717.
[26] Song, Qingle, Javid, Amaneh, Zhang, Guofang, Li, Yang. Applications of Magnetite Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future Perspectives. FRONTIERS IN IMMUNOLOGY. 2021, 第 4 作者  通讯作者  12: http://dx.doi.org/10.3389/fimmu.2021.701485.
[27] Ferretti, Anna M, Usseglio, Sandro, Mondini, Sara, Drago, Carmelo, La Mattina, Rosa, Chini, Bice, Verderio, Claudia, Leonzino, Marianna, Cagnoli, Cinzia, Joshi, Pooja, Boraschi, Diana, Italiani, Paola, Li, Yang, Swartzwelter, Benjamin J, Sironi, Luigi, Gelosa, Paolo, Castiglioni, Laura, Guerrini, Uliano, Ponti, Alessandro. Towards bio-compatible magnetic nanoparticles: Immune-related effects, in-vitro internalization, and in-vivo bio-distribution of zwitterionic ferrite nanoparticles with unexpected renal clearance. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2021, 第 13 作者582: 678-700, http://dx.doi.org/10.1016/j.jcis.2020.08.026.
[28] Zhang, Shu, Xiao, Ming, Zhang, Yuqian, Li, Yang, Liu, Huan, Han, Gang, Rathi, Brijesh, Lyu, Kaiyu, Wu, Lidong. Mimicking neuromelanin nanoparticles as a selective Pb2+ probe. ANALYTICA CHIMICA ACTA[J]. 2020, 第 4 作者1105: 208-213, http://dx.doi.org/10.1016/j.aca.2020.01.051.
[29] Zhang, Litian, Afolabi, Lukman O, Wan, Xiaochun, Li, Yang, Chen, Liang. Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2020, 第 4 作者  通讯作者  8: https://doaj.org/article/9b7e1e698d4148fabfa6aac24b0f1b03.
[30] Zhao, Jing, Lu, Danping, Moya, Sergio, Yan, Haoying, Qiu, Miaojuan, Chen, JunZong, Wang, Xincheng, Li, Yang, Pan, Haobo, Chen, Guochuang, Wang, Guocheng. Bispecific T-cell engager (BiTE) immunotherapy of ovarian cancer based on MIL-88A MOF/MC gene delivery system. APPLIED MATERIALS TODAY[J]. 2020, 第 8 作者20: http://dx.doi.org/10.1016/j.apmt.2020.100701.
[31] Liu, Yanfeng, Tao, Shishi, Liao, Lijuan, Li, Yang, Li, Hongchang, Li, Zhihuan, Lin, Lilong, Wan, Xiaochun, Yang, Xiaolu, Chen, Liang. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. NATURE COMMUNICATIONS[J]. 2020, 第 4 作者11(1): https://doaj.org/article/8a113faa8cad44bca1e2d4948f32e7c0.
[32] Zhang, Yuqian, Zhang, Guofang, Chen, Liang, Li, Yang. Modulation of the inflammatory tumor microenvironment: a new approach for photothermal-synergized cancer immunotherapy. NANOMEDICINE. 2019, 第 4 作者  通讯作者  14(16): 2101-2104, http://dx.doi.org/10.2217/nnm-2019-0156.
[33] Menon, Dinoop Ravindran, Luo, Yuchun, Arcaroli, John J, Liu, Sucai, KrishnanKutty, Lekha Nair, Osborne, Douglas G, Li, Yang, Samson, Jenny Mae, Bagby, Stacey, Tan, AikChoon, Robinson, William A, Messersmith, Wells A, Fujita, Mayumi. CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma. CANCER RESEARCH[J]. 2018, 第 7 作者78(23): 6561-6574, https://www.webofscience.com/wos/woscc/full-record/WOS:000452369300005.
[34] Li, Yang, Shi, Zhenzhen, RadauerPreiml, Isabella, Andosch, Ancuela, Casals, Eudald, LuetzMeindl, Ursula, Cobaleda, Macarena, Lin, Zhoumeng, JaberiDouraki, Majid, Italiani, Paola, HorejsHoeck, Jutta, Himly, Martin, MonteiroRiviere, Nancy A, Duschl, Albert, Puntes, Victor F, Boraschi, Diana. Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation. NANOTOXICOLOGY[J]. 2017, 第 1 作者  通讯作者  11(9-10): 1157-1175, https://www.webofscience.com/wos/woscc/full-record/WOS:000417956500006.
[35] Li, Yang, Fujita, Mayumi, Boraschi, Diana. Endotoxin Contamination in Nanomaterials Leads to the Misinterpretation of immunosafety Results. FRONTIERS IN IMMUNOLOGY[J]. 2017, 第 1 作者  通讯作者  8: https://doaj.org/article/156ac0927e9048439ae400d58f14d1a4.
[36] Li, Yang, Italiani, Paola, Casals, Eudald, Valkenborg, Dirk, Mertens, Inge, Baggerman, Geert, Nelissen, Inge, Puntes, Victor F, Boraschi, Diana. Assessing the Immunosafety of Engineered Nanoparticles with a Novel in Vitro Model Based on Human Primary Monocytes. ACSAPPLIEDMATERIALSINTERFACES[J]. 2016, 第 1 作者  通讯作者  8(42): 28437-28447, https://www.webofscience.com/wos/woscc/full-record/WOS:000386540300023.
[37] Li, Yang, Boraschi, Diana. Endotoxin contamination: a key element in the interpretation of nanosafety studies. NANOMEDICINE[J]. 2016, 第 1 作者  通讯作者  11(3): 269-287, https://www.webofscience.com/wos/woscc/full-record/WOS:000369078000007.
[38] Li, Yang, MonteiroRiviere, Nancy A. Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles. NANOMEDICINE[J]. 2016, 第 1 作者11(24): 3185-3203, https://www.webofscience.com/wos/woscc/full-record/WOS:000389453100002.
[39] Murali, Kumarasamy, Kenesei, Kata, Li, Yang, Demeter, Kornel, Koernyei, Zsuzsanna, Madarasz, Emilia. Uptake and bio-reactivity of polystyrene nanoparticles is affected by surface modifications, ageing and LPS adsorption: in vitro studies on neural tissue cells. NANOSCALE[J]. 2015, 第 3 作者7(9): 4199-4210, https://www.webofscience.com/wos/woscc/full-record/WOS:000350143700046.
[40] Li, Yang, Italiani, Paola, Casals, Eudald, Ngoc Tran, Puntes, Victor F, Boraschi, Diana. Optimising the use of commercial LAL assays for the analysis of endotoxin contamination in metal colloids and metal oxide nanoparticles. NANOTOXICOLOGY[J]. 2014, 第 1 作者  通讯作者  9(4): 462-473, https://www.webofscience.com/wos/woscc/full-record/WOS:000361329100007.
[41] Peng Wang, Xin Nie, Yue Wang, Yang Li, Cuicui Ge, Lili Zhang, Liming Wang, Ru Bai, Zhiyun Chen, Yuliang Zhao, Chunying Chen. Multiwall Carbon Nanotubes Mediate Macrophage Activation and Promote Pulmonary Fibrosis Through TGF‐β/Smad Signaling Pathway. SMALL[J]. 2013, 第 4 作者9(22): 3799-3811, 
[42] Cuicui Ge, Yang Li, Jun-Jie Yin, Ying Liu, Liming Wang, Yuliang Zhao, Chunying Chen. The contributions of metal impurities and tube structure to the toxicity of carbon nanotube materials. NPG ASIA MATERIALS[J]. 2012, 第 2 作者4(12): e32, https://www.webofscience.com/wos/woscc/full-record/WOS:000312963200001.
[43] Li, Yang, Liu, Ying, Fu, Yujian, Wei, Taotao, Le Guyader, Laurent, Gao, Ge, Liu, RuShi, Chang, YanZhong, Chen, Chunying. The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. BIOMATERIALS[J]. 2012, 第 1 作者33(2): 402-411, http://dx.doi.org/10.1016/j.biomaterials.2011.09.091.
[44] Cuicui Ge, Li Meng, Ligeng Xu, Ru Bai, Jiangfeng Du, Lili Zhang, Yang Li, Yanzhong Chang, Yuliang Zhao, Chunying Chen. Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes. NANOTOXICOLOGY[J]. 2012, 第 7 作者6(5): 526-542, http://dx.doi.org/10.3109/17435390.2011.587905.

（1） Immunological Effects of Nano-Imaging Materials, Frontiers Media SA, 2022-04, 第 1 作者

   

（ 1 ） 纳米颗粒蛋白质晕(biocorona)对炎症小体激活和白介素1分泌的调控, 负责人, 国家任务, 2018-01--2020-12
（ 2 ） EGCG及其纳米制剂抑制PD-L1表达的抗肿瘤免疫治疗研究, 负责人, 地方任务, 2020-06--2022-06
（ 3 ） Folate-functionalized PUVA-SPIO NPs mediated targeting of CD24 signaling pathway in ovarian cancer, 负责人, 中国科学院计划, 2021-03--2023-02
（ 4 ） Probing the medical use of oxide nanoparticles: a New therapeutic concept to treat liver cancer, 负责人, 中国科学院计划, 2020-08--2021-07
（ 5 ） Advanced strategies for precision immunotherapy of tumors by nanoparticle-based reprogramming of macrophage memory, 负责人, 中国科学院计划, 2020-08--2021-07
（ 6 ） 微塑料颗粒胃肠道暴露后的长短期毒性及免疫安全性分析, 负责人, 国家任务, 2022-01--2025-12
（ 7 ） 人体抗新冠病毒免疫水平评估及宿主易感性诊断工具研发, 负责人, 国家任务, 2023-01--2025-12
（ 8 ） 纳米铈抗炎抑癌的分子免疫学机制解析及肿瘤免疫治疗应用, 负责人, 地方任务, 2023-01--2026-12
（ 9 ） 基于新型纳米材料的抗微生物及检测技术研发, 负责人, 中国科学院计划, 2021-11--2024-10

（1）Autoinflammation from the imbalance of IL-1 over IL-1Ra contributes to tumor progression in metastatic melanoma   Yang Li   2017-08-26
（2）An imbalance between IL-1 and IL-1Ra in human melanoma cells accounts for autoinflammation and contributes to tumor progression in metastatic melanoma   Yang Li   2017-04-26
（3）Protein coronas affect the mechanisms of cell uptake and inflammatory effects of gold nanoparticles   2016-10-26
（4）Cellular uptake mechanism of gold nanoparticles with three different surface coatings and protein corona effects on cell uptake in human epidermal keratinocytes   2016-06-01
（5）Evaluating engineered nanoparticle immunosafety: effects on the course of the innate immune reaction of human primary monocytes in vitro   2014-06-18
（6）Bacterial endotoxin binds to the surface of gold nanoparticles and triggers inflammation   2014-04-23
（7）An in vitro model based on human primary monocytes for evaluating the effects of engineered nanoparticles on the course of an inflammatory defence reaction   2014-04-23
（8）Assessing interference of nanoparticles with the inflammatory response by a novel in vitro model based on human primary monocytes   2013-09-05
（9）Assessing immune toxicity of engineered nanoparticles: modulation of inflammation in a novel in vitro model based on human primary monocytes   Yang LI   2013-08-22
（10）Human primary monocytes as reference cells for assessing interference of nanoparticles with the inflammatory defence reaction   Yang Li   2013-02-27
（11）The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways   2012-09-04

Martin Himly, PLUS, Austria

Albert Duschl, PLUS, Austria

Victor F. Puntes, ICN2, Spain

Diana Boraschi, CNR, Italy

Paola Italiani, CNR, Italy