肖远胜-中国科学院大学-UCAS

基本信息

肖远胜男大连化学物理研究所
电子邮件：xiaoys@dicp.ac.cn
通信地址：大连市中山路457号1803组
邮政编码：116023

     肖远胜，男，博士，1973年生。1995年毕业于湖南科技大学，2004年在大连化学物理研究所获得博士学位，留所工作至今。现主要从事中药等复杂体系高通量纯化制备及其方法学研究。

个人兴趣主要集中在发展复杂未知体系的二维正交分离评价方法和目标性高效化合物纯化制备。发展未知体系多维制备结果预测及优化方法，提高对未知复杂体系分离分析行为的预测，实现高通量制备的效率和提高其制备组分的实际应用价值。针对中药化合物的物化特征甚至活性特征，发展高效的标准品、对照品及基准物的制备方法与技术，提高高通量制备效率，并建立相应的活性化合物制备方法。

    在工作以后，用BCB完成了复杂体系液相条件保留时间预测软件的设计与开发，以Python言语完成了液相分离紫外与质谱等二维及三维数据的处理脚本开发，并以Php言语完成了实验室电子实验记录本的开发和应用。熟悉Waters和Agilent等国际大公司主流液相及质谱的基本原理和构造，并根据具体实验进行实验平台的改造和搭建，以满足实验要求。

     通过申请和主持国家863项目及十一五专项等项目共3项，结题3项。主持国家自然科学基金2项，结题1项，在研1项。其它参与项目多个，负责并完成多个横向项目。发表学术论文数十篇，申请或获得专利多项。

研究领域

以中药化学成分信息表征为目标，通过系统分离与高效纯化，建立中药化学成分液相分离、结构表征和生物学表征等多维信息综合的中药化学成分信息数据系统。通过数据信息挖掘工具，以质量控制为突破口，形成特色中药研究线路。

1. 中药化学成分分离分析研究
研究中药等复杂体系的分离分析方法及中药化学成分的高通量制备。开展中药化学成分目标制备、系统制备与纯化研究。

2. 基于数据库的中药化学成分信息研究
基于中药化学成分高通量制备与纯化，以数据库建设为手段，通过色谱数据处理方法开发，研究基于数据库搜索的中药化学成分在线定性定量新方法。

3. 基于大数据分析的中药质量控制方法
应用大数据分析手段和数据挖掘技术，开展中药化学成分组成、含量和结构研究，发展中药质量控制新技术新方法

招生信息

招生专业

070302-分析化学

招生方向

分析化学：中药分离分析
中药化学：中药化学信息学

教育背景

1998-09--2004-09 中国科学院大连化学物理研究所博士
1995-09--1998-08 南开大学硕士
1991-09--1995-09 湖南科技大学学士

工作经历

工作简历

2011-09--2015-06 中国科学院大连化学物理研究所副研究员
2004-09--2011-09 中国科学院大连化学物理研究所助理研究员

出版信息

发表论文

[1] Hui Jiang, Yuansheng Xiao, Xingya Xue, Hongli Jin, Yang Xiang, Yanfang Liu, Gaowa Jin. Computer-Aided Rapid Establishment of Fingerprint of Xiaojin Capsule by HPLC. INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2021, 2021: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826213/.
[2] Xu, Fangfang, Hou, Tao, Shen, Aijin, Jin, Hongli, Xiao, Yuansheng, Yu, Wenyi, Li, Xiaonong, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of Coronavirus Disease 2019 (COVID-19) by label-free integrative pharmacology assays. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2021, 280: http://dx.doi.org/10.1016/j.jep.2021.114488.
[3] Wei Si, Yanfang Liu, Yuansheng Xiao, Zhimou Guo, Gaowa Jin, Jingyu Yan, Aijin Shen, Han Zhou, Fan Yang, Xinmiao Liang. An offline two-dimensional supercritical fluid chromatography × reversed phase liquid chromatography tandem quadrupole time-of-flight mass spectrometry system for comprehensive gangliosides profiling in swine brain extract. TALANTA. 2020, 208: http://dx.doi.org/10.1016/j.talanta.2019.120366.
[4] Fu, Dongmei, Liu, Yujie, Shen, Aijin, Xiao, Yuansheng, Yu, Long, Liang, Xinmiao. Preparation of glutathione-functionalized zwitterionic silica material for efficient enrichment of sialylated N-glycopeptides. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2019, 411(18): 4131-4140,
[5] Yang, Fan, Zhao, Manxi, Zhang, Xiuli, Li, Qiang, Xiao, Yuansheng, Ke, Xiao, He, Jian, Ye, Liang, Feng, Jiatao, Hao, Xiaofeng, Ke, Zunhong, Liang, Xinmiao. Exploratory Purification of Compounds from Aqueous Extracts of Pinus massoniana Lamb. by Two-Dimensional Preparative Liquid Chromatography. CHROMATOGRAPHIA[J]. 2017, 80(1): 39-43, http://cas-ir.dicp.ac.cn/handle/321008/151872.
[6] Liu, Yujie, Fu, Dongmei, Yu, Long, Xiao, Yuansheng, Peng, Xiaojun, Liang, Xinmiao. Oxidized dextran facilitated synthesis of a silica-based concanavalin a material for lectin affinity enrichment of glycoproteins/glycopeptides. JOURNAL OF CHROMATOGRAPHY A[J]. 2016, 1455: 147-155, http://cas-ir.dicp.ac.cn/handle/321008/170462.
[7] Jin, Gaowa, Guo, Zhimou, Xiao, Yuansheng, Yan, Jingyu, Dong, Xuefang, Shen, Aijin, Wang, Chaoran, Liang, Xinmiao. Practical method for the definition of chromatographic peak parameters in preparative liquid chromatography. JOURNAL OF SEPARATION SCIENCE[J]. 2016, 39(20): 3917-3926, http://cas-ir.dicp.ac.cn/handle/321008/150411.
[8] Liu, Yujie, Fu, Dongmei, Xiao, Yuansheng, Guo, Zhimou, Yu, Long, Liang, Xinmiao. Synthesis and evaluation of a silica-bonded concanavalin A material for lectin affinity enrichment of N-linked glycoproteins and glycopeptides. ANALYTICAL METHODS[J]. 2015, 7(1): 25-28, https://www.webofscience.com/wos/woscc/full-record/WOS:000346249600002.
[9] Wang, Jixia, Guo, Zhimou, Shen, Aijin, Yu, Long, Xiao, Yuansheng, Xue, Xingya, Zhang, Xiuli, Liang, Xinmiao. Hydrophilic-subtraction model for the characterization and comparison of hydrophilic interaction liquid chromatography columns. JOURNAL OF CHROMATOGRAPHY A[J]. 2015, 1398: 29-46, http://dx.doi.org/10.1016/j.chroma.2015.03.065.
[10] Wang, Jixia, Wang, Chaoran, Guo, Zhimou, Dong, Xuefang, Xiao, Yuansheng, Xue, Xingya, Zhang, Xiuli, Liang, Xinmiao. A novel method for characterization and comparison of reversed-phase column selectivity. JOURNAL OF CHROMATOGRAPHY A[J]. 2014, 1361(1): 153-161, http://dx.doi.org/10.1016/j.chroma.2014.08.005.
[11] Ding, Ling, Guo, Zhimou, Xiao, Yuansheng, Xue, Xingya, Zhang, Xiuli, Liang, Xinmiao. Evaluation and comparison of n-alkyl chain and polar ligand bonded stationary phases for protein separation in reversed-phase liquid chromatography. JOURNAL OF SEPARATION SCIENCE[J]. 2014, 37(18): 2467-2473, http://159.226.238.44/handle/321008/143196.
[12] Zhang, Xiuli, Deng, Huayun, Xiao, Yuansheng, Xue, Xingya, Ferrie, Ann M, Elizabeth Tran, Liang, Xinmiao, Fang, Ye. Label-free cell phenotypic profiling identifies pharmacologically active compounds in two traditional Chinese medicinal plants. RSC ADVANCES[J]. 2014, 4(50): 26368-26377, http://www.irgrid.ac.cn/handle/1471x/858870.
[13] 丁玲, 董军, 肖远胜, 张秀莉, 薛兴亚, 梁鑫淼. 蛋白质的反相液相色谱保留方程研究. 分析化学[J]. 2013, 41(2): 181-186, http://lib.cqvip.com/Qikan/Article/Detail?id=45003946.
[14] Guo, Xiujie, Zhang, Xiuli, Feng, Jiatao, Guo, Zhimou, Xiao, Yuansheng, Liang, Xinmiao. Purification of saponins from leaves of Panax notoginseng using preparative two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2013, 405(10): 3413-3421, http://159.226.238.44/handle/321008/137552.
[15] Ding Ling, Dong Jun, Xiao YuanSheng, Zhang XiuLi, Xue XingYa, Liang XinMiao. Study on Retention Equation for Protein in Reversed Phase Liquid Chromatography. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2013, 41(2): 181-186, http://159.226.238.44/handle/321008/137791.
[16] Zhang, Xiuli, Liu, Yanfang, Guo, Zhimou, Feng, Jiatao, Dong, Jun, Fu, Qing, Wang, Chaoran, Xue, Xingya, Xiao, Yuansheng, Liang, Xinmiao. The herbalome-an attempt to globalize Chinese herbal medicine. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2012, 402(2): 573-581, http://159.226.238.44/handle/321008/142856.
[17] Li Cunman, Xiao Yuansheng, Xue Xingya, Feng Jiatao, Zhang Xiuli, Liang Xinmiao. Isolation and Purification of Unstable Iridoid Glucosides from Traditional Chinese Medicine by Preparative High Performance Liquid Chromatography Coupled with Solid-phase Extraction. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES[J]. 2011, 27(3): 392-396, http://lib.cqvip.com/Qikan/Article/Detail?id=38035893.
[18] Xu, Ning, Zhao, DeFeng, Liang, XinMiao, Zhang, Hua, Xiao, YuanSheng. Identification of Diterpenoid Alkaloids from the Roots of Aconitum kusnezoffii Reihcb. MOLECULES[J]. 2011, 16(4): 3345-3350, http://www.irgrid.ac.cn/handle/1471x/456707.
[19] Feng, Jiatao, Xiao, Yuansheng, Guo, Zhimou, Yu, Danhua, Jin, Yu, Liang, Xinmiao. Purification of compounds from Lignum Dalbergia Odorifera using two-dimensional preparative chromatography with Click oligo (ethylene glycol) and C18 column. JOURNAL OF SEPARATION SCIENCE[J]. 2011, 34(3): 299-307, http://www.irgrid.ac.cn/handle/1471x/456720.
[20] Liu, Yanfang, Feng, Jiatao, Xiao, Yuansheng, Guo, Zhimou, Zhang, Jing, Xue, Xingya, Ding, Jin, Zhang, Xiuli, Liang, Xinmiao. Purification of active bufadienolides from toad skin by preparative reversed-phase liquid chromatography coupled with hydrophilic interaction chromatography. JOURNAL OF SEPARATION SCIENCE[J]. 2010, 33(10): 1487-1494, http://dx.doi.org/10.1002/jssc.200900848.
[21] Zeng, Jing, Guo, Zhimou, Xiao, Yuansheng, Wang, Chaoran, Zhang, Xiuli, Liang, Xinmiao. Purification of polar compounds from Radix isatidis using conventional C18 column coupled with polar-copolymerized C18 column. JOURNAL OF SEPARATION SCIENCE[J]. 2010, 33(21): 3341-3346, http://159.226.238.44/handle/321008/141772.
[22] 徐宁, 张峰, 肖远胜, 张华, 梁鑫淼. 中药黄酮类化合物. 大学化学[J]. 2010, 25(B04): 105-108, http://lib.cqvip.com/Qikan/Article/Detail?id=35096345.
[23] Liu, Yanfang, Xiao, Yuansheng, Xue, Xingya, Zhang, Xiuli, Liang, Xinmiao. Systematic screening and characterization of novel bufadienolides from toad skin using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY[J]. 2010, 24(5): 667-678, http://dx.doi.org/10.1002/rcm.4436.
[24] Zhang, Jing, Xiao, Yuansheng, Feng, Jiatao, Wu, Sophia L, Xue, Xingya, Zhang, Xiuli, Liang, Xinmiao. Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2010, 52(4): 446-451, http://dx.doi.org/10.1016/j.jpba.2010.01.023.
[25] 曾静, 郭志谋, 张秀莉, 肖远胜, 王超然, 薛兴亚, 梁鑫淼. 离线二维液相色谱-质谱分离鉴定板蓝根中的微量化合物. 24th international symposium on microscale bioseparations. 2009, 272/1, http://159.226.238.44/handle/321008/113896.
[26] Liang, Xinmiao, Jin, Yu, Wang, Yanping, Jin, Gaowa, Fu, Qing, Xiao, Yuansheng. Qualitative and quantitative analysis in quality control of traditional Chinese medicines. JOURNAL OF CHROMATOGRAPHY A[J]. 2009, 1216(11): 2033-2044, http://dx.doi.org/10.1016/j.chroma.2008.07.026.
[27] Li, Wei, Feng, JiaTao, Xiao, YuanSheng, Wang, YaQin, Xue, XingYa, Liang, XinMiao. Three novel terpenoids from the rhizomes of Curcuma longa. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2009, 11(6): 569-575, http://dx.doi.org/10.1080/10286020902939182.
[28] Zhang, Jing, Jin, Yu, Liu, Yanfang, Xiao, Yuansheng, Feng, Jiatao, Xue, Xingya, Zhang, Xiuli, Liang, Xinmiao. Two-dimensional RPLC-RPLC system with different pH in two dimensions for separation of alkaloids from Corydalis yanhusuo W. T. Wang. JOURNAL OF SEPARATION SCIENCE[J]. 2009, 32(12): 2084-2089, http://dx.doi.org/10.1002/jssc.200800703.
[29] Li, Wei, Wang, Shisheng, Feng, Jiatao, Xiao, Yuansheng, Xue, Xingya, Zhang, Hui, Wang, Yaqin, Liang, Xinmiao. Structure elucidation and NMR assignments for curcuminoids from the rhizomes of Curcuma longa. MAGNETIC RESONANCE IN CHEMISTRY[J]. 2009, 47(10): 902-908, http://159.226.238.44/handle/321008/102673.
[30] Wang, Yanping, Zhang, Feifang, Xue, Xingya, Xiao, Yuansheng, Feng, Jiatao, Liang, Xinmiao. Use of an Orthogonal System, RP-LC-HILIC, for Evaluation of Purity. CHROMATOGRAPHIA[J]. 2009, 69(11-12): 1379-1384, http://dx.doi.org/10.1365/s10337-009-1077-0.
[31] Zhang, Jing, Jin, Yu, Dong, Jun, Xiao, Yuansheng, Feng, Jiatao, Xue, Xingya, Zhang, Xiuli, Liang, Xinmiao. Systematic screening and characterization of tertiary and quaternary alkaloids from corydalis yanhusuo W.T. Wang using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. TALANTA[J]. 2009, 78(2): 513-522, http://dx.doi.org/10.1016/j.talanta.2008.12.002.
[32] 王艳萍, 丰加涛, 金郁, 刘艳芳, 肖远胜, 章飞芳, 薛兴亚, 张秀莉, 梁鑫淼. 中药物质基础研究的思路与方法. 中国天然药物[J]. 2009, 7(1): 13-18, http://lib.cqvip.com/Qikan/Article/Detail?id=29251270.
[33] 曾静, 郭志谋, 张秀莉, 肖远胜, 王超然, 薛兴亚, 梁鑫淼. Identification and Characterization of the low-abundant constituents of Radix isatidis by off-line 2D-LC coupled with Q-TOF MS. 24th international symposium on microscale bioseparations. 2009, 272/1, http://159.226.238.44/handle/321008/113896.
[34] Zhang, Hui, Guo, Zhimou, Li, Wei, Feng, Jiatao, Xiao, Yuansheng, Zhang, Feifang, Xue, Xingya, Liang, Xinmiao. Purification of flavonoids and triterpene saponins from the licorice extract using preparative HPLC under RP and HILIC mode. JOURNAL OF SEPARATION SCIENCE[J]. 2009, 32(4): 526-535, http://159.226.238.44/handle/321008/102611.
[35] Jin, Yu, Liang, Tu, Fu, Qing, Xiao, YuanSheng, Feng, JiaTao, Ke, YanXiong, Liang, XinMiao. Fingerprint analysis of Ligusticum chuanxiong using hydrophilic interaction chromatography and reversed-phase liquid chromatography. JOURNAL OF CHROMATOGRAPHY A[J]. 2009, 1216(11): 2136-2141, http://dx.doi.org/10.1016/j.chroma.2008.04.010.
[36] Jin, Yu, Xue, Xingya, Zhang, Feifang, Zhang, Jing, Shi, Hui, Xiao, Yuansheng, Ke, Yanxiong, Liang, Xinmiao. Rapid prediction and optimization of concentration conditions for preparative fractions by solid-phase extraction. JOURNAL OF SEPARATION SCIENCE[J]. 2008, 31(4): 615-621, http://159.226.238.44/handle/321008/100101.
[37] 金郁, 薛兴亚, 肖远胜, 章飞芳, 石慧, 梁鑫淼. 中药复杂样品高效液相色谱和超高效液相色谱分析条件转换方法. 世界科学技术：中医药现代化[J]. 2008, 10(1): 80-84, http://lib.cqvip.com/Qikan/Article/Detail?id=26941539.
[38] Jin, Yu, Zhang, Xiuli, Shi, Hui, Xiao, Yuansheng, Ke, Yanxiong, Xue, Xingya, Zhang, Feifang, Liang, Xinmiao. Characterization of C-glycosyl quinochalcones in Carthamus tinctorius L. by ultraperformance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY[J]. 2008, 22(8): 1275-1287, http://159.226.238.44/handle/321008/140892.
[39] Guo, Zhimou, Xiao, Yuansheng, Liu, Yanfang, Liang, Tu, Liang, Xinmiao. Purification of chitooligosaccharides by using purification factory. JOURNAL OF BIOTECHNOLOGY[J]. 2008, 136: S83-S83, http://dx.doi.org/10.1016/j.jbiotec.2008.07.187.
[40] Wang, Yanping, Xue, Xingya, Xiao, Yuansheng, Zhang, Feifang, Xu, Qing, Liang, Xinmiao. Purification and preparation of compounds from an extract of Scutellaria barbata D. Don using preparative parallel high performance liquid chromatography. JOURNAL OF SEPARATION SCIENCE[J]. 2008, 31(10): 1669-1676, http://159.226.238.44/handle/321008/100187.
[41] 郭志谋, 肖远胜, 刘艳芳, 梁图, 梁鑫淼. Purification of chitooligosaccharides by using purification factory. 13th international biotechnology symposium & exhibition. 2008, s83/2, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208979400193&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[42] Jin, Yu, Xue, Xingya, Liu, Yanfang, Xiao, Yuansheng, Zhang, Jing, Shi, Hui, Zhang, Feifang, Liang, Xinmiao. A novel method of prediction and optimization for preparative high-performance liquid chromatography separation. JOURNAL OF CHROMATOGRAPHY A[J]. 2008, 1183(1-2): 76-86, http://dx.doi.org/10.1016/j.chroma.2008.01.008.
[43] 丰加涛, 金郁, 王金成, 肖远胜, 梁鑫淼. 基于定量指纹图谱技术的中药质量控制. 色谱[J]. 2008, 26(2): 180-185, http://lib.cqvip.com/Qikan/Article/Detail?id=26840115.
[44] Jin, Yu, Xiao, Yuansheng, Zhang, Feifang, Xue, Xingya, Xu, Qing, Liang, Xinmiao. Systematic screening and characterization of flavonoid glycosides in Carthamus tinctorius L. by liquid chromatography/UV diode-array detection/electrospray ionization tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2008, 46(3): 418-430, http://dx.doi.org/10.1016/j.jpba.2007.10.036.
[45] 金郁, 石慧, 肖远胜, 薛兴亚, 章飞芳, 梁鑫淼. 复杂样品分离的液相色谱条件优化方法. Dalian International Symposia and Exhibition on Chromatography. 2007, 8/2, http://159.226.238.44/handle/321008/112480.
[46] 金郁, 石慧, 肖远胜, 薛兴亚, 章飞芳, 梁鑫淼. 复杂样品分离的液相色谱条件优化方法. Dalian International Symposia and Exhibition on Chromatography. 2007, 8/2, http://159.226.238.44/handle/321008/112480.
[47] 石慧, 金郁, 肖远胜, 薛兴亚, 梁鑫淼. 大孔树脂联用分离大黄水提组分. 世界科学技术：中医药现代化[J]. 2007, 9(5): 60-67, http://lib.cqvip.com/Qikan/Article/Detail?id=25971628.
[48] 张静, 金郁, 肖远胜, 梁鑫淼. Determination of dissociation constant of alkaloids by gradient elution system using UPLC. dalian international symposia and exhibition on chromatography. 2007, 24/2, http://159.226.238.44/handle/321008/112498.
[49] 石慧, 金郁, 肖远胜, 薛兴亚, 梁鑫淼. 大孔树脂联用分离大黄水提组分. 世界科学技术：中医药现代化[J]. 2007, 9(5): 60-67, http://lib.cqvip.com/Qikan/Article/Detail?id=25971628.
[50] 石慧, 金郁, 肖远胜, 薛兴亚, 梁鑫淼. LC/MS方法对大黄水提组分游离蒽醌类化合物的快速鉴定. Dalian International Symposia and Exhibition on Chromatography. 2007, 15/3, http://159.226.238.44/handle/321008/112488.
[51] 石慧, 金郁, 肖远胜, 薛兴亚, 梁鑫淼. 大孔树脂联用分离大黄水提组分. 世界科学技术-世界科学技术[J]. 2007, 9(5): 60-67, http://159.226.238.44/handle/321008/99793.
[52] 金郁, 章飞芳, 肖远胜, 薛兴亚, 徐青, 梁鑫淼. 中药标准组分的高效液相色谱／质谱联用（HPLC／MS）表征. 世界科学技术：中医药现代化[J]. 2006, 8(3): 99-105, http://lib.cqvip.com/Qikan/Article/Detail?id=22205932.
[53] 金郁, 章飞芳, 肖远胜, 薛兴亚, 徐青, 梁鑫淼. 中药标准组分的高效液相色谱／质谱联用（HPLC／MS）表征. 世界科学技术：中医药现代化[J]. 2006, 8(3): 99-105, http://lib.cqvip.com/Qikan/Article/Detail?id=22205932.
[54] 丰加涛, 徐青, 薛兴亚, 章飞芳, 肖远胜, 梁鑫淼. 中药标准组分制备与组分库的构建. 世界科学技术中医药现代化[J]. 2006, 8(3): 95-98, http://lib.cqvip.com/Qikan/Article/Detail?id=22205931.
[55] 杨帆, 肖远胜, 章飞芳, 薛兴亚, 徐青, 梁鑫淼. 当归化学成分的HPLC-MS/MS分析；. 药学学报[J]. 2006, 41(11): 1078-1083, http://159.226.238.44/handle/321008/97805.
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