基本信息
吴惠丰 男 博导 中国科学院烟台海岸带研究所
电子邮件： hfwu@yic.ac.cn
通信地址： 山东省烟台市莱山区春晖路17号
邮政编码： 264003
电子邮件： hfwu@yic.ac.cn
通信地址： 山东省烟台市莱山区春晖路17号
邮政编码： 264003
研究领域
海洋生态毒理
招生信息
招生专业
083001-环境科学
085238-生物工程
070703-海洋生物学
085238-生物工程
070703-海洋生物学
招生方向
海岸带生态毒理学、环境生物学
海岸带生态毒理与环境基准
海岸带生态毒理与环境基准
海岸带生态毒理与环境基准
海岸带生态毒理与环境基准
教育背景
2000-09--2005-06 中国科学院长春应用化学研究所 理学博士
1996-09--2000-06 南京大学 理学学士
1996-09--2000-06 南京大学 理学学士
工作经历
工作简历
2009-03~现在, 中国科学院烟台海岸带研究所, 研究员
2008-08~现在, 香港科技大学, 博士后
2005-08~2008-07,英国伯明翰大学, 博士后
2008-08~现在, 香港科技大学, 博士后
2005-08~2008-07,英国伯明翰大学, 博士后
专利与奖励
奖励信息
（1） 中国科学院优秀研究生指导教师奖, 院级, 2014
（2） 中国科学院优秀导师奖, 院级, 2013
（3） 黄河三角洲滨海湿地退化机制、植被修复原理与优化对策, 二等奖, 市地级, 2013
（4） 中国科学院大学-澳大利亚必和必拓导师科研奖, 其他, 2012
（2） 中国科学院优秀导师奖, 院级, 2013
（3） 黄河三角洲滨海湿地退化机制、植被修复原理与优化对策, 二等奖, 市地级, 2013
（4） 中国科学院大学-澳大利亚必和必拓导师科研奖, 其他, 2012
出版信息
发表论文
[1] Science of the Total Environment. 2024, 第 4 作者
[2] Science of the Total Environment. 2024, 通讯作者
[3] Marine Pollution Bulletin. 2024, 通讯作者
[4] Environmental Science and Technology. 2024, 通讯作者
[5] Science of The Total Environment. 2023, 通讯作者
[6] Science of The Total Environment. 2023, 第 7 作者
[7] Journal of Hazardous Materials. 2023, 通讯作者
[8] Aquatic Toxicology. 2023, 第 6 作者
[9] Marine Environmental Research. 2023, 通讯作者
[10] Ecotoxicology and Environmental Safety. 2023, 通讯作者
[11] Marine Environmental Research. 2023, 第 6 作者
[12] Science of The Total Environment. 2023, 通讯作者
[13] Science of The Total Environment. 2023, 第 5 作者
[14] Science of the Total Environment. 2023, 第 5 作者
[15] Environmental Pollution. 2023, 通讯作者
[16] Ecotoxicology and Environmental Safety. 2022, 第 4 作者
[17] Journal of Hazardous Materials. 2022, 通讯作者
[18] 生态毒理学报. 2022, 第 4 作者
[19] Journal of Hazardous Materials. 2022, 通讯作者
[20] 生态毒理学报. 2022, 通讯作者
[21] Chemosphere. 2022, 通讯作者
[22] Science of The Total Environment. 2022, 第 5 作者
[23] Environment International. 2022, 通讯作者
[24] Environmental Pollution. 2022, 第 6 作者
[25] Science of The Total Environment. 2022, 通讯作者
[26] Chemosphere. 2022, 通讯作者
[27] Journal of Hazardous Materials. 2021, 通讯作者
[28] Ecotoxicology and Environmental Safety. 2021, 通讯作者
[29] Environmental Pollution. 2021, 通讯作者
[30] ACS Sustainable Chemistry & Engineering. 2021, 通讯作者
[31] Ecotoxicology and Environmental Safety. 2021, 通讯作者
[32] Ecotoxicology and Environmental Safety. 2021, 通讯作者
[33] Environmental Pollution. 2021, 通讯作者
[34] Science of the Total Environment. 2021, 通讯作者
[35] Journal of Hazardous Materials. 2021, 通讯作者
[36] Elsevier Ecotoxicology and Environmental Safety. 2021, 通讯作者
[37] Science of The Total Environment. 2021, 通讯作者
[38] 科学通报. 2020, 第 5 作者
[39] Marine Pollution Bulletin. 2020, 通讯作者
[40] Environmental pollution. 2020, 通讯作者
[41] Marine Pollution Bulletin. 2020, 通讯作者
[42] Aquaculture. 2020, 第 6 作者
[43] Ecotoxicology and Environmental Safety. 2020, 通讯作者
[44] Marine Pollution Bulletin. 2020, 通讯作者
[45] Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2020, 第 2 作者
[46] Aging. 2020, 通讯作者
[47] Environmental Pollution. 2020, 通讯作者
[48] Science of The Total Environment. 2020, 通讯作者
[49] Wetlands. 2020, 第 9 作者
[50] 生态毒理学报. 2020, 通讯作者
[51] Environmental pollution. 2020, 通讯作者
[52] Journal of Invertebrate Pathology. 2019, 第 4 作者
[53] Journal of oceanology and limnology. 2019, 第 5 作者
[54] Environmental Toxicology and Pharmacology. 2019, 第 5 作者
[55] Environmental pollution. 2019, 通讯作者
[56] Ecotoxicology and Environmental Safety. 2019, 第 3 作者
[57] Environmental Pollution. 2019, 通讯作者
[58] Ecotoxicology and Environmental Safety. 2019, 通讯作者
[59] 生态毒理学报. 2019, 第 5 作者
[60] Chemosphere. 2019, 第 6 作者
[61] Journal of Hazardous Materials. 2019, 通讯作者
[62] 生态毒理学报. 2019, 通讯作者
[63] Environmental Toxicology and Pharmacology. 2019, 通讯作者
[64] Science of The Total Environment. 2018, 第 2 作者
[65] Science of The Total Environment. 2018, 第 7 作者
[66] Fish & Shellfish Immunology. 2018, 第 7 作者
[67] Environmental Toxicology and Pharmacology. 2018, 第 1 作者
[68] Aquatic Toxicology. 2018, 通讯作者
[69] Cong Ming, Wu Huifeng, Cao Tengfei, Lv Jiasen, Wang Qing, Ji Chenglong, Li Chenghua, Zhao Jianmin. Digital gene expression analysis in the gills of Ruditapes philippinarum exposed to short- and long-term exposures of ammonia nitrogen. AQUATIC TOXICOLOGY[J]. 2018, 第 2 作者
[70] Wu, Huifeng, Zhong, Mingyu, Lu, Zhen, Shan, Xiujuan, Li, Fei, Ji, Chenglong, Cong, Ming. Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY[J]. 2018, 第 1 作者61: 102-106, http://dx.doi.org/10.1016/j.etap.2018.05.022.
[71] Chemosphere. 2017, 通讯作者
[72] Bulletin of Environmental Contamination and Toxicology. 2017, 第 8 作者
[73] Wu, Huifeng, Xu, Lanlan, Yu, Deliang, Ji, Chenglong. Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium. ECOTOXICOLOGY[J]. 2017, 第 1 作者 通讯作者 26(1): 74-80, http://www.irgrid.ac.cn/handle/1471x/1174251.
[74] 李斐, 丁家旺, 吴惠丰, 孟祥敬, 赵建民. 电化学方法研究石墨烯和磷酸三苯酯（TPP）与模拟生物膜间的相互作用. 科学通报[J]. 2017, 第 3 作者62(36): 4285-4293, http://lib.cqvip.com/Qikan/Article/Detail?id=674323678.
[75] Li, Fei, Wang, Li, Ji, Chenglong, Wu, Huifeng, Zhao, Jianmin, Tang, Jianhui. Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells. CHEMOSPHERE[J]. 2017, 第 4 作者 通讯作者 187: 88-96, http://dx.doi.org/10.1016/j.chemosphere.2017.08.083.
[76] Zhong, Mingyu, Tang, Jianhui, Mi, Lijie, Li, Fei, Wang, Runmei, Huang, Guopei, Wu, Huifeng. Occurrence and spatial distribution of organophosphorus flame retardants and plasticizers in the Bohai and Yellow Seas, China. MARINE POLLUTION BULLETIN[J]. 2017, 第 7 作者121(1-2): 331-338, http://dx.doi.org/10.1016/j.marpolbul.2017.06.034.
[77] Huifeng Wu, Jialin Liu, Zhen Lu, Lanlan Xu, Chenglong Ji, Qing Wang, Jianmin Zhao. Metabolite and gene expression responses in juvenile flounder Paralichthys olivaceus exposed to reduced salinities. FISH AND SHELLFISH IMMUNOLOGY. 2017, 第 1 作者63: 417-423, http://dx.doi.org/10.1016/j.fsi.2017.02.042.
[78] Cong Ming, Wu Huifeng, Yang Haiping, Zhao Jianmin, Lv Jiasen. Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum. ECOTOXICOLOGY[J]. 2017, 第 2 作者
[79] Fish & Shellfish Immunology. 2017, 第 6 作者
[80] 吴惠丰. roteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis. Chemosphere. 2016, 第 1 作者 通讯作者
[81] Ji Chenglong, Yu Deliang, Wang Qing, Li Fei, Zhao Jianmin, Wu Huifeng. Impact of metal pollution on shrimp Crangon affinis by NMR-based metabolomics. MARINE POLLUTION BULLETIN[J]. 2016, 第 6 作者
[82] Ji, Chenglong, Wang, Qing, Wu, Huifeng, Tan, Qiaoguo, Wang, WenXiong. A metabolomic study on the biological effects of metal pollutions in oysters Crassostrea sikamea. MARINE POLLUTION BULLETIN[J]. 2016, 第 3 作者 通讯作者 102(1): 216-222, http://dx.doi.org/10.1016/j.marpolbul.2015.11.037.
[83] Ji, Chenglong, Li, Fei, Wang, Qing, Zhao, Jianmin, Sun, Zuodeng, Wu, Huifeng. An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA). CHEMOSPHERE[J]. 2016, 第 6 作者 通讯作者 144: 527-539, http://dx.doi.org/10.1016/j.chemosphere.2015.08.052.
[84] Chenglong Ji, Huifeng Wu, Mo Zhou, Jianmin Zhao. Multiple biomarkers of biological effects induced by cadmium in clam Ruditapes philippinarum. FISH AND SHELLFISH IMMUNOLOGY. 2015, 第 2 作者430-435, http://dx.doi.org/10.1016/j.fsi.2015.03.024.
[85] Wei, Lei, Wang, Qing, Wu, Huifeng, Ji, Chenglong, Zhao, Jianmin. Proteomic and metabolomic responses of Pacific oyster Crassostrea gigas to elevated pCO(2) exposure. JOURNAL OF PROTEOMICS[J]. 2015, 第 3 作者 通讯作者 112: 83-94, http://dx.doi.org/10.1016/j.jprot.2014.08.010.
[86] Li, Fei, Cao, Lulu, Li, Xuehua, Li, Na, Wang, Zijian, Wu, Huifeng. Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study. TOXICOLOGY LETTERS[J]. 2015, 第 6 作者 通讯作者 232(2): 533-541, http://dx.doi.org/10.1016/j.toxlet.2014.12.006.
[87] 曹璐璐, 李斐, 吴惠丰, 赵建民. BDE-47对人胚肾细胞HEK293的毒理效应及作用机制. 生态毒理学报[J]. 2015, 第 3 作者10(2): 236-242, http://lib.cqvip.com/Qikan/Article/Detail?id=665395115.
[88] Chenglong Ji, Haie Xu, Qing Wang, Jianmin Zhao, Huifeng Wu. Comparative investigations on the biological effects of As (III) and As (V) in clam Ruditapes philippinarum using multiple biomarkers. FISH AND SHELLFISH IMMUNOLOGY. 2015, 第 5 作者79-84, http://dx.doi.org/10.1016/j.fsi.2015.08.028.
[89] 于倩, 王清, 袁泽轶, 吴惠丰, 赵建民. 不同形态磷源对具槽帕拉藻（Paralia sulcata）生长和磷酸酶活性的影响. 海洋与湖沼[J]. 2015, 第 4 作者46(5): 1018-1023, http://ir.yic.ac.cn/handle/133337/17381.
[90] Li Fei, Wu Huifeng, Wang Qing, Li Xuehua, Zhao Jianmin. Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2015, 第 2 作者 通讯作者 33(3): 705-713, http://www.irgrid.ac.cn/handle/1471x/963435.
[91] Li, Lianzhen, Wu, Huifeng, Peijnenburg, Willie J G M, van Gestel, Cornelis A M. Both released silver ions and particulate Ag contribute to the toxicity of AgNPs to earthworm Eisenia fetida. NANOTOXICOLOGY[J]. 2015, 第 2 作者 通讯作者 9(6): 792-801, http://www.irgrid.ac.cn/handle/1471x/1036902.
[92] Ji, Chenglong, Wang, Qing, Wu, Huifeng, Tan, Qiaoguo, Wang, WenXiong. A metabolomic investigation of the effects of metal pollution in oysters Crassostrea hongkongensis. MARINE POLLUTION BULLETIN[J]. 2015, 第 3 作者 通讯作者 90(1-2): 317-322, http://dx.doi.org/10.1016/j.marpolbul.2014.11.006.
[93] 吴惠丰, 曹璐璐, 李斐, 李雪花, 赵建民. 典型持久性有机污染物与抑癌基因相互作用的分子模拟与验证. 科学通报[J]. 2015, 第 1 作者60(19): 1804-1809, http://ir.yic.ac.cn/handle/133337/17363.
[94] Li, LianZhen, Wu, Huifeng, Ji, Chenglong, van Gestel, Cornelis A M, Allen, Herbert E, Peijnenburg, Willie J G M. A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2015, 第 2 作者 通讯作者 119: 66-73, http://dx.doi.org/10.1016/j.ecoenv.2015.05.005.
[95] Wu, Huifeng, Cao, Lulu, Li, Fei, Lian, Peiwen, Zhao, Jianmin. Multiple biomarkers of the cytotoxicity induced by BDE-47 in human embryonic kidney cells. CHEMOSPHERE[J]. 2015, 第 1 作者126: 32-39, http://dx.doi.org/10.1016/j.chemosphere.2015.01.055.
[96] Zhang, Linbao, Yang, Dinglong, Wang, Qing, Yuan, Zeyi, Wu, Huifeng, Pei, Dong, Cong, Ming, Li, Fei, Ji, Chenglong, Zhao, Jianmin. A defensin from clam Venerupis philippinarum: Molecular characterization, localization, antibacterial activity, and mechanism of action. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2015, 第 5 作者 通讯作者 51(1): 29-38, http://dx.doi.org/10.1016/j.dci.2015.02.009.
[97] Wei, Lei, Wang, Qing, Ning, Xuanxuan, Mu, Changkao, Wang, Chunlin, Cao, Ruiwen, Wu, Huifeng, Cong, Ming, Li, Fei, Ji, Chenglong, Zhao, Jianmin. Combined metabolome and proteome analysis of the mantle tissue from Pacific oyster Crassostrea gigas exposed to elevated pCO(2). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2015, 第 7 作者 通讯作者 13: 16-23, http://dx.doi.org/10.1016/j.cbd.2014.12.001.
[98] Ji, Chenglong, Wu, Huifeng, Wei, Lei, Zhao, Jianmin. iTRAQ-based quantitative proteomic analyses on the gender-specific responses in mussel Mytilus galloprovincialis to tetrabromobisphenol A. AQUATIC TOXICOLOGY[J]. 2014, 第 2 作者 通讯作者 157: 30-40, http://dx.doi.org/10.1016/j.aquatox.2014.09.008.
[99] Ji, Chenglong, Zhao, Jianmin, Wu, Huifeng. Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY[J]. 2014, 第 3 作者 通讯作者 37(3): 1116-1122, http://dx.doi.org/10.1016/j.etap.2014.04.007.
[100] Yingying Zhang, Qing Wang, Yinglu Ji, Qian Zhang, Huifeng Wu, Jia Xie, Jianmin Zhao. Identification and mRNA expression of two 17β-hydroxysteroid dehydrogenase genes in the marine mussel Mytilus galloprovincialis following exposure to endocrine disrupting chemicals. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 2014, 第 5 作者37(3): 1243-1255, http://dx.doi.org/10.1016/j.etap.2014.04.027.
[101] Lianzhen Li, Huifeng Wu, Cornelis A.M. van Gestel, Willie J.G.M. Peijnenburg, Herbert E. Allen. Soil acidification increases metal extractability and bioavailability in old orchard soils of Northeast Jiaodong Peninsula in China. ENVIRONMENTAL POLLUTION. 2014, 第 2 作者http://dx.doi.org/10.1016/j.envpol.2014.02.003.
[102] 吴惠丰. Evaluation of protein extraction protocols for 2DE in marine ecotoxicoproteomics.. Proteomics. 2014, 第 1 作者 通讯作者
[103] Li, Fei, Yang, Xianhai, Li, Xuehua, Li, Renmin, Zhao, Jianmin, Wu, Huifeng. Determination and Prediction of the Binding Interaction between Organophosphate Flame Retardants and p53. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2014, 第 6 作者27(11): 1918-1925, http://www.irgrid.ac.cn/handle/1471x/963506.
[104] Wang, Q, Ning, X, Zhang, Q, Liu, F, Wu, H, Zhang, Y, Zhao, J. Molecular characterization of two glutathione peroxidase genes in Mytilus galloprovincialis and their transcriptional responses to sub-chronic arsenate and cadmium exposure. ISJ-INVERTEBRATE SURVIVAL JOURNAL[J]. 2014, 11(1): 149-162, https://doaj.org/article/85e2684b19c64c24b0480bba91f5f8bf.
[105] Williams, Tim D, Davies, Ian M, Wu, Huifeng, Diab, Amer M, Webster, Lynda, Viant, Mark R, Chipman, J Kevin, Leaver, Michael J, George, Stephen G, Moffat, Colin F, Robinson, Craig D. Molecular responses of European flounder (Platichthys flesus) chronically exposed to contaminated estuarine sediments. CHEMOSPHERE[J]. 2014, 第 3 作者108: 152-158, http://dx.doi.org/10.1016/j.chemosphere.2014.01.028.
[106] You Liping, Ning Xuanxuan, Chen Leilei, Zhang Linbao, Zhao Jianmin, Liu Xiaoli, Wu Huifeng. Expression profiles of two small heat shock proteins and antioxidant enzyme activity in Mytilus galloprovincialis exposed to cadmium at environmentally relevant concentrations. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2014, 第 7 作者32(2): 334-343, http://www.irgrid.ac.cn/handle/1471x/846431.
[107] Ji, Chenglong, Wei, Lei, Zhao, Jianmin, Wu, Huifeng. Metabolomic analysis revealed that female mussel Mytilus galloprovincialis was sensitive to bisphenol A exposures. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY[J]. 2014, 第 4 作者 通讯作者 37(2): 844-849, http://dx.doi.org/10.1016/j.etap.2014.02.015.
[108] Li, Fei, Li, Renmin, Yang, Xianhai, You, Liping, Zhao, Jianmin, Wu, Huifeng. The interaction between organic phosphate ester and p53: An integrated experimental and in silico approach. MARINE POLLUTION BULLETIN[J]. 2014, 第 6 作者85(2): 516-521, http://dx.doi.org/10.1016/j.marpolbul.2013.12.038.
[109] 吴惠丰. A metabolomics investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities.. Ecotoxicol. Environ. Saf.. 2013, 第 1 作者
[110] Qing Wang, Zeyi Yuan, Huifeng Wu, Feng Liu, Jianmin Zhao. Molecular characterization of a manganese superoxide dismutase and copper/zinc superoxide dismutase from the mussel Mytilus galloprovincialis. FISH AND SHELLFISH IMMUNOLOGY. 2013, 第 3 作者1345-1351, http://dx.doi.org/10.1016/j.fsi.2013.01.011.
[111] Wu Huifeng, Liu Xiaoli, Zhang Xingyan, Ji Chenglong, Zhao Jianmin, Yu Junbao. Proteomic and metabolomic responses of clam Ruditapes philippinarum to arsenic exposure under different salinities.. AQUATIC TOXICOLOGY (AMSTERDAM, NETHERLANDS). 2013, 第 1 作者http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD13110700457943&DbName=SJPD_05&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[112] Wang Qing, Ning Xuanxuan, Pei Dong, Zhao Jianmin, You Liping, Wang Chunyan, Wu Huifeng. Molecular cloning, characterization and expression profiles of thioredoxin 1 and thioredoxin 2 genes in Mytilus galloprovincialis. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2013, 第 7 作者31(3): 493-503, http://www.irgrid.ac.cn/handle/1471x/671231.
[113] Liping You, Xuanxuan Ning, Feng Liu, Jianmin Zhao, Qing Wang, Huifeng Wu. The response profiles of HSPA12A and TCTP from Mytilus galloprovincialis to pathogen and cadmium challenge. FISH AND SHELLFISH IMMUNOLOGY. 2013, 第 6 作者343-350, http://dx.doi.org/10.1016/j.fsi.2013.04.021.
[114] Chenglong Ji, Huifeng Wu, Lei Wei, Jianmin Zhao, Qing Wang, Hongjian Lu. Responses of Mytilus galloprovincialis to bacterial challenges by metabolomics and proteomics. FISH AND SHELLFISH IMMUNOLOGY. 2013, 第 2 作者489-498, http://dx.doi.org/10.1016/j.fsi.2013.05.009.
[115] Wang, Qing, Wang, Chunyan, Mu, Changkao, Wu, Huifeng, Zhang, Linbao, Zhao, Jianmin. A Novel C-Type Lysozyme from Mytilus galloprovincialis: Insight into Innate Immunity and Molecular Evolution of Invertebrate C-Type Lysozymes. PLOS ONE[J]. 2013, 第 4 作者 通讯作者 8(6): http://www.irgrid.ac.cn/handle/1471x/846516.
[116] Ji, Chenglong, Wu, Huifeng, Wei, Lei, Zhao, Jianmin, Lu, Hongjian, Yu, Junbao. Proteomic and metabolomic analysis of earthworm Eisenia fetida exposed to different concentrations of 2,2 ',4,4 '-tetrabromodiphenyl ether. JOURNAL OF PROTEOMICS[J]. 2013, 第 2 作者 通讯作者 91: 405-416, http://dx.doi.org/10.1016/j.jprot.2013.08.004.
[117] Wu Huifeng, Ji Chenglong, Wang Qing, Liu Xiaoli, Zhao Jianmin, Feng Jianghua. Manila clam Venerupis philippinarum as a biomonitor to metal pollution. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2013, 第 1 作者 通讯作者 31(1): 65-74, https://www.webofscience.com/wos/woscc/full-record/WOS:000313654000007.
[118] Wu, Huifeng, Liu, Xiaoli, Zhao, Jianmin, Yu, Junbao. Regulation of Metabolites, Gene Expression, and Antioxidant Enzymes to Environmentally Relevant Lead and Zinc in the Halophyte Suaeda salsa. JOURNAL OF PLANT GROWTH REGULATION[J]. 2013, 第 1 作者 通讯作者 32(2): 353-361, http://dx.doi.org/10.1007/s00344-012-9305-5.
[119] Liu, Xiaoli, Wu, Huifeng, Ji, Chenglong, Wei, Lei, Zhao, Jianmin, Yu, Junbao. An Integrated Proteomic and Metabolomic Study on the Chronic Effects of Mercury in Suaeda salsa under an Environmentally Relevant Salinity. PLOS ONE[J]. 2013, 第 2 作者 通讯作者 8(5): https://doaj.org/article/8cc7be7680734675a72aff874e36d36d.
[120] Wu, Huifeng, Ji, Chenglong, Wei, Lei, Zhao, Jianmin, Lu, Hongjian. Proteomic and metabolomic responses in hepatopancreas of Mytilus galloprovincialis challenged by Micrococcus luteus and Vibrio anguillarum. JOURNAL OF PROTEOMICS[J]. 2013, 第 1 作者 通讯作者 94: 54-67, http://dx.doi.org/10.1016/j.jprot.2013.09.001.
[121] Cong Ming, Lu Jiasen, Wu Huifeng, Zhao Jianmin. Effect of cadmium on the defense response of Pacific oyster Crassostrea gigas to Listonella anguillarum challenge. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2013, 第 3 作者 通讯作者 31(5): 1002-1009, http://www.irgrid.ac.cn/handle/1471x/846487.
[122] Ji Chenglong, Wu Huifeng, Liu Xiaoli, Zhao Jianmin, Yu Junbao, Yin Xiuli. The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2013, 第 2 作者 通讯作者 31(2): 345-352, https://www.webofscience.com/wos/woscc/full-record/WOS:000316018300010.
[123] Ji, Chenglong, Wu, Huifeng, Wei, Lei, Zhao, Jianmin, Yu, Junbao. Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE 47). AQUATIC TOXICOLOGY[J]. 2013, 第 2 作者 通讯作者 140: 449-457, http://dx.doi.org/10.1016/j.aquatox.2013.07.009.
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[128] 吴惠丰. Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis philippinarum exposed to benzo[a]pyrene, cadmium and copper.. Environ. Toxicol. Pharmacol.. 2012, 第 1 作者 通讯作者
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[130] Zhang Linbao, Wu Huifeng, Liu Xiaoli, Chen Leilei, Wang Qing, Zhao Jianmin, You Liping. Molecular cloning and differential expression patterns of sigma and omega glutathione S-transferases from Venerupis philippinarum to heavy metals and benzoapyrene exposure. 中国海洋湖沼学报(英文版)[J]. 2012, 第 2 作者30(3): 413-423, http://lib.cqvip.com/Qikan/Article/Detail?id=41783558.
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[171] 吴惠丰. Studies of the acute toxicities of Lu(NO3)3 by NMR and pattern recognition techniques. Chem. J. Chin. Univ.. 2005, 第 1 作者
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[143] Li, Fei, Li, Xuehua, Liu, Xiaoli, Zhang, Linbao, You, Liping, Zhao, Jianmin, Wu, Huifeng. Docking and 3D-QSAR studies on the Ah receptor binding affinities of polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY[J]. 2011, 第 7 作者 通讯作者 32(3): 478-485, http://dx.doi.org/10.1016/j.etap.2011.09.001.
[144] Wu, Huifeng, Liu, Xiaoli, Zhao, Jianmin, Yu, Junbao. NMR-Based Metabolomic Investigations on the Differential Responses in Adductor Muscles from Two Pedigrees of Manila Clam Ruditapes philippinarum to Cadmium and Zinc. MARINE DRUGS[J]. 2011, 第 1 作者 通讯作者 9(9): 1566-1579, https://doaj.org/article/e2cf7603778f44e29d7831f58d818ae8.
[145] Zhang, Linbao, Liu, Xiaoli, You, Liping, Zhou, Di, Wu, Huifeng, Li, Lianzhen, Zhao, Jianmin, Feng, Jianghua, Yu, Junbao. Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics. MARINE ENVIRONMENTAL RESEARCH[J]. 2011, 第 5 作者 通讯作者 72(1-2): 33-39, http://dx.doi.org/10.1016/j.marenvres.2011.04.002.
[146] Qing Wang, Xuanxuan Ning, Leilei Chen, Dong Pei, Jianmin Zhao, Linbao Zhang, Xiaoli Liu, Huifeng Wu. Responses of thioredoxin 1 and thioredoxin-related protein 14 mRNAs to cadmium and copper stresses in Venerupis philippinarum. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, PART C. 2011, 第 8 作者154-160, http://dx.doi.org/10.1016/j.cbpc.2011.04.009.
[147] Li, Fei, Li, Xuehua, Liu, Xiaoli, Zhang, Linbao, You, Liping, Zhao, Jianmin, Wu, Huifeng. Noncovalent interactions between hydroxylated polycyclic aromatic hydrocarbon and DNA: Molecular docking and QSAR study. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY[J]. 2011, 第 7 作者 通讯作者 32(3): 373-381, http://dx.doi.org/10.1016/j.etap.2011.08.001.
[148] Zhang, Linbao, Liu, Xiaoli, Chen, Leilei, You, Liping, Pei, Dong, Cong, Ming, Zhao, Jianmin, Li, Chenghua, Liu, Dongyan, Yu, Junbao, Wu, Huifeng. Transcriptional regulation of selenium-dependent glutathione peroxidase from Venerupis philippinarum in response to pathogen and contaminants challenge. FISH & SHELLFISH IMMUNOLOGY[J]. 2011, 第 11 作者31(6): 831-837, http://dx.doi.org/10.1016/j.fsi.2011.07.026.
[149] Liu, Xiaoli, Yang, Cuiyun, Zhang, Linbao, Li, Lianzhen, Liu, Sujing, Yu, Junbao, You, Liping, Zhou, Di, Xia, Chuanhai, Zhao, Jianmin, Wu, Huifeng. Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics. ECOTOXICOLOGY[J]. 2011, 第 11 作者 通讯作者 20(6): 1422-1431, http://ir.yic.ac.cn/handle/133337/5120.
[150] Liu, Xiaoli, Zhang, Linbao, You, Liping, Wu, Huifeng, Zhao, Jianmin, Cong, Ming, Li, Fei, Wang, Qing, Li, Lianzhen, Li, Chenghua, Han, Guangxuan, Wang, Guangmei, Xia, Chuanhai, Yu, Junbao. Metabolomic Study on the Halophyte Suaeda salsa in the Yellow River Delta. CLEAN-SOIL AIR WATER[J]. 2011, 第 4 作者 通讯作者 39(8): 720-727, https://www.webofscience.com/wos/woscc/full-record/WOS:000294720700002.
[151] Li, F, Liu, X, Zhang, L, You, L, Wu, H, Li, X, Zhao, J, Yu, J. QSAR studies on the depuration rates of polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and polychlorinated biphenyls in mussels (Elliptio complanata). SAR AND QSAR IN ENVIRONMENTAL RESEARCH[J]. 2011, 22(5-6): 561-573, https://www.webofscience.com/wos/woscc/full-record/WOS:000299560600008.
[152] Liu, Xiaoli, Zhang, Linbao, You, Liping, Yu, Junbao, Zhao, Jianmin, Li, Lianzhen, Wang, Qing, Li, Fei, Li, Chenghua, Liu, Dongyan, Wu, Huifeng. Differential toxicological effects induced by mercury in gills from three pedigrees of Manila clam Ruditapes philippinarum by NMR-based metabolomics. ECOTOXICOLOGY[J]. 2011, 第 11 作者 通讯作者 20(1): 177-186, https://www.webofscience.com/wos/woscc/full-record/WOS:000286003700019.
[153] Williams, Tim D, Turan, Nil, Diab, Amer M, Wu, Huifeng, Mackenzie, Carolynn, Bartie, Katie L, Hrydziuszko, Olga, Lyons, Brett P, Stentiford, Grant D, Herbert, John M, Abraham, Joseph K, Katsiadaki, Ioanna, Leaver, Michael J, Taggart, John B, George, Stephen G, Viant, Mark R, Chipman, Kevin J, Falciani, Francesco. Towards a System Level Understanding of Non-Model Organisms Sampled from the Environment: A Network Biology Approach. PLOS COMPUTATIONAL BIOLOGY[J]. 2011, 第 4 作者7(8): http://dx.doi.org/10.1371/journal.pcbi.1002126.
[154] Santos, Eduarda M, Ball, Jonathan S, Williams, Tim D, Wu, Huifeng, Ortega, Fernando, Van Aerle, Ronny, Katsiadaki, Ioanna, Falciani, Francesco, Viant, Mark R, Chipman, James K, Tyler, Charles R. Identifying Health Impacts of Exposure to Copper Using Transcriptomics and Metabolomics in a Fish Model. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2010, 第 4 作者44(2): 820-826, https://www.webofscience.com/wos/woscc/full-record/WOS:000273433200045.
[155] Wu, Huifeng, Wang, WenXiong. NMR-based metabolomic studies on the toxicological effects of cadmium and copper on green mussels Perna viridis. AQUATIC TOXICOLOGY[J]. 2010, 第 1 作者100(4): 339-345, http://dx.doi.org/10.1016/j.aquatox.2010.08.005.
[156] Zhou, Hailong, Qu, Ying, Wu, Huifeng, Liao, Chunyang, Zheng, Jiping, Diao, Xiaoping, Xue, Qinzhao. Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs). CHEMOSPHERE. 2010, 第 3 作者78(2): 193-205, http://dx.doi.org/10.1016/j.chemosphere.2009.09.012.
[157] Williams, Tim D, Wu, Huifeng, Santos, Eduarda M, Ball, Jon, Katsiadaki, Ioanna, Brown, Margaret M, Baker, Paul, Ortega, Fernando, Falciani, Francesco, Craft, John A, Tyler, Charles R, Chipman, James K, Viant, Mark R. Hepatic Transcriptomic and Metabolomic Responses in the Stickleback (Gasterosteus aculeatus) Exposed to Environmentally Relevant Concentrations of Dibenzanthracene. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2009, 第 2 作者43(16): 6341-6348, https://www.webofscience.com/wos/woscc/full-record/WOS:000268907700040.
[158] 吴惠丰. Metabolic profiling studies on the toxicological effects of Realgar in rats by 1H NMR spectroscopy. Toxicol. Appl. Pharmacol.. 2009, 第 1 作者
[159] 吴惠丰. High throughput tissue extraction protocol for NMR and Mass spectrometry based metabolomics. Anal. Biochem.. 2008, 第 1 作者
[160] Wei, Lai, Liao, Peiqiu, Wu, Huifeng, Li, Xiaojing, Pei, Fengkui, Li, Weisheng, Wu, Yijie. Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2008, 第 3 作者227(3): 417-429, http://dx.doi.org/10.1016/j.taap.2007.11.015.
[161] Lin, Ching Yu, Wu, Huifeng, Tjeerdema, Ronald S, Viant, Mark R. Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics. METABOLOMICS[J]. 2007, 第 2 作者3(1): 55-67, https://www.webofscience.com/wos/woscc/full-record/WOS:000245323200006.
[162] 吴惠丰. NMR-Based metabonomic study on the sub-acute biochemical effects of (Aristolochic acid). Food Chem. Toxicol.. 2006, 第 1 作者
[163] 吴惠丰, 李晓晶, 冯江华, 李伟生, 李中峰. Comparison of Biochemical Effects Induced by Changle between Male and Female Rats Using NMR and ICP-MS Techniques. 稀土学报(英文版)[J]. 2006, 第 1 作者24(1): 108-114, http://lib.cqvip.com/Qikan/Article/Detail?id=21377413.
[164] Huifeng Wu, Xiaoyu Zhang, Xiaojing Li, Peiqiu Liao, Weisheng Li, Zhongfeng Li, Yijie Wu, Fengkui Pei. Studies on Acute Toxicity of Model Toxins by Proton Magnetic Resonance Spectroscopy of Urine Combined with Two-step Cluster Analysis. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY. 2006, 第 1 作者21-25, http://dx.doi.org/10.1016/S1872-2040(06)60004-2.
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[166] 吴惠丰. Comparison of metabolic profiles from serum for the hepatotoxin-treated rats by NMR spectroscopic-based metabonomic analysis. Anal. Biochem.. 2005, 第 1 作者
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[171] 吴惠丰. Studies of the acute toxicities of Lu(NO3)3 by NMR and pattern recognition techniques. Chem. J. Chin. Univ.. 2005, 第 1 作者
[172] 吴惠丰. 1H NMR spectroscopic studies on the acute toxicities of Lu(NO3)3 by biological fluids. Chin. J. Anal. Chem.. 2004, 第 1 作者
[173] HuiFeng Wu, XiaoYu Zhang, JiangHua Feng, GuoYing Sun, YiJie Wu, FengKui Pei, YuXiu Nie. NMR and pattern recognition studies on the acute biochemical effects of Lu(NO3)3. CHINESE JOURNAL OF CHEMISTRY[J]. 2004, 第 1 作者 通讯作者 849-853, http://ir.ciac.jl.cn/handle/322003/15653.
科研活动
科研项目
（ 1 ） 典型海洋污染物毒性生物标记物及其机理研究, 主持, 部委级, 2009-06--2012-06
（ 2 ） 海岸带典型污染物生态毒理效应研究, 主持, 部委级, 2010-09--2013-09
（ 3 ） 痕量重金属在菲律宾蛤仔体内毒理的系统生物学研究, 主持, 省级, 2010-05--2012-05
（ 4 ） 特征污染物对重要渔业生物的毒性效应, 主持, 国家级, 2015-01--2019-12
（ 5 ） 典型湿地生态系统恢复与重建关键技术研究与示范, 主持, 国家级, 2010-10--2014-12
（ 6 ） 海岸带生态毒理学, 主持, 省级, 2013-10--2016-10
（ 7 ） 中国南方典型河口生物的重金属生物动力学与毒理, 主持, 国家级, 2013-01--2017-12
（ 8 ） 渤海典型重金属污染物对菲律宾蛤仔毒理效应的代谢组学研究, 主持, 国家级, 2012-01--2014-12
（ 2 ） 海岸带典型污染物生态毒理效应研究, 主持, 部委级, 2010-09--2013-09
（ 3 ） 痕量重金属在菲律宾蛤仔体内毒理的系统生物学研究, 主持, 省级, 2010-05--2012-05
（ 4 ） 特征污染物对重要渔业生物的毒性效应, 主持, 国家级, 2015-01--2019-12
（ 5 ） 典型湿地生态系统恢复与重建关键技术研究与示范, 主持, 国家级, 2010-10--2014-12
（ 6 ） 海岸带生态毒理学, 主持, 省级, 2013-10--2016-10
（ 7 ） 中国南方典型河口生物的重金属生物动力学与毒理, 主持, 国家级, 2013-01--2017-12
（ 8 ） 渤海典型重金属污染物对菲律宾蛤仔毒理效应的代谢组学研究, 主持, 国家级, 2012-01--2014-12
指导学生
已指导学生
张林宝 01 19367
张杏艳 02 49789
刘小莉 01 19367
章盈盈 02 63224
吉成龙 01 19367
由丽萍 01 19367
曹璐璐 02 67011
魏磊 01 19367
陈丽竹 02 19156
现指导学生
刘佳琳 01 19367
于德良 01 19367
张明兴 02 19156
钟鸣宇 01 19156
徐兰兰 01 19156
王爽 02 19156
路珍 01 19156