(1)海洋药用微生物资源的挖掘

(2)海洋来源新颖结构天然产物的分离鉴定和活性筛选

(3)海洋药物先导化合物的机制研究和成药性评价

(1) 海洋药物递送系统靶向治疗肾脏疾病获得重要进展

 http://scsio.cas.cn/news/kydt/202403/t20240319_7039789.html

(2) 红树林真菌来源抗骨质疏松药物先导物发现和机制研究获新进展

 http://scsio.cas.cn/news/kydt/202402/t20240204_6962258.html

(3) 海洋微生物来源粉蝶霉素类抗肾癌先导物成药性研究取得重要进展

 https://www.x-mol.com/news/687631

(4) 海洋微生物来源粉蝶霉素类天然产物及其抗肾癌研究取得重要进展

 https://www.x-mol.com/news/18570

(5) 南海礁栖海藻共附生微生物药用天然产物研究取得重要进展

 http://www.scsio.cas.cn/xwzx/kydt/202007/t20200702_5615248.html

2018-12至今      中国科学院南海海洋研究所 研究员

2010-12--2018-12  中国科学院南海海洋研究所 副研究员

2014-06--2015-06  美国加州大学圣地亚哥分校Scripps海洋研究所(Fenical's Lab)访问学者

2008-07--2010-12  中国科学院南海海洋研究所 助理研究员

2003-09--2008-06  华中科技大学同济医学院   研究生  博士

1999-09--2003-06  华中科技大学同济医学院   本科生  学士

承担科研项目

(1) 国家自然科学基金项目：北部湾海洋微生物来源粉蝶霉素糖苷抗肿瘤新机制和成药性优化(联合重点,2025-2028);北部湾海洋微生物资源多样性评估、药用开发与利用的前期研究(联合重点,合作单位负责人,2021-2024);海洋放线菌来源粉蝶霉素衍生物的定向构建和以PRDX1为靶点的抗肾癌先导物优化(面上, 2020-2023);基于组学技术的粉蝶霉素糖苷抗肾癌特异性靶点研究(应急, 2018) ;南海深海放线中gp41为靶点的HIV进入抑制剂的筛选发现(面上, 2014-2017) ;基于海绵化学防御功能的抗菌活性成分研究(青年,2010-2012)。

(2) 科技部任务：深海药源天然产物底盘宿主细胞和异源表达体系的构建(重点研发子课题负责人, 2020-2021);南海海洋(微)生物次生代谢产物库建设(重大专项任务负责人,2018-2020);深海微生物化学生态效应活性物质的发现与利用(863子课题负责人,2012-2015)。

(3)广东省科技厅项目：海洋微生物来源粉蝶霉素糖苷逆转肾癌耐药作用和机制研究(省杰青,2019-2022); 红树林底泥微生物中抗纤维化药源分子的定向挖掘和机制研究(省基金面上,2024-2026); 南海微生物来源药物先导物的发现、优化和成药性评价(省重点研发任务负责人,2020-2023);南海微生物中作用于抗肿瘤新靶点的吡啶酮类天然产物的筛选发现(社会发展项目，2016-2018); 深海放线菌来源抗污损生态活性物质的筛选和发现(省基金面上,2013-2015)。

(4)广东省资源厅海洋经济发展专项：基于海洋中药药源分子及新靶标发现与创新药物开发(2024-2026,合作单位负责人);海洋微生物来源防治心血管疾病的新型药物先导物的发现优化及其成药性评价(2023-2025,合作单位负责人);基于ADME/T成药特性的抗肾癌海洋候选药GPAs靶向制剂研发(2021-2023,合作单位负责人);海洋微生物抗生物污损活性物质的研究和开发(2018-2020,合作单位负责人)。

(5)海南省重大科技计划：南海海洋微生物药物先导物资源发现及活性评价(2020-2023)。

(6)广州市科技局项目：海洋微生物中粉蝶霉素类化合物的资源研究和GOLPH3抑制活性筛选(珠江新星, 2016-2019)；以RNA聚合酶保守性靶点筛选海洋微生物来源新型抗病毒先导化合物(2021-2023).

发表论文情况（第一/通讯作者）

2024年度

(90)  Ping Yu#, Tanwei Gu#, Yueyang Rao, Weimin Liang, Xi Zhang, Huanguo Jiang, Jindi Lu, Jianglian She, Jianmin Guo, Wei Yang, Yonghong Liu, Yingfeng Tu*, Lan Tang*, Xuefeng Zhou*. A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization. Acta Pharmaceutica Sinica B 2024, 14(7), 3232–3250. (IF14.5)

(89) Chunmei Chen#, Lingxiang Xiao#, Xiaowei Luo#, Jian Cai, Lishan Huang, Huaming Tao, Xuefeng Zhou*, Yanhui Tan,* and Yonghong Liu*. Identifying marine-derived tanzawaic acid derivatives as novel inhibitors against osteoclastogenesis and osteoporosis via downregulation of NF-κB and NFATc1 activation. Journal of Medicinal Chemistry, 2024, 67, 4, 2602-2618

(88) Jian Cai#, Li Gao#, Yue Wang#, Yuanteng Zheng, Xiuling Lin, Pingzheng Zhou, Chunmei Chen, Kechun Liu, Lan Tang, Yonghong Liu, Yanhui Tan*, Meng Jin*, Xuefeng Zhou*. Discovery of a novel anti-osteoporotic agent from marine fungus-derived structurally diverse sirenins. European Journal of Medicinal Chemistry, 2024, 265, 116068. 

(87) Jian Cai^#, Qian Zhou^#, Xin Qi, Furong Zhang, Jiafan Yang, Chunmei Chen, Kai Zhang, Zhexin Chen, Hai-Bin Luo, Yonghong Liu, Yi-You Huang*, Xuefeng Zhou*. Discovery of Oxidized p-Terphenyls as Phosphodiesterase 4 Inhibitors from Marine-Derived Fungi. Journal of Natural Products 2024, 87(7), 1808–1816.

(86) Jian Cai^#, Min Li^#, Chunmei Chen^#, Bin Yang, Chenghai Gao, Yonghong Liu, Xiaowei Luo*, Yanhui Tan*, Xuefeng Zhou*. Peniditerpenoids A and B: oxidized indole diterpenoids with osteoclast differentiation inhibitory activity from a mangrove-sediment-derived Penicillium sp. Journal of Natural Products 2024, 87(5), 1401–1406.

(85) Yuwei Fang^#, Jianglian She^#, Xi Zhang, Tanwei Gu, Danni Xie, Xiaowei Luo, Xiangxi Yi, Chenghai Gao, Yonghong Liu, Cuixian Zhang, Lan Tang*, Xuefeng Zhou*. Discovery of Anti-Hypercholesterolemia Agents Targeting LXRα from Marine Microorganism-Derived Natural Products. Journal of Natural Products 2024. 87(2), 322-331.

(84) Chunmei Chen^#, Xueni Wang^#, Wenxuan Fang, Jiaqi Liang, Jian Cai, Dehua Yang, Xiaowei Luo, Chenghai Gao, Xiangxi Yi, Yonghong Liu*, Xuefeng Zhou*, Talaketides AG, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027. Chinese Journal of Natural Medicines, 2024. 22(11): 1047-1056.

(83) Weimin Liang^#, Jindi Lu^#, Ping Yu, Meiqun Cai, Danni Xie, Xini Chen, Xi Zhang, Lingmin Tian, Liyan Yan, Wenxun Lan, Zhongqiu Liu, Xuefeng Zhou*, Lan Tang*. Evaluation of Pharmacokinetics and Metabolism of Three Marine-derived Piericidins for Guiding Drug Lead Selection. Chinese Journal of Natural Medicines, 2024. doi: 10.1016/S1875-5364(24)60669-2.

(82) Tanwei Gu^#, Jian Cai^#, Danni Xie, Jianglian She, Yonghong Liu, Xuefeng Zhou*, Lan Tang*. New Sesquiterpenoids from the Mangrove-Derived Fungus Talaromyces sp. as Modulators of Nuclear Receptors. Marine Drugs 22(9), 403.

(81) Yi Chen^#, Jian Cai^#, Ziwei Xia, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe, Xueni Wang*, Xuefeng Zhou*. New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411. Marine Drugs 2024, 22(9), 384.

(80) Xinlong Li, Jian Cai*, Xinqi Chen, Yanghongyu Wu, Yonghong Liu, Xiaowei Luo*, Xuefeng Zhou*. Discovery and Bioactivity Evaluation of Citrinin Derivatives from the Mangrove Sediment-Derived Fungus Talaromyces sp. SCSIO 41428. Chemistry & Biodiversity 2024, doi: 10.1002/cbdv.202401938.

(79) Zhu Chen, Jianglian She, Juan Liu, Bo Peng, Zhimin Yuan*, Xuefeng Zhou*. Pyripyropene U, a new alkaloid from the sponge-derived fungus Aspergillus sp. SCSIO41420. Natural Product Research, 2024, doi:10.1080/14786419.2023.2284866.

(78) Xiao-Wei Luo*, Gui-Hua Yang, Miao-Ping Lin, Hu-Mu Lu, Yong-Hong Liu, Xue-Feng Zhou*. Nitrogenous and phenolic compounds from mangrove-derived actinomycete Streptomyces psammoticus. Chemistry of Natural Compounds 2024, 60: 997–999

(77) 陈仪, 佘江链, 唐斓, 刘永宏, 周雪峰*. 海洋特征天然产物——硝基苯酯倍半萜类的研究进展[J]. 药学学报, 2024, 59(1): 35-42.

2023年度

(76) Bo Peng, Jian Cai, Zimin Xiao, Manli Liu, Xinlong Li, Bin Yang, Wei Fang, Yi-You Huang, Chunmei Chen*, Xuefeng Zhou* and Huaming Tao*. Bioactive Polyketides and Benzene Derivatives from Two Mangrove Sediment-Derived Fungi in the Beibu Gulf. Marine Drugs 2023, 21, 327.

(75) Jiaqi Liang, Jianglian She, Jun Fu, Jiamin Wang, Yuxiu Ye, Bin Yang, Yonghong Liu, Xuefeng Zhou*, Huaming Tao*. Advances in Natural Products from the Marine-Sponge-Associated Microorganisms with Antimicrobial Activity in the Last Decade. Marine Drugs 2023, 21, 236.

(74) Jiamin Wang, Yuning Qin, Miaoping Lin, Yingying Song, Humu Lu, Xinya Xu, Yonghong Liu, Xuefeng Zhou*, Chenghai Gao*, Xiaowei Luo*. Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities. Marine Drugs 2023, 21, 63.

(73) Jian Cai, Xueni Wang, Xia Gan, Qian Zhou, Xiaowei Luo, Bin Yang, Yonghong Liu, Disna Ratnasekera*, and Xuefeng Zhou*. New Chlorinated Metabolites and Antiproliferative Polyketone from the Mangrove Sediments-Derived Fungus Mollisia sp. SCSIO41409. Marine Drugs 2023; 21(1):32.

(72) Yuxiu Ye, Jiaqi Liang, Jianglian She, Xiuping Lin, Junfeng Wang, Yonghong Liu, Dehua Yang, Yanhui Tan*, Xiaowei Luo*, and Xuefeng Zhou*. Two New Alkaloids and a New Butenolide Derivative from the Beibu Gulf Sponge-Derived Fungus Penicillium sp. SCSIO 41413. Marine Drugs. 2023; 21(1):27. (IF 6.085)

(71) Tanwei Gu, Weihao Chen, Jianglian She, Bin Yang, Lan Tang, Huaming Tao, Jingxia Huang*, and Xuefeng Zhou*. Lipid metabolism regulatory activity and adverse effects of fungi-derived butyrolactone I. Natural Product Research, 2023, 37(11):1897-1901.

2022年度

(70) Canzhen Liu^#, Xiaoxu Wang^#, Xiaonan Wang^#, Yunfang Zhang^#, Wenjian Min, Ping Yu, Jinhua Miao, Weiwei Shen, Shuangqin Chen, Shan Zhou, Xiaolong Li, Ping Meng, Qinyu Wu, Fan Fan Hou, Youhua Liu, Peng Yang, Cheng Wang*, Xu Lin*, Lan Tang*, Xuefeng Zhou*, Lili Zhou*. A new LKB1 activator, piericidin analogue S14, retards renal fibrosis through promoting autophagy and mitochondrial homeostasis in renal tubular epithelial cells. Theranostics. 2022; 12(16): 7158-7179. (IF 11.6)

(69) Jianglian She, Yi Chen, Yuxiu Ye, Xiuping Lin, Bin Yang, Jiao Xiao, Yonghong Liu, and Xuefeng Zhou*. New Carboxamides and a New Polyketide from the Sponge-Derived Fungus Arthrinium sp. SCSIO 41421. Marine Drugs. 2022, 20, 475. (IF 6.085)

(68) Bo Peng, Qingyun Peng*, Jianglian She, Bin Yang, Xuefeng Zhou*. Secondary Metabolites from the Coral-Derived Fungus Aspergillus terreus SCSIO41404 with Pancreatic Lipase Inhibitory Activities. Records of Natural Products. 2022, 16(6), 639 - 644

(67) Kunlong Li, Siqiang Chen, Xiaoyan Pang, Jian Cai, Xinya Zhang, Yonghong Liu, Yiguang Zhu*, Xuefeng Zhou*. Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis. European Journal of Medicinal Chemistry. 2022, 230, 114117. (Cover Article, IF 7.088)

(66) Qingyun Peng^#,Weihao Chen^#, Xiuping Lin, Jiao Xiao, Yonghong Liu, Xuefeng Zhou*. Butenolides from the Coral-Derived Fungus Aspergillius terreus SCSIO41404. Marine Drugs. 2022, 20, 212. (IF 6.085)

(65) Ziqi Su, Kunlong Li, Xiaowei Luo, Yongyan Zhu, Shao-Yu Mai, Quanhong Zhu, Bin Yang, Xuefeng Zhou*, Huaming Tao*. Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities. Marine Drugs. 2022, 20, 259. (IF 6.085)

(64) Jian Cai, Xueni Wang, Zaizhun Yang, Yanhui Tan*, Bo Peng*, Yonghong Liu, Xuefeng Zhou*. Thiodiketopiperazines and Alkane Derivatives Produced by the Mangrove Sediment-Derived Fungus Penicillium ludwigii SCSIO 41408. Frontiers in Microbiology 2022, 13, 857041. (IF 6.064)

(63) Jianglian She, Tanwei Gu, Xiaoyan Pang, Yonghong Liu, Lan Tang*, Xuefeng Zhou*. Natural Products Targeting Liver X Receptors or Farnesoid X Receptor. Frontiers in Pharmacology. 2022, 12, 772435 (IF 5.81)

(62) Yanhui Tan, Minhong Ke, Zhichao Li, Yan Chen, Jiehuang Zheng, Yiyuan Wang, Xuefeng Zhou* , Gang Huang* and Xiaojuan Li*. A Nitrobenzoyl Sesquiterpenoid Insulicolide A Prevents Osteoclast Formation via Suppressing c-Fos-NFATc1 Signaling Pathway. Frontiers in Pharmacology. 2022, 12, 753240 (IF 5.81)

(61) Kunlong Li^#, Yu Dai^#, Jianglian She, Yanbo Zeng, Hao-fu Dai, Shunlin Ou*, Xuefeng Zhou*, Yonghong Liu*. Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus Colletotrichum sp. Journal of Asian Natural Products Research 2022, 24, 88-95

(60) Zhou Xuefeng*. Mangrove soil-derived Streptomyces: an important resource of pharmaceutical active natural products. Journal of Holistic Integrative Pharmacy. 2022, 3(3):284-298

(59) 叶禹秀, 罗小卫, 杨斌, 林秀萍, 刘永宏, 周雪峰*.南海礁栖海藻共附生真菌Pestalotiopsis neglecta SCSIO41403次级代谢产物研究[J]. 热带海洋学报, 2022,  41(3): 186-190.

2021年度

(58) Zhi Liang, Yulian Chen, Tanwei Gu, Jianglian She, Fahong Dai, Huanguo Jiang, Zhikun Zhan, Kunlong Li, Yonghong Liu, Xuefeng Zhou*, Lan Tang*. LXR-mediated regulation of marine-derived piericidins aggravates high cholesterol diet-induced cholesterol metabolism disorder in mice. Journal of Medicinal Chemistry. 2021, 64, 9943−9959 (Cover Article, IF 8.039)

(57) Luo, Xiaowei^#*; Cai, Guodi^#; Guo, Yinfeng^#; Gao, Chenghai; Huang, Weifeng; Zhang, Zhenhua; Lu, Humu; Liu, Kai; Chen, Jianghe; Xiong, Xiao-Feng; Lei, jinping; Zhou, Xuefeng*; Wang, Junjian*; Liu, Yonghong*. Exploring the Marine-Derived Ascochlorins as Novel hDHODH Inhibitors for Treatment of Triple-Negative Breast Cancer. Journal of Medicinal Chemistry. 2021, 64, 13918–13932. (Cover Article, IF 8.039)

(56) Kunlong Li, Ziqi Su, Yongli Gao, Xiuping Lin, Xiaoyan Pang, Bin Yang, Huaming Tao, Xiaowei Luo*, Yonghong Liu*, and Xuefeng Zhou*. Cytotoxic Minor Piericidin Derivatives from the Actinomycete Strain Streptomyces psammoticus SCSIO NS126. Marine Drugs. 2021, 19, 428. (IF 6.085)

(55) Liang, Zhi^#; Gu, Tanwei^#; Wang, Jianjiao^#; Jianglian She, Yuxiu Ye, Wenyu Cao, Xiaowei Luo, Jiao Xiao, Yonghong Liu, Lan Tang*, Xuefeng Zhou*. Chromene and chromone derivatives as liver X receptors modulators from a marine-derived Pestalotiopsis neglecta fungus. Bioorganic Chemistry. 2021, 112: 104927. (IF 5.307)

(54) Jian Cai, Chunmei Chen, Yanhui Tan, Weihao Chen, Xiaowei Luo, Lianxiang Luo, Bin Yang, Yonghong Liu, Xuefeng Zhou*. Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407. Molecules. 2021, 26, 4851. (IF 4.411)

(53) Qingyun Peng, Jian Cai, Jieyi Long, Bin Yang, Xiuping Lin, Junfeng Wang, Jiao Xiao, Yonghong Liu, Xuefeng Zhou*. New azaphthalide and phthalide derivatives from the marine coral-derived fungus Aspergillus sp. SCSIO41405. Phytochemistry Letters 2021, 43, 94–97.

(52) She Jianglian, Zhou Xuefeng*. New insights into the antitumor potential of natural piericidins. Journal of Holistic Integrative Pharmacy. 2021,2(3): 153-162

(51) 蔡健, 梁曼颖, 王健娇, 周雪峰*.长棘海星中含氮类化学成分研究[J].中国海洋药物, 2021, 40(4): 45-49.

(50) 李骏^#, 周雪峰^#, 潘剑宇^#, 田新朋, 鞠建华*. 广东省海洋生物医药产业现状与发展机遇的思考[J].中国海洋药物, 2021, 40(1): 41-48.

2020年度

(49) Yanhui Tan^#, Wende Deng^#, Yueyang Zhang, Minhong Ke, Binhua Zou, Xiaowei Luo, Jianbin Su, Yiyuan Wang, Jialan Xu, Kutty Selva Nandakumar, Yonghong Liu, Xuefeng Zhou* and Xiaojuan Li*. A marine fungus-derived nitrobenzoyl sesquiterpenoid suppresses RANKL-induced osteoclastogenesis and attenuates inflammatory bone destruction. British Journal of Pharmacology. 2020, 177: 4242–4260. (IF 9.473)

(48) Jianjiao Wang^#, Zhi Liang^#, Kunlong Li, Bin Yang, Yonghong Liu, Wei Fang*, Lan Tang*, Xuefeng Zhou*. Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha. Journal of Natural Products. 2020, 83, 1258−1264 (Cover Article, IF 4.803)

(47) Yu Dai^#, Kunlong Li^#, Jianglian She, Yanbo Zeng, Hao Wang, Shengrong Liao, Xiuping Lin, Bin Yang, Junfeng Wang, Huaming Tao, Haofu Dai, Xuefeng Zhou*, and Yonghong Liu*. Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401. Marine Drugs. 2020, 18, 547. (IF 5.118)

(46) Li Kunlong, Cai Jian, Su Ziqi, Yang Bin, Liu Yonghong, Zhou Xuefeng*, Huang Jingxia* and Tao Huaming*. Glycosylated Natural Products from Marine Microbes. Frontiers in Chemistry. 2020, 7: 879. (IF 5.221)

(45) Jianjiao Wang, Qingyun Peng, Xingang Yao, Yonghong Liu, Xuefeng Zhou*. New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403. The Journal of Antibiotics. 2020, 73, 585-588.

(44) 杨曦亮, 王健娇, 姜睿, 刘永宏, 周雪峰*. 海藻共附生真菌活性天然产物研究进展[J]. 广西科学, 2020,27(5): 462-474

2019年度

(43) Zhou Xuefeng^#,*; Liang Zhi^#; Li Kunlong; Fang Wei; Tian Yuanxin; Luo Xiaowei; Chen Yulian; Zhan Zhikun; Zhang Tao; Liao Shengrong; Liu Shuwen; Liu Yonghong; Fenical William; Tang Lan*. Exploring the natural piericidins as anti-renal cell carcinoma agents targeting peroxiredoxin 1. Journal of Medicinal Chemistry, 2019, 62, 7058−7069. (IF 8.039)

(42) Li Kunlong, Liang Zhi, Chen Weihao, Luo Xiaowei, Fang Wei, Liao Shengrong, Lin Xiuping, Yang Bin, Wang Junfeng, Tang Lan,* Liu Yonghong,* and Zhou Xuefeng*. Iakyricidins A‒D, antiproliferative piericidin analogs bearing carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104. The Journal of Organic Chemistry, 2019, 84 (19): 12626−12631. (Cover Article, IF 4.198)

(41) Wang Jianjiao, Li Kunlong, Luo Xiaowei, Wu Zhaoyuan, Gu Tanwei, Liao Shengrong, Lin Xiuping, Yang Bin, Liu Yonghong, Fang Wei*, Zhou Xuefeng*.Sorbicillfurans A and B, two novel sorbicillinoid adducts from the fungus Penicillium citrinum SCSIO41402. Organic & Biomolecular Chemistry, 2019, 17: 8721−8725. (Cover Article)

(40) Lu Xianyuan, Dong Yaqian, Jian Zhichao, Li Qingyun, Gong Linna, Tang Lan, Zhou Xuefeng*, Liu Menghua*.Systematic investigation of the effects of long-term administration of a high-fat diet on drug transporters in the mouse liver, kidney and intestine. Current Drug Metabolism. 2019, 20: 742-755

(39) He Jingyu, Dong Yaqian, Liu Xiaoyan, Wan Yiling, Gu Tanwei, Zhou Xuefeng*, Liu Menghua*.Comparison of chemical compositions, antioxidant, and anti-photoaging activities of Paeonia suffruticosa flowers at different flowering stages. Antioxidants, 2019, 8(9), 345. (IF 6.312)

(38) Luo Xiaowei; Chen Chunmei; Tao Huaming; Lin Xiuping; Yang Bin; Zhou Xuefeng*; Liu Yonghong*. Structurally diverse diketopiperazine alkaloids from the marine-derived fungusAspergillus versicolor SCSIO 41016. Organic Chemistry Frontiers, 2019, 6: 736~740.  (IF 5.281)

(37) Luo Xiao-Wei; Lin Yun; Lu Yong-Jun; Zhou Xue-feng*; Liu Yong-hong*. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. Chinese Journal of Natural Medicines, 2019, 17(2): 149~154.

(36) Lin Xiuping^#; Li Kunlong^#; Yang Lilin; Peng Xiaoying; Fang Wei; Tian Xinpeng*; Liu Yonghong; Zhou Xuefeng*. Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field. Natural Product Research, 2019, 33(4): 494–499.

(35) Tan Suiyi^#; Yang Bin^#; Liu Juan; Xun Tianrong; Liu Yonghong; Zhou Xuefeng*. Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent. Natural Product Research, 2019, 33(10): 1467-1471. (ESI高被引)

2018年度

(34) Wang Jianjiao^#; Chen Feimin^#; Liu Yunhao; Liu Yuxuan; Li Kunlong; Yang Xiliang; Liu Shuwen*; Zhou Xuefeng*, Yang Jie*. Spirostaphylotrichin X from a marine-derived fungus as an anti-influenza agent targeting RNA polymerase PB2. Journal of Natural Products, 2018, 81(12): 2722~2730.( IF 4.05，Top 20 Most Read Articles in December, 2018)

(33) Fang Wei; Wang Jianjiao; Wang Junfeng; Shi Liqiao; Li Kunlong; Lin Xiuping; Min Yong; Yang Bin; Tang Lan; Liu Yonghong; Zhou Xuefeng*. Cytotoxic and antibacterial eremophilane sesquiterpenes from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Journal of Natural Products, 2018, 81(6): 1405~1410. (IF 4.05)

(32) Luo Xiaowei; Lin Xiuping; Tao Huaming; Wang Junfeng; Li Jiayi; Yang Bin;Zhou Xuefeng*; Liu Yonghong*. Isochromophilones A-F, cytotoxic chloroazaphilones from the marine mangrove endophytic fungus Diaporthe sp. SCSIO 41011. Journal of Natural Products, 2018, 81(4): 934~941. (IF 4.05)

(31) Tan Yanhui^#; Yang Bin^#; Lin Xiuping; Luo Xiaowei; Pang Xiaoyan; Tang Lan; Liu Yonghong; Li Xiaojuan*; Zhou Xuefeng*. Nitrobenzoyl sesquiterpenoids with cytotoxic activities from a marine-derived Aspergillus ochraceus fungus. Journal of Natural Products, 2018, 81(1): 92~97. (IF 4.05)

(30) Tian Yongqi; Lin Xiuping; Zhou Xuefeng*; Liu Yonghong*. Phenol derivatives from the sponge-derived fungus Didymellaceae sp. SCSIO F46. Frontiers in Chemistry, 2018, 6: 536. (IF 5.221)

(29) Luo Xiaowei^#; Yang Jie^#; Chen Feimin; Lin Xiuping; Chen Chunmei;Zhou Xuefeng*; Liu Shuwen*; Liu Yonghong*. Structurally diverse polyketides from the mangrove-derived fungus Diaporthe sp. SCSIO 41011 with their anti-influenza A virus activities. Frontiers in Chemistry, 2018, 6: 282. (IF 5.221)

(28) Yang Bin; Tao Huaming; Lin Xiuping; Wang Junfeng; Liao Shengrong; Dong Junde; Zhou Xuefeng*; Liu Yonghong*. Prenylated indole alkaloids and chromone derivatives from the fungus Penicillium sp SCSI0041218.Tetrahedron, 2018, 74(1): 77~82.

(27) Luo Xiaowei; Zhou Xuefeng*; Liu Yonghong*. Nitrogenous compounds produced by the deep sea derived fungus Leptosphaeria sp SCSIO 41005. Natural Product Communications, 2018, 13(6): 677~678.

2011-2017年

(26) Lin Xiuping^#; Wu Qinyu^#; Yu Yuying; Liang Zhi; Liu Yonghong; Zhou Lili*; Tang Lan*; Zhou Xuefeng*. Penicilliumin B, a novel sesquiterpene methylcyclopentenedione from a deep sea-derived Penicillium strain with renoprotective activities. Scientific Reports, 2017, 7: 10757.

(25) Luo Xiaowei; Lin Xiuping; Salendra Limbadri; Pang Xiaoyan; Dai Yu; Yang Bin; Liu Juan; Wang Junfeng; Zhou Xuefeng*; Liu Yonghong*.Isobenzofuranones and isochromenones from the deep-sea derived fungus Leptosphaeria sp SCSIO 41005. Marine Drugs, 2017, 15(7): 204.

(24) Yang Xiliang*; Peng Qingyun; Liu Qian; Hu Jie; Tang Zhipeng; Cui Lianjie; Lin Zonghao; Xu Bing; Lu Kuojian; Yang Fang; Sheng Zhizheng; Yuan Qiong; Liu Song; Zhang Jiuliang; Zhou Xuefeng*.Antioxidant activity against H₂O₂-induced cytotoxicity of the ethanol extract and compounds from Pyrola decorate leaves. Pharmaceutical Biology, 2017, 55(1): 1843~1848.

(23)Zhou Xuefeng^#; Fang Wei^#; Tan Suiyi^#; Lin Xiuping; Xun Tianrong; Yang Bingjie; Liu Shuwen*; Liu Yonghong*. Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. Bioorganic & Medicinal Chemistry Letters, 2016, 26(2): 361~365.

(22)Zhou Xuefeng; Fenical William*. The unique chemistry and biology of the piericidins. Journal of Antibiotics. 2016, 69(8): 582~593.

(21) Fang Wei^#; Lin Xiuping^#; Wang Jianjiao; Liu Yonghong; Tao Huaming*; Zhou Xuefeng*. Asperpyrone-type bis-naphtho-pyrones with COX-2-inhibitory activities from marine-derived fungus Aspergillus niger. Molecules, 2016, 21: 941.

(20) Fang Wei^#; Lin Xiuping^#; Zhou Xuefeng*; Wan Junting; Lu Xin; Yang Bin; Ai Wen; Lin Ji; Zhang Tianyu; Tu Zhengchao; Liu Yonghong*. Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17. MedChemComm, 2014, 5(6): 701~705. (Cover Article)

(19) Fredimoses Mangaladoss^#;Zhou Xuefeng^#; Lin Xiuping; Tian Xinpeng; Ai Wen; Wang Junfeng; Liao Shengrong; Liu Juan; Yang Bin; Yang Xianwen; Liu Yonghong*.New prenylxanthones from the deep-Sea derived fungusEmericella sp. SCSIO 05240. Marine Drugs, 2014, 12(6): 3190~3202.

(18)Zhou Xuefeng; Sun Jianfan; Ma Wanlei; Fang Wei; Chen Zhefan; Yang Bin; Liu Yonghong*. Bioactivities of six sterols isolated from marine invertebrates. Pharmaceutical Biology, 2014, 52(2): 187~190.

(17)Zhou Xuefeng^#; Lin Xiuping^#; Ma Wanlei; Fang Wei; Chen Zhefang; Yang Bin; Liu Yonghong*. A new aromatic amine from fungus Pestalotiopsis vaccinii. Phytochemistry Letters, 2014, 7: 35~37.

(16)Zhou Xuefeng; Liu Juan; Yang Bin; Lin Xiuping; Yang Xian-Wen; Liu Yonghong*. Marine natural products with anti-HIV activities in the last decade.Current Medicinal Chemistry, 2013, 20(7): 953~973.

(15)Zhou Xuefeng; Lin Xiuping; Guo Xieyang; Yang Bin; Yang Xian-Wen; Liu Yonghong*.Chemical constituents of the sponge Mycalespecies from South China Sea. Records of Natural Products, 2013, 7(2): 119~123.

(14)Zhou Xuefeng; Lu Yanan; Lin Xiuping; Yang Bin; Yang Xian-Wen; Liu Yonghong*. Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities. Chemistry and Physics of Lipids, 2011, 164(7): 703~706.

2009-2010年

(13)Xuefeng Zhou, Tunhai Xu, Yonghong Liu. Alisma orientale(Sam.) Juzep., a Common Traditional Chinese Medicine Plant as a Diuretic Agent. Recent Progress in Medicinal Plants Vol. 28: Drug Plants II. ISBN:1933699183, Houston: Studium Press LLC, 2010. P461~480.

(12)Zhou X.; Xu T.; Yang X.-W.; Huang R.; Yang B.; Tang L.; Liu Y.*. Chemical and biological aspects of marine sponges of the genus Xestospongia. Chemistry and Biodiversity, 2010, 7(9): 2201~2227.

(11)Zhou X.; Xu T.; Wen K.; Yang X.-W.; Xu S.-H.*; Liu Y.*.New N-Acyl taurine from the sea urchin Glyptocidaris crenularis. Bioscience Biotechnology and Biochemistry, 2010, 74(5): 1089~1091.

(10)Zhou X.; Wen K.; Yang X.; Huang R.; Dong G.; Yang B.; Liu Y.*.Chemical constituents from the sea urchin Glyptocidaris crenularis. Biochemical Systematics and Ecology, 2010, 38: 103~105.

(9)Zhou X; Liu Y; Tang L; Zhang P*; Wu J.Chemical constituents from the roots of Actinidia chinensis. Chemistry of Natural Compounds, 2010, 46(2): 308~309.

(8)Zhou X; Tang L*; Liu Y.An isomeric mixture of novel cerebrosides isolated from Impatiens pritzellii reduces lipopolysaccharide-induced release of IL-18 from human peripheral blood mononuclear cells. Lipids, 2009, 44(8): 759~763.

(7)Zhou X-F; Tang L; Zhang P*; Zhao X-Y; Pi H-F; Zhang Y-H; Wu J-Z.The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var.hupehensis. Zeitschrift fur Naturforschung Section C. 2009, 64: 369~372.

(6)Zhou X-F; Zhang P*; Pi H-F; Zhang Y-H; Ruan H-L; Wang H; Wu J-Z. Triterpenoids from the roots of Actinidia chinensis. Chemistry and Biodiversity, 2009, 6: 1202~1207.

2005-2008年

(5) 周雪峰,唐斓,张鹏,阮汉利,张勇慧,皮慧芳,吴继洲. 冷水七单体皂苷抗炎镇痛和免疫活性研究.中药药理与临床. 2008, 24(1):27~28.

(4)Zhou X-F; Tang L; Zhang Y-H; Pi H-F; Ruan H-L; Wu J-Z*. Nitrogenous compounds from Impatiens pritzellii var. hupehensis (Balsaminaceae). Biochemical Systematics and Ecology, 2007, 35(5): 308~310.

(3) Zhou X-F; Zhao X-Y; Tang L; Zhang Y-H; Ruan H-L; Pi H-F; Qiu J; Wu J-Z*. Immunomodulatory activity of the rhizomes ofImpatiens pritzellii var.hupehensison collagen-induced arthritis mice. Journal of Ethnopharmacology, 2007, 109(3): 505~509.

(2) Zhou X-F; Zhao X-Y; Tang L; Ruan H-L; Zhang Y-H; Pi H-F; Xiao W-L; Sun H-D; Wu J-Z*.Three new triterpenoid saponins from the rhizomes of Impatiens pritzellii var. hupehensis. Journal of Asian Natural Products Research, 2007, 9(4): 379~385.

(1)周雪峰,尹仁杰,阮汉利,张勇慧,皮慧芳,赵晓亚,吴继洲.泽泻抑制尿草酸钙结石形成活性成分的2D NMR分析.波谱学杂志, 2005, 22(2):195~200.

专利申请/授权/转让情况：
24) 蔡健,周雪峰,顾倓玮,唐斓,刘永宏. 海洋真菌来源倍半萜talaroterpene D 及其制备方法和在制备RORα 激动剂中的应用. 2024112116178.申请日：2024年08月30日

23) 周雪峰,李鑫龙,蔡健,王雪妮,刘永宏. 海洋真菌来源桔霉素衍生物cladosporin C 在制备抗前列腺癌药物中的应用.        202411089752X. 申请日：2024年08月09日

22) 周雪峰,陈仪,蔡健,王雪妮,刘永宏. 海洋真菌来源苯醌衍生物embelin A 及其制备方法和应用. 2024110897483. 申请日：2024年08月09日

21) 周雪峰,唐斓,梁嘉琦,刘永宏. 一株链霉菌和生产粉蝶霉素糖苷的发酵方法及其应用. 202410857442.1. 申请日：2024年06月28日(已转让)

20)陈春梅;周雪峰;王雪妮;蔡健;王俊锋;杨斌;刘永宏. 海洋真菌来源链状多烯酸类化合物在制备抗前列腺癌药物中的应用. 2024100935008.申请日：2024.01.23

19)陈春梅;周雪峰;谭艳辉;罗小卫;蔡健;刘永宏.海洋真菌来源坦桑瓦酸类化合物及其制备方法和应用. 2024100548876.申请日：2024.01.15

18)唐斓;周雪峰;于萍;梁伟敏;谢丹旎;蔡美裙.一种PRDX1诱导剂及其在制备抗急性肾损伤药物中的应用2024101768549授权日：2024.10.25 (已转让)

17)唐斓;周雪峰;于萍;涂盈锋;梁伟敏.一种粉蝶霉素类纳米靶向制剂及其制备方法和应用. 2024101768553授权日：2024.09.06 (已转让)

16)唐斓,周雪峰,于萍,顾倓玮,梁嘉琦. A PRDX1 inducer and its application in the preparation of anti-acute kidney injury drugs.国际申请号：PCT/CN2024/103668 (已转让)

15)周雪峰;蔡健;陈春梅;谭艳辉;杨斌;庞小艳;唐斓;刘永宏. 海洋真菌来源开环吲哚二萜类化合物peniditerpenoid A及其制备方法和应用. ZL2023102419470, 授权日2024.04.30

14)周雪峰;蔡健;陈春梅;唐斓;杨斌;庞小艳;谭艳辉;刘永宏.海洋真菌来源化合物eupenicisirenin C及其制备方法和应用. ZL 2023102419432, 授权日2024.05.07

13)周雪峰,唐斓,李坤龙,杨斌,陶华明,刘永宏. 一种吡啶酮粉蝶霉素及其制备方法和在制备抗癌药物中的应用. ZL202110687275.7, 申请日2021.06.21, 授权日2022-08-05(已转让)

12)周雪峰,戴昱,杨斌,林秀萍,刘永宏. 一种苯酞甘油醚类化合物及其制备方法和在抗海洋生物污损方面的应用. ZL 202011023962.0, 申请日2020-09-25；授权日2022-07-12.

11)周雪峰,唐斓,王健娇,杨斌,林秀萍,刘永宏. 一种香叶基三羟基色酮及其制备方法和在制备肝X受体激动剂中的应用. ZL202010442043.0, 申请日2020.05.22, 授权日2022-04-26

10)周雪峰,李坤龙,唐斓,杨斌,刘永宏. 两个支链异构化粉蝶霉素类化合物及其在抗肾癌药物中的应用. 202010442011.0, 申请日2020.05.22, 授权日2021.08.24(已转让)

9)周雪峰,唐斓,王健娇,李坤龙,杨斌,刘永宏.一种炔烯对苯二酚糖苷及其在制备肝X受体激动剂中的应用. ZL202010258928.5, 授权日2021.06.11.

8)杨斌；刘永宏; 周雪峰; 王俊锋; 董俊德；廖升荣. 一类吲哚细胞松弛素类化合物及其制备方法和在制备抗肿瘤药物中的应用. ZL 201710892685.9授权日：2021.01.29(已转让)

7)周雪峰,唐斓,方伟,罗小卫,李坤龙,刘永宏. 两个粉蝶霉素葡萄糖苷及其在抗肾癌药物中的应用. ZL201811340841.1, 授权日2020.11.06. (已转让)

6)周雪峰,唐斓,方伟,李坤龙,刘永宏. 三个粉蝶霉素类天然产物及其在制备抗肾癌药物中的应用. ZL201811340842.6, 授权日2020.10.20. (已转让)

5)周雪峰,杨斌,林秀萍,唐斓,李晓娟,刘永宏. 一类硝基苯酯倍半萜类化合物及其在制备抗肾癌药物中的应用. ZL201710861987.X, 授权日2020.08.11. (已转让)

4)周雪峰,唐斓,李坤龙,方伟,刘永宏. 一种链霉菌及其代谢产物粉蝶霉素类化合物在抗肾癌中的应用. ZL201710344174.3, 授权日2020.05.12. (已转让)

3)杨洁;唐斓;周雪峰;刘叔文;陈飞敏. 螺圆孢菌素X及其制备治疗甲型流感药物中的应用. ZL 2018113530269. 授权日: 2020.06.19 (已转让)

2)周雪峰,方伟,林秀萍,刘永宏.倍半萜硝基苯酯类化合物及其制备方法和在制备抗肿瘤药物中的应用. ZL 201310464296.8, 授权日2015.03.11 (已转让)

1)周雪峰; 刘永宏; 徐暾海; 杨献文; 黄日明; 王隶书. 一种来源于海绵的甾醇及其提取方法和应用. ZL200910193049.2, 授权日2012.09.26

中国药学会海洋药物专业委员会委员

中国药学会海洋药物专业委员会“海洋药物博士论坛”青年委员会委员

广东省海洋协会海洋生物分会秘书长

​国际期刊Marine Drugs编委（Editorial Board Member）

《Chinese Chemistry Letters》青年编委

J Med Chem，Org Lett, J Nat Prod, PhytoMedicine, Phytochemistry, Front Chem, Curr Med Chem, Chin J Nat Med, BMCL, Nat Prod Res, Nat Prod Comm等国际期刊审稿人