1．  非共价结合导向的、生物兼容的选择性化学新转化的发展，尤其是针对蛋白质上广泛存在的羧基、羟基、氨基、巯基等官能团的高效成键反应的开发。

2．  多元杂环类化合物的不对称模块化构建方法，并对积累的化合物库进行化学蛋白组学筛选，寻找新的致病靶点和活性化合物。

​3．  针对K-Ras 各类变异蛋白等“难成药”靶点的共价抑制剂的开发。

   

070303-有机化学
100701-药物化学
0703Z1-化学生物学

有机合成方法学
药物化学
化学生物学

2009-09--2014-07   中国科学院上海有机化学研究所   理学博士
2005-09--2009-06   武汉大学   理学学士

博士研究生

理学博士

   

2020-10~2021-04,The Scripps Research Institute, Staff Scientist
2018-03~2020-10,The Scripps Research Institute/Broad Institute, Research Associate
2015-10~2018-03,The Scripps Research Institute, Research Associate
2014-08~2015-10,中国科学院上海有机化学研究所, 助理研究员

   

[1] Yue Wang, Suping Zhang, Ke Zeng, 夏国钦. Deoxygenative radical cross-coupling of C(sp3)−O/C(sp3)−H bonds promoted by hydrogen-bond interaction. Nature Communications[J]. 2024, 第 4 作者  通讯作者  15(null): 6745, https://www.nature.com/articles/s41467-024-50897-7.
[2] Yiming Du, Shuxin Chen, Hexiang Cao, Yichen Zhang, Hongtao Lei, 夏国钦, Huicai Huang, Zhaodong Li. Nickel-Catalyzed, Enantioselective Hydrofluoromethylation of Olefins: Access to Chiral α-Fluoromethylated Amides and Esters. Organic Letters[J]. 2023, 第 6 作者  通讯作者  25(13): 2218-2222, https://pubs.acs.org/doi/10.1021/acs.orglett.3c00357.
[3] Herron, Alastair N, Liu, Dongxin, Xia, Guoqin, Yu, JinQuan. delta-C-H Mono- and Dihalogenation of Alcohols. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 第 3 作者142(6): 2766-2770, https://www.webofscience.com/wos/woscc/full-record/WOS:000514255300013.
[4] Xia Guoqin. Ligand-Enabled b-Methylene C(sp3)-H Arylation of Masked Aliphatic Alcohols. Angew. Chem. Int. Ed[J]. 2020, 第 1 作者
[5] Xia, Guoqin, Weng, Jiang, Liu, Luoyan, Verma, Pritha, Li, Ziqi, Yu, JinQuan. Reversing conventional site-selectivity in C(sp(3))-H bond activation. NATURE CHEMISTRY[J]. 2019, 第 1 作者11(6): 571-577, https://www.webofscience.com/wos/woscc/full-record/WOS:000468760800011.
[6] Wang, Peng, Erma, Pritha V, Xia, Guoqin, Shi, Jun, Qiao, Jennifer X, Tao, Shiwei, Cheng, Peter T W, Poss, Michael A, Farmer, Marcus E, Yeung, KapSun, Yu, JinQuan. Ligand-accelerated non-directed C-H functionalization of arenes. NATURE[J]. 2017, 第 3 作者551(7681): 489-+, http://dx.doi.org/10.1038/nature24632.
[7] Jain, Pankaj, Verma, Pritha, Xia, Guoqin, Yu, JinQuan. Enantioselective amine alpha-functionalization via palladium-catalysed C-H arylation of thioamides. NATURE CHEMISTRY[J]. 2017, 第 3 作者9(2): 140-144, https://www.webofscience.com/wos/woscc/full-record/WOS:000394541900010.
[8] Shen, Kun, Han, Xiuling, Xia, Guoqin, Lu, Xiyan. Cationic Pd(II)-catalyzed cyclization of N-tosyl-aniline tethered alkynyl ketones initiated by hydropalladation of alkynes: a facile way to 1,2-dihydro or 1,2,3,4-tetrahydroquinoline derivatives. ORGANIC CHEMISTRY FRONTIERS[J]. 2015, 第 3 作者2(2): 145-149, https://www.webofscience.com/wos/woscc/full-record/WOS:000364443200010.
[9] 夏国钦, 韩秀玲, 陆熙炎. Efficient Synthesis of Heterocyle-Fused beta-Naphthylamines via Intramolecular Addition to a Cyano Group Initiated by Nucleopalladation of Alkynes. ORG. LETT.[J]. 2014, 第 1 作者16(23): 6184-6187, http://ir.sioc.ac.cn/handle/331003/39137.
[10] 夏国钦, 韩秀玲, 陆熙炎. Pd(II)-Catalyzed One-Step Construction of Cycloalkane-Fused Indoles and Its Application in Formal Synthesis of (+/-)-Aspidospermidine. ORG. LETT.[J]. 2014, 第 1 作者16(7): 2058-2061, http://ir.sioc.ac.cn/handle/331003/39051.
[11] Xia Guoqin, Han Xiuling, Lu Xiyan. Palladium(II)-Catalyzed Cyclization Reaction of 2-(Alk-2 '-ynyloxy)benzonitriles or 2-(Alk-2 '-ynylamino)benzonitriles: A Facile Way to 2H-Chromene and 1,2-Dihydroquinoline Derivatives. ADV. SYNTH. CATAL.[J]. 2012, 第 1 作者354(14-15): 2701-2705, http://www.irgrid.ac.cn/handle/1471x/682114.