聚焦天然多糖领域的关键科学问题，研究多糖及寡糖的化学结构、生物活性和作用机制，阐明构效关系和药理学特征，为候选药物发现及新药研发奠定基础。

   

100706-药理学
100701-药物化学

天然聚糖结构与功能，糖尿病足溃疡
天然糖类药物的发现，心脑血管药理学
聚糖基生物材料的研发

2005-09--2010-06   天津大学   研究生/博士学位

博士研究生

博士

长期从事天然产物糖化学、糖生物学及糖类药物（含农药）的研发，尤其在多糖及寡糖类活性天然产物的分离纯化、结构修饰、寡糖纯化、活性筛选评价及其药理学作用机制等研究方面具有一定的专业特长，积累了较为丰富的经验，取得了系列原创性成果。应用基础研究方面，专长于多糖及寡糖类创新药物的纯化制备工艺、半合成修饰、原料药小试中试的工艺优化、结构确证及质量研究等药学研究，以及药代药效等初步的成药性评价。

以第一作者或通讯作者(含共同通讯)在PNAS, Angew. Chem. Int. Ed., Eur. J. Med. Chem., Carbohydr. Polym., J. Biol. Chem.及 Chem. Eur. J.等天然药物领域SCI期刊上发表研究论文25篇。以2020年JCR计总IF值大于200，其中IF>9 有8篇，中科院期刊分区一区10篇，这些论文均聚焦于聚糖制备、结构解析及药理机制阐明，为创新候选药物的发现和药学研究提供了科学理论依据及奠定了关键技术基础。目前，全部论文被  Chem. Soc. Rev., Med. Res. Rev., J. Med. Chem.及Anal. Chem.等国际SCI杂志引用达1000余次（Web of Science 2021.6.15检索数据），并获得国内外研究领域专家学者的肯定，2019年9月当选中国化学会首届糖化学专业委员会委员。作为主要发明人申请国内外发明专利23件，获授权11件，获美国、欧洲、日本、澳大利亚等授权专利8件。作为核心骨干，参与完成的国家一类新药LFG实现技术成果的企业转化，现已获得美国FDA批准进入临床研究阶段。

受邀为国际SCI学术期刊European Journal of Medicinal Chemistry, Food Chemistry, Carbohydrate Polymers, Food and Chemical Toxicology, Marine Drugs及International Journal of Biological Macromolecules等杂志的审稿人。

2019-01~现在, 中国科学院昆明植物研究所, 研究员
2013-01~2018-12,中国科学院昆明植物研究所, 副研究员
2010-07~2012-12,中国科学院昆明植物研究所, 助理研究员

2019-09-01-今,中国化学会糖化学专业委员会, 委员

   

[1] 赵金华, 何金星, 吴明一, 刘峙汶, 高娜, 赵龙岩, 李姿, 卢锋, 徐丽, 肖创, 杨莲, 陈钧, 周路坦, 彭文烈, 刘吉开. Fuc3S4S取代的低聚糖胺聚糖及其制备方法. CN: CN103788222A, 2014-05-14.

[2] 赵金华, 吴明一, 李姿. 一种抗消化性溃疡的组合物及其应用. CN: CN103735591A, 2014-04-23.

[3] 赵金华, 吴明一, 李姿. 一种含石斛多糖和苍术硬脂的组合物及其应用. CN: CN103690582A, 2014-04-02.

[4] 赵金华, 吴明一, 高娜, 李姿, 赖森森, 赵龙岩. 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物. CN: CN103214591A, 2013-07-24.

[5] 赵金华, 刘吉开, 吴明一, 高娜, 卢锋, 李姿. 一种低分子量糖胺聚糖衍生物及其药物组合物和其制备方法与应用. CN: CN103145868A, 2013-06-12.

[6] 刘吉开, 郑永唐, 赵金华, 吴明一, 黄宁, 李姿, 高娜, 文丹丹, 连武, 何江波. 低分子量岩藻糖化糖胺聚糖的羧基还原衍生物及其制备方法与用途. CN: CN102558389A, 2012-07-11.

[7] 赵金华, 吴明一, 高娜, 文丹丹, 连武, 李姿. 一种岩藻糖化糖胺聚糖衍生物及其制备方法. CN: CN102329397A, 2012-01-25.

[8] 赵金华, 刘吉开, 郑永唐, 吴明一, 黄宁, 李姿, 何江波. 低分子量糖基化硫酸软骨素及其在抗HIV-1药物制备中的用途. CN: CN102247401A, 2011-11-23.

[1] Zhang, Junyin, Chen, Hulan, Luo, Lan, Zhou, Zhipeng, Wang, Yingxiang, Gao, Tianyu, Yang, Lian, Peng, Teng, Wu, Mingyi. Structures of fructan and galactan from Polygonatum cyrtonema and their utilization by probiotic bacteria. CARBOHYDRATE POLYMERS[J]. 2021, 267: http://dx.doi.org/10.1016/j.carbpol.2021.118219.

[2] Wu, Yuebo, Zhou, Zhipeng, Luo, Lan, Tao, Maixian, Chang, Xiao, Yang, Lian, Huang, Xingyong, Hu, Lin, Wu, Mingyi. A non-anticoagulant heparin-like snail glycosaminoglycan promotes healing of diabetic wound. CARBOHYDRATE POLYMERS[J]. 2020, 247: http://dx.doi.org/10.1016/j.carbpol.2020.116682.

[3] Xiao, Chuang, Zhao, Longyan, Gao, Na, Wu, Mingyi, Zhao, Jinhua. Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa-Factor VIIIa Interactions. THROMBOSIS AND HAEMOSTASIS[J]. 2019, 119(5): 705-715, http://ir.kib.ac.cn/handle/151853/66866.

[4] Gao, Na, Wu, Mingyi, Xiao, Chuang, Lin, Lisha, Xu, Li, Zhao, Jinhua, Zhou, Lutan. Plasma contact activation by a fucosylated chondroitin sulfate and its structure-activity relationship study. MOLECULES[J]. 2018, 23(10): 2429-, http://www.irgrid.ac.cn/handle/1471x/1781679.

[5] Xu, Li, Gao, Na, Xiao, Chuang, Lin, Lisha, Purcell, Steven W, Wu, Mingyi, Zhao, Jinhua. Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 154: 133-143, http://ir.kib.ac.cn/handle/151853/64728.

[6] Zhao, Jinhua, Wu, Mingyi, Xu, Li, Gao, Na, Xiao, Chuang, Lin, Lisha, Purcell, Steven W.. Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition. FRONTIERS IN GENETICS[J]. 2018, 9: 223-, http://ir.kib.ac.cn/handle/151853/63355.

[7] Wu Mingyi. Synthesis of fucosylated chondroitin sulfate glycoclusters: a robust route to novel anticoagulant agents. Chemistry–A European Journal. 2018, 
[8] Yin, Ronghua, Zhou, Lutan, Gao, Na, Li, Zi, Zhao, Longyan, Shang, Feineng, Wu, Mingyi, Zhao, Jinhua. Oligosaccharides from depolymerized fucosylated glycosaminoglycan: Structures and minimum size for intrinsic factor Xase complex inhibition. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 293(36): 14089-14099, https://www.webofscience.com/wos/woscc/full-record/WOS:000444070700030.

[9] Wu, Mingyi, Yang, Wenjiao, Cai, Ying, Yin, Ronghua, Lin, Lisha, Li, Zhongkun, Zhao, Jinhua. Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber. PHYTOCHEMISTRY LETTERS[J]. 2018, 26: 50-54, http://ir.kib.ac.cn/handle/151853/63320.

[10] Yang, Wenjiao, Cai, Ying, Yin, Ronghua, Lin, Lisha, Li, Zhongkun, Wu, Mingyi, Zhao, Jinhua. Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2018, 115: 1055-1062, http://ir.kib.ac.cn/handle/151853/64701.

[11] Shang, Feineng, Mou, Rongrong, Zhang, Zhidong, Gao, Na, Lin, Lisha, Li, Zhongkun, Wu, Mingyi, Zhao, Jinhua. Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors. CARBOHYDRATE POLYMERS[J]. 2018, 195: 257-266, http://dx.doi.org/10.1016/j.carbpol.2018.04.117.

[12] Liu, Jie, Zhou, Lutan, He, Zhicheng, Gao, Na, Shang, Feineng, Xu, Jianping, Li, Zi, Yang, Zengming, Wu, Mingyi, Zhao, Jinhua. Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica. CARBOHYDRATE POLYMERS[J]. 2018, 181: 433-441, http://dx.doi.org/10.1016/j.carbpol.2017.10.091.

[13] Cai, Ying, Yang, Wenjiao, Yin, Ronghua, Zhou, Lutan, Li, Zhongkun, Wu, Mingyi, Zhao, Jinhua. An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer. CARBOHYDRATE RESEARCH[J]. 2018, 464: 12-18, http://dx.doi.org/10.1016/j.carres.2018.05.007.

[14] Liu, Huiying, Zhang, Xiao, Wu, Mingyi, Li, Zhongjun. Synthesis and anticoagulation studies of "short-armed" fucosylated chondroitin sulfate glycoclusters. CARBOHYDRATE RESEARCH[J]. 2018, 467: 45-51, http://dx.doi.org/10.1016/j.carres.2018.07.008.

[15] Lin, Lisha, Xu, Li, Xiao, Chuang, Zhou, Lutan, Gao, Na, Wu, Mingyi, Zhao, Jinhua. Plasma contact activation by a fucosylated chondroitin sulfate and its structure-activity relationship study. GLYCOBIOLOGY[J]. 2018, 28(10): 754-764, http://ir.kib.ac.cn/handle/151853/64686.

[16] Shang, Feineng, Gao, Na, Yin, Ronghua, Lin, Lisha, Xiao, Chuang, Zhou, Lutan, Li, Zi, Purcell, Steven W, Wu, Mingyi, Zhao, Jinhua. Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 148: 423-435, http://dx.doi.org/10.1016/j.ejmech.2018.02.047.

[17] Liu Jie, Zhou Lutan, He Zhicheng, Gao Na, Shang Feineng, Xu Jianping, Li Zi, Yang Zengming, Wu Mingyi, Zhao Jinhua. Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica. Carbohydrate Polymers[J]. 2018, 
[18] Zhang, Xiao, Liu, Huiying, Lin, Lisha, Yao, Wang, Zhao, Jinhua, Wu, Mingyi, Li, Zhongjun. Synthesis of Fucosylated Chondroitin Sulfate Nonasaccharide as a Novel Anticoagulant Targeting Intrinsic Factor Xase Complex. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(39): 12880-12885, http://dx.doi.org/10.1002/anie.201807546.

[19] Lin, Lisha, Wu, Mingyi, Zhao, Jinhua. The initiation and effects of plasma contact activation: an overview. INTERNATIONAL JOURNAL OF HEMATOLOGY[J]. 2017, 105(3): 235-243, http://www.irgrid.ac.cn/handle/1471x/1185335.

[20] Liu Jie, Shang Feineng, Yang Zengming, Wu Mingyi, Zhao Jinhua. Structural analysis of a homogeneous polysaccharide from Achatina fulica. International Journal of Biological Macromolecules[J]. 2017, 
[21] Li, Xiaomei, Luo, Lan, Cai, Ying, Yang, Wenjiao, Lin, Lisha, Li, Zi, Gao, Na, Purcell, Steven W, Wu, Mingyi, Zhao, Jinhua. Structural Elucidation and Biological Activity of a Highly Regular Fucosylated Glycosaminoglycan from the Edible Sea Cucumber Stichopus herrmanni. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2017, 65(42): 9315-9323, https://www.webofscience.com/wos/woscc/full-record/WOS:000413992900018.

[22] Xiao, Chuang, Lian, Wu, Zhou, Lutan, Gao, Na, Xu, Li, Chen, Jun, Wu, Mingyi, Peng, Wenlie, Zhao, Jinhua. Interactions between depolymerized fucosylated glycosaminoglycan and coagulation proteases or inhibitors. THROMBOSIS RESEARCH[J]. 2016, 146: 59-68, http://dx.doi.org/10.1016/j.thromres.2016.08.027.

[23] 刘程程, 李姿, 高娜, 吴明一, 王志平, 赵金华, 张庆芝. 糙海参质量标准研究. 中国医院药学杂志[J]. 2016, 36(14): 1176-1180, http://lib.cqvip.com/Qikan/Article/Detail?id=669586447.

[24] Wu, Mingyi, Xu, Li, Zhao, Longyan, Xiao, Chuang, Gao, Na, Luo, Lan, Yang, Lian, Li, Zi, Chen, Lingyun, Zhao, Jinhua. Structural Analysis and Anticoagulant Activities of the Novel Sulfated Fucan Possessing a Regular Well-Defined Repeating Unit from Sea Cucumber. MARINE DRUGS[J]. 2015, 13(4): 2063-2084, http://www.irgrid.ac.cn/handle/1471x/959097.

[25] Gao, Na, Lu, Feng, Xiao, Chuang, Yang, Lian, Chen, Jun, Zhou, Kai, Wen, Dandan, Li, Zi, Wu, Mingyi, Jiang, Jianmin, Liu, Guangming, Zhao, Jinhua. beta-Eliminative depolymerization of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments. CARBOHYDRATE POLYMERS[J]. 2015, 127: 427-437, http://www.irgrid.ac.cn/handle/1471x/963665.

[26] Zhao, Longyan, Wu, Mingyi, Xiao, Chuang, Yang, Lian, Zhou, Lutan, Gao, Na, Li, Zi, Chen, Jun, Chen, Jianchao, Liu, Jikai, Qin, Hongbo, Zhao, Jinhua. Discovery of an intrinsic tenase complex inhibitor: Pure nonasaccharide from fucosylated glycosaminoglycan. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2015, 112(27): 8284-8289, http://www.irgrid.ac.cn/handle/1471x/1000675.

[27] Wu, Mingyi, Wen, Dandan, Gao, Na, Xiao, Chuang, Yang, Lian, Xu, Li, Lian, Wu, Peng, Wenlie, Jiang, Jianmin, Zhao, Jinhua. Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2015, 92: 257-269, http://dx.doi.org/10.1016/j.ejmech.2014.12.054.

[28] 罗兰, 赵金华, 向静颖, 李姿, 吴明一, 王盛民. 巴西海参Ludwigothurea grisea的体壁多糖类型、性质及活性研究. 云南中医学院学报[J]. 2013, 36(2): 14-19, http://lib.cqvip.com/Qikan/Article/Detail?id=45556671.

[29] Zhao, Longyan, Lai, Sensen, Huang, Rong, Wu, Mingyi, Gao, Na, Xu, Li, Qin, Hongbo, Peng, Wenlie, Zhao, Jinhua. Structure and anticoagulant activity of fucosylated glycosaminoglycan degraded by deaminative cleavage. CARBOHYDRATE POLYMERS[J]. 2013, 98(2): 1514-1523, http://dx.doi.org/10.1016/j.carbpol.2013.07.063.

[30] Huang, Ning, Wu, MingYi, Zheng, ChangBo, Zhu, Lin, Zhao, JinHua, Zheng, YongTang. The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry. CARBOHYDRATE RESEARCH[J]. 2013, 380(X): 64-69, http://dx.doi.org/10.1016/j.carres.2013.07.010.

[31] Lian, Wu, Wu, Mingyi, Huang, Ning, Gao, Na, Xiao, Chuang, Li, Zi, Zhang, Zhigang, Zheng, Yongtang, Peng, Wenlie, Zhao, Jinhua. Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS[J]. 2013, 1830(10): 4681-4691, http://dx.doi.org/10.1016/j.bbagen.2013.06.003.

[32] 卢锋, 吴明一, 高娜, 刘光明, 赵金华. 黑乳海参硫酸化多糖的提取纯化、结构特征及其抗凝活性. 大理学院学报[J]. 2013, 12-16, http://lib.cqvip.com/Qikan/Article/Detail?id=46179875.

[33] Luo, Lan, Wu, Mingyi, Xu, Li, Lian, Wu, Xiang, Jingying, Lu, Feng, Gao, Na, Xiao, Chuang, Wang, Shengmin, Zhao, Jinhua. Comparison of Physicochemical Characteristics and Anticoagulant Activities of Polysaccharides from Three Sea Cucumbers. MARINE DRUGS[J]. 2013, 11(2): 399-417, http://www.irgrid.ac.cn/handle/1471x/660281.

[34] 高娜, 刘韶, 吴明一, 赵金华. 糖胺聚糖的结构修饰及其衍生物应用的研究进展. 中国生化药物杂志[J]. 2012, 33(3): 307-311, http://lib.cqvip.com/Qikan/Article/Detail?id=42191896.

[35] Gao, Na, Wu, Mingyi, Liu, Shao, Lian, Wu, Li, Zi, Zhao, Jinhua. Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber. MARINE DRUGS[J]. 2012, 10(8): 1647-1661, http://www.irgrid.ac.cn/handle/1471x/522628.

（ 1 ） 抗凝新药LFG的组成寡糖对内源性凝血途径选择性抑制的研究, 主持, 国家级, 2019-01--2022-12
（ 2 ） 复杂FG的确切结构及其取代基对Xase抑制活性的影响, 主持, 国家级, 2017-01--2020-12
（ 3 ） 中国科学院青年创新促进会人才项目, 主持, 部委级, 2017-01--2020-12
（ 4 ） 作用于gp120保守区CD4i的 TAG衍生物抑制HIV侵入活性的构效关系, 主持, 国家级, 2012-01--2014-12
（ 5 ） FuCS衍生物依赖HC-II的抗凝血酶活性及其构效关系, 主持, 省级, 2012-10--2015-09
（ 6 ） FD 类P-选择素抑制剂候选新药研究, 主持, 市地级, 2017-01--2018-12
（ 7 ） 化学创新药DCP118研发, 主持, 院级, 2020-04--2039-12
（ 8 ） 天然多糖及色素等新型化妆品原料研发, 主持, 院级, 2020-08--2028-12
（ 9 ） AFG寡糖促进糖尿病足溃疡愈合的构效关系及药理机制研究, 主持, 部委级, 2021-01--2023-12

已指导学生

付欣蕊  硕士研究生  105500-药学  

现指导学生

蒋泽秀  硕士研究生  105500-药学  

吴鑫  硕士研究生  078006-药理学  

宋雪梅  硕士研究生  071010-生物化学与分子生物学  

邓拓  博士研究生  100701-药物化学