基本信息
徐敏 男 博导 中国科学院脑科学与智能技术卓越创新中心(神经科学研究所)
电子邮件: mxu@ion.ac.cn
通信地址: 中科院神经所
邮政编码:
电子邮件: mxu@ion.ac.cn
通信地址: 中科院神经所
邮政编码:
研究领域
中枢神经系统的一项重要功能是随时根据外界环境的变化来调控动物的行为。为了理解此种调控背后神经系统运行的机理,我们需要全面系统的分析与特定行为相关的神经环路。本实验室目前致力于研究参与睡眠-觉醒行为调控的神经环路。
睡眠-觉醒是在哺乳动物中普遍存在的一个行为。已有报道表明,包括下丘脑(Hypothalamus)在内的多个脑区都参与了该行为的调控。然而,我们对这些调控的机制却缺乏了解。
最近在小鼠系统上技术的进步,为在多个层面上来研究该问题提供了一个非常宝贵的时机:我们可以采用光遗传辅助的细胞外记录或者钙成像技术来监测睡眠-觉醒周期中多种类型细胞的放电活动;采用光遗传或者药理遗传手段来激活和抑制不同种类细胞的放电,以评估他们对动物睡眠的影响;采用光遗传辅助的脑片记录或者病毒介导的解剖学示踪技术来分析相关神经环路内部以及长程的突触联系。在以发表的研究工作中,我们成功的采用该研究策略阐明了基底前脑(Basal forebrain)中对睡眠-觉醒调控的神经环路(Xu, et. al. 2015)。在当前进行的研究中,我们将采用类似的策略来研究下丘脑神经环路对睡眠-觉醒的调控。该研究的最终目的是要帮助我们回答睡眠研究中的一个核心问题:睡眠的生物学基础是什么?
本实验室另一个研究方向是进一步揭示视觉注意行为(Attention)的神经环路基础(Zhang, et. al. 2014)。该研究是与上海交大医学院张思宇老师的合作课题。
出版信息
发表论文
[1] Neuron. 2024, 通讯作者 [2] Nature Communications. 2023, 通讯作者 [3] Cell Discovery. 2023, 通讯作者 [4] Advanced Science. 2023, 通讯作者 [5] Science. 2023, 第 12 作者[6] Nature Communications. 2022, 通讯作者 [7] PNAS. 2022, 第 12 作者[8] Ma, Guofen, Liu, Yanmei, Wang, Lizhao, Xiao, Zhongyi, Song, Kun, Wang, Yanjie, Peng, Wanling, Liu, Xiaotong, Wang, Ziyue, Jin, Sen, Tao, Zi, Li, Chengyu T, Xu, Tianle, Xu, Fuqiang, Xu, Min, Zhang, Siyu. Hierarchy in sensory processing reflected by innervation balance on cortical interneurons. SCIENCE ADVANCES[J]. 2021, 第 15 作者 通讯作者 7(20): http://dx.doi.org/10.1126/sciadv.abf5676.[9] Wan, Jinxia, Peng, Wanling, Li, Xuelin, Qian, Tongrui, Song, Kun, Zeng, Jianzhi, Deng, Fei, Hao, Suyu, Feng, Jiesi, Zhang, Peng, Zhang, Yajun, Zou, Jing, Pan, Sunlei, Shin, Mimi, Venton, B Jill, Zhu, J Julius, Jing, Miao, Xu, Min, Li, Yulong. A genetically encoded sensor for measuring serotonin dynamics. NATURE NEUROSCIENCE[J]. 2021, 第 18 作者24(5): 746-752, http://dx.doi.org/10.1038/s41593-021-00823-7.[10] Nat Commun. 2021, 第 12 作者[11] Jing, Miao, Li, Yuexuan, Zeng, Jianzhi, Huang, Pengcheng, Skirzewski, Miguel, Kljakic, Ornela, Peng, Wanling, Qian, Tongrui, Tan, Ke, Zou, Jing, Trinh, Simon, Wu, Runlong, Zhang, Shichen, Pan, Sunlei, Hires, Samuel A, Xu, Min, Li, Haohong, Saksida, Lisa M, Prado, Vania F, Bussey, Timothy J, Prado, Marco A M, Chen, Liangyi, Cheng, Heping, Li, Yulong. An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. NATURE METHODS[J]. 2020, 第 16 作者17(11): 1139-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606762/.[12] Peng, Wanling, Wu, Zhaofa, Song, Kun, Zhang, Siyu, Li, Yulong, Xu, Min. Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons. SCIENCE[J]. 2020, 第 6 作者 通讯作者 369(6508): 1208-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000567525400045.[13] Chen, KaiSiang, Xu, Min, Zhang, Zhe, Chang, WeiCheng, Gaj, Thomas, Schaffer, David V, Dan, Yang. A Hypothalamic Switch for REM and Non-REM Sleep. NEURON[J]. 2018, 第 2 作者97(5): 1168-+, http://dx.doi.org/10.1016/j.neuron.2018.02.005.[14] Sun, Fangmiao, Zeng, Jianzhi, Jing, Miao, Zhou, Jingheng, Feng, Jiesi, Owen, Scott F, Luo, Yichen, Li, Funing, Wang, Huan, Yamaguchi, Takashi, Yong, Zihao, Gao, Yijing, Peng, Wanling, Wang, Lizhao, Zhang, Siyu, Du, Jiulin, Lin, Dayu, Xu, Min, Kreitzer, Anatol C, Cui, Guohong, Li, Yulong. A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice. CELL[J]. 2018, 第 18 作者174(2): 481-+, http://dx.doi.org/10.1016/j.cell.2018.06.042.[15] Zhang, Siyu, Xu, Min, Chang, WeiCheng, Ma, Chenyan, Johnny Phong Hoang Do, Jeong, Daniel, Lei, Tiffany, Fan, Jiang Lan, Dan, Yang. Organization of long-range inputs and outputs of frontal cortex for top-down control. NATURE NEUROSCIENCE[J]. 2016, 第 2 作者19(12): 1733-1742, https://www.webofscience.com/wos/woscc/full-record/WOS:000389011900034.[16] Do, Johnny Phong, Xu, Min, Lee, SeungHee, Chang, WeiCheng, Zhang, Siyu, Chung, Shinjae, Yung, Tyler J, Fan, Jiang Lan, Miyamichin, Kazunari, Luo, Liqun, Dan, Yang. Cell type-specific long-range connections of basal forebrain circuit. ELIFE[J]. 2016, 第 2 作者5: https://doaj.org/article/f7337e71b17240a9a9607efbbceaea13.[17] Xu, Min, Chung, Shinjae, Zhang, Siyu, Zhong, Peng, Ma, Chenyan, Chang, WeiCheng, Weissbourd, Brandon, Sakai, Noriaki, Luo, Liqun, Nishino, Seiji, Dan, Yang. Basal forebrain circuit for sleep-wake control. NATURE NEUROSCIENCE[J]. 2015, 第 1 作者18(11): 1641-1647, https://www.webofscience.com/wos/woscc/full-record/WOS:000363830700022.[18] Weber, Franz, Chung, Shinjae, Beier, Kevin T, Xu, Min, Luo, Liqun, Dan, Yang. Control of REM sleep by ventral medulla GABAergic neurons. NATURE[J]. 2015, 第 4 作者526(7573): 435-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000362730200052.[19] 蒲慕明. Representation of interval timing by temporally scalable firing patterns in rat prefrontal cortex. PROC NATL ACAD SCI USA. 2014, 111: 480-485, [20] Siyu Zhang, Min Xu, Tsukasa Kamigaki, Johnny Phong Hoang Do, WeiCheng Chang, Sean Jenvay, Kazunari Miyamichi, Liqun Luo, Yang Dan. Long-Range and Local Circuits for Top-Down Modulation of Visual Cortical Processing. SCIENCE (NEW YORK, N.Y.). 2014, 第 2 作者345(6197): 660-665, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776147/.[21] Pinto, Lucas, Goard, Michael J, Estandian, Daniel, Xu, Min, Kwan, Alex C, Lee, SeungHee, Harrison, Thomas C, Feng, Guoping, Dan, Yang. Fast modulation of visual perception by basal forebrain cholinergic neurons. NATURE NEUROSCIENCE[J]. 2013, 第 4 作者16(12): 1857-1863, https://www.webofscience.com/wos/woscc/full-record/WOS:000327416800024.[22] Zhang, Siyu, Xu, Min, Miao, Qinglong, Poo, Muming, Zhang, Xiaohui. Endocannabinoid-Dependent Homeostatic Regulation of Inhibitory Synapses by Miniature Excitatory Synaptic Activities. JOURNAL OF NEUROSCIENCE[J]. 2009, 第 2 作者29(42): 13222-13231, http://www.irgrid.ac.cn/handle/1471x/502245.[23] Xu Min, Liu Chun Hua, Xiong Ying, He Jufang. Corticofugal modulation of the auditory thalamic reticular nucleus of the guinea pig. THE JOURNAL OF PHYSIOLOGY. 第 1 作者585(Pt 1): 15-28, http://202.127.22.60/handle/331001/1748.
科研活动
科研项目
( 1 ) 睡眠的环路基础及调控, 主持, 市地级, 2016-09--2020-09( 2 ) 基于蛋白质机器的抑郁障碍脑分子网络图谱 构建及应用, 参与, 国家级, 2018-01--2023-01