基本信息
薛超友 男 博导 中国科学院天津工业生物技术研究所
电子邮件： xuechy@tib.cas.cn
通信地址： 天津市东丽区西七道32号
邮政编码：
电子邮件： xuechy@tib.cas.cn
通信地址： 天津市东丽区西七道32号
邮政编码：
招生信息
招生专业
071010-生物化学与分子生物学
071007-遗传学
071007-遗传学
招生方向
基因编辑，DNA修复，合成生物学，绿色生物制造，单分子DNA帘，单分子荧光能量共振转移
教育背景
2013-08--2017-12 美国爱荷华州立大学 博士学位
2010-08--2013-07 天津大学 硕士学位
2006-09--2010-07 西北农林科技大学 学士学位
2010-08--2013-07 天津大学 硕士学位
2006-09--2010-07 西北农林科技大学 学士学位
工作经历
工作简历
2021-01~现在, 中国科学院天津工业生物技术研究所, 研究员
2017-12~2020-12,美国哥伦比亚大学, 博士后
2017-12~2020-12,美国哥伦比亚大学, 博士后
教授课程
分子生物物理实验
专利与奖励
奖励信息
（1） 最佳博士论文奖, , 研究所（学校）, 2017
（2） 天津市优秀硕士论文奖, 省级, 2015
（2） 天津市优秀硕士论文奖, 省级, 2015
出版信息
发表论文
[1] Unciuleac, MihaelaCarmen, Meir, Aviv, Xue, Chaoyou, Warren, Garrett M, Greene, Eric C, Shuman, Stewart. Clutch mechanism of chemomechanical coupling in a DNA resecting motor nuclease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 118(11): https://www.webofscience.com/wos/woscc/full-record/WOS:000629635100083.
[2] Xue, Chaoyou, Greene, Eric C. DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing. TRENDS IN GENETICSnull. 2021, 37(7): 639-656, http://dx.doi.org/10.1016/j.tig.2021.02.008.
[3] Adolph, Madison B, Mohamed, Taha M, Balakrishnan, Swati, Xue, Chaoyou, Morati, Florian, Modesti, Mauro, Greene, Eric C, Chazin, Walter J, Cortez, David. RADX controls RAD51 filament dynamics to regulate replication fork stability. MOLECULAR CELL[J]. 2021, 81(5): 1074-1083.e5, http://dx.doi.org/10.1016/j.molcel.2020.12.036.
[4] Xue, Chaoyou, Molnarova, Lucia, Steinfeld, Justin B, Zhao, Weixing, Ma, Chujian, Spirek, Mario, Kaniecki, Kyle, Kwon, Youngho, Belan, Ondrej, Krejci, Katerina, Boulton, Simon J, Sung, Patrick, Greene, Eric C, Krejci, Lumir. Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(1): 285-305, https://www.webofscience.com/wos/woscc/full-record/WOS:000610552100027.
[5] Kong, Muwen, Cutts, Erin E, Pan, Dongqing, Beuron, Fabienne, Kaliyappan, Thangavelu, Xue, Chaoyou, Morris, Edward P, Musacchio, Andrea, Vannini, Alessandro, Greene, Eric C. Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA. MOLECULAR CELL[J]. 2020, 79(1): 99-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335352/.
[6] Yan, Zhenxin, Xue, Chaoyou, Kumar, Sandeep, Crickard, J Brooks, Yu, Yang, Wang, Weibin, Nhung Pham, Li, Yuxi, Niu, Hengyao, Sung, Patrick, Greene, Eric C, Ira, Grzegorz. Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast. MOLECULAR CELL[J]. 2019, 76(5): 699-+, http://dx.doi.org/10.1016/j.molcel.2019.08.017.
[7] Crickard, J Brooks, Xue, Chaoyou, Wang, Weibin, Kwon, Youngho, Sung, Patrick, Greene, Eric C. The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(9): 4694-4706, https://www.webofscience.com/wos/woscc/full-record/WOS:000473756300031.
[8] Xue, Chaoyou, Daley, James M, Xue, Xiaoyu, Steinfeld, Justin, Kwon, Youngho, Sung, Patrick, Greene, Eric C. Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates. NUCLEICACIDSRESEARCH[J]. 2019, 47(21): 11225-11237, [9] Jia, Ning, Unciuleac, Mihaela C, Xue, Chaoyou, Greene, Eric C, Patel, Dinshaw J, Shuman, Stewart. Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(49): 24507-24516, http://dx.doi.org/10.1073/pnas.1913546116.
[10] Chaoyou Xue, Dipali G Sashital. Mechanisms of type I-E and I-F CRISPR-Cas systems in Enterobacteriaceae. ECOSAL PLUS. 2019, 8(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368399/.
[11] Phan, Phong T, Schelling, Michael, Xue, Chaoyou, Sashital, Dipali G, Bailey, S. Fluorescence-based methods for measuring target interference by CRISPR-Cas systems. CRISPR-CAS ENZYMESnull. 2019, 616: 61-85, [12] Xue, Chaoyou, Greene, Eric C. New roles for RAD52 in DNA repair. CELLRESEARCH[J]. 2018, 28(12): 1127-1128, http://lib.cqvip.com/Qikan/Article/Detail?id=6100228433.
[13] Xue, Chaoyou, Zhu, Yicheng, Zhang, Xiangmei, Shin, YeonKyun, Sashital, Dipali G. Real-Time Observation of Target Search by the CRISPR Surveillance Complex Cascade. CELL REPORTS[J]. 2017, 21(13): 3717-3727, http://dx.doi.org/10.1016/j.celrep.2017.11.110.
[14] Xue, Chaoyou, Whitis, Natalie R, Sashital, Dipali G. Conformational Control of Cascade Interference and Priming Activities in CRISPR Immunity. MOLECULAR CELL[J]. 2016, 64(4): 826-834, http://dx.doi.org/10.1016/j.molcel.2016.09.033.
[2] Xue, Chaoyou, Greene, Eric C. DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing. TRENDS IN GENETICSnull. 2021, 37(7): 639-656, http://dx.doi.org/10.1016/j.tig.2021.02.008.
[3] Adolph, Madison B, Mohamed, Taha M, Balakrishnan, Swati, Xue, Chaoyou, Morati, Florian, Modesti, Mauro, Greene, Eric C, Chazin, Walter J, Cortez, David. RADX controls RAD51 filament dynamics to regulate replication fork stability. MOLECULAR CELL[J]. 2021, 81(5): 1074-1083.e5, http://dx.doi.org/10.1016/j.molcel.2020.12.036.
[4] Xue, Chaoyou, Molnarova, Lucia, Steinfeld, Justin B, Zhao, Weixing, Ma, Chujian, Spirek, Mario, Kaniecki, Kyle, Kwon, Youngho, Belan, Ondrej, Krejci, Katerina, Boulton, Simon J, Sung, Patrick, Greene, Eric C, Krejci, Lumir. Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(1): 285-305, https://www.webofscience.com/wos/woscc/full-record/WOS:000610552100027.
[5] Kong, Muwen, Cutts, Erin E, Pan, Dongqing, Beuron, Fabienne, Kaliyappan, Thangavelu, Xue, Chaoyou, Morris, Edward P, Musacchio, Andrea, Vannini, Alessandro, Greene, Eric C. Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA. MOLECULAR CELL[J]. 2020, 79(1): 99-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335352/.
[6] Yan, Zhenxin, Xue, Chaoyou, Kumar, Sandeep, Crickard, J Brooks, Yu, Yang, Wang, Weibin, Nhung Pham, Li, Yuxi, Niu, Hengyao, Sung, Patrick, Greene, Eric C, Ira, Grzegorz. Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast. MOLECULAR CELL[J]. 2019, 76(5): 699-+, http://dx.doi.org/10.1016/j.molcel.2019.08.017.
[7] Crickard, J Brooks, Xue, Chaoyou, Wang, Weibin, Kwon, Youngho, Sung, Patrick, Greene, Eric C. The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(9): 4694-4706, https://www.webofscience.com/wos/woscc/full-record/WOS:000473756300031.
[8] Xue, Chaoyou, Daley, James M, Xue, Xiaoyu, Steinfeld, Justin, Kwon, Youngho, Sung, Patrick, Greene, Eric C. Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates. NUCLEICACIDSRESEARCH[J]. 2019, 47(21): 11225-11237, [9] Jia, Ning, Unciuleac, Mihaela C, Xue, Chaoyou, Greene, Eric C, Patel, Dinshaw J, Shuman, Stewart. Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(49): 24507-24516, http://dx.doi.org/10.1073/pnas.1913546116.
[10] Chaoyou Xue, Dipali G Sashital. Mechanisms of type I-E and I-F CRISPR-Cas systems in Enterobacteriaceae. ECOSAL PLUS. 2019, 8(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368399/.
[11] Phan, Phong T, Schelling, Michael, Xue, Chaoyou, Sashital, Dipali G, Bailey, S. Fluorescence-based methods for measuring target interference by CRISPR-Cas systems. CRISPR-CAS ENZYMESnull. 2019, 616: 61-85, [12] Xue, Chaoyou, Greene, Eric C. New roles for RAD52 in DNA repair. CELLRESEARCH[J]. 2018, 28(12): 1127-1128, http://lib.cqvip.com/Qikan/Article/Detail?id=6100228433.
[13] Xue, Chaoyou, Zhu, Yicheng, Zhang, Xiangmei, Shin, YeonKyun, Sashital, Dipali G. Real-Time Observation of Target Search by the CRISPR Surveillance Complex Cascade. CELL REPORTS[J]. 2017, 21(13): 3717-3727, http://dx.doi.org/10.1016/j.celrep.2017.11.110.
[14] Xue, Chaoyou, Whitis, Natalie R, Sashital, Dipali G. Conformational Control of Cascade Interference and Priming Activities in CRISPR Immunity. MOLECULAR CELL[J]. 2016, 64(4): 826-834, http://dx.doi.org/10.1016/j.molcel.2016.09.033.
科研活动
科研项目
（ 1 ） 单分子技术介导的微生物基因组工程改造及应用, 主持, 省级, 2021-01--2024-01