利用X射线晶体学和小角散射等结构生物学手段，研究生物大分子三维结构，在分子水平上阐明生物大分子在重要生理和重大疾病中的作用机制，为疾病治疗新靶点的发现和药物开发提供基础。

1.表遗传调控因子在发育和癌症发生中的作用机制研究

2.囊泡运输及信号转导调控机制研究

   

071010-生物化学与分子生物学

生物大分子结构与功能

2006-09--2012-06   中国科学技术大学   博士
2002-09--2006-06   江西师范大学   本科

博士研究生

理学博士

   

2024-04~现在, 中国科学院广州生物医药与健康研究院, 研究员
2017-01~2024-04,中国科学院广州生物医药与健康研究院, 副研究员
2012-07~2016-12,中国科学院广州生物医药与健康研究院, 助理研究员

   

[1] Biochemical and Biophysical Research Communications. 2023,   通讯作者  
[2] Yulong Zhang, Rui Chen, Yan Dong, Jiabin Zhu, Kai Su, Jinsong Liu, Jinxin Xu. Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins. Journal of Molecular Biology[J]. 2022, 第 7 作者  通讯作者  434(21): http://dx.doi.org/10.1016/j.jmb.2022.167823.
[3] Xu, Jinxin, Jiang, Xin, Zhang, Yulong, Dong, Yan, Ma, Changli, Jiang, Hanqiu, Zuo, Taisen, Chen, Rui, Ke, Yubin, Cheng, He, Wang, Howard, Liu, Jinsong. Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2. Communications Biology[J]. 2022, 第 1 作者5(1): http://dx.doi.org/10.1038/s42003-022-03892-x.
[4] Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li, Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu, Donghai Wu, Jinsong Liu, Yong Xu. Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist. J Med Chem[J]. 2021, 第 12 作者
[5] Xu, Jinxin, Tang, Xiaowen, Zhu, Yiguang, Yu, Zhijun, Su, Kai, Zhang, Yulong, Dong, Yan, Zhu, Weiming, Zhang, Changsheng, Wu, Ruibo, Liu, Jinsong. Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition. Communications Biology[J]. 2020, 第 1 作者  通讯作者  3(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000567406600004.
[6] Pang, Pengfei, Hu, Xiaojun, Zhou, Bin, Mao, Junjie, Liang, Yu, Jiang, Zaibo, Huang, Mingsheng, Liu, Ruihong, Zhang, Youyong, Qian, Jiesheng, Liu, Jinsong, Xu, Jinxin, Zhang, Yaqin, Zu, Maoheng, Wang, Yiming, He, Huanhuan, Shan, Hong. DDX24 Mutations Associated With Malformations of Major Vessels to the Viscera. HEPATOLOGY[J]. 2019, 第 12 作者69(2): 803-816, https://www.webofscience.com/wos/woscc/full-record/WOS:000457447700026.
[7] Zhang, Yan, Wu, Xishan, Xue, Xiaoqian, Li, Chenchang, Wang, Junjian, Wang, Rui, Zhang, Cheng, Wang, Chao, Shi, Yudan, Zou, Lingjiao, Li, Qiu, Huang, Zenghong, Hao, Xiaojuan, Loomes, Kerry, Wu, Donghai, Chen, HongWu, Xu, Jinxin, Xu, Yong. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 第 17 作者62(9): 4716-4730, http://dx.doi.org/10.1021/acs.jmedchem.9b00327.
[8] Na Wang, Qingan Zou, Jinxin Xu, Jiancun Zhang, Jinsong Liu. Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding. JOURNAL OF BIOLOGICAL CHEMISTRY. 2018, 第 3 作者293(47): 18180-18191, http://dx.doi.org/10.1074/jbc.RA118.004652.
[9] Xu, Jinxin, Zhang, Leilei, Ye, Yinghua, Shan, Yongli, Wan, Chanjuan, Wang, Junfeng, Pei, Duanqing, Shu, Xiaodong, Liu, Jinsong. SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding. Structure[J]. 2017, 第 1 作者25(8): 1251-+, http://dx.doi.org/10.1016/j.str.2017.06.015.
[10] Su, Kai, Xu, Tingting, Yu, Zhijun, Zhu, Jiabin, Zhang, Yulong, Wu, Minhao, Xiong, Ying, Liu, Jinsong, Xu, Jinxin. Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain. FEBS LETTERS[J]. 2017, 第 9 作者  通讯作者  591(13): 2011-2018, https://www.doi.org/10.1002/1873-3468.12688.
[11] Hou, Shulin, Xu, Tingting, Xu, Jinxin, Qu, Linbing, Xu, Yong, Chen, Ling, Liu, Jinsong. Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A(2) group IIE. SCIENTIFIC REPORTS[J]. 2017, 第 3 作者7(1): https://doaj.org/article/b20fd0d4f09a4ae6b3ee5de809b75eaa.
[12] Wu, You, Xu, Tingting, Liu, Jinsong, Ding, Ke, Xu, Jinxin. Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2017, 第 5 作者  通讯作者  487(2): 339-343, http://dx.doi.org/10.1016/j.bbrc.2017.04.061.
[13] Zhu, Yiguang, Xu, Jinxin, Mei, Xiangui, Feng, Zhan, Zhang, Liping, Zhang, Qingbo, Zhang, Guangtao, Zhu, Weiming, Liu, Jinsong, Zhang, Changsheng. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis. ACS CHEMICAL BIOLOGY[J]. 2016, 第 2 作者11(4): 943-952, 
[14] Guo, Shaohua, Xu, Jinxin, Pavlidis, Ioannis V, Lan, Dongming, Bornscheuer, Uwe T, Liu, Jinsong, Wang, Yonghua. Structure of product-bound SMG1 lipase: active site gating implications. FEBS JOURNAL[J]. 2015, 第 2 作者282(23): 4538-4547, http://ir.gibh.ac.cn/handle/344009/451.
[15] Xu Jinxin, Xu Tingting, Wu Bin, Ye Yinghua, You Xiaojuan, Shu Xiaodong, Pei Duanqing, Liu Jinsong. Structure of Sorting Nexin 11 (SNX11) Reveals a Novel Extended Phox Homology (PX) Domain Critical for Inhibition of SNX10-induced Vacuolation *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 第 1 作者288(23): 16598-16605, http://dx.doi.org/10.1074/jbc.M112.449306.

   

（ 1 ） RGS-PX蛋白调节内涵体上GPCR-G蛋白信号转导的分子机制研究, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） NudCMab调节脓肿分枝杆菌抵抗异烟肼和乙硫异烟胺的机制研究, 负责人, 其他, 2024-01--2026-12
（ 3 ） 磷酸酶蛋白IMD-P01和IMD-P02的纯化及其相关晶体结构测定, 负责人, 境内委托项目, 2023-08--2025-08