基本信息
杨静华  女  硕导  中国科学院微生物研究所
电子邮件: yangjh@im.ac.cn
通信地址: 朝阳区北辰西路1号院3号微生物研究所
邮政编码: 100101

研究领域

主要从事病原细菌的感染和致病机制的基础研究,从事糖蛋白疫苗的研发用于致病细菌的防治




教育背景

2001-09--2004-07   南开大学生命科学学院   理学博士
1993-09--1996-07   内蒙古大学生命科学学院   理学硕士
1989-09--1993-07   内蒙古大学生命科学学院   本科

工作经历

2013-12~现在, 中国科学院微生物研究所真菌学国家重点实验室, 副研究员
2010-01~2013-12, 美国国立卫生研究院(NIH), Research Fellow
2005-01~2009-12,美国国立卫生研究院(NIH), 博士后
1996-08~2001-08, 内蒙古大学生命科学院, 讲师


社会兼职
2020-08-19-2025-08-20,中国生物工程学会糖生物工程专业委员会, 委员
2010-12-29-2013-06-29,美国“Microbiology”杂志的评审人,

教授课程

糖生物学和糖组学

专利与奖励

授权专利23项,在审专利2项,部分授权专利已经转化给企业。


奖励信息
(1) 优秀教师, 研究所(学校), 2020
(2) 优秀教师, , 研究所(学校), 2019
专利成果
[1] 杨静华, 刘翔远. 一种氧化三甲胺生物传感器及其应用. 2023103586220, 2023-04-06.

[2] 杨静华, 刘翔远. 一种用于多种代谢性疾病诊断的生物传感器及其应用. 2023103586841, 2023-04-06.

[3] 杨静华, 周慧, 金城. 一株荚膜多聚唾液酸高度O-乙酰化修饰的大肠杆菌及其应用. CN: CN112375707A, 2021-02-19.

[4] 杨静华. 对大肠杆菌O86的O抗原特异的核苷酸. 200410019034.1, 2004-04-19.

[5] 王磊, 杨静华. 对鲍氏志贺氏菌17型的O抗原特异的核苷酸. 200410019050.0, 2004-04-19.

[6] 王磊, 杨静华. 对大肠杆菌O163的O抗原特异的核苷. 200410019044.5, 2004-04-19.

[7] 王磊, 杨静华. 对大肠杆菌O49的O抗原特异的核苷酸. 200410019029, 2004-04-19.

[8] 王磊, 杨静华. 对大肠杆菌O164的O抗原特异的核苷酸. ZL200410019045x, 2004-04-19.

[9] 王磊, 杨静华. 对鲍氏志贺氏菌17型的O抗原特异的核苷酸. 200410019049.8, 2004-04-19.

[10] 王磊, 杨静华. 对大肠杆菌O136的O抗原特异的核苷酸. 200410019041.1, 2004-04-19.

[11] 王磊, 杨静华. 对大肠杆菌O161的O抗原特异的核苷酸. 200410019043.0, 2004-04-19.

[12] 王磊, 杨静华. 对大肠杆菌O41的O抗原特异的核苷酸. 200410019028.6, 2004-04-19.

[13] 王磊, 杨静华. 对大肠杆菌O61的O抗原特异的核苷酸. 200410019032.2, 2004-04-19.

[14] 杨静华. 对大肠杆菌O43的O抗原特异的核苷酸. 200410019047.9, 2004-04-19.

[15] 王磊, 杨静华. 对大肠杆菌O39的O抗原特异的核苷酸. 200410019026.7, 2004-04-19.

[16] 王磊, 杨静华. 对鲍氏志贺氏菌16型的O抗原特异的核苷酸. 200410019048.3, 2004-04-19.

[17] 王磊, 杨静华. 对鲍氏志贺氏菌12型的O抗原特异的核苷酸. 200410019049.8, 2004-04-19.

[18] 王磊, 杨静华. 对鲍氏志贺氏菌2型的O抗原特异的核苷酸. 200310107158.0, 2003-12-03.

[19] 王磊, 杨静华. 对鲍氏志贺氏菌10型的O抗原特异的核苷酸. 200310107160.8, 2003-12-03.

[20] 王磊, 杨静华. 对大肠杆菌O54的O抗原特异的核苷酸. 200310107159.5, 2003-10-10.

[21] 王磊, 杨静华. 对大肠杆菌O59的O抗原特异的核苷酸. 03129935.0, 2003-05-27.

[22] 王磊, 杨静华. 对大肠杆菌O52的O抗原特异的核苷酸. 03129936.9, 2003-05-27.

[23] 王磊, 杨静华. 对痢疾志贺氏菌3型、大肠杆菌O124与O164的O抗原特异的核苷酸. 03109587.9, 2003-04-15.

[24] 王磊, 杨静华. 对鲍氏志贺氏菌13型的O抗原特异的核苷酸及其应用. 03100537.3, 2003-01-20.

[25] 王磊, 杨静华. 对痢疾志贺氏菌12型和大肠杆菌O152的O抗原特异的核苷酸及其应用. 02158726.4, 2002-12-26.

[26] 杨静华, 周慧, 金城. 一株荚膜多聚唾液酸高度O-乙酰化修饰的大肠杆菌及其应用. CN: CN112375707B, 2022-03-01.

出版信息


发表论文
[1] 赵文旭, 杨帆, 黄蕾, 董文博, 杨静华. 肺炎链球菌荚膜多糖结构与合成的研究进展. 微生物学报[J]. 2024, 
[2] Caixia Pei, Hua Lu, Jiayin Ma, Jerry Eichler, Ziqiang Guan, Linlu Gao, Li Liu, Hui Zhou, Jinghua Yang, Cheng Jin. AepG is a glucuronosyltransferase involved in acidic exopolysaccharide synthesis and contributes to environmental adaptation of Haloarcula hispanica. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2023, 299(2): http://dx.doi.org/10.1016/j.jbc.2023.102911.
[3] Gao, Linlu, Ouyang, Haomiao, Pei, Caixia, Zhou, Hui, Yang, Jinghua, Jin, Cheng. Emp47 and Vip36 are required for polarized growth and protein trafficking between ER and Golgi apparatus in opportunistic fungal pathogen Aspergillus fumigatus. FUNGAL GENETICS AND BIOLOGY[J]. 2022, 158: 
[4] Ouyang, Haomiao, Zhang, Yi, Zhou, Hui, Ma, Yubo, Li, Ruoyu, Yang, Jinghua, Wang, Xiaowen, Jin, Cheng. Deficiency of GPI Glycan Modification by Ethanolamine Phosphate Results in Increased Adhesion and Immune Resistance of Aspergillus fumigatus. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY[J]. 2021, 11: http://dx.doi.org/10.3389/fcimb.2021.780959.
[5] 王晟旭, 乔建军, 曹禹琪, 财音青格乐, 杨静华. 肺炎链球菌荚膜多糖O-乙酰化修饰的研究进展. 微生物学报[J]. 2021, 61(8): 2316-2337, 
[6] Jinghua Yang, Wei Ma, Yuanyuan Wu, Hui Zhou, Siyu Song, Yuqi Cao, Chengxu Wang, Xiangyuan Liu, Jinwei Ren, Jinyou Duan, Zhichao Pei, Cheng Jin. O -Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli -Containing Vacuoles in Macrophage-Like Cells. MICROBIOLOGY SPECTRUM[J]. 2021, 9(3): 
[7] 杨静华. 口腔细菌表面糖苷酶的生物学功能研究. 广西科学[J]. 2017, 24(1): 25-32, http://lib.cqvip.com/Qikan/Article/Detail?id=671521010.
[8] K. Aaron Geno, C. Allen Bush, Mengnan Wang, Moon H. Nahm, Jinghua Yang. WciG O-Acetyltransferase Functionality Differentiates Pneumococcal Serotypes 35C and 42. JOURNAL OF CLINICAL MICROBIOLOGY[J]. 2017, 55(9): 2775-2784, https://www.webofscience.com/wos/woscc/full-record/WOS:000408223700023.
[9] Zhou, Yuan, Yang, Jinghua, Zhang, Luxia, Zhou, Xuedong, Cisar, John O, Palmer, Robert J, Jr. Differential Utilization of Basic Proline-Rich Glycoproteins during Growth of Oral Bacteria in Saliva. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2016, 82(17): 5249-5258, https://www.webofscience.com/wos/woscc/full-record/WOS:000381500700019.
[10] Yang, Jinghua, Zhou, Yuan, Zhang, Luxia, Shah, Nehal, Jin, Cheng, Palmer, Robert J, Jr, Cisar, John O. Cell Surface Glycoside Hydrolases of Streptococcus gordonii Promote Growth in Saliva. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2016, 82(17): 5278-5286, http://dx.doi.org/10.1128/AEM.01291-16.
[11] Bush, C Allen, Cisar, John O, Yang, Jinghua. Structures of Capsular Polysaccharide Serotypes 35F and 35C of Streptococcus pneumoniae Determined by Nuclear Magnetic Resonance and Their Relation to Other Cross-Reactive Serotypes. JOURNAL OF BACTERIOLOGY[J]. 2015, 197(17): 2762-2769, https://www.webofscience.com/wos/woscc/full-record/WOS:000358786200004.
[12] C. Allen Bush, Jinghua Yang, Bingwu Yu, John O. Cisar. Chemical structure of the capsular polysaccharides (CPS) of Streptococcus pneumonia type 39, 47F and 34 by NMR spectroscopy and their relation to CPS10A.. J Bacteriol.[J]. 2014, 
[13] Jinghua Yang, C. Allen Bush, John O. Cisar. Genetic Basis of coaggeragation receptor polysaccharide biosynthesis in Streptococcus sanguinis and related species. Molecular Oral Microbiology[J]. 2014, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899595/pdf/nihms544698.pdf.
[14] Yasuo Yoshida, Jinghua Yang, Keiji Nagano, Fuminobu Yoshimura, John O. Cisar. Cell surface coaggregation receptor polysaccharide of oral streptococci. JOURNAL OF ORAL BIOSCIENCES. 2014, 56(4): 125-130, http://dx.doi.org/10.1016/j.job.2014.07.002.
[15] DeQi Xu, John O. Cisar, Frédéric Poly, Jinghua Yang, Jason Albanese, Tint Wai, Dennis J. Kopecko. The genomic sequence of Salmonella enterica serovar typhi oral vaccine strain Ty21a.. J Bacteriol.[J]. 2013, 
[16] Jinghua Yang, Moon H. Nahm, C. Allen Bush, John O. Cisar. Comparative Structural and Molecular Characterization of Streptococcus pneumoniae Capsular Polysaccharide Serogroup 10. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(41): 35813-35822, http://dx.doi.org/10.1074/jbc.M111.255422.
[17] Chenggang Wu, Arunima Mishra, Jinghua Yang, John O. Cisar, Huang Ton-That. Dual function of a tip fimbrilin of Actinomyces in fimbrial assembly and receptor binding. J Bacteriol.[J]. 2011, 
[18] Jinghua Yang, John O. Cisar, C. Allen Bush. tructure of type 3Gn coaggregation receptor polysaccharide for Streptococcus cristatus LS4. Carbohydrate Research.[J]. 2011, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534726/pdf/nihms427893.pdf.
[19] Arunima Mishra, Chenggang Wu, Jinghua Yang, John O. Cisar, Asis Das, Hung Ton-That. The Actinomyces oris type 2 fimbrial shaft FimA mediates coaggregation with oral streptococci, adherence to RBS and biofilm development.. Mol Microbiol.[J]. 2010, 
[20] Jinghua Yang, Nirav Y. Shelat, C. Allen Bush, John O. Cisar. Structure and molecular characterization of Streptococcus pneumoniae capsular polysaccharide 10F by carbohydrate engineering in Streptococcus oralis.. THE JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2010, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD12102101145893&DbName=SJPD_01&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[21] Jinghua Yang, Yoshida Yasuo, C. Allen Bush, John O. Cisar. Comparative Structural and Molecular characterization of Ribitol-5-phosphate-Containing Streptococcus oralis Caggregation Receptor Polysaccharides.. J Bacteriol.[J]. 2009, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648373/.
[22] Yoshida, Yasuo, Yang, Jinghua, Peaker, PauleEsther, Kato, Hirohisa, Bush, C Allen, Cisar, John O. Molecular and antigenic characterization of a Streptococcus oralis coaggregation receptor polysaccharide by carbohydrate engineering in Streptococcus gordonii. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2008, 283(18): 12654-12664, http://dx.doi.org/10.1074/jbc.M801412200.
[23] Yoshida Yasuo, Robert J. Palmer, Jinghua Yang, KOLENBRANDER, PAUL E, John O. Cisar. Streptococcal Receptor Polysaccharides: Recognition Molecules for Oral Biofilm Formation. BMC ORAL HEALTH[J]. 2006, 6: https://doaj.org/article/9c282e29f9ba44268cce75ea45d18562.
[24] Sof’ya N. Senchenkova, Lu Feng, Jinghua Yang, Cheng, JS, Liu, D, Knirel, YA, Reeves, PR, Jin, Q, Ye, Q, Lei WANG. Structural and genetic characterization of the Shigella boydii type 10 and type 6 O antigens. JOURNAL OF BACTERIOLOGY[J]. 2005, 187(7): 2551-2554, 
[25] Jinghua Yang, Feng, L, Senchenkova, SN, Shashkov, AS, Tao, J, Guo, HJ, Zhao, G, Knirel, YA, Reeves, P, Wang, L. Structural and genetic characterization of the Shigella boydii type 13 O antigen. JOURNAL OF BACTERIOLOGY[J]. 2004, 186(2): 383-392, https://www.webofscience.com/wos/woscc/full-record/WOS:000188066800015.
[26] Jinghua Yang, Lu Feng, Sof’ya N. Senchenkova, Peter Reeves, Lei Wang. Synthesis of the O-Antigen heteropolysaccharide of Escherichia coli O52 requires an ABC2 transporter: structural and genetic evidence.. J Bacteriol.[J]. 2004, 

合作情况

合成生物学肠道菌群研究

皮肤真菌病治疗新策略和新药物研究

牛主要传染病防治技术研究


项目协作单位

天津大学

广西医科大学

西藏自治区农牧科学院畜牧兽医研究所

指导学生

现指导学生

赵文旭  硕士研究生  071005-微生物学  

杨帆  硕士研究生  086000-生物与医药  

学历

南开大学博士