基本信息
肖亮 男 硕导 其他
电子邮件： xiaoliang@genomics.cn
通信地址： 广东省深圳市
邮政编码：
电子邮件： xiaoliang@genomics.cn
通信地址： 广东省深圳市
邮政编码：
招生信息
招生专业
071005-微生物学
0710Z1-基因组学
0710J3-生物信息学
0710Z1-基因组学
0710J3-生物信息学
招生方向
宏基因组
共生微生物
益生菌
共生微生物
益生菌
教育背景
2006-09--2010-06 南开大学 微生物学博士
2003-09--2006-06 南开大学 微生物学硕士
1999-09--2003-06 北京工商大学 工学学士
2003-09--2006-06 南开大学 微生物学硕士
1999-09--2003-06 北京工商大学 工学学士
工作经历
工作简历
2010-08~现在, 深圳华大生命科学研究院, 精准健康研究所副所长
教授课程
微生物基因组学
专利与奖励
奖励信息
（1） 深圳市后备级领军人才, 二等奖, 市地级, 2020
（2） 深圳市盐田区梧桐人才, 市地级, 2020
（3） 深圳市盐田区生物产业高层次人才, 二等奖, 市地级, 2016
（2） 深圳市盐田区梧桐人才, 市地级, 2020
（3） 深圳市盐田区生物产业高层次人才, 二等奖, 市地级, 2016
专利成果
[1] 吕金丽, 邹远强, 肖亮. 加氏乳杆菌在预防和/或治疗代谢性疾病中的用途和组合物. CN: CN111281894B, 2022-03-25.
[2] 魏文博, 陈娟娟, 肖亮. 一种仿生肠道器官芯片及其制备方法和应用. CN: CN111971383B, 2022-02-22.
[3] 戴莹, 邹远强, 肖亮. 单形巨单胞菌在预防和/或治疗代谢性疾病中的用途. CN: CN112888448A, 2021-06-01.
[4] 戴莹, 邹远强, 肖亮. 人粪厌氧棒形菌在预防和/或治疗代谢性疾病中的用途. CN: CN112867500A, 2021-05-28.
[5] 张笑薇, 吕金丽, 赵少伟, 高蒙玙, 邹远强, 肖亮. 用于预防和/或治疗生殖道菌群紊乱和/或骨质流失引起的疾病的鼠李糖乳杆菌. CN: CN112760247A, 2021-05-07.
[6] 张笑薇, 吕金丽, 赵少伟, 邹远强, 肖亮. 用于预防和/或治疗生殖道菌群紊乱相关疾病的格氏乳杆菌. CN: CN112458006A, 2021-03-09.
[7] 张笑薇, 吕金丽, 赵少伟, 高蒙玙, 邹远强, 肖亮. 用于预防和/或治疗生殖道菌群紊乱相关疾病的卷曲乳杆菌. CN: CN112458007A, 2021-03-09.
[8] 江媛, 王丹, 章登位, 戴雪辰, 汪晓珏, 纪泽阳, 王琦, 赵静, 李卓坤, 顾颖, 欧阳文杰, 沈玥, 陈奥, 章文蔚, 肖亮. 新型的Cas蛋白、Crispr-Cas系统及其在基因编辑领域中的用途. CN: CN112301018A, 2021-02-02.
[9] 邹远强, 薛文斌, 肖亮. 一种组合物及其应用. CN: CN112236154A, 2021-01-15.
[10] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏. 一种组合物及其应用. CN: CN112236155A, 2021-01-15.
[11] 邹远强, 肖亮, 李晓平, 余靖宏. 一种组合物及其应用. CN: CN112218646A, 2021-01-12.
[12] 魏文博, 陈娟娟, 邹远强, 肖亮. 一种仿生肠-肝器官芯片及其制备方法和应用. CN: CN111971384A, 2020-11-20.
[13] 魏文博, 肖亮, 陈娟娟. 一种高通量器官芯片及其制备方法和应用. CN: CN111971378A, 2020-11-20.
[14] 邹远强, 肖亮, 李晓平, 余靖宏, 刘传. 粪厌氧棒形菌(Anaerofustis stercorihominis)及其应用. CN: CN111448306A, 2020-07-24.
[15] 邹远强, 肖亮. 长双歧杆菌长亚种、含其的组合物及用途. CN: CN111280252A, 2020-06-16.
[16] 邹远强, 肖亮, 李晓平, 余靖宏, 刘传. 丁酸杆菌(Butyribacter intestini)在预防和/或治疗炎症相关疾病的应用. CN: CN111093682A, 2020-05-01.
[17] 揭著业, 粱穗莎, 夏慧华, 邹远强, 肖亮, 贾慧珏. 沙氏别样杆菌在制备预防和/或治疗脂质代谢性相关疾病组合物中的应用. CN: CN110869035A, 2020-03-06.
[18] 魏文博, 陈娟娟, 肖亮. 一种多器官芯片及其制备方法和应用. CN: CN110511866A, 2019-11-29.
[19] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 粪厌氧棒杆菌(Anaerostipes caccae)及其应用. CN: CN110062806A, 2019-07-26.
[20] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 深圳柯林斯菌(Collinsella shenzhenensis)及其应用. CN: CN110049772A, 2019-07-23.
[21] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 一种假小链状双歧杆菌及其培养方法和应用. CN: CN110023484A, 2019-07-16.
[22] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 一种嗜酸乳杆菌及其培养方法和应用. CN: CN110023486A, 2019-07-16.
[23] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 一种加氏乳杆菌及其培养方法和应用. CN: CN109983115A, 2019-07-05.
[24] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 一种产丁酸栖粪杆菌及其培养方法和应用. CN: CN109874329A, 2019-06-11.
[25] 邹远强, 肖亮, 李晓平, 余靖宏, 刘传. 单形巨单胞菌（Megamonas funiformis）及其应用. CN: CN109504615A, 2019-03-22.
[26] 揭著业, 梁穗莎, 夏慧华, 邹远强, 肖亮, 贾慧珏. 解纤维素拟杆菌在预防和/或治疗心脏疾病方面的应用. CN: CN109419816A, 2019-03-05.
[27] 冯强, 张东亚, 贾慧珏, 刘传, 肖亮, 王俊. 极巨巨单胞菌在治疗或预防类风湿性关节炎中的应用. CN: CN104546938B, 2019-02-01.
[28] 冯强, 张东亚, 贾慧珏, 刘传, 肖亮, 王俊. 浑浊戴阿利斯特菌在治疗或预防类风湿性关节炎中的应用. CN: CN104546939B, 2019-02-01.
[29] 邹远强, 薛文斌, 肖亮, 刘传. 长栖粪杆菌（Faecalibacterium longum）及其应用. CN: CN109219656A, 2019-01-15.
[30] 冯强, 张东亚, 贾慧珏, 刘传, 肖亮, 王俊. 卷曲乳杆菌在治疗或预防类风湿性关节炎中的应用. CN: CN104546947B, 2019-01-08.
[31] 冯强, 张东亚, 贾慧珏, 刘传, 肖亮, 王俊. 小斑点普雷沃氏菌在治疗或预防类风湿性关节炎中的应用. CN: CN104546936B, 2019-01-08.
[2] 魏文博, 陈娟娟, 肖亮. 一种仿生肠道器官芯片及其制备方法和应用. CN: CN111971383B, 2022-02-22.
[3] 戴莹, 邹远强, 肖亮. 单形巨单胞菌在预防和/或治疗代谢性疾病中的用途. CN: CN112888448A, 2021-06-01.
[4] 戴莹, 邹远强, 肖亮. 人粪厌氧棒形菌在预防和/或治疗代谢性疾病中的用途. CN: CN112867500A, 2021-05-28.
[5] 张笑薇, 吕金丽, 赵少伟, 高蒙玙, 邹远强, 肖亮. 用于预防和/或治疗生殖道菌群紊乱和/或骨质流失引起的疾病的鼠李糖乳杆菌. CN: CN112760247A, 2021-05-07.
[6] 张笑薇, 吕金丽, 赵少伟, 邹远强, 肖亮. 用于预防和/或治疗生殖道菌群紊乱相关疾病的格氏乳杆菌. CN: CN112458006A, 2021-03-09.
[7] 张笑薇, 吕金丽, 赵少伟, 高蒙玙, 邹远强, 肖亮. 用于预防和/或治疗生殖道菌群紊乱相关疾病的卷曲乳杆菌. CN: CN112458007A, 2021-03-09.
[8] 江媛, 王丹, 章登位, 戴雪辰, 汪晓珏, 纪泽阳, 王琦, 赵静, 李卓坤, 顾颖, 欧阳文杰, 沈玥, 陈奥, 章文蔚, 肖亮. 新型的Cas蛋白、Crispr-Cas系统及其在基因编辑领域中的用途. CN: CN112301018A, 2021-02-02.
[9] 邹远强, 薛文斌, 肖亮. 一种组合物及其应用. CN: CN112236154A, 2021-01-15.
[10] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏. 一种组合物及其应用. CN: CN112236155A, 2021-01-15.
[11] 邹远强, 肖亮, 李晓平, 余靖宏. 一种组合物及其应用. CN: CN112218646A, 2021-01-12.
[12] 魏文博, 陈娟娟, 邹远强, 肖亮. 一种仿生肠-肝器官芯片及其制备方法和应用. CN: CN111971384A, 2020-11-20.
[13] 魏文博, 肖亮, 陈娟娟. 一种高通量器官芯片及其制备方法和应用. CN: CN111971378A, 2020-11-20.
[14] 邹远强, 肖亮, 李晓平, 余靖宏, 刘传. 粪厌氧棒形菌(Anaerofustis stercorihominis)及其应用. CN: CN111448306A, 2020-07-24.
[15] 邹远强, 肖亮. 长双歧杆菌长亚种、含其的组合物及用途. CN: CN111280252A, 2020-06-16.
[16] 邹远强, 肖亮, 李晓平, 余靖宏, 刘传. 丁酸杆菌(Butyribacter intestini)在预防和/或治疗炎症相关疾病的应用. CN: CN111093682A, 2020-05-01.
[17] 揭著业, 粱穗莎, 夏慧华, 邹远强, 肖亮, 贾慧珏. 沙氏别样杆菌在制备预防和/或治疗脂质代谢性相关疾病组合物中的应用. CN: CN110869035A, 2020-03-06.
[18] 魏文博, 陈娟娟, 肖亮. 一种多器官芯片及其制备方法和应用. CN: CN110511866A, 2019-11-29.
[19] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 粪厌氧棒杆菌(Anaerostipes caccae)及其应用. CN: CN110062806A, 2019-07-26.
[20] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 深圳柯林斯菌(Collinsella shenzhenensis)及其应用. CN: CN110049772A, 2019-07-23.
[21] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 一种假小链状双歧杆菌及其培养方法和应用. CN: CN110023484A, 2019-07-16.
[22] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 一种嗜酸乳杆菌及其培养方法和应用. CN: CN110023486A, 2019-07-16.
[23] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 一种加氏乳杆菌及其培养方法和应用. CN: CN109983115A, 2019-07-05.
[24] 邹远强, 薛文斌, 肖亮, 李晓平, 余靖宏, 刘传. 一种产丁酸栖粪杆菌及其培养方法和应用. CN: CN109874329A, 2019-06-11.
[25] 邹远强, 肖亮, 李晓平, 余靖宏, 刘传. 单形巨单胞菌（Megamonas funiformis）及其应用. CN: CN109504615A, 2019-03-22.
[26] 揭著业, 梁穗莎, 夏慧华, 邹远强, 肖亮, 贾慧珏. 解纤维素拟杆菌在预防和/或治疗心脏疾病方面的应用. CN: CN109419816A, 2019-03-05.
[27] 冯强, 张东亚, 贾慧珏, 刘传, 肖亮, 王俊. 极巨巨单胞菌在治疗或预防类风湿性关节炎中的应用. CN: CN104546938B, 2019-02-01.
[28] 冯强, 张东亚, 贾慧珏, 刘传, 肖亮, 王俊. 浑浊戴阿利斯特菌在治疗或预防类风湿性关节炎中的应用. CN: CN104546939B, 2019-02-01.
[29] 邹远强, 薛文斌, 肖亮, 刘传. 长栖粪杆菌（Faecalibacterium longum）及其应用. CN: CN109219656A, 2019-01-15.
[30] 冯强, 张东亚, 贾慧珏, 刘传, 肖亮, 王俊. 卷曲乳杆菌在治疗或预防类风湿性关节炎中的应用. CN: CN104546947B, 2019-01-08.
[31] 冯强, 张东亚, 贾慧珏, 刘传, 肖亮, 王俊. 小斑点普雷沃氏菌在治疗或预防类风湿性关节炎中的应用. CN: CN104546936B, 2019-01-08.
出版信息
发表论文
[1] Liu, Xiaomin, Zou, Leying, Nie, Chao, Qin, Youwen, Tong, Xin, Wang, Jian, Yang, Huanming, Xu, Xun, Jin, Xin, Xiao, Liang, Zhang, Tao, Min, Junxia, Zeng, Yi, Jia, Huijue, Hou, Yong. Mendelian randomization analyses reveal causal relationships between the human microbiome and longevity. SCIENTIFIC REPORTS[J]. 2023, 第 10 作者13(1): http://dx.doi.org/10.1038/s41598-023-31115-8.
[2] Hu, Xiangwei, Xia, Kai, Dai, Minhui, Han, Xiaofeng, Yuan, Peng, Liu, Jia, Liu, Shiwei, Jia, Fuhuai, Chen, Jiayu, Jiang, Fangfang, Yu, Jieyao, Yang, Huanming, Wang, Jian, Xu, Xun, Jin, Xin, Kristiansen, Karsten, Xiao, Liang, Chen, Wei, Han, Mo, Duan, Shenglin. Intermittent fasting modulates the intestinal microbiota and improves obesity and host energy metabolism. NPJ BIOFILMS AND MICROBIOMES[J]. 2023, 第 17 作者9(1): http://dx.doi.org/10.1038/s41522-023-00386-4.
[3] 刘雪梅, 丁佳虹, 聂超, 肖亮, 李桃. 两样本孟德尔随机化分析肠道微生物与精神分裂症的因果关系. 现代预防医学. 2023, 第 4 作者50(1): 27-32, http://lib.cqvip.com/Qikan/Article/Detail?id=7108775818.
[4] Liu, Xiaomin, Tong, Xin, Jie, Zhuye, Zhu, Jie, Tian, Liu, Sun, Qiang, Ju, Yanmei, Zou, Leying, Lu, Haorong, Qiu, Xuemei, Li, Qiang, Liao, Yunli, Lian, Heng, Zuo, Yong, Chen, Xiaomin, Rao, Weiqiao, Ren, Yan, Wang, Yuan, Zi, Jin, Wang, Rong, Xu, Xun, Yang, Huanming, Wang, Jian, Zong, Yang, Liu, Weibin, Hou, Yong, Jin, Xin, Xiao, Liang, Kristiansen, Karsten, Jia, Huijue, Zhang, Tao. Sex differences in the oral microbiome, host traits, and their causal relationships. ISCIENCE[J]. 2023, 第 28 作者26(1): http://dx.doi.org/10.1016/j.isci.2022.105839.
[5] Xiaoqian Lin, Tongyuan Hu, Jianwei Chen, Hewei Liang, Jianwei Zhou, Zhinan Wu, Chen Ye, Xin Jin, Xun Xu, Wenwei Zhang, Xiaohuan Jing, Tao Yang, Jian Wang, Huanming Yang, Karsten Kristiansen, Liang Xiao, Yuanqiang Zou. The genomic landscape of reference genomes of cultivated human gut bacteria. NATURE COMMUNICATIONS[J]. 2023, 第 16 作者 通讯作者 14(1): 1-11, http://dx.doi.org/10.1038/s41467-023-37396-x.
[6] Jie, Zhuye, Chen, Chen, Hao, Lilan, Li, Fei, Song, Liju, Zhang, Xiaowei, Zhu, Jie, Tian, Liu, Tong, Xin, Cai, Kaiye, Zhang, Zhe, Ju, Yanmei, Yu, Xinlei, Li, Ying, Zhou, Hongcheng, Lu, Haorong, Qiu, Xuemei, Li, Qiang, Liao, Yunli, Zhou, Dongsheng, Lian, Heng, Zuo, Yong, Chen, Xiaomin, Rao, Weiqiao, Ren, Yan, Wang, Yuan, Zi, Jin, Wang, Rong, Liu, Na, Wu, Jinghua, Zhang, Wei, Liu, Xiao, Zong, Yang, Liu, Weibin, Xiao, Liang, Hou, Yong, Xu, Xun, Yang, Huanming, Wang, Jian, Kristiansen, Karsten, Jia, Huijue. Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2022, 第 35 作者20(2): 304-321, http://dx.doi.org/10.1016/j.gpb.2021.01.005.
[7] Zhu, Jie, Tian, Liu, Chen, Peishan, Han, Mo, Song, Liju, Tong, Xin, Sun, Xiaohuan, Yang, Fangming, Lin, Zhipeng, Liu, Xing, Liu, Chuan, Wang, Xiaohan, Lin, Yuxiang, Cai, Kaiye, Hou, Yong, Xu, Xun, Yang, Huanming, Wang, Jian, Kristiansen, Karsten, Xiao, Liang, Zhang, Tao, Jia, Huijue, Jie, Zhuye. Over 50,000 Metagenomically Assembled Draft Genomes for the Human Oral Microbiome Reveal New Taxa. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2022, 第 20 作者20(2): 246-259, http://dx.doi.org/10.1016/j.gpb.2021.05.001.
[8] Dong, Bo, Lin, Xiaoqian, Jing, Xiaohuan, Hu, Tongyuan, Zhou, Jianwei, Chen, Jianwei, Xiao, Liang, Wang, Bo, Chen, Zhuang, Liu, Jing, Hu, Yiyin, Liu, Guilin, Liu, Shanshan, Liu, Junnian, Wei, Wenkang, Zou, Yuanqiang. A Bacterial Genome and Culture Collection of Gut Microbial in Weanling Piglet. MICROBIOLOGY SPECTRUM[J]. 2022, 第 7 作者10(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000766015800219.
[9] Liu, Xiaomin, Tong, Xin, Zou, Yuanqiang, Lin, Xiaoqian, Zhao, Hui, Tian, Liu, Jie, Zhuye, Wang, Qi, Zhang, Zhe, Lu, Haorong, Xiao, Liang, Qiu, Xuemei, Zi, Jin, Wang, Rong, Xu, Xun, Yang, Huanming, Wang, Jian, Zong, Yang, Liu, Weibin, Hou, Yong, Zhu, Shida, Jia, Huijue, Zhang, Tao. Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome. NATURE GENETICS[J]. 2022, 第 11 作者54(1): 52-+, http://dx.doi.org/10.1038/s41588-021-00968-y.
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发表著作
（1） The Human Microbiota and Microbiome (Advances in Molecular and Cellular Microbiology), CAB International, 2014-10, 第 1 作者
科研活动
科研项目
（ 1 ） 利用多组学手段研究肠道微生态与食物过敏之间的关联, 主持, 国家级, 2016-01--2021-06
（ 2 ） 肠道与下丘脑在糖尿病发生发展中的作用及干预新方案研究, 参与, 国家级, 2018-01--2021-06
（ 3 ） 特殊保障食品制造关键技术研究及新产品创制/水下长航特殊食品制造关键技术研究与新产品创制, 参与, 国家级, 2017-01--2021-06
（ 2 ） 肠道与下丘脑在糖尿病发生发展中的作用及干预新方案研究, 参与, 国家级, 2018-01--2021-06
（ 3 ） 特殊保障食品制造关键技术研究及新产品创制/水下长航特殊食品制造关键技术研究与新产品创制, 参与, 国家级, 2017-01--2021-06
参与会议
（1）人体多部位共生微生物研究及新型益生菌应用转化 第14届益生菌与健康国际研讨会 2019-05-22
（2）The Role of Gut Microbiome in Precision Nutrition 第三届人体微生物组创新未来者大会 2018-07-28
（3）The Research & Application of Human Commensal Microbiome 2018-06-24
（4）Microbiome and Human Health 第4届东方消化病大会 2017-07-14
（2）The Role of Gut Microbiome in Precision Nutrition 第三届人体微生物组创新未来者大会 2018-07-28
（3）The Research & Application of Human Commensal Microbiome 2018-06-24
（4）Microbiome and Human Health 第4届东方消化病大会 2017-07-14
指导学生
现指导学生
吴智楠 硕士研究生 086000-生物与医药
刘文韬 硕士研究生 086000-生物与医药