基本信息
徐林  男  博导  中国科学院昆明动物研究所
电子邮件: lxu@vip.163.com
通信地址: 云南省昆明市教场东路32号
邮政编码: 650223

研究领域

针对神经科学的重大前沿问题---记忆的获取、储存和提取机制开展研究,涉及宏观层面行为学药理学、介观层面神经环路和微观层面的细胞分子生物学技术方法。同时,针对相关脑重大疾病开展新药和新技术发现、药理药效学等研发,为这些脑疾病的诊断、治疗提供新途径。


1、海马环路与突触可塑性---基础研究

四十多年来,国际学习记忆研究领域取得了丰硕的卓越成果,例如发现和证明了突触传递效率长时程增强(LTP)和减弱(LTD)是学习记忆的重要细胞分子机理。尽管如此,学习记忆研究领域仍然面临着巨大挑战:还几乎完全不清楚记忆以什么形式储存在哪里、记忆又怎么被提取等。由于海马在记忆形成和提取中起着重要作用,我们试图探索海马各亚区如何处理信息、又如何与其它脑区进行信息交流,最终实现记忆的储存和提取。拟采用多通路突触传递记录、微电极阵列神经放电记录、光遗传、基因操作和行为药理等技术来研究这些重大的科学问题。

2、基于异常记忆的动物模型与精神疾病---应用基础研究

大脑无时无刻处理着海量信息,然而仅有少量信息以未知方式被编码并储存为长时记忆,绝大多数信息被迅速遗忘。记忆和遗忘这一对矛盾遵循着自然界“动态平衡”法则。一旦这一平衡法则被打破,既可导致“忘不了”如创伤后应激综合症(PTSD)、抑郁症和成瘾,也可导致“记不住”如孤独症和老年痴呆症(AD)。这些异常记忆相关的脑疾病均存在严重的精神障碍或残疾,已导致了沉重的社会和经济负担,其发病机理还不完全清楚,仍然缺乏有效的临床预防、诊断和治疗措施。我们试图建立异常的记忆和遗忘动物模型,研究其细胞分子机理,进而阐述为什么一些情况下如急性应激相关的记忆就难以遗忘,而另一些情况下如慢性应激相关的记忆容易遗忘甚至过度遗忘。重要的是通过人类疾病的动物模型不仅可找到诊断和治疗新措施,也可观测疾病的发生发展过程,进而可能找到有效的早期预防和干预措施。这些应用基础研究进展又为深入理解记忆的储存和提取机理等重大基础科学问题提供独特的视角。

3、抗精神疾病新药的药理药效学---应用研究

神经系统区别于其它系统的最显著特点在于神经细胞间通过上千个突触进行信息传递构成功能性神经网络,并且突触信息传递效率具有普遍的高度可塑性如LTP和LTD。重要的是,从昆虫、鸟类、哺乳类到人类,突触结构和分子构成高度保守,其传递效率的可塑性也高度保守,充分展现了系统演化过程中在突触水平上动物与人类的高度相似性。然而随着神经细胞数量急剧增加、以及神经细胞构成的神经环路和调控机理的复杂性高度增加,从动物到人类也存在巨大的、难以跨越的差异性:更卓越的智慧、更高级的认知能力和更复杂的行为。神经系统新药的研发就面临着这样的一致性和差异性挑战。因此,神经系统新药的药理药效学研究必然涉及两大系统检测:证明新药在人类疾病的动物模型中有效;证明新药在突触传递和突触可塑性中也有效以及新药的作用靶点和机理。我们已经建立了实现上述检测系统的技术手段,成功地完成了抗AD(酚克络酮)、抗抑郁症(奥生乐赛特)两个一类新药的全套药理药效学研究,目前正在II期临床试验中。还可针对孤独症、焦虑症、抑郁症、精神分裂症、毒品成瘾、慢性疼痛、PTSD、AD、缺血性中风等脑疾病,系统研究治疗新药的药效学和药理学。我们正在针对AD、PTSD、血性中风后神经保护开展中药来源的活性物质筛选和新药研发。

招生信息

每年招收1-2名硕士研究生、1-2名博士研究生。主要培养从事学习记忆研究方面的电生理学或神经药理学才人。

招生专业
071006-神经生物学
071009-细胞生物学
招生方向
精神疾病动物模型与疾病机理研究

教育背景

1995-08--1998-08   爱尔兰三一学院   博士学位
1987-09--1990-02   中科院昆明动物研究所脑与行为实验室   硕士学位
1981-09--1985-07   四川南充师范学院   学士学位

专利与奖励

   
奖励信息
(1) 科技领军人才, 省级, 2015
(2) 云岭学者, 省级, 2014
(3) 谈家桢生命科学创新奖, 院级, 2008
(4) 973计划先进个人, 院级, 2008
(5) 国务院政府特别津贴, 院级, 2008
(6) 云南省科技进步一等奖, 国家级, 2002
专利成果
[1] 徐林, 黄京飞, 周启心, 李功华, 谭继伟, 熊贵静, 韩会丽. 一种阻断突触长时程增强(LTP)的短肽及其应用. CN: CN106632601B, 2020-10-20.

[2] 王妮娅, 徐林, 谭娅红, 毛榕榕, 李津南, 周启心. 阿魏酸在制备治疗血管疾病的药物中的应用. CN: CN111481533A, 2020-08-04.

[3] Chen Jijun, Xu Lin, Zhou Jun, Lu Jun, Mao Rongrong, Tian Meng, Zhou Qixin, Zhang Xuemei, Shen Yong, Jiang Zhiyong, Zuo Aixue. Application of 5-methyl-1,3-benzenediol or derivatives thereof in the preparation of medicines and functional foods for treatment or prevention of depression. 美国: US8859508(B2), 2014-10-14.

[4] 郭昊, 徐林. 一种动物社交及摄食行为动机检测系统. CN: CN103876753A, 2014-06-25.

[5] 王静, 柴安平, 徐林, 杨跃雄. 一种树鼩社交行为监测箱. 中国: CN203505261U, 2014-04-02.

[6] 于成龙, 周恒, 张晨, 毛榕榕, 徐林. 一种评价缺血后脑功能损伤的动物模型的制备方法. CN: CN103385766A, 2013-11-13.

[7] 徐林, 杨跃雄, 王静, 张晨. 一种用于树鼩的一次性被捕获笼具装置. 中国: CN202999031U, 2013-06-19.

[8] 陈纪军, 徐林, 周俊, 吕俊, 毛榕榕, 田孟, 周启心, 张雪梅, 沈勇, 江志勇, 左爱学. 5-甲基-1,3苯二酚或其衍生物用于制备治疗或预防抑郁症的药物或功能食品中的用途. CN: CN101742992A, 2010-06-16.

[9] 陈纪军, 徐林, 周俊, 吕俊, 毛蓉蓉, 田孟, 张雪梅, 沈勇. 抗抑郁药物及其应用. CN: CN101134041A, 2008-03-05.

[10] 蔡景霞, 郝小江, 王永富, 徐林, 杨小生, 汪冶. 芬克罗酮的应用. CN: CN1759831A, 2006-04-19.

[11] 郝小江, 杨小生, 周俊, 蔡景霞, 徐林, 胡新天. N-取代基-4-取代苯基-5-烷基-5-取代苄基吡咯烷酮-2,其中间体,其合成方其法及应用. 中国: CN1040747, 1998-11-18.

出版信息

   
发表论文
[1] Chen, Ling, Gong, WanKun, Yang, Cuiping, Shao, ChanChan, Song, NingNing, Chen, JiaYin, Zhou, LiQiang, Zhang, KunShan, Li, Siguang, Huang, Zhili, RichterLevin, Gal, Xu, Lin, Ding, YuQiang. Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice. TRANSLATIONAL PSYCHIATRY[J]. 2021, 11(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998026/.
[2] Wang, NiYa, Li, JinNan, Liu, WeiLin, Huang, Qi, Li, WenXing, Tan, YaHong, Liu, Fang, Song, ZiHua, Wang, MengYue, Xie, Ning, Mao, RongRong, Gan, Ping, Ding, YuQiang, Zhang, Zhi, Shan, BaoCi, Chen, LiDian, Zhou, QiXin, Xu, Lin. Ferulic Acid Ameliorates Alzheimer's Disease-like Pathology and Repairs Cognitive Decline by Preventing Capillary Hypofunction in APP/PS1 Mice. NEUROTHERAPEUTICS[J]. 2021, 18(2): 1064-1080, http://dx.doi.org/10.1007/s13311-021-01024-7.
[3] Huang, Ying, Huang, Jing, Zhou, QiXin, Yang, ChunXian, Yang, CuiPing, Mei, WanYing, Zhang, Lei, Zhang, Qiong, Hu, Ling, Hu, YunQing, Song, NingNing, Wu, ShengXi, Xu, Lin, Ding, YuQiang. ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors. MOLECULAR PSYCHIATRY. 2020, https://www.webofscience.com/wos/woscc/full-record/WOS:000597435700001.
[4] Ni, RongJun, Wang, Jing, Shu, YuMian, Xu, Lin, Zhou, JiangNing. Mapping of c-Fos expression in male tree shrew forebrain. NEUROSCIENCE LETTERS[J]. 2020, 714: http://dx.doi.org/10.1016/j.neulet.2019.134603.
[5] WenXing Li, GongHua Li, Xin Tong, PengPeng Yang, JingFei Huang, Lin Xu, ShaoXing Dai. Systematic metabolic analysis of potential target, therapeutic drug, diagnostic method and animal model applicability in three neurodegenerative diseases. Aging (Albany NY). 2020, 12(10): 9882-9914, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288927/.
[6] Li, WenXing, Li, GongHua, Tong, Xin, Yang, PengPeng, Huang, JingFei, Xu, Lin, Dai, ShaoXing. Systematic metabolic analysis of potential target, therapeutic drug, diagnostic method and animal model applicability in three neurodegenerative diseases. AGING-US[J]. 2020, 12(10): 9882-9914, https://www.webofscience.com/wos/woscc/full-record/WOS:000537718700067.
[7] Yin, Qiuyuan, Jian, Youli, Xu, Meng, Huang, Xiahe, Wang, Niya, Liu, Zhifang, Li, Qian, Li, Jinglin, Zhou, Hejiang, Xu, Lin, Wang, Yingchun, Yang, Chonglin. CDK4/6 regulate lysosome biogenesis through TFEB/TFE3. JOURNAL OF CELL BIOLOGY[J]. 2020, 219(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000573631300004.
[8] Shuang Liu, Yuqi Cheng, Yueyin Zhao, Aiyun Lai, Zhaoping Lv, Zhongqi Xie, Bibhuti Upreti, Xiangyu Wang, Xiufeng Xu, Chunrong Luo, Hongjun Yu, Baoci Shan, Lin Xu, Jian Xu. Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. JOURNAL OF IMMUNOLOGY RESEARCH[J]. 2020, 2020: https://doaj.org/article/9e4fcf9c28a94db3a599b9be92f34b53.
[9] Ardi, Z, RichterLevin, A, Xu, L, Cao, X, Volkmer, H, Stork, O, RichterLevin, G. The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience. SCIENTIFIC REPORTS[J]. 2019, 9(1): http://dx.doi.org/10.1038/s41598-019-49824-4.
[10] Wu, Wenjuan, Du, Shuwen, Shi, Wei, Liu, Yunlong, Hu, Ying, Xie, Zuolei, Yao, Xinsheng, Liu, Zhenyu, Ma, Weiwei, Xu, Lin, Ma, Chao, Zhong, Yi. Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer's disease. PROTEIN & CELL[J]. 2019, 10(10): 745-759, http://lib.cqvip.com/Qikan/Article/Detail?id=7100271926.
[11] Zhou, Wenjie, Jin, Yan, Meng, Qian, Zhu, Xia, Bai, Tongjian, Tian, Yanghua, Mao, Yu, Wang, Likui, Xie, Wen, Zhong, Hui, Zhang, Na, Luo, MinHua, Tao, Wenjuan, Wang, Haitao, Li, Jie, Li, Juan, Qiu, BenSheng, Zhou, JiangNing, Li, Xiangyao, Xu, Han, Wang, Kai, Zhang, Xiaochu, Liu, Yong, RichterLevin, Gal, Xu, Lin, Zhang, Zhi. A neural circuit for comorbid depressive symptoms in chronic pain. NATURE NEUROSCIENCE[J]. 2019, 22(10): 1649-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000493396200015.
[12] Zhang, Tianhao, Huang, Qi, Jiao, Chunxiang, Liu, Hua, Nie, Binbin, Liang, Shengxiang, Li, Panlong, Sun, Xi, Feng, Ting, Xu, Lin, Shan, Baoci. Modular architecture of metabolic brain network and its effects on the spread of perturbation impact. NEUROIMAGE[J]. 2019, 186: 146-154, http://dx.doi.org/10.1016/j.neuroimage.2018.11.003.
[13] Xu, Lin, Mao, Rongrong, Fang, Y. Neurophysiologic Advance in Depressive Disorder. DEPRESSIVE DISORDERS: MECHANISMS, MEASUREMENT AND MANAGEMENT[J]. 2019, 1180: 99-116, [14] Gal RichterLevin, Lin Xu. How could stress lead to major depressive disorder?. IBRO Reports[J]. 2018, 4(4): 38–43-, http://159.226.149.26:8080/handle/152453/12327.
[15] Liu, Shuang, Cheng, Yuqi, Zhao, Yueyin, Yu, Hongjun, Lai, Aiyun, Lv, Zhaoping, Xu, Xiufeng, Luo, Chunrong, Shan, Baoci, Xu, Lin, Xu, Jian. Clinical Factors Associated with Brain Volume Reduction in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. FRONTIERS IN PSYCHIATRY[J]. 2018, 9(9): http://159.226.149.26:8080/handle/152453/12300.
[16] Huang, Qi, Nie, Binbin, Ma, Chen, Wang, Jing, Zhang, Tianhao, Duan, Shaofeng, Wu, Shang, Liang, Shengxiang, Li, Panlong, Liu, Hua, Sun, Hua, Zhou, Jiangning, Xu, Lin, Shan, Baoci. Stereotaxic F-18-FDG PET and MRI templates with three-dimensional digital atlas for statistical parametric mapping analysis of tree shrew brain. JOURNAL OF NEUROSCIENCE METHODS[J]. 2018, 293: 105-116, http://www.corc.org.cn/handle/1471x/2177835.
[17] Guo, Yujie, Tang, Xun, Zhang, Jichuan, Jin, Sen, Li, Jinnan, Ding, Lufeng, Zhang, Keming, Yang, Chaoyu, Zhou, Hua, He, Xiaobin, Xu, Fuqiang, Bi, GuoQiang, Xu, Lin, Lau, PakMing. Corticosterone Signaling and a Lateral Habenula-Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model. JOURNAL OF NEUROSCIENCE[J]. 2018, 38(23): S251-S266, https://www.webofscience.com/wos/woscc/full-record/WOS:000435412100002.
[18] WANG, Wei-sheng, JU, Yun-yue, WANG, Yu-jun, 刘景根. S4A-3 The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABAA Receptor Endocytosis in the vmPFC. 神经药理学报. 2018, 8(4): 65-66, http://lib.cqvip.com/Qikan/Article/Detail?id=7000824349.
[19] Huang, Baihui, Wu, Shihao, Wang, Zhengbo, Ge, Longjiao, Rizak, Joshua D, Wu, Jing, Li, Jiali, Xu, Lin, Lv, Longbao, Yin, Yong, Hu, Xintian, Li, Hao. Phosphorylated alpha-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP. NEUROSCIENCE[J]. 2018, 379: 302-315, https://www.webofscience.com/wos/woscc/full-record/WOS:000430884100027.
[20] Liu, Shuang, Cheng, Yuqi, Xiel, Zhongqi, Lai, Aiyun, Lyl, Zhaoping, Zhao, Yueyin, Xu, Xiufeng, Luo, Chunrong, Yu, Hongjun, Shan, Baoci, Xu, Lin, Xu, Jian. A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations. FRONTIERS IN PSYCHIATRY[J]. 2018, 9: https://doaj.org/article/ba8de4d461cd4fe4b9392795f779acc1.
[21] Jiao CX, Zhou H, Yang CX, Ma C, Yang YX, Mao RR, Xu L, Zhou QX. Protective efficacy of a single salvianolic acid A treatment on photothrombosis-induced sustained spatial memory impairments. NEUROPSYCHIATRIC DISEASE AND TREATMENT[J]. 2017, 13(X): 1181-1191, http://159.226.149.26:8080/handle/152453/11485.
[22] Zhong, Haixing, Tong, Li, Gu, Ning, Gao, Fang, Lu, Yacheng, Xie, Rougang, Liu, Jingjing, Li, Xin, Bergeron, Richard, Pomeranz, Lisa E, Mackie, Ken, Wang, Feng, Luo, ChunXia, Ren, Yan, Wu, ShengXi, Xie, Zhongcong, Xu, Lin, Li, Jinlian, Dong, Hailong, Xiong, Lize, Zhang, Xia. Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice. JOURNAL OF CLINICAL INVESTIGATION[J]. 2017, 127(6): 2295-2309, https://www.webofscience.com/wos/woscc/full-record/WOS:000402620800025.
[23] Omer Horovitz, Alon RichterLevin, Lin Xu, Liang Jing, Gal RichterLevin. Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress. SCIENTIFIC REPORTS[J]. 2017, 7(1): http://www.irgrid.ac.cn/handle/1471x/1174101.
[24] Heng Zhou, GuiJing Xiong, Liang Jing, NingNing Song, DeLin Pu, Xun Tang, XiaoBing He, FuQiang Xu, JingFei Huang, LingJiang Li, Gal RichterLevin, RongRong Mao, QiXin Zhou, YuQiang Ding, Lin Xu. The interhemispheric CA1 circuit governs rapid generalisation but not fear memory. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/6f601220edfe4f3a85ff0a10e8ee31e9.
[25] Yu, Dafu, Zhou, Heng, Zou, Lin, Jiang, Yong, Wu, Xiaoqun, Jiang, Lizhu, Zhou, Qixin, Yang, Yuexiong, Xu, Lin, Mao, Rongrong. Hippocampal Administration of Levothyroxine Impairs Contextual Fear Memory Consolidation in Rats. FRONTIERS IN CELLULAR NEUROSCIENCE[J]. 2017, 11(X): http://159.226.149.26:8080/handle/152453/12032.
[26] Lin Xu. The interhemispheric CA1 circuit governs rapid generalization but not fear memory. Nature Communications. 2017, [27] Wang, Weisheng, Ju, YunYue, Zhou, QiXin, Tang, JianXin, Li, Meng, Zhang, Lei, Kang, Shuo, Chen, ZhongGuo, Wang, YuJun, Ji, Hui, Ding, YuQiang, Xu, Lin, Liu, JingGen. The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABA(A) Receptor Endocytosis in the vmPFC. JOURNAL OF NEUROSCIENCE[J]. 2017, 37(30): 7096-7110, http://159.226.149.26:8080/handle/152453/11759.
[28] Gan, Ping, Ding, ZeYang, Gan, Cheng, Mao, RongRong, Zhou, Heng, Xu, Lin, Zhou, QiXin. Corticosterone regulates fear memory via Rac1 activity in the hippocampus. PSYCHONEUROENDOCRINOLOGY[J]. 2016, 71(X): 86-93, http://dx.doi.org/10.1016/j.psyneuen.2016.05.011.
[29] Jiang, Lizhu, Mao, Rongrong, Zhou, Qixin, Yang, Yuexiong, Cao, Jun, Ding, Yuqiang, Yang, Yuan, Zhang, Xia, Li, Lingjiang, Xu, Lin. Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory. MOLECULAR NEUROBIOLOGY[J]. 2016, 53(2): 1247-1253, http://www.irgrid.ac.cn/handle/1471x/1153978.
[30] 熊志奇, 徐林, 周江宁. 脑重大疾病的机理和诊治. 中国科学院院刊[J]. 2016, 31(7): 765-772, http://www.irgrid.ac.cn/handle/1471x/1154016.
[31] Hao Li, Xiaoguang Lei, Baihui Huang, Joshua D. Rizak, Lichuan Yang, Shangchuan Yang, Jing Wu, Longbao Lü, Jianhong Wang, Ting Yan, Hongwei Li, Zhengbo Wang, Yingzhou Hu, Weidong Le, Xingli Deng, Tianzhuang Huang, Jiali Li, Lin Xu, Baorong Zhang, Xintian Hu. Corrigendum to "A quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections" J. Neurosci. Methods 251 (2015) 99–107. Journal of Neuroscience Methods. 2016, 258: 135-135, http://dx.doi.org/10.1016/j.jneumeth.2015.08.021.
[32] Chen, Jiu, Shu, Hao, Wang, Zan, Liu, Duan, Shi, Yongmei, Xu, Lin, Zhang, Zhijun. Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer's disease. ONCOTARGET[J]. 2016, 7(37): 58789-58801, http://www.irgrid.ac.cn/handle/1471x/1154003.
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[94] Zhang, XiaoBing, Jiang, Peng, Gong, Neng, Hu, XiaoLing, Fei, Da, Xiong, ZhiQi, Xu, Lin, Xu, TianLe. A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol. PLOS ONE[J]. 2008, 3(10): http://www.irgrid.ac.cn/handle/1471x/502202.
[95] Dai, JinXia, Han, HuiLi, Tian, Meng, Cao, Jun, Xiu, JianBo, Song, NingNing, Huang, Ying, Xu, TianLe, Ding, YuQiang, Xu, Lin. Enhanced contextual fear memory in central serotonin-deficient mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2008, 105(33): 11981-11986, http://www.irgrid.ac.cn/handle/1471x/502398.
[96] Zhang, HongXing, Zhao, JingPing, Lv, LuXian, Li, WenQiang, Xu, Lin, Ouyang, Xuan, Yuan, ZhiQing, Huang, JinSong. Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia. NEUROSCIENCE LETTERS[J]. 2008, 438(1): 1-5, http://dx.doi.org/10.1016/j.neulet.2007.09.051.
[97] Zhang, LongHua, Gong, Neng, Fei, Da, Xu, Lin, Xu, TianLe. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. NEUROPSYCHOPHARMACOLOGY[J]. 2008, 33(3): 701-711, http://159.226.149.42:8080:8088/handle/152453/5923.
[98] Liu, Haihong, Li, Lin, Hao, Yihui, Cao, Dong, Xu, Lin, Rohrbaugh, Robert, Xue, Zhimin, Hao, Wei, Shan, Baoci, Liu, Zhening. Disrupted white matter integrity in heroin dependence: A controlled study utilizing diffusion tensor imaging. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE[J]. 2008, 34(5): 562-575, http://www.corc.org.cn/handle/1471x/2175902.
[99] 徐林. 抑郁症的神经可塑性机制. 中南大学学报:医学版. 2008, 33(4): 326-330, http://lib.cqvip.com/Qikan/Article/Detail?id=27211324.
[100] Dong, ZhiFang, Han, HuiLi, Cao, Jun, Zhang, Xia, Xu, Lin. Coincident Activity of Converging Pathways Enables Simultaneous Long-Term Potentiation and Long-Term Depression in Hippocampal CA1 Network In Vivo. PLOS ONE[J]. 2008, 3(8): https://doaj.org/article/ac471ca5a42a49e5ae9e55d37b12d9ce.
[101] Ma, WenPei, Cao, Jun, Tian, Meng, Cui, MingHu, HuiLi, Han, Yang, YueXiong, Xu, Lin. Exposure to chronic constant light impairs spatial memory and influences long-term depression in rats. NEUROSCIENCE RESEARCH[J]. 2007, 59(2): 224-230, http://dx.doi.org/10.1016/j.neures.2007.06.1474.
[102] Yang, Jianli, Hou, Cailan, Ma, Ning, Liu, Jun, Zhang, Yan, Zhou, Jiansong, Xu, Lin, Li, Lingjiang. Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress. NEUROBIOLOGY OF LEARNING AND MEMORY[J]. 2007, 87(2): 257-263, http://dx.doi.org/10.1016/j.nlm.2006.09.001.
[103] 段波, 伍龙军, 于耀清, 丁瑜, 井亮, 徐林, 陈军, 徐天乐. 酸敏感离子通道和炎性痛中枢敏化的机制研究. 中国基础科学[J]. 2007, 30-31, http://lib.cqvip.com/Qikan/Article/Detail?id=1000780943.
[104] 周燕, 田磊, 徐林, 莫宁. 三七总皂苷对大鼠海马CA1区突触传递的作用及机制. 中草药. 2007, 38(7): 1032-1036, http://lib.cqvip.com/Qikan/Article/Detail?id=24952886.
[105] 周燕, 田磊, 徐林, 莫宁. 三七总苷对大鼠海马CA1区兴奋性突触活动的影响. 中国药理学会第九次全国会员代表大会暨全国药理学术会议[J]. 2007, http://www.irgrid.ac.cn/handle/1471x/1179828.
[106] 唐劲松, 陈晓岗, 赵靖平, 徐西嘉, 刘铁桥, 徐林. NMDA受体NR1亚单位基因与精神分裂症的连锁分析. 中国神经精神疾病杂志. 2007, 33(2): 73-76, http://lib.cqvip.com/Qikan/Article/Detail?id=24020690.
[107] Dong, Zhifang, Mao, Rongrong, Han, Huili, Cao, Jun, Xu, Lin. Morphine withdrawal modifies antinociceptive effects of acute morphine in rats. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2006, 346(2): 578-582, http://159.226.149.42:8080:8088/handle/152453/5889.
[108] MeiNa WANG, ZhiFang DONG, Jun CAO, Lin XU. Repeated morphine treatment influences operant and spatial learning dif- ferentially. Neuroscience bulletin[J]. 2006, 22(3): 137-142, http://lib.cqvip.com/Qikan/Article/Detail?id=22005222.
[109] 蔡培强, 汤逊, 林月秋, Blits B, Oudega M, 阳运康, 徐林, 周田华. 基因工程化分泌神经营养因子-3的鼠胚神经干细胞实验研究. 中国康复医学杂志. 2006, 21(5): 398-400, http://lib.cqvip.com/Qikan/Article/Detail?id=22031960.
[110] Mei-Na WANG, Zhi-Fang DONG, Jun CAO, Lin XU. Repeated morphine treatment influences operant and spatial learning differentially. 神经科学通报:英文版. 2006, 22(3): 137-143, http://lib.cqvip.com/Qikan/Article/Detail?id=22005222.
[111] Zhong, Weixia, Dong, Zhifang, Tian, Meng, Cao, Jun, Xu, Tianle, Xu, Lin, Luo, Jianhong. Opiate withdrawal induces dynamic-expressions of AMPA receptors and its regulatory molecule CaMKII alpha in hippocampal synapses. LIFE SCIENCES[J]. 2006, 79(9): 861-869, http://www.irgrid.ac.cn/handle/1471x/502475.
[112] Wang, Meina, Yang, Ya, Dong, Zhifang, Cao, Jun, Xu, Lin. NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo. NEUROREPORT[J]. 2006, 17(12): 1343-1346, http://159.226.149.42:8080:8088/handle/152453/5881.
[113] Dong, Zhifang, Zhong, Weixia, Tian, Meng, Han, Huili, Cao, Jun, Xu, Tianle, Luo, Jianhong, Xu, Lin. Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo. HIPPOCAMPUS[J]. 2006, 16(12): 1017-1025, http://159.226.149.42:8080:8088/handle/152453/5877.
[114] 徐林. 第四届海内外华人神经科学研讨会圆满闭幕. 动物学研究. 2006, 27(4): 374-374, http://lib.cqvip.com/Qikan/Article/Detail?id=22626381.
[115] Yang, Jianli, Li, Weihui, Liu, Xiaohua, Li, Zexuan, Li, Hongying, Yang, Guifu, Xu, Lin, Li, Lingjiang. Enriched environment treatment counteracts enhanced addictive and depressive-like behavior induced by prenatal chronic stress. BRAIN RESEARCH[J]. 2006, 1125: 132-137, http://dx.doi.org/10.1016/j.brainres.2006.10.028.
[116] 蔡培强, 汤逊, 林月秋, OudegaMart, 徐林, B lits, 阳运康. Lentivirus介导神经营养因子- 3促进脊髓损伤大鼠功能恢复. 中华创伤杂志[J]. 2005, 21(7): 485-490, http://www.irgrid.ac.cn/handle/1471x/1153897.
[117] 蔡培强, 汤逊, 林月秋, Martin Oudega, Bas Blits, 徐林, 阳运康. Lentivirus介导分泌神经营养因子-3的基因工程神经干细胞移植治疗脊髓损伤的实验研究. 中华外科杂志. 2005, 43(16): 1091-1093, http://lib.cqvip.com/Qikan/Article/Detail?id=20002313.
[118] 郝以辉, 刘哲宁, 赵靖平, 刘海洪, 徐林. 弥散张量成像在精神分裂症的研究. 国际精神病学杂志. 2005, 32(4): 210-213, http://lib.cqvip.com/Qikan/Article/Detail?id=20586535.
[119] 彭文华, 曹军, 徐林. 在体大鼠海马CA1区侧枝/联合纤维通路和TA通路的不同EPSP空间整合特性. 动物学研究[J]. 2005, 26(5): 534-538, http://lib.cqvip.com/Qikan/Article/Detail?id=20623828.
[120] 谢玉波, 徐林, 刘敬臣, 陈建华. 咪唑安定或丙泊酚拮抗戊四氮对突触传递的影响. 广西医科大学学报. 2005, 22(2): 163-165, http://lib.cqvip.com/Qikan/Article/Detail?id=15835458.
[121] 蔡培强, 汤逊, 林月秋, OudegaMart, 徐林, BlitsB, 阳运康. Lentivims介导神经营养因子-3促进脊髓损伤大鼠功能恢复. 中华创伤杂志. 2005, 21(7): 485-490, http://lib.cqvip.com/Qikan/Article/Detail?id=16032932.
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[123] 谢玉波, 曾邦雄, 徐林, 李兴旺. 丙泊酚对大鼠海马CA1区长时程抑制的影响. 临床麻醉学杂志. 2004, 20(12): 730-732, http://lib.cqvip.com/Qikan/Article/Detail?id=11244117.
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发表著作
( 1 ) 《树鼩基础生物学与疾病模型》, 云南科技出版社, 2014-10, 第 3 作者

科研活动

   
科研项目
( 1 ) 树鼩的人类疾病模型建立, 主持, 部委级, 2011-01--2013-12
( 2 ) 阿片成瘾及戒断的基础和应用研究, 主持, 国家级, 2011-01--2014-12
( 3 ) 神经网络功能发育中的可塑性机制, 参与, 国家级, 2009-01--2013-12
( 4 ) 海马脑区局部环路和调控机制, 主持, 部委级, 2012-09--2016-12
( 5 ) 遗忘的功能和机制研究, 主持, 国家级, 2013-01--2017-08
( 6 ) 阿片类物质精神依赖的神经生物学机制, 参与, 国家级, 2014-01--2018-12

合作情况

   
项目协作单位

加拿大渥太华大学; 

中国科学技术大学;

同济大学;

东南大学;

中国科学院植物研究所;

中国科学院高能物理研究所;

中国科学院上海药物研究所;

中南大学湘雅二医院精神卫生研究所。

指导学生

已指导学生

熊文勇  博士研究生  071002-动物学  

董志芳  博士研究生  071002-动物学  

王美娜  博士研究生  071002-动物学  

张继川  博士研究生  071002-动物学  

杨雅  博士研究生  071002-动物学  

李红斌  博士研究生  071002-动物学  

彭文华  硕士研究生  071009-细胞生物学  

毛榕榕  博士研究生  071002-动物学  

周启心  博士研究生  071002-动物学  

韩会丽  博士研究生  071002-动物学  

田孟  博士研究生  071002-动物学  

程宇琪  博士研究生  071002-动物学  

吴坤  硕士研究生  071009-细胞生物学  

温菲  硕士研究生  071006-神经生物学  

井亮  博士研究生  071009-细胞生物学  

谭继伟  博士研究生  071006-神经生物学  

贾云芳  博士研究生  071006-神经生物学  

熊贵静  博士研究生  071006-神经生物学  

郭昊  硕士研究生  071006-神经生物学  

王静  博士研究生  071006-神经生物学  

唐研平  硕士研究生  071006-神经生物学  

单丽丽  博士研究生  071006-神经生物学  

现指导学生

柴安平  博士研究生  071006-神经生物学  

焦春香  博士研究生  071006-神经生物学  

王妮娅  硕士研究生  071006-神经生物学  

浦德林  硕士研究生  071006-神经生物学  

杨春先  博士研究生  071006-神经生物学  

李津南  博士研究生  071006-神经生物学  

陈雪峰  博士研究生  071006-神经生物学  

刘超  硕士研究生  071006-神经生物学  

赵白真  硕士研究生  071006-神经生物学  

马晨  博士研究生  071006-神经生物学  

李勐  博士研究生  071006-神经生物学