新策略新方法导向的活性萜类天然产物的高效合成，基于化学生物学与人工智能等多学科交叉开展天然药物先导化合物发掘，推动天然药物创新。

已协助指导博、硕士研究生近十人次，先后获得院长奖1人次，国家和院级奖学金等4人次。欢迎药学、有机化学相关专业背景同学报考。

拟招收硕士1-2名。

100701-药物化学

天然药物化学
天然产物有机合成与结构修饰

2015-09--2018-06   中国科学院大学（昆明植物所与上海有机所联合培养）   博士（导师：孙汉董院士、普诺•白玛丹增、李昂）
2012-09--2015-06   中国科学院大学，昆明植物研究所   硕士 （导师：普诺•白玛丹增）
2008-09--2012-07   沈阳药科大学   理学学士

   

2022-03~现在, 中国科学院昆明植物研究所, 副研究员，引进优秀人才
2020-02~2022-02,中国科学院昆明植物研究所, 博士后
2018-07~2020-01,中国科学院昆明植物研究所, 助理研究员

2023-12-01-2028-12-31,沈阳药科大学硕士生导师,
2023-06-30-今,大理大学硕士生导师,

云南省优秀青年基金（2024年）

中国科学院青年创新促进会会员（2023年）

云南省"兴滇英才支持计划”青年人才（2023年）

云南省省直机关青年学习标兵（2023年）

（1） 云南省博士后科研基金优秀成果一等奖, 一等奖, 省级, 2021

（ 1 ） 毛萼内酯素B衍生物及其药物组合物与抗新冠肺炎的应用, 发明专利, 2022, 第 5 作者, 专利号: CN114890971A

（ 2 ） 毛萼内酯素B衍生物与其在制备抗肿瘤药物中的应用, 发明专利, 2022, 第 4 作者, 专利号: CN114805269A

（ 3 ） 毛萼内酯素A和毛萼内酯素B及其制备方法, 发明专利, 2022, 第 4 作者, 专利号: CN114805270A

（ 4 ） 一种帚状异酯素、其制备方法和应用，以及药物组合物, 发明专利, 2021, 第 2 作者, 专利号: CN112876366A

（ 5 ） 一种含四元环的杂二萜类化合物、其制备方法和应用，以及药物组合物, 发明专利, 2021, 第 2 作者, 专利号: CN112812015A

   

[1] Xiao-Zheng Su, Lin-Fei Zhang, Kun Hu, Yang An, Qiao-Peng Zhang, Jian-Wei Tang, Bing-Chao Yan, Xing-Ren Li, Jie Cai, Xiao-Nian Li, Han-Dong Sun, Shi-You Jiang, Pema-Tenzin Puno. Discovery of Natural Potent HMG-CoA Reductase Degraders for Lowering Cholesterol. Angewandte Chemie International Edition[J]. 2024, 第 7 作者63(6): e202313859, 
[2] He, Tao-Bin, Yan, Bing-Chao, Zhou, Yuan-Fei, Sang, Yue-Qian, Li, Xiao-Nian, Sun, Han-Dong, Wang, Chu, Xue, Xiao-Song, Puno, Pema-Tenzin. Discovery and bioinspired total syntheses of unprecedented sesquiterpenoid dimers unveiled bifurcating 4+2 cycloaddition and target differentiation of enantiomers. CHEMICAL SCIENCE[J]. 2024, 第 2 作者15(4): 1260-1270, 
[3] Jia-Meng Dai, Bing-Chao Yan, Kun Hu, Xing-Ren Li, Xiao-nian Li, Han-Dong Sun, Pema-Tenzin Puno. Isoxerophilusins A and B, Two Novel Polycyclic Asymmetric Diterpene Dimers from Isodon xerophilus: Structural Elucidation, Modification, and Inhibitory Activities against α-Glucosidase. Organic Letters[J]. 2024, 第 2 作者26(29): 6203-6208, 
[4] Dai, Jia-Meng, Yan, Bing-Chao, Kong, Ling-Mei, Hu, Kun, Li, Xing-Ren, Li, Xiao-Nian, Sun, Han-Dong, Li, Yan, Puno, Pema-Tenzin. Isoxerophilins A and B, two diterpene heterodimers from Isodon xerophilus : structural elucidation and semisynthesis of isoxerophilin analogues. ORGANIC CHEMISTRY FRONTIERS[J]. 2024, 第 2 作者11(1): 37-46, 
[5] Li, Ming-Xiang, Yan, Bing-Chao, Zhou, Min, Li Xing-Ren, Li, Xiao-Nian, He, Shi-Jun, Sun, Handong, Puno, Pema-Tenzin. Cyclobutane-containing meroditerpenoids, (+)-isoscopariusins B and C: structure elucidation and biomimetic synthesis. Organic Letters[J]. 2023, 第 2 作者25(17): 2981-2985, https://pubs.acs.org/doi/10.1021/acs.orglett.3c00742.
[6] Rong Chen, Li-Jing Guo, Xue-Dan Li, Xing-Ren Li, Kun Hu, Jian-Wei Tang, Zhen-Nan Ye, Bing-ChaoYan, Pema-Tenzin Puno. Phomopsischalins A-C, polycyclic-fused cytochalasins from the endophytic fungus Phomopsis sp. shj2 and their abilities to induce lysosomal function. Organic Chemistry Frontiers[J]. 2023, 第 8 作者  通讯作者  10(9): 2218-2225, https://pubs.rsc.org/en/content/articlelanding/2023/QO/D3QO00252G.
[7] Li, Xing-Ren, Hu, Kun, Yan, Bing-Chao, Li, Xiao-Nian, Sun, Han-Dong, Liu, Yang, Pema-Tenzin Puno. Scopariusicides D-M, ent-clerodane-based isomeric meroditerpenoids with a cyclobutane-fused gamma/delta-lactone core from Isodon scoparius. BIOORGANIC CHEMISTRY[J]. 2022, 第 3 作者127(null): 105973, http://dx.doi.org/10.1016/j.bioorg.2022.105973.
[8] Li, Xing-Ren, Chen, Li, Hu, Kun, Yan, Bing-Chao, Du, Xue, Li, Xiao-Nian, Sun, Han-Dong, He, Shi-Jun, Puno, Pema-Tenzin. Discovery and biological evaluation of dispirocyclic and polycyclic ent-clerodane dimers from Isodon scoparius as novel inhibitors of Toll-like receptor signaling. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 4 作者9(15): 4023-4033, http://dx.doi.org/10.1039/d2qo00723a.
[9] Wang, Bin, Jiang, Hua-Yi, Yang, Jin, Li, Jun, Yan, Bing-Chao, Chen, Xi, Hu, Kun, Li, Xing-Ren, Sun, Han-Dong, Deng, Jun, Puno, Pema-Tenzin. Isolation and Bioinspired Total Synthesis of Rugosiformisin A, A Skeleton-Rearranged Abietane-Type Diterpenoid from Isodon rugosiformis. ORGANIC LETTERS[J]. 2022, 第 5 作者24(44): 8104-8108, http://dx.doi.org/10.1021/acs.orglett.2c02834.
[10] Ye, Zhen-Nan, Qiu, Cai-Ling, Yan, Bing-Chao, Hu, Kun, Yang, Jin, Yang, Xing-Zhi, Li, Hong-Mei, Li, Xiao-Nian, Sun, Han-Dong, Puno, Pema-Tenzin. Structurally diverse diterpenoids from Isodon oresbius and their bioactivity. BIOORGANIC CHEMISTRY[J]. 2022, 第 3 作者  通讯作者  124(null): 105811, http://dx.doi.org/10.1016/j.bioorg.2022.105811.
[11] Bing-Chao Yan, Wei-Guang Wang, Ling-Mei Kong, Jian-Wei Tang, Xue Du, Yan Li, Pema-Tenzin Puno. Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities. JOURNAL OF FUNGI[J]. 2022, 第 1 作者8(5): 543, https://doaj.org/article/8550758b2ec84aea8873d04ed09fce07.
[12] Yuan-Fei Zhou, Yan, Bing-Chao, Qian Yang, Xin-Yan Long, Dan-Qi Zhang, Rong-Hua Luo, Han-Yu Wang, Han-Dong Sun, Xiao-Song Xue, Yong-Tang Zheng, Pema-Tenzin Puno. Harnessing natural products by a pharmacophore-oriented semisynthesis approach for the discovery of potential anti-SARS-CoV-2 agents. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 第 2 作者61(28): e202201684-e202201684, https://onlinelibrary.wiley.com/doi/10.1002/anie.202201684.
[13] Li, Xing-Ren, Yan, Bing-Chao, Hu, Kun, He, Shijun, Sun, Han-Dong, Zuo, Jianping, Puno, Pema-Tenzin. Spiro ent-Clerodane Dimers: Discovery and Green Approaches for a Scalable Biomimetic Synthesis. ORGANIC LETTERS[J]. 2021, 第 2 作者23(15): 5647-5651, http://dx.doi.org/10.1021/acs.orglett.1c01724.
[14] Yan, Bing-Chao, Zhou, Min, Li, Jian, Li, Xiao-Nian, He, Shi-Jun, Zuo, Jian-Ping, Sun, Han-Dong, Li, Ang, Puno, Pema-Tenzin. (-)-Isoscopariusin A, a Naturally Occurring Immunosuppressive Meroditerpenoid: Structure Elucidation and Scalable Chemical Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 第 1 作者60(23): 12859-12867, http://dx.doi.org/10.1002/anie.202100288.
[15] Hao-Yi Li, Bing-Chao Yan, Li-Xin Wei, Han-Dong Sun, Pema-Tenzin Puno. Tangutidines A-C, Three Amphoteric Diterpene Alkaloids fromAconitum tanguticum. Natural Products and Bioprospecting[J]. 2021, 第 2 作者11(4): 459-464, 
[16] Huang, Lihong, Fu, Qiang, Dai, Jia-Meng, Yan, BingChao, Wang, Dawei, Puno, Pema-Tenzin, Yue, Jianbo. High-content screening of diterpenoids from Isodon species as autophagy modulators and the functional study of their antiviral activities. CELL BIOLOGY AND TOXICOLOGY[J]. 2021, 第 4 作者37(5): 695-713, http://dx.doi.org/10.1007/s10565-021-09580-6.
[17] Tang, Jianwei, Hu, Kun, Su, Xiaozheng, Li, Xiaonian, Yan, Bingchao, Sun, Handong, Puno, Pematenzin. Phomopsisins A-C: Three new cytochalasans from the plant endophytic fungus Phomopsis sp. sh917. TETRAHEDRON[J]. 2020, 第 5 作者76(39): 131475, http://dx.doi.org/10.1016/j.tet.2020.131475.
[18] Jia-Meng Dai, Kun Hu, Bing-Chao Yan, Xing-Ren Li, Xiao-Nian Li, Han-Dong Sun, Pema-Tenzin Puno. ent-Kaurane-Based Diterpenoids, Dimers, and Meroditerpenoids from Isodon xerophilus. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 第 3 作者83(12): 3717-3725, https://www.webofscience.com/wos/woscc/full-record/WOS:000603402900026.
[19] Xue-Chun Jiang, Bing-Chao Yan, Xing-Ren Li, Xiao-Nian Li, Han-Dong Sun, Pema-Tenzin Puno. 4,5-Seco-18-nor-ent-clerodanoids and their derivatives: Structure elucidation, synthesis and resistant reversal activities against fluconazole-resistance Candida albicans. TETRAHEDRON[J]. 2020, 第 2 作者76(14): 131043, http://dx.doi.org/10.1016/j.tet.2020.131043.
[20] He, Tao-Bin, Yan, Bing-Chao, Hu, Kun, Li, Xiao-Nian, Sun, Han-Dong, Puno, Pema-Tenzin. Neuroprotective schinortriterpenoids with diverse scaffolds from Schisandra henryi. BIOORGANIC CHEMISTRY[J]. 2020, 第 2 作者105(null): 104353, http://dx.doi.org/10.1016/j.bioorg.2020.104353.
[21] Zhang, Qin-Yu, Yan, Bing-Chao, Hu, Kun, Li, Xiao-Nian, Sun, Han-Dong, Puno, Pema-Tenzin. Isorugosiformins A-F, six ent-kaurane diterpenoids from Isodon rugosiformis. FITOTERAPIA[J]. 2020, 第 2 作者142(null): 104529, 
[22] Tang, JianWei, Kong, LingMei, Zu, WenYu, Hu, Kun, Li, XiaoNian, Yan, BingChao, Wang, WeiGuang, Sun, HanDong, Li, Yan, Puno, PemaTenzin. Isopenicins A-C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18. ORGANIC LETTERS[J]. 2019, 第 6 作者21(3): 771-775, http://ir.kib.ac.cn/handle/151853/64235.
[23] Yang, Qian, Hu, Kun, Yan, BingChao, Liu, Miao, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Maoeriocalysins A-D, four novel ent-kaurane diterpenoids from Isodon eriocalyx and their structure determination utilizing quantum chemical calculation in conjunction with quantitative interproton distance analysis. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 第 3 作者6(1): 45-53, http://ir.kib.ac.cn/handle/151853/64294.
[24] Tang, JianWei, Wang, WeiGuang, Li, Ao, Yan, BingChao, Chen, Rong, Li, XiaoNian, Du, Xue, Sun, HanDong, Pu, JianXin. Polyketides from the endophytic fungus Phomopsis sp sh917 by using the one strain/many compounds strategy. TETRAHEDRON[J]. 2017, 第 4 作者73(26): 3577-3584, http://dx.doi.org/10.1016/j.tet.2017.02.019.
[25] Wong, TinLong, An, YaQi, Yan, BingChao, Yue, RuiQi, Zhang, TianBo, Ho, HingMan, Ren, TianJing, Fung, HauYee, Ma, DikLung, Leung, ChungHang, Liu, ZhongLiang, Pu, JianXin, Han, QuanBin, Sun, HanDong. Comprehensive quantitative analysis of Chinese patent drug YinHuang drop pill by ultra high-performance liquid chromatography quadrupole time of flight mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2016, 第 3 作者125: 415-426, http://dx.doi.org/10.1016/j.jpba.2016.04.008.
[26] Yan, Bing-Chao, Wang, Wei-Guang, Hu, Dong-Bao, Sun, Xiang, Kong, Ling-Mei, Li, Xiao-Nian, Du, Xue, Luo, Shi-Hong, Liu, Yan, Li, Yan, Sun, Han-Dong, Pu, Jian-Xin. Phomopchalasins A and B, Two Cytochalasans with Polycyclic-Fused Skeletons from the Endophytic Fungus Phomopsis sp shj2. ORGANIC LETTERS[J]. 2016, 第 1 作者18(5): 1108-1111, https://pubs.acs.org/doi/full/10.1021/acs.orglett.6b00214.
[27] Wang, WeiGuang, Li, Ao, Yan, BingChao, Niu, ShuBin, Tang, JianWei, Li, XiaoNian, Du, Xue, Challis, Gregory L, Che, Yongsheng, Sung, HanDong, Pu, JianXin. LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 第 3 作者79(1): 149-155, https://pubs.acs.org/doi/10.1021/acs.jnatprod.5b00814.
[28] Wang, WeiGuang, Yan, BingChao, Li, XiaoNian, Du, Xue, Wu, HaiYan, Zhan, Rui, Li, Yan, Pu, JianXin, Sun, HanDong. 6,7-Seco-ent-kaurane-type diterpenoids from Isodon eriocalyx var. laxiflora. TETRAHEDRON[J]. 2014, 第 2 作者70(41): 7445-7453, http://dx.doi.org/10.1016/j.tet.2014.08.018.

   

（ 1 ） 新颖6/6/3骨架杂萜类选择性T型钙通道失活调节剂的设计、合成和活性研究, 负责人, 国家任务, 2021-01--2023-12
（ 2 ） 中国科学院青年创新促进会——若干新颖天然萜类产物的多样性全合成与生物活性研究, 负责人, 中国科学院计划, 2023-03--2027-01
（ 3 ） 新型环丙烷化杂萜类T型钙通道调节剂的设计、合成与成药性研究, 负责人, 地方任务, 2023-01--2027-12
（ 4 ） 引进优秀人才-新颖杂萜类似物的设计、合成及其T型钙通道调节活性研究, 负责人, 研究所自主部署, 2022-03--2027-02
（ 5 ） 新颖杂二萜scopariusicide G及其类似物的化学合成与生物活性研究, 负责人, 国家任务, 2022-07--2025-06
（ 6 ） 三种新颖萜类天然产物的多样性不对称全合成和生物活性研究, 负责人, 地方任务, 2024-03--2027-02

（1）天然杂二萜isoscopariusin A的合成及生物活性研究   中国化学会第十二届全国有机化学会   颜秉超   2022-09-27

   

在读研究生：

2022级硕士生  1名

2023级硕士生  2名

2024级硕士生  1名