药物化学，有机合成

   

100701-药物化学

小分子药物，抗肿瘤，抗病毒，有机合成方法学

2012-09--2017-07   中国科学院上海药物研究所   博士
2008-09--2012-06   四川大学   学士

   

2018-06~2021-02,Baylor College of Medicine, 博士后
2017-08~2018-06,H. Lee Moffitt Cancer Center and Research Institute, 博士后

   

（1） Design, Synthesis and pharmacological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors, Acta Pharmaceutica Sinica B, 2021, 第 1 作者
（2） Additive-Controlled Divergent Synthesis of Tetrasubstituted 1,3-Enynes and Alkynylated 3H-pyrrolo[1,2-a]indol-3-ones via Rhodium Catalysis, Organic Letters, 2021, 通讯作者
（3） Rhodium(III)-Catalyzed C–H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes, Organic Letters, 2020, 第 1 作者
（4） Synthesis of Indole-Fused Polyheterocycles via Rh(III)-Catalyzed Regioselective [4+2] Annulation/Lactonization of Indoles with 4-Hydroxy-2-Alkynoates, Advanced Synthesis & Catalysis, 2020, 第 1 作者
（5） The Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as Novel Covalent FGFR Inhibitors by Rational Drug Design, Journal of Medicinal Chemistry, 2019, 第 3 作者
（6） Ruthenium(II)-Catalyzed Regio- and Stereoselective C−H Allylation of Indoles with Allyl Alcohols, Organic Letters, 2018, 第 1 作者
（7） Ruthenium-Catalyzed C–H Allylation of Alkenes with Allyl Alcohols via C–H Bond Activation in Aqueous Solution, Journal of Organic Chemistry, 2018, 第 1 作者
（8） Rhodium-Catalyzed [4 + 1] Cyclization via C-H Activation for Divergent Heterocycle Bearing a Quaternary Carbon Synthesis, Journal of Organic Chemistry, 2018, 第 1 作者
（9） Rhodium(III)-catalyzed C–H allylation of indoles with allyl alcohols via β-hydroxide elimination, Organic & Biomolecular Chemistry, 2018, 第 1 作者
（10） Ruthenium-Catalyzed Redox-Neutral [4+1] Annulation of Benzamides and Propargyl alcohols via C-H Bond Activation, ACS Catalysis, 2017, 第 1 作者
（11） Propargyl alcohols as one-carbon synthons: redox-neutral Rh (III)-catalyzed C-H bond activation for the synthesis of isoindolinones bearing a quaternary carbon, Organic Letters, 2017, 第 1 作者

   

（ 1 ） 小分子创新药物设计、合成及药理活性研究, 主持, 市地级, 2021-03--2026-03