药物化学，有机合成

   

100701-药物化学

小分子药物，抗肿瘤，抗病毒，有机合成方法学

2012-09--2017-07   中国科学院上海药物研究所   博士
2008-09--2012-06   四川大学   学士

   

2018-06~2021-02,Baylor College of Medicine, 博士后
2017-08~2018-06,H. Lee Moffitt Cancer Center and Research Institute, 博士后

   

[1] Organic Letters. 2024,   通讯作者  
[2] Organic Chemistry Frontiers. 2023,   通讯作者  
[3] Cancers. 2023, 第 2 作者
[4] Organic Chemistry Frontiers. 2023,   通讯作者  
[5] Chem Catalysis. 2023,   通讯作者  
[6] Green Chemistry. 2022,   通讯作者  
[7] Xiaowei Wu, Mengdi Dai, Rongrong Cui, Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai, Mingyue Zheng, Hong Liu. Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors. ACTA PHARMACEUTICA SINICA B[J]. 2021, 第 1 作者11(3): 781-794, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982429/.
[8] Zhao, Fei, Gong, Xin, Lu, Yangbin, Qiao, Jin, Jia, Xiuwen, Ni, Hangcheng, Wu, Xiaowei, Zhang, Xiaoning. Additive-Controlled Divergent Synthesis of Tetrasubstituted 1,3-Enynes and Alkynylated 3H-Pyrrolo1,2-aindol-3-ones via Rhodium Catalysis. ORGANIC LETTERS[J]. 2021, 第 7 作者  通讯作者  23(3): 727-733, http://dx.doi.org/10.1021/acs.orglett.0c03950.
[9] Wu Xiaowei. Design, Synthesis and pharmacological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors. Acta Pharmaceutica Sinica B. 2021, 第 1 作者
[10] ACS Catalysis. 2021,   通讯作者  
[11] Wu, Xiaowei, Lu, Yangbin, Qiao, Jin, Dai, Wenhao, Jia, Xiuwen, Ni, Hangcheng, Zhang, Xiaoning, Liu, Hong, Zhao, Fei. Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes. ORGANIC LETTERS[J]. 2020, 第 1 作者22(23): 9163-9168, https://www.webofscience.com/wos/woscc/full-record/WOS:000598141000004.
[12] Xiaowei Wu, Haitao Ji. Ruthenium-Catalyzed C–H Allylation of Alkenes with Allyl Alcohols via C–H Bond Activation in Aqueous Solution. THE JOURNAL OF ORGANIC CHEMISTRY. 2020, 第 1 作者83(19): 12094-12102, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771258/.
[13] Wu Xiaowei. Synthesis of Indole-Fused Polyheterocycles via Rh(III)-Catalyzed Regioselective [4+2] Annulation/Lactonization of Indoles with 4-Hydroxy-2-Alkynoates. Advanced Synthesis & Catalysis. 2020, 第 1 作者
[14] Wang, Yulan, Dai, Yang, Wu, Xiaowei, Li, Fei, Liu, Bo, Li, Chunpu, Liu, Qiufeng, Zhou, Yuanyang, Wang, Bao, Zhu, Mingrui, Cui, Rongrong, Tan, Xiaoqin, Xiong, Zhaoping, Liu, Jia, Tan, Minjia, Xu, Yechun, Geng, Meiyu, Jiang, Hualiang, Liu, Hong, Ai, Jing, Zheng, Mingyue. Discovery and Development of a Series of Pyrazolo3,4-dpyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 第 3 作者62(16): 7473-7488, http://dx.doi.org/10.1021/acs.jmedchem.9b00510.
[15] Wu Xiaowei. The Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as Novel Covalent FGFR Inhibitors by Rational Drug Design. Journal of Medicinal Chemistry. 2019, 第 1 作者
[16] Dai, Wenhao, Wu, Xiaowei, Li, Chunpu, Zhang, Rui, Wang, Jiang, Liu, Hong. Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes. RSC ADVANCES[J]. 2018, 第 2 作者8(49): 28261-28265, https://www.webofscience.com/wos/woscc/full-record/WOS:000442078800065.
[17] Wu, Xiaowei, Ji, Haitao. Rhodium(III)-catalyzed C-H allylation of indoles with allyl alcohols via beta-hydroxide elimination. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 第 1 作者16(31): 5691-5698, https://www.webofscience.com/wos/woscc/full-record/WOS:000441028200018.
[18] 吴小伟, 王江, 柳红. 先导化合物结构优化策略（六）——改善化合物血浆稳定性. 药学学报[J]. 2018, 第 1 作者53(2): 192, http://lib.cqvip.com/Qikan/Article/Detail?id=674406146.
[19] Wu, Xiaowei, Ji, Haitao. Ruthenium(II)-Catalyzed Regio- and Stereoselective C-H Allylation of Indoles with Allyl Alcohols. ORGANIC LETTERS[J]. 2018, 第 1 作者20(8): 2224-2227, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771326/.
[20] Wu Xiaowei. Rhodium-Catalyzed [4 + 1] Cyclization via C-H Activation for Divergent Heterocycle Bearing a Quaternary Carbon Synthesis. Journal of Organic Chemistry. 2018, 第 1 作者
[21] Wu Xiaowei. Propargyl alcohols as one-carbon synthons: redox-neutral Rh (III)-catalyzed C-H bond activation for the synthesis of isoindolinones bearing a quaternary carbon. Organic Letters. 2017, 第 1 作者
[22] Wu, Xiaowei, Wang, Bao, Zhou, Yu, Liu, Hong. Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon. ORGANIC LETTERS[J]. 2017, 第 1 作者19(6): 1294-1297, https://www.webofscience.com/wos/woscc/full-record/WOS:000397077400008.
[23] Wu, Xiaowei, Wang, Bao, Zhou, Shengbin, Zhou, Yu, Liu, Hong. Ruthenium-Catalyzed Redox-Neutral 4+1 Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation. ACS CATALYSIS[J]. 2017, 第 1 作者7(4): 2494-2499, https://www.webofscience.com/wos/woscc/full-record/WOS:000398986700030.
[24] Xie, Yanan, Wu, Xiaowei, Li, Chunpu, Wang, Jiang, Li, Jian, Liu, Hong. Ruthenium(II)-Catalyzed Redox-Neutral 3+2 Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold. JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 第 2 作者82(10): 5263-5273, https://www.webofscience.com/wos/woscc/full-record/WOS:000402023200026.
[25] Wu, Xiaowei, Zhang, Dengyou, Zhou, Shengbin, Gao, Feng, Liu, Hong. Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides. CHEMICAL COMMUNICATIONS[J]. 2015, 第 1 作者  通讯作者  51(63): 12571-12573, https://www.webofscience.com/wos/woscc/full-record/WOS:000358520200014.
[26] Yang, Wei, Li, Lixuan, Wang, Yulan, Wu, Xiaowei, Li, Tingting, Yang, Nan, Su, Mingbo, Sheng, Li, Zheng, Mingyue, Zang, Yi, Li, Jia, Liu, Hong. Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2015, 第 4 作者23(17): 5881-5890, http://dx.doi.org/10.1016/j.bmc.2015.06.071.
[27] Yang, Wei, Li, Lixuan, Ji, Xun, Wu, Xiaowei, Su, Mingbo, Sheng, Li, Zang, Yi, Li, Jia, Liu, Hong. Design, synthesis and biological evaluation of 4-anilinothieno2,3-dpyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2014, 第 4 作者22(21): 6146-6155, http://dx.doi.org/10.1016/j.bmc.2014.08.030.

   

（ 1 ） 小分子创新药物设计、合成及药理活性研究, 主持, 市地级, 2021-03--2026-03