基本信息
刘欣安  女  博导  中国科学院深圳先进技术研究院
电子邮件: xa.liu@siat.ac.cn
通信地址: 深圳南山区西丽大学城学苑大道1068号
邮政编码:

招生信息

   
招生专业
071006-神经生物学
100705-微生物与生化药学
100800-中药学
招生方向
精神疾病的脑肠轴机制
神经-微生物互作机制在疾病中的作用
电子烟成瘾

教育背景

2005-09--2010-06   华中科技大学同济医学院   博士

工作经历

   
工作简历
2015-12~2019-01,Icahn School of Medicine at Mount Sinai, 博士后
2010-10~2015-06,The Scripps Research Institute, 博士后

出版信息

1.     Chen Z, Liu XA#, Kenny PJ#. Central and peripheral actions of nicotine that influence blood glucose homeostasis and the development of diabetes. Pharmacol Res. 2023 Jul 21; 194:106860. (# Co-corresponding authors)

2.     Muhammad F, Fan B, Wang R, Ren J, Jia S, Wang L, Chen Z, Liu XA. Int J Mol Sci. 2022 Dec 6; 23(23):15389.

3.     Jia S, Guo X, Chen Z, Li S, Liu XA. The roles of the circadian hormone melatonin in drug addiction. Pharmacol Res. 2022 Jul 28; 183:106371.

4.     Jia X, Chen S, Li X, Tao S, Lai J, Liu H, Huang K, Tian Y, Wei P, Yang F, Lu Z, Chen Z, Liu XA, Xu F, Wang L. Divergent neurocircuitry dissociates two components of the stress response: glucose mobilization and anxiety-like behavior. Cell Rep. 2022 Nov 8; 41(6):111586.

5.     Li F#, Fu L#, Liu X#, Liu XA#, Liang Y, Lv Y, Yang Z, Guo A, Chen Z, Li W, Pan F, Luo Q. Serum metabolomic abnormalities in survivors of non-severe COVID-19. Heliyon. 2022 Sep;8(9):e10473. (# Co-first authors)

6.     Xu ZB#, Tian Y#, Li AX#, Tang JH, Jing XY, Deng CS, Mo ZZ, Wang JX, Lai J, Liu XM, Guo XT, Li T, Li SP, Wang LP, Lu ZH, Chen ZX*, Liu XA*.  Menthol Flavor in E-Cigarette Vapor Modulates Social Behavior Correlated With Central and Peripheral Changes of Immunometabolic Signalings. Front. Mol. Neurosci., 10 March 2022.

7.     Chu M, Fu G, Deng J, Wang R, Fan Q, Chen Z, Lu J, Liu XA. Evaluation of the inhalation toxicity of arecoline benzoate aerosol in rats. J Appl Toxicol. 2022 Feb 15.

8.     Wang Y, Tang J, Lv Q, Tan Y, Dong X, Liu H, Zhao N, He Z, Kou Y, Tan Y, Liu XA, Wang L, Liu YY, Dai L. Establishment and resilience of transplanted gut microbiota in aged mice. iScience. 2021 Dec 18;25(1):103654.

9.     Swarnkar S, Avchalumov Y#, Espadas I#, Grinman E, Liu XA, Raveendra BL, Zucca A, Mediouni S, Sadhu A, Valente S, Page D, Miller K, Puthanveettil SV. Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation. Cell Rep. 2021 Jul 13;36(2):109369. (# Contributed equally)

10.  Zeng Z, Xu L, Xie XY, Yan HL, Xie BJ, Xu WZ, Liu XA, Kang GJ, Jiang WL, Yuan JP. Pulmonary pathology of early-phase COVID-19 pneumonia in a patient with a benign lung lesion. Histopathology. 2020 Nov;77(5):823-831.

11.  Jia XL#, Liu XA#, Shi Y, Yao SQ, Zhong X, Tian Y, Tian Q, Chen ZX*, Wang LP*. Profiling of key brain nuclei involved in CNS control of stress and glucose homeostasis. Biochem Biophys Res Commun. 2020 Jan 8;521(2):441-448. (# Contributed equally)

12.  Duncan A#, Heyer MP#, Ishikawa M#, Caligiuri SPB#, Liu XA, Chen Z, Vittoria Micioni Di Bonaventura M, Elayouby KS, Ables JL, Howe WM, Bali P, Fillinger C, Williams M, O'Connor RM, Wang Z, Lu Q, Kamenecka TM, Ma'ayan A, O'Neill HC, Ibanez-Tallon I, Geurts AM, Kenny PJ. Nature. 2019 Oct;574(7778):372-377. (# Contributed equally)

13.  Liu XA & Kenny PJ. Cocaine-metabolizing skin grafts. Nat Biomed Eng. 2019 Feb;3(2):81-82.

14.  Badal KK, Akhmedov K, Lamoureux P, Liu XA, Reich A, Fallahi-Sichani M, Swarnkar S, Miller KE, Puthanveettil SV. Synapse Formation Activates a Transcriptional Program for Persistent Enhancement in the Bi-directional Transport of Mitochondria. Cell Rep. 2019 Jan 15;26(3):507-517.e3.

15.  Raveendra BL, Swarnkar S, Avchalumov Y, Liu XA, Grinman E, Badal K, Reich A, Pascal BD, Puthanveettil SV. Long noncoding RNA GM12371 acts as a transcriptional regulator of synapse function. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10197-E10205.

16.  Liu XA & Kenny PJ. α5 nicotinic receptors link smoking to schizophrenia. Nature Medicine. 2017. Mar 7; 23(3):277-278. 

17.  Tuesta LM, Chen Z, Duncan A, Fowler CD, Ishikawa M, Lee BR, Liu XA, Lu Q, Cameron M, Hayes MR, Kamenecka TM, Pletcher M, Kenny PJ. GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat Neurosci. 2017 May; 20(5):708-716.

18.  Wang Y, Tian Q, Liu EJ, Zhao L, Song J, Liu XA, Ren QG, Jiang X, Zeng J, Yang YT, Wang JZ. Activation of GSK-3 disrupts cholinergic homoeostasis in nucleus basalis of Meynert and frontal cortex of rats. J Cell Mol Med. 2017 Jun 28.

19.  Chen L, Liu X, Wang H, Qu M. Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice. Neurosci Bull. 2016 Dec 1.

20.  Rizzo V, Touzani K, Raveendra BL, Swarnkar S, Lora J, Kadakkuzha BM, Liu XA, Zhang C, Betel D, Stackman RW, Puthanveettil SV. Encoding of Contextual Fear Memory Requires De Novo Proteins in the Prelimbic Cortex. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar;2(2):158-169.

21.  Carletti F, Sardo P, Gambino G, Liu XA, Ferraro G, Rizzo V. Hippocampal Hyperexcitability is Modulated by Microtubule-Active Agent: Evidence from In Vivo and In Vitro Epilepsy Models in the Rat. Front Cell Neurosci. 2016 Feb; 10:29.

22.  Miller KE, Liu XA, Puthanveettil SV. Automated measurement of fast mitochondrial transport in neurons. Front Cell Neurosci. 2015 Nov 3; 9:435.

23.  Kadakkuzha B, Liu XA, Mccrate J, Shankar G, Rizzo V, Afinogenova A, Young B, Fallahi M, Carvalloza AC, Raveendra B, Puthanveettil SV. Transcriptome analyses of adult mouse brain reveal enrichment of lncRNAs in specific brain regions and neuronal populations. Frontiers in Cellular Neuroscience. 2015. 9, 63.

24.  Liu XA, Kadakkuzha B, Pascal BD, Steckler C, Akhmedov K, Yan L, Chalmers MJ, Puthanveettil SV. New approach to capture and characterize synaptic proteome. Proc Natl Acad Sci U S A. 2014 Nov; 111(45): 16154-9.

25.  Choi YB, Kadakkuzha B, Liu XA, Akhmedov K, Kandel ER, Puthanveettil SV. Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in Aplysia. PLoS One. 2014. 2014 Jul 23; 9(7): e103004.

26.  Kadakkuzha B#, Liu XA#, Narvaez M, Kaye A, Akhmedov K, Puthanveettil SV. Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity. Frontiers in Genetics. 2014 Apr 22; 5:84. (# Contributed equally)

27.  Liu XA, Rizzo V, Puthanveettil SV. Pathologies of axonal transport in neurodegenerative diseases. Translational Neuroscience. 2012 Dec 1; 3(4): 355-72. Invited Review.

28.  Liu XA, Song J, Jiang Q, Wang Q, Tian Q, Wang JZ. Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response. Apoptosis. 2012 Oct; 17(10): 1039-49.

29.  Liu XA, Liao K, Liu R, Wang HH, Zhang Y, Zhang Q, Wang Q, Li HL, Tian Q, Wang JZ. Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2. Journal of Alzheimer's Disease. 2010 Jan; 19(3): 953-62.

30.  Liu XA#, Zhu LQ#, Zhang Q, Shi HR, Wang SH, Wang Q, Wang JZ. Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochemical Research. 2008 Sep; 33(9): 1811-20. (#Contributed equally) 


发表著作
(1) Frontiers in Clinical Drug Research-Alzheimer Disorders, Frontiers in Clinical Drug Research-Alzheimer Disorders, 2018-04, 第 1 作者

科研活动

   
科研项目
( 1 ) 尼古丁调控脂代谢异常的脑-肠-脂轴机制解析, 负责人, 地方任务, 2023-01--2025-12
( 2 ) 儿童发育性疾病肠道营养感知特征数据库的建立与应用, 参与, 地方任务, 2022-07--2025-07
( 3 ) 脆弱拟杆菌BF839在小鼠癫痫模型中的作用及其机制研究, 负责人, 其他, 2022-01--2023-12
( 4 ) 物质X与尼古丁的成瘾性比较, 负责人, 其他, 2022-01--2023-12
( 5 ) 电子烟对生理效应的评估研究, 负责人, 其他, 2020-08--2023-12

指导学生

已指导学生

贾淑慧  硕士研究生  071000-生物学  

蒋蓝萍  硕士研究生  085238-生物工程  

田野  硕士研究生  071006-神经生物学  

现指导学生

刘子俊  硕士研究生  086000-生物与医药  

马蕾  硕士研究生  086000-生物与医药