基本信息

李洋  男  博导  中国科学院深圳先进技术研究院
电子邮件: yang.li@siat.ac.cn
通信地址: 中科院深圳医药所炎症与疫苗研究室
课题组主页:https://www.lilaboratory.org/ (最新课题组内容请查看课题组主页)

研究领域

  1. 纳米生物学

  2. 纳米免疫毒理学

  3. 纳米医学

  4. 免疫学

  5. 肿瘤免疫治疗

招生信息

  1.  免疫学, 生物学
  2.  纳米医学,纳米生物学
  3.  化学生物学

招生专业
071010-生物化学与分子生物学
0703Z1-化学生物学
071009-细胞生物学
招生方向
纳米医学,纳米免疫安全性
肿瘤免疫学,免疫检查点肿瘤治疗
免疫学,天然免疫记忆

教育背景

2011-11--2014-10   萨尔斯堡大学   博士

工作经历

   
工作简历
2022-12~现在, 中国科学院深圳先进技术研究院, 研究员
2017-12~2022-12,中国科学院深圳先进技术研究院, 副研究员
2016-09~2018-06,科罗拉多大学, 博士后
2015-07~2016-08,堪萨斯纳米技术研发中心, 博士后
2014-10~2014-12,意大利国家研究院, 博士后
2011-10~2014-10,意大利国家研究院, 玛丽居里研究员/博士

教授课程

化学生物学进展

专利与奖励

   
奖励信息
(1) 河北省自然科学奖, 一等奖, 省级, 2019
(2) 国际纳米毒理学大会旅行奖, 一等奖, 专项, 2016
(3) 国家优秀自费留学生奖学金, 一等奖, 国家级, 2013
(4) 玛丽居里基金, 一等奖, 其他, 2011
专利成果
( 1 ) 茶多酚在作为免疫检查点抑制剂及制备用于抗肿瘤的药物中的应用, 发明专利, 2018, 第 1 作者, 专利号: 201811478060.9

出版信息

   
发表论文
[1] Guofang Zhang, Xiaofeng Wang, Guocheng Wang, Xiaoman Suo, Yu Qiu, RongHua Luo, Yingnan Liu, Qi Li, Wenhe Luo, Zhenzhen Shi, Fangfang Liu, Zhongda Li, Jing Qu, Liang Li, Neus G Basts, Martin Himly, Liming Wang, FengLiang Liu, YongTang Zheng, Victor Puntes, Yang Li. Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2. NANO TODAY. 2024, 55: http://dx.doi.org/10.1016/j.nantod.2024.102183.
[2] Nahar Jannatun, Yuqian Zhang, Ben Wu, Qingle Song, Guoli Cao, Wenhe Luo, Feng Yuan, Qi Li, Yanqiao Zeng, Guofang Zhang, Guocheng Wang, Yang Li. Tea Polyphenol Coordinated with Nanoparticles of ZIF-8 and Coated with Polydopamine and PEG for Immuno-Oncotherapy. ACS Applied Nano Materials[J]. 2023, [3] Yang, Wenjie, Yang Li, Boraschi, Diana. Association between Microorganisms and Microplastics: How Does It Change the Host-Pathogen Interaction and Subsequent Immune Response?. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, [4] Zhengjiang Xu, Yuan Zhang, Danping Lu, Guofang Zhang, Yang Li, Zufu Lu, Fei Wang, Guocheng Wang. Antisenescence ZIF-8/Resveratrol Nanoformulation with Potential for Enhancement of Bone Fracture Healing in the Elderly. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2023, [5] Yichuan Zhang, Quan Gao, Weishuo Li, Rongkun He, Liwei Zhu, Qianjin Lian, Liang Wang, Yang Li, Mark Bradley, Jin Geng. Controlled Intracellular Polymerization for CancerTreatment. JACS AU[J]. 2022, 2(3): 579-589, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970002/.
[6] Zhang, Guofang, Cao, Guoli, Luo, RongHua, Song, Qingle, Zeng, Yanqiao, Liu, Ke, Qu, Jing, Lin, Xian, Liu, FengLiang, Wang, Guocheng, Li, Hongchang, Li, Liang, Zheng, YongTang, Boraschi, Diana, Wu, Lidong, Chang, YanZhong, Li, Yang. Microplastics interact with SARS-CoV-2 and facilitate host cell infection. ENVIRONMENTAL SCIENCE-NANO[J]. 2022, 9(8): 2653-2664, http://dx.doi.org/10.1039/d2en00019a.
[7] Wenjie Yang, Nahar Jannatun, Yanqiao Zeng, Tinghao Liu, Guofang Zhang, Chunying Chen, Yang Li. Impacts of microplastics on immunity. FRONTIERS IN TOXICOLOGY[J]. 2022, 4: https://doaj.org/article/f8964d5ff6d0491b8254acf2b6e0dd3a.
[8] Wenjie Yang, Nahar Jannatun, Yanqiao Zeng, Tinghao Liu, Guofang Zhang, Chunying Chen, Yang Li. Impacts of microplastics on immunity. FRONTIERS IN TOXICOLOGY[J]. 2022, 4: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552327/.
[9] Della Camera, Giacomo, Liu, Tinghao, Yang, Wenjie, Li, Yang, Puntes, Victor F, Gioria, Sabrina, Italiani, Paola, Boraschi, Diana. Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, [10] Xuejin Li, Dongjie Li, Guofang Zhang, Yanqiao Zeng, Nancy A MonteiroRiviere, YanZhong Chang, Yang Li. Biocorona modulates the inflammatory response induced by gold nanoparticles in human epidermal keratinocytes. TOXICOLOGY LETTERS. 2022, 369: 34-42, http://dx.doi.org/10.1016/j.toxlet.2022.08.009.
[11] Chen, Yuange, Ouyang, Longling, Liu, Na, Li, Fang, Li, Peiyi, Sun, Mengmeng, Qin, Haiyang, Li, Yang, Xiang, Xueping, Wu, Lidong. pH-responsive magnetic artificial melanin with tunable aggregation-induced stronger magnetism for rapid remediation of plastic fragments. JOURNAL OF HAZARDOUS MATERIALS[J]. 2022, 435: http://dx.doi.org/10.1016/j.jhazmat.2022.128962.
[12] Shi Qiu, Jiawen Ji, Wei Sun, Jia Pei, Jian He, Yang Li, Jiao Jiao Li, Guocheng Wang. Recent advances in surface manipulation using micro-contact printing for biomedical applications. SMART MATERIALS IN MEDICINE[J]. 2021, 2: 65-73, http://dx.doi.org/10.1016/j.smaim.2020.12.002.
[13] Guofang Zhang, Yalin Cong, Guoli Cao, Liang Li, Peng Yu, Qingle Song, Ke Liu, Jing Qu, Jing Wang, Wei Xu, Shumin Liao, Yunping Fan, Yufeng Li, Guocheng Wang, Lijing Fang, Yanzhong Chang, Yuliang Zhao, Diana Boraschi, Hongchang Li, Chunying Chen, Liming Wang, Yang Li. Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination. bioRxiv[J]. 2021, [14] Boraschi, Diana, Li, Dongjie, Li, Yang, Italiani, Paola. In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH[J]. 2021, 18(22): http://dx.doi.org/10.3390/ijerph182211769.
[15] Ravindran Menon, Dinoop, Li, Yang, Yamauchi, Takeshi, Osborne, Douglas Grant, Vaddi, Prasanna Kumar, Wempe, Michael F, Zhai, Zili, Fujita, Mayumi. EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses. PHARMACEUTICALS[J]. 2021, 14(11): http://dx.doi.org/10.3390/ph14111081.
[16] Shao, Ximing, Ding, Zhihao, Zhou, Wenhua, Li, Yanyan, Li, Zhibin, Cui, Haodong, Lin, Xian, Cao, Guoli, Cheng, Binghua, Sun, Haiyan, Li, Meiqing, Liu, Ke, Lu, Danyi, Geng, Shengyong, Shi, Wenli, Zhang, Guofang, Song, Qingle, Chen, Liang, Wang, Guocheng, Su, Wu, Cai, Lintao, Fang, Lijing, Leong, David Tai, Li, Yang, Yu, XueFeng, Li, Hongchang. Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase. NATURE NANOTECHNOLOGY[J]. 2021, 16(10): 1150-+, http://dx.doi.org/10.1038/s41565-021-00952-x.
[17] Qingle Song, Guofang Zhang, Bo Wang, Guoli Cao, Dongjie Li, Yu Wang, Yuqian Zhang, Jin Geng, Hongchang Li, Yang Li. Reinforce the Combinational Immuno-Oncotherapy of Switching "Cold" Tumor to "Hot" by Responsive Penetrating Nanogels. ACS Applied Materials and Interfaces[J]. 2021, [18] Qingle Song, Amaneh Javid, Guofang Zhang, Yang Li. Applications of Magnetite Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future Perspectives. FRONTIERS IN IMMUNOLOGY,12,(2021-10-04)[J]. 2021, [19] Cao, Qiang, Liu, Na, Xiao, Yushi, Huang, Rong, Li, Yang, Wu, Lidong. Hybrid Magnetic Hydrogels Used as Artificial Marine Animals for Noncontact Cleaning. ACS APPLIED POLYMER MATERIALS[J]. 2021, 3(2): 1182-1189, http://dx.doi.org/10.1021/acsapm.1c00019.
[20] Della Camera, Giacomo, Madej, Mariusz, Ferretti, Anna Maria, La Spina, Rita, Li, Yang, Corteggio, Annunziata, Heinzl, Tommaso, Swartzwelter, Benjamin J, Sipos, Gergo, Gioria, Sabrina, Ponti, Alessandro, Boraschi, Diana, Italiani, Paola. Personalised Profiling of Innate Immune Memory Induced by Nano-Imaging Particles in Human Monocytes. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fimmu.2021.692165.
[21] Zhang, Yuqian, Zhang, Guofang, Wang, Guocheng, Wu, Lidong, MonteiroRiviere, Nancy A, Li, Yang. The synergistic strategies for the immuno-oncotherapy with photothermal nanoagents. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGYnull. 2021, 13(5): http://dx.doi.org/10.1002/wnan.1717.
[22] Song, Qingle, Javid, Amaneh, Zhang, Guofang, Li, Yang. Applications of Magnetite Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future Perspectives. FRONTIERS IN IMMUNOLOGYnull. 2021, 12: http://dx.doi.org/10.3389/fimmu.2021.701485.
[23] Ferretti, Anna M, Usseglio, Sandro, Mondini, Sara, Drago, Carmelo, La Mattina, Rosa, Chini, Bice, Verderio, Claudia, Leonzino, Marianna, Cagnoli, Cinzia, Joshi, Pooja, Boraschi, Diana, Italiani, Paola, Li, Yang, Swartzwelter, Benjamin J, Sironi, Luigi, Gelosa, Paolo, Castiglioni, Laura, Guerrini, Uliano, Ponti, Alessandro. Towards bio-compatible magnetic nanoparticles: Immune-related effects, in-vitro internalization, and in-vivo bio-distribution of zwitterionic ferrite nanoparticles with unexpected renal clearance. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2021, 582: 678-700, http://dx.doi.org/10.1016/j.jcis.2020.08.026.
[24] Zhang, Shu, Xiao, Ming, Zhang, Yuqian, Li, Yang, Liu, Huan, Han, Gang, Rathi, Brijesh, Lyu, Kaiyu, Wu, Lidong. Mimicking neuromelanin nanoparticles as a selective Pb2+ probe. ANALYTICA CHIMICA ACTA[J]. 2020, 1105: 208-213, http://dx.doi.org/10.1016/j.aca.2020.01.051.
[25] Zhang, Litian, Afolabi, Lukman O, Wan, Xiaochun, Li, Yang, Chen, Liang. Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2020, 8: https://doaj.org/article/9b7e1e698d4148fabfa6aac24b0f1b03.
[26] Zhao, Jing, Lu, Danping, Moya, Sergio, Yan, Haoying, Qiu, Miaojuan, Chen, JunZong, Wang, Xincheng, Li, Yang, Pan, Haobo, Chen, Guochuang, Wang, Guocheng. Bispecific T-cell engager (BiTE) immunotherapy of ovarian cancer based on MIL-88A MOF/MC gene delivery system. APPLIED MATERIALS TODAY[J]. 2020, 20: http://dx.doi.org/10.1016/j.apmt.2020.100701.
[27] Liu, Yanfeng, Tao, Shishi, Liao, Lijuan, Li, Yang, Li, Hongchang, Li, Zhihuan, Lin, Lilong, Wan, Xiaochun, Yang, Xiaolu, Chen, Liang. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. NATURE COMMUNICATIONS[J]. 2020, 11(1): https://doaj.org/article/8a113faa8cad44bca1e2d4948f32e7c0.
[28] Zhang, Yuqian, Zhang, Guofang, Chen, Liang, Li, Yang. Modulation of the inflammatory tumor microenvironment: a new approach for photothermal-synergized cancer immunotherapy. NANOMEDICINEnull. 2019, 14(16): 2101-2104, http://dx.doi.org/10.2217/nnm-2019-0156.
[29] Menon, Dinoop Ravindran, Luo, Yuchun, Arcaroli, John J, Liu, Sucai, KrishnanKutty, Lekha Nair, Osborne, Douglas G, Li, Yang, Samson, Jenny Mae, Bagby, Stacey, Tan, AikChoon, Robinson, William A, Messersmith, Wells A, Fujita, Mayumi. CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma. CANCER RESEARCH[J]. 2018, 78(23): 6561-6574, https://www.webofscience.com/wos/woscc/full-record/WOS:000452369300005.
[30] Li, Yang, Shi, Zhenzhen, RadauerPreiml, Isabella, Andosch, Ancuela, Casals, Eudald, LuetzMeindl, Ursula, Cobaleda, Macarena, Lin, Zhoumeng, JaberiDouraki, Majid, Italiani, Paola, HorejsHoeck, Jutta, Himly, Martin, MonteiroRiviere, Nancy A, Duschl, Albert, Puntes, Victor F, Boraschi, Diana. Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation. NANOTOXICOLOGY[J]. 2017, 11(9-10): 1157-1175, https://www.webofscience.com/wos/woscc/full-record/WOS:000417956500006.
[31] Li, Yang, Fujita, Mayumi, Boraschi, Diana. Endotoxin Contamination in Nanomaterials Leads to the Misinterpretation of immunosafety Results. FRONTIERS IN IMMUNOLOGY[J]. 2017, 8: https://doaj.org/article/156ac0927e9048439ae400d58f14d1a4.
[32] Li, Yang, Italiani, Paola, Casals, Eudald, Valkenborg, Dirk, Mertens, Inge, Baggerman, Geert, Nelissen, Inge, Puntes, Victor F, Boraschi, Diana. Assessing the Immunosafety of Engineered Nanoparticles with a Novel in Vitro Model Based on Human Primary Monocytes. ACSAPPLIEDMATERIALSINTERFACES[J]. 2016, 8(42): 28437-28447, https://www.webofscience.com/wos/woscc/full-record/WOS:000386540300023.
[33] Li, Yang, Boraschi, Diana. Endotoxin contamination: a key element in the interpretation of nanosafety studies. NANOMEDICINE[J]. 2016, 11(3): 269-287, https://www.webofscience.com/wos/woscc/full-record/WOS:000369078000007.
[34] Li, Yang, MonteiroRiviere, Nancy A. Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles. NANOMEDICINE[J]. 2016, 11(24): 3185-3203, https://www.webofscience.com/wos/woscc/full-record/WOS:000389453100002.
[35] Murali, Kumarasamy, Kenesei, Kata, Li, Yang, Demeter, Kornel, Koernyei, Zsuzsanna, Madarasz, Emilia. Uptake and bio-reactivity of polystyrene nanoparticles is affected by surface modifications, ageing and LPS adsorption: in vitro studies on neural tissue cells. NANOSCALE[J]. 2015, 7(9): 4199-4210, https://www.webofscience.com/wos/woscc/full-record/WOS:000350143700046.
[36] Li, Yang, Italiani, Paola, Casals, Eudald, Ngoc Tran, Puntes, Victor F, Boraschi, Diana. Optimising the use of commercial LAL assays for the analysis of endotoxin contamination in metal colloids and metal oxide nanoparticles. NANOTOXICOLOGY[J]. 2014, 9(4): 462-473, https://www.webofscience.com/wos/woscc/full-record/WOS:000361329100007.
[37] Peng Wang, Xin Nie, Yue Wang, Yang Li, Cuicui Ge, Lili Zhang, Liming Wang, Ru Bai, Zhiyun Chen, Yuliang Zhao, Chunying Chen. Multiwall Carbon Nanotubes Mediate Macrophage Activation and Promote Pulmonary Fibrosis Through TGF‐β/Smad Signaling Pathway. SMALL[J]. 2013, 9(22): 3799-3811, [38] Cuicui Ge, Yang Li, Jun-Jie Yin, Ying Liu, Liming Wang, Yuliang Zhao, Chunying Chen. The contributions of metal impurities and tube structure to the toxicity of carbon nanotube materials. NPG ASIA MATERIALS[J]. 2012, 4(12): e32-, https://www.webofscience.com/wos/woscc/full-record/WOS:000312963200001.
[39] Li, Yang, Liu, Ying, Fu, Yujian, Wei, Taotao, Le Guyader, Laurent, Gao, Ge, Liu, RuShi, Chang, YanZhong, Chen, Chunying. The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. BIOMATERIALS[J]. 2012, 33(2): 402-411, http://dx.doi.org/10.1016/j.biomaterials.2011.09.091.
[40] Cuicui Ge, Li Meng, Ligeng Xu, Ru Bai, Jiangfeng Du, Lili Zhang, Yang Li, Yanzhong Chang, Yuliang Zhao, Chunying Chen. Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes. NANOTOXICOLOGY[J]. 2012, 6(5): 526-542, http://dx.doi.org/10.3109/17435390.2011.587905.
发表著作
(1) Immunological Effects of Nano-Imaging Materials, Frontiers Media SA, 2022-04, 第 1 作者

科研活动

   
科研项目
( 1 ) 纳米颗粒蛋白质晕(biocorona)对炎症小体激活和白介素1分泌的调控, 负责人, 国家任务, 2018-01--2020-12
( 2 ) EGCG及其纳米制剂抑制PD-L1表达的抗肿瘤免疫治疗研究, 负责人, 地方任务, 2020-06--2022-06
( 3 ) Folate-functionalized PUVA-SPIO NPs mediated targeting of CD24 signaling pathway in ovarian cancer, 负责人, 中国科学院计划, 2021-03--2023-02
( 4 ) Probing the medical use of oxide nanoparticles: a New therapeutic concept to treat liver cancer, 负责人, 中国科学院计划, 2020-08--2021-07
( 5 ) Advanced strategies for precision immunotherapy of tumors by nanoparticle-based reprogramming of macrophage memory, 负责人, 中国科学院计划, 2020-08--2021-07
( 6 ) 微塑料颗粒胃肠道暴露后的长短期毒性及免疫安全性分析, 负责人, 国家任务, 2022-01--2025-12
( 7 ) 人体抗新冠病毒免疫水平评估及宿主易感性诊断工具研发, 负责人, 国家任务, 2023-01--2025-12
( 8 ) 纳米铈抗炎抑癌的分子免疫学机制解析及肿瘤免疫治疗应用, 负责人, 地方任务, 2023-01--2026-12
( 9 ) 基于新型纳米材料的抗微生物及检测技术研发, 负责人, 中国科学院计划, 2021-11--2024-10
参与会议
(1)Autoinflammation from the imbalance of IL-1 over IL-1Ra contributes to tumor progression in metastatic melanoma   Yang Li   2017-08-26
(2)An imbalance between IL-1 and IL-1Ra in human melanoma cells accounts for autoinflammation and contributes to tumor progression in metastatic melanoma   Yang Li   2017-04-26
(3)Protein coronas affect the mechanisms of cell uptake and inflammatory effects of gold nanoparticles   2016-10-26
(4)Cellular uptake mechanism of gold nanoparticles with three different surface coatings and protein corona effects on cell uptake in human epidermal keratinocytes   2016-06-01
(5)Evaluating engineered nanoparticle immunosafety: effects on the course of the innate immune reaction of human primary monocytes in vitro   2014-06-18
(6)Bacterial endotoxin binds to the surface of gold nanoparticles and triggers inflammation   2014-04-23
(7)An in vitro model based on human primary monocytes for evaluating the effects of engineered nanoparticles on the course of an inflammatory defence reaction   2014-04-23
(8)Assessing interference of nanoparticles with the inflammatory response by a novel in vitro model based on human primary monocytes   2013-09-05
(9)Assessing immune toxicity of engineered nanoparticles: modulation of inflammation in a novel in vitro model based on human primary monocytes   Yang LI   2013-08-22
(10)Human primary monocytes as reference cells for assessing interference of nanoparticles with the inflammatory defence reaction   Yang Li   2013-02-27
(11)The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways   2012-09-04

合作情况

Martin Himly, PLUS, Austria

Albert Duschl, PLUS, Austria

Victor F. Puntes, ICN2, Spain

Diana Boraschi, CNR, Italy

Paola Italiani, CNR, Italy