(1) 分选转运相关蛋白调控内涵体运输以及信号转导的分子机制研究；

(2) 表观遗传调控因子或复合物的结构与功能研究；

(3) 基于靶点结构的药物发现。

   

071010-生物化学与分子生物学

生物大分子结构与功能

2006-09--2012-06   中国科学技术大学   博士
2002-09--2006-06   江西师范大学   本科

博士研究生

理学博士

   

2024-04~现在, 中国科学院广州生物医药与健康研究院, 研究员
2017-01~2024-04,中国科学院广州生物医药与健康研究院, 副研究员
2012-07~2016-12,中国科学院广州生物医药与健康研究院, 助理研究员

   

[1] 孙益嵘, 徐进新, 王凌. α-硫辛酸的生物合成方法、工程菌株及其制备方法. 202411522888.5, 2024-10-29.

   

[1] NATURE COMMUNICATIONS. 2025, 第 2 作者
[2] Wenjing Bai, Jinxin Xu, Wenbin Gu, Danyang Wang, Ying Cui, Weidong Rong, Xiaoan Du, Xiaoxia Li, Cuicui Xia, Qingqing Gan, Guantao He, Huahui Guo, Jinfeng Deng, Yuqiong Wu, RayWhay Chiu Yen, Srinivasan Yegnasubramanian, Scott B Rothbart, Cheng Luo, Linping Wu, Jinsong Liu, Stephen B Baylin, Xiangqian Kong. Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy. NATURE COMMUNICATIONS[J]. 2025, 第 2 作者16(null): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707192/.
[3] Rui Chen, Feng Shen, Yulong Zhang, Mingze Sun, Yan Dong, Yue Yin, Chen Su, Chao Peng, Jinsong Liu, Jinxin Xu. Calcium modulates the tethering of BCOR-PRC1.1 enzymatic core to KDM2B via liquid-liquid phase separation. COMMUNICATIONS BIOLOGY[J]. 2024, 第 10 作者  通讯作者  7(null): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387744/.
[4] Meng, Lingyu, Sun, Zhaojian, Zhang, Yulong, Dong, Yan, Du, Xiaoan, Wu, Yujian, Yuan, Yuan, Sun, Yirong, Xu, Yong, Ding, Huaiwei, Liu, Jinsong, Xu, Jinxin. Structural Studies on Mycobacterial NudC Reveal a Class of Zinc Independent NADH Pyrophosphatase. JOURNAL OF MOLECULAR BIOLOGY[J]. 2024, 第 12 作者  通讯作者  436(23): http://dx.doi.org/10.1016/j.jmb.2024.168864.
[5] Yulong Zhang, Zhijun Yu, Mingwei Sun, Ruyue Du, Hanhan Gao, Qiankun Dai, Yan Dong, Cuicui Liu, Menghui Yin, Tingting Xu, Xiaofei Zhang, Jinsong Liu, Jinxin Xu. Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes. REDOX BIOLOGY[J]. 2024, 第 13 作者  通讯作者  75(null): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259961/.
[6] Chen, Rui, Su, Kai, Zhang, Yulong, Zhu, Yiguang, Liu, Jinsong, Xu, Jinxin. Co-crystal structure provides insights on transaminase CrmG recognition amino donor L-Arg. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2023, 第 6 作者  通讯作者  675(null): 41-45, http://dx.doi.org/10.1016/j.bbrc.2023.07.009.
[7] Yulong Zhang, Rui Chen, Yan Dong, Jiabin Zhu, Kai Su, Jinsong Liu, Jinxin Xu. Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins. Journal of Molecular Biology[J]. 2022, 第 7 作者  通讯作者  434(21): http://dx.doi.org/10.1016/j.jmb.2022.167823.
[8] Xu, Jinxin, Jiang, Xin, Zhang, Yulong, Dong, Yan, Ma, Changli, Jiang, Hanqiu, Zuo, Taisen, Chen, Rui, Ke, Yubin, Cheng, He, Wang, Howard, Liu, Jinsong. Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2. Communications Biology[J]. 2022, 第 1 作者5(1): http://dx.doi.org/10.1038/s42003-022-03892-x.
[9] Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li, Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu, Donghai Wu, Jinsong Liu, Yong Xu. Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist. J Med Chem[J]. 2021, 第 12 作者
[10] Xu, Tingting, Gan, Qingqing, Wu, Bin, Yin, Menghui, Xu, Jinxin, Shu, Xiaodong, Liu, Jinsong. Molecular Basis for PI(3,5)P-2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation. JOURNAL OF MOLECULAR BIOLOGY[J]. 2020, 第 5 作者432(16): 4750-4761, http://dx.doi.org/10.1016/j.jmb.2020.06.010.
[11] Hou, Shulin, Zhang, Yulong, Xu, Jinxin, Bai, Junping, Liu, Jinsong, Xie, Jun, Xu, Tingting. Residue Asn21 acts as a switch for calcium binding to modulate the enzymatic activity of human phospholipase A2 group IIE. BIOCHIMIE[J]. 2020, 第 3 作者176: 117-121, http://dx.doi.org/10.1016/j.biochi.2020.07.003.
[12] Xu, Jinxin, Tang, Xiaowen, Zhu, Yiguang, Yu, Zhijun, Su, Kai, Zhang, Yulong, Dong, Yan, Zhu, Weiming, Zhang, Changsheng, Wu, Ruibo, Liu, Jinsong. Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition. Communications Biology[J]. 2020, 第 1 作者  通讯作者  3(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000567406600004.
[13] Pang, Pengfei, Hu, Xiaojun, Zhou, Bin, Mao, Junjie, Liang, Yu, Jiang, Zaibo, Huang, Mingsheng, Liu, Ruihong, Zhang, Youyong, Qian, Jiesheng, Liu, Jinsong, Xu, Jinxin, Zhang, Yaqin, Zu, Maoheng, Wang, Yiming, He, Huanhuan, Shan, Hong. DDX24 Mutations Associated With Malformations of Major Vessels to the Viscera. HEPATOLOGY[J]. 2019, 第 12 作者69(2): 803-816, https://www.webofscience.com/wos/woscc/full-record/WOS:000457447700026.
[14] Zhang, Yan, Wu, Xishan, Xue, Xiaoqian, Li, Chenchang, Wang, Junjian, Wang, Rui, Zhang, Cheng, Wang, Chao, Shi, Yudan, Zou, Lingjiao, Li, Qiu, Huang, Zenghong, Hao, Xiaojuan, Loomes, Kerry, Wu, Donghai, Chen, HongWu, Xu, Jinxin, Xu, Yong. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 第 17 作者62(9): 4716-4730, http://dx.doi.org/10.1021/acs.jmedchem.9b00327.
[15] Wang, Na, Zou, Qingan, Xu, Jinxin, Zhang, Jiancun, Liu, Jinsong. Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 第 3 作者293(47): 18180-18191, https://www.webofscience.com/wos/woscc/full-record/WOS:000451375200013.
[16] Lan, Dongming, Xu, Huan, Xu, Jinxin, Dubin, Grzegorz, Liu, Jinsong, Khan, Faez Iqbal, Wang, Yonghua. Malassezia globosa MgMDL2 lipase: Crystal structure and rational modification of substrate specificity. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2017, 第 3 作者488(2): 259-265, http://dx.doi.org/10.1016/j.bbrc.2017.04.103.
[17] Xu, Jinxin, Zhang, Leilei, Ye, Yinghua, Shan, Yongli, Wan, Chanjuan, Wang, Junfeng, Pei, Duanqing, Shu, Xiaodong, Liu, Jinsong. SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding. Structure[J]. 2017, 第 1 作者25(8): 1251-+, http://dx.doi.org/10.1016/j.str.2017.06.015.
[18] Su, Kai, Xu, Tingting, Yu, Zhijun, Zhu, Jiabin, Zhang, Yulong, Wu, Minhao, Xiong, Ying, Liu, Jinsong, Xu, Jinxin. Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain. FEBS LETTERS[J]. 2017, 第 9 作者  通讯作者  591(13): 2011-2018, https://www.doi.org/10.1002/1873-3468.12688.
[19] Hou, Shulin, Xu, Tingting, Xu, Jinxin, Qu, Linbing, Xu, Yong, Chen, Ling, Liu, Jinsong. Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A(2) group IIE. SCIENTIFIC REPORTS[J]. 2017, 第 3 作者7(1): https://doaj.org/article/b20fd0d4f09a4ae6b3ee5de809b75eaa.
[20] Wu, You, Xu, Tingting, Liu, Jinsong, Ding, Ke, Xu, Jinxin. Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2017, 第 5 作者  通讯作者  487(2): 339-343, http://dx.doi.org/10.1016/j.bbrc.2017.04.061.
[21] Zhu, Yiguang, Xu, Jinxin, Mei, Xiangui, Feng, Zhan, Zhang, Liping, Zhang, Qingbo, Zhang, Guangtao, Zhu, Weiming, Liu, Jinsong, Zhang, Changsheng. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis. ACS CHEMICAL BIOLOGY[J]. 2016, 第 2 作者11(4): 943-952, 
[22] Lan, Dongming, Wang, Qian, Xu, Jinxin, Zhou, Pengfei, Yang, Bo, Wang, Yonghua. Residue Asn277 Affects the Stability and Substrate Specificity of the SMG1 Lipase from Malassezia globosa. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2015, 第 3 作者16(4): 7273-7288, http://ir.gibh.ac.cn/handle/344009/564.
[23] Guo, Shaohua, Xu, Jinxin, Pavlidis, Ioannis V, Lan, Dongming, Bornscheuer, Uwe T, Liu, Jinsong, Wang, Yonghua. Structure of product-bound SMG1 lipase: active site gating implications. FEBS JOURNAL[J]. 2015, 第 2 作者282(23): 4538-4547, https://www.doi.org/10.1111/febs.13513.
[24] Xu, Tingting, Xu, Jinxin, Ye, Yinghua, Wang, Qi, Shu, Xiaodong, Pei, Duanqing, Liu, Jinsong. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS[J]. 2014, 第 2 作者82(12): 3483-3489, https://www.doi.org/10.1002/prot.24689.
[25] Xu, Jinxin, Xu, Tingting, Wu, Bin, Ye, Yinghua, You, Xiaojuan, Shu, Xiaodong, Pei, Duanqing, Liu, Jinsong. Structure of Sorting Nexin 11 (SNX11) Reveals a Novel Extended Phox Homology (PX) Domain Critical for Inhibition of SNX10-induced Vacuolation. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2013, 第 1 作者288(23): 16598-16605, http://dx.doi.org/10.1074/jbc.M112.449306.
[26] Xu, Tingting, Liu, Lu, Hou, Shulin, Xu, Jinxin, Yang, Bo, Wang, Yonghua, Liu, Jinsong. Crystal structure of a mono- and diacylglycerol lipase from Malassezia globosa reveals a novel lid conformation and insights into the substrate specificity. JOURNAL OF STRUCTURAL BIOLOGY[J]. 2012, 第 4 作者178(3): 363-369, http://dx.doi.org/10.1016/j.jsb.2012.03.006.
[27] Yulong Zhang, Rui Chen, Yan Dong, Jiabin Zhu, Kai Su, Jinsong Liu, Jinxin Xu. Structural studies reveal unique non-canonical regulators of G protein signaling homology (RH) domains in sorting nexins. JOURNAL OF MOLECULAR BIOLOGY. 第 7 作者  通讯作者  http://dx.doi.org/10.1016/j.jmb.2022.167823.
[28] Xu Jinxin, Xu Tingting, Wu Bin, Ye Yinghua, You Xiaojuan, Shu Xiaodong, Pei Duanqing, Liu Jinsong. Structure of Sorting Nexin 11 (SNX11) Reveals a Novel Extended Phox Homology (PX) Domain Critical for Inhibition of SNX10-induced Vacuolation *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 第 1 作者288(23): 16598-16605, http://dx.doi.org/10.1074/jbc.M112.449306.

   

（ 1 ） RGS-PX蛋白调节内涵体上GPCR-G蛋白信号转导的分子机制研究, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） NudCMab调节脓肿分枝杆菌抵抗异烟肼和乙硫异烟胺的机制研究, 负责人, 其他, 2024-01--2026-12
（ 3 ） 磷酸酶蛋白IMD-P01和IMD-P02的纯化及其相关晶体结构测定, 负责人, 境内委托项目, 2023-08--2025-08