1) Biomedical Contrast Agents (MRI, Ultrasound and CT) Based On Metal Oxide/Functional Nanoparticles

2) Rapid Detection Agents Based on Noble Metal Nanoparticles

-- 博士 

EDUCATION

Ph.D.    Analytical Chemistry

        State Key Laboratory of Electroanalytical Chemistry

Changchun Institute of Applied Chemistry,

Chinese Academy of Sciences, China

        Advisors: Erkang Wang & Zhuang Li

B. S.       Department of Chemistry

Nanchang University, Nanchang, China

Advisor: Yongnian Ni

EXPERIENCE

1) 6/2009-Present   Division of Functional Materials and Nanodevices

Ningbo Institute of Materials Technology & Engineering (NIMTE), Chinese Academy of Sciences (CAS), China

2) 5/2006 – 6/2009:     Research Associate in Medical Sciences

               Department of Radiation Oncology & Department of Radiology

                    Feinberg School of Medicine Northwestern University, USA

                    Supervisor：Gayle E. Woloschak

3) 7/2005- 4/2006         Postdoctoral Scholar/Research Associate in Chemistry

               Chemistry and Chemical Engineering Division

                    California Institute of Technology, USA

                    Supervisor: Ahmed H. Zewail (Nobel Prize for Chemistry, 1999)

4) 2/2004-7/2005   Postdoctor

Department of Chemistry

University of Marburg, Germany

Supervisor: Norbert A. Hampp

Honors and Awards:

1. Visiting Professor in Univeristy of Marburg, Germany, 2015

2.      CAIA Special Prize (R2/10), China, 2014

3. Adjunct Professor, Northwestern University (2013-2016), USA, 2012

4. Award for Thousand Talents Program, Zhejiang Province, 2012

5. Award for Hundred Talents Program, Chinese Academy of Sciences, 2010

6. Award for Returnees Startup Program, Ministry of Human Resources and Social Security of China, 2010

7. Award for Outstanding Talents Program, Ningbo City, 2010

8. YinGang Peng Outstanding Postgraduate Student Prize, Chinese Academy of Sciences, China, 2001

9. Honor thesis, Nanchang University, Nanchang, Jiangxi, China, and July 1998

10. A Silver Prize of Mathematics Modeling Contest for Chinese University Student, JiangXi Contest Zone, Nanchang, Jiangxi, China, 1997

11. Outstanding Undergraduate Student Awards in Nanchang University, Nanchang, Jiangxi, China, 1995-1998

1) A Paper List of Refereed Journals (100+)

1.          Zeng, L., Pan, Y., Zou, R., Zhang, J., Tian, Y., Teng, Z., Wang, S., Ren, W., Xiao, X., Zhang, J., Zhang, L., Li, A., Lu, G., and Wu, A. (2016): 808 nm-excited upconversion nanoprobes with low heating effect for targeted magnetic resonance imaging and high-efficacy photodynamic therapy in HER2-overexpressed breast cancer, Biomaterials, 103, 116-127.

2.          Zhang, Y., Xie, Z., Wang, Z., Feng, X., Wang, Y., and Wu, A. (2016): Unveiling the adsorption mechanism of zeolitic imidazolate framework-8 with high efficiency for removal of copper ions from aqueous solutions, Dalton Transactions, 45, 12653-12660. (Back Cover)

3.          Pan, Y., Zhang, L. e., Zeng, L., Ren, W., Xiao, X., Zhang, J., Zhang, L., Li, A., Lu, G., and Wu, A. (2016): Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer, Nanoscale 8, 878-888.

4.          Chen, N., Zhang, Y., Liu, H., Wu, X., Li, Y., Miao, L., Shen, Z., and Wu, A. (2016): High-Performance Colorimetric Detection of Hg²⁺ Based on Triangular Silver Nanoprisms, ACS Sensors, 1, 521-527.

5.        Wang, Z., Huang, Y., Wang, M., Wu, G., Geng, T., Zhao, Y., and Wu, A. (2016): Macroporous calcium alginate aerogel as sorbent for Pb²⁺ removal from water media, Journal of Environmental Chemical Engineering, 4, 3185-3192.

6.          Kang, J., Zhang, Y., Li, X., Miao, L., and Wu, A. (2016): A Rapid Colorimetric Sensor of Clenbuterol Based on Cysteamine-Modified Gold Nanoparticles, ACS Applied Materials & Interfaces, 8, 1-5.

7.        Wang, M., Wang, Z., Wu, G., Zhang, Y., and Wu, A. (2016): Synthesis and application of magnetic adsorbent for mercury ions[J], Environmental Chemistry, 35, 540-547.

8.          Wang, L., Sun, Y., Li, Z., Wu, A., and Wei, G. (2016): Bottom-Up Synthesis and Sensor Applications of Biomimetic Nanostructures, Materials, 9, 53.

9.          Yu, Z., Zeng, L., and Wu, A. (2016): Near-infrared Light Responsive Upconversion Nanoparticles for Imaging, Drug Delivery and Therapy of Cancers, Current Nanoscience, 12, 18-32. (Invited Review)

10.       Shen, Z., Wu, H., Yang, S., Ma, X., Li, Z., Tan, M., and Wu, A. (2015): A novel Trojan-horse targeting strategy to reduce the non-specific uptake of nanocarriers by non-cancerous cells, Biomaterials, 70, 1-11.

11.       Xu, Y., Shi, Z., Zhang, L. e., Brown, E. M. B., and Wu, A. (2016): Layered bismuth oxyhalide nanomaterials for highly efficient tumor photodynamic therapy, Nanoscale, 8, 12715-12722. (Hot Paper)

12.       Dong, C., Wu, G., Wang, Z., Ren, W., Zhang, Y., Shen, Z., Li, T., and Wu, A. (2016): Selective colorimetric detection of Cr(iii) and Cr(vi) using gallic acid capped gold nanoparticles, Dalton Transactions, 45, 8347-8354. (Back Cover)

13.       Zeng, L., Pan, Y., Wang, S., Wang, X., Zhao, X., Ren, W., Lu, G., and Wu, A. (2015): Raman Reporter-Coupled Agcore@Aushell Nanostars for in Vivo Improved Surface Enhanced Raman Scattering Imaging and Near-infrared-Triggered Photothermal Therapy in Breast Cancers, ACS Applied Materials & Interfaces, 7, 16781-16791.

14.       Pan, L., Sun, S., Zhang, A., Jiang, K., Zhang, L., Dong, C., Huang, Q., Wu, A., and Lin, H. (2015): Truly Fluorescent Excitation-Dependent Carbon Dots and Their Applications in Multicolor Cellular Imaging and Multidimensional Sensing, Advanced Materials, 27, 7782-7787.

15.       Li, J., Tian, Y., and Wu, A. (2015): Neuropeptide Y receptors: a promising target for cancer imaging and therapy, Regenerative Biomaterials, 2, 215-219.

16.       Zeng, L., Pan, Y., Tian, Y., Wang, X., Ren, W., Wang, S., Lu, G., and Wu, A. (2015): Doxorubicin-loaded NaYF₄:Yb/Tm–TiO₂ inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers, Biomaterials, 57, 93-106.

17.       Zhang, L., Zeng, L., Pan, Y., Luo, S., Ren, W., Gong, A., Ma, X., Liang, H., Lu, G., and Wu, A. (2015): Inorganic photosensitizer coupled Gd-based upconversion luminescent nanocomposites for in vivo magnetic resonance imaging and near-infrared-responsive photodynamic therapy in cancers, Biomaterials, 44, 82-90.

18.       Li, J., Shen, Z., Ma, X., Ren, W., Xiang, L., Gong, A., Xia, T., Guo, J., and Wu, A. (2015): Neuropeptide Y Y1 Receptors Meditate Targeted Delivery of Anticancer Drug with Encapsulated Nanoparticles to Breast Cancer Cells with High Selectivity and Its Potential for Breast Cancer Therapy, ACS Applied Materials & Interfaces, 7, 5574-5582.

19.       Zeng, L., Luo, L., Pan, Y., Luo, S., Lu, G., and Wu, A. (2015): In vivo targeted magnetic resonance imaging and visualized photodynamic therapy in deep-tissue cancers using folic acid-functionalized superparamagnetic-upconversion nanocomposites, Nanoscale, 7, 8946-8954.

20.       Iqbal, M. Z., Ma, X., Chen, T., Zhang, L. e., Ren, W., Xiang, L., and Wu, A. (2015): Silica-coated super-paramagnetic iron oxide nanoparticles (SPIONPs): a new type contrast agent of T1 magnetic resonance imaging (MRI), Journal of Materials Chemistry B, 3, 5172-5181. (Featured in Back Cover)

21.       Ren, W., Yan, Y., Zeng, L., Shi, Z., Gong, A., Schaaf, P., Wang, D., Zhao, J., Zou, B., Yu, H., Chen, G., Brown, E. M. B., and Wu, A. (2015): A Near Infrared Light Triggered Hydrogenated Black TiO₂ for Cancer Photothermal Therapy, Advanced Healthcare Materials, 4, 1526-1536. (Featured in Back Cover)

22.       Wu, X., Luo, L., Yang, S., Ma, X., Li, Y., Dong, C., Tian, Y., Zhang, L., Shen, Z., and Wu, A. (2015): Improved SERS Nanoparticles for Direct Detection of Circulating Tumor Cells in the Blood, ACS Applied Materials & Interfaces, 7, 9965-9971.

23.       Ma, X., Gong, A., Chen, B., Zheng, J., Chen, T., Shen, Z., and Wu, A. (2015): Exploring a new SPION-based MRI contrast agent with excellent water-dispersibility, high specificity to cancer cells and strong MR imaging efficacy, Colloids and Surfaces B: Biointerfaces, 126, 44-49.

24.       Li, T., Li, Y., Zhang, Y., Dong, C., Shen, Z., and Wu, A. (2015): A colorimetric nitrite detection system with excellent selectivity and high sensitivity based on Ag@Au nanoparticles, Analyst, 140, 1076-1081.

25.       Wu, G., Dong, C., Li, Y., Wang, Z., Gao, Y., Shen, Z., and Wu, A. (2015): A novel AgNPs-based colorimetric sensor for rapid detection of Cu²⁺ or Mn²⁺ via pH control, RSC Advances, 5, 20595-20602

26.       Du, Y., Ren, W., Li, Y., Zhang, Q., Zeng, L., Chi, C., Wu, A., and Tian, J. (2015): The enhanced chemotherapeutic effects of doxorubicin loaded PEG coated TiO₂ nanocarriers in an orthotopic breast tumor bearing mouse model, Journal of Materials Chemistry B, 3, 1518-1528. (Highlighted in J Mater. Chem. B. 2015 Year Article)

27.       Yan, X., Niu, G., Lin, J., Jin, A. J., Hu, H., Tang, Y., Zhang, Y., Wu, A., Lu, J., Zhang, S., Huang, P., Shen, B., and Chen, X. (2015): Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide, Biomaterials, 42, 94-102.

28.       Jiang, K., Sun, S., Zhang, L., Lu, Y., Wu, A., Cai, C., and Lin, H. (2015): Red, Green, and Blue Luminescence by Carbon Dots: Full-Color Emission Tuning and Multicolor Cellular Imaging, Angewandte Chemie International Edition, 54, 5360-5363.

29.       Shi, Z., Ren, W., Gong, A., Zhao, X., Zou, Y., Brown, E. M. B., Chen, X., and Wu, A. (2014): Stability enhanced polyelectrolyte-coated gold nanorod-photosensitizer complexes for high/low power density photodynamic therapy, Biomaterials, 35, 7058-7067.

30.       Li, Y., Li, Z., Gao, Y., Gong, A., Zhang, Y., Hosmane, N. S., Shen, Z., and Wu, A. (2014): "Red-to-blue" colorimetric detection of cysteine via anti-etching of silver nanoprisms, Nanoscale, 6, 10631-10637.

31.       Li, Y., Leng, Y., Zhang, Y., Li, T., Shen, Z., and Wu, A. (2014): A new simple and reliable Hg²⁺ detection system based on anti-aggregation of unmodified gold nanoparticles in the presence of O-phenylenediamine, Sensors and Actuators B: Chemical, 200, 140-146.

32.     Liao, J., Zhao, X., Zeng, L., Song, Y., Wang, L., and Wu, A. (2014): Studies of TiO₂ Nanoparticles and Their Precursors for the Photocatalytic Degradation of Dihydroxybenzenes. Biochemical and Biophysical Journal of Neutron Therapy & Cancer Treatments (BBJNCT), 2, 7pp.

33.       Wang, Z., Wang, M., Wu, G., Wu, D., and Wu, A. (2014): Colorimetric detection of copper and efficient removal of heavy metal ions from water by diamine-functionalized SBA-15, Dalton Transactions, 43, 8461-8468.

34.       Magaye, R., Yue, X., Shi, H., Yu, H., Liu, K., Lin, X., Xu, J., Yang, C., Wu, A., and Zhao, J.(2014): Acute toxicity of nickel nanoparticles in rats after intravenous injection, International Journal of Nanomedicine, 9, 1393–1402.

35.       Gao, Y., Li, X., Li, Y., Li, T., Zhao, Y., and Wu, A. (2014): A simple visual and highly selective colorimetric detection of Hg²⁺ based on gold nanoparticles modified by 8-hydroxyquinolines and oxalates, Chemical Communications, 50, 6447-6450. (Featured in Back Cover)

36.       Yang, N., Gao, Y., Zhang, Y., Shen, Z., and Wu, A. (2014): A new rapid colorimetric detection method of Al³⁺ with high sensitivity and excellent selectivity based on a new mechanism of aggregation of smaller etched silver nanoparticles, Talanta, 122, 272-277.

37.       Chen, L., Li, J., Wang, S., Lu, W., Wu, A., Choo, J., and Chen, L. (2014): FITC functionalized magnetic core–shell Fe₃O₄/Ag hybrid nanoparticle for selective determination of molecular biothiols, Sensors and Actuators B: Chemical, 193, 857-863.

38.       Gong, A., Ma, X., Xiang, L., Ren, W., Shen, Z., and Wu, A. (2014): Improved double emulsion technology for fabricating autofluorescent microcapsules as novel ultrasonic/fluorescent dual-modality contrast agents, Colloids and Surfaces B: Biointerfaces, 116, 561-567.

39.       Zhang, W., Li, B., Chen, L., Wang, Y., Gao, D., Ma, X., and Wu, A. (2014): Brushing, a simple way to fabricate SERS active paper substrates, Analytical Methods, 6, 2066-2071.

40.       Xin, J., Yin, X., Chen, S., and Wu, A. (2014): Synthesis of uniform and stable silver nanoparticles by a gold seed-mediated growth approach in a buffer system, Journal of Experimental Nanoscience, 9, 382-390.

41.       Shen, Z., Wu, A., and Dai, S. (2013): Low-positively charged thermosensitive copolymers as gene delivery vectors without toxic effect, Journal of Controlled Release, 172, e122-e123.

42.       Ma, X., Gong, A., Xiang, L., Chen, T., Gao, Y., Liang, X., Shen, Z., and Wu, A. (2013): Biocompatible composite nanoparticles with large longitudinal relaxivity for targeted imaging and early diagnosis of cancer, Journal of Materials Chemistry B, 1, 3419-3428.

43.       Ren, W., Zeng, L., Shen, Z., Xiang, L., Gong, A., Zhang, J., Mao, C., Li, A., Paunesku, T., Woloschak, G. E., Hosmane, N. S., and Wu, A. (2013): Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO₂ nanocarriers, RSC Advances, 3, 20855-20861.

44.       Zeng, L., Xiang, L., Ren, W., Zheng, J., Li, T., Chen, B., Zhang, J., Mao, C., Li, A., and Wu, A. (2013): Multifunctional photosensitizer-conjugated core-shell Fe₃O₄@NaYF₄:Yb/Er nanocomplexes and their applications in T₂-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells, RSC Advances, 3, 13915-13925.

45.       Xu, J., Shi, H., Ruth, M., Yu, H., Lazar, L., Zou, B., Yang, C., Wu, A., and Zhao, J. (2013): Acute Toxicity of Intravenously Administered Titanium Dioxide Nanoparticles in Mice, Plos One, 8, 70618.

46.       Falaschetti, C., Paunesku, T., Kurepa, J., Nanavati, D., Chou, S., De, M., Song, M., Jang, J., Wu, A., Dravid, V., Cheon, J., Smalle, J., and Woloschak, G. (2013): Negatively Charged Metal Oxide Nanoparticles Interact with the 20S Proteasome and Differentially Modulate Its Biologic Functional Effects, ACS Nano, 7, 7759-7772.

47.       Gao, S., Liu, X., Xu, T., Ma, X., Shen, Z., Wu, A., Zhu, Y., and Hosmane, N. S. (2013): Synthesis and Characterization of Fe¹⁰BO₃/Fe₃O₄/SiO₂ and GdFeO₃/Fe₃O₄/SiO₂: Nanocomposites of Biofunctional Materials, ChemistryOpen, 2, 88-92.

48.       Leng, Y., Li, Y., Gong, A., Shen, Z., Chen, L., and Wu, A. (2013): Colorimetric Response of Dithizone Product and Hexadecyl Trimethyl Ammonium Bromide Modified Gold Nanoparticle Dispersion to 10 Types of Heavy Metal Ions: Understanding the Involved Molecules from Experiment to Simulation, Langmuir, 29, 7591-7599. (Highlighted by Nature China:  http://www.natureasia.com/en/ nchina /article/ 10.1038 / nchina.2013.61)

49.       Zhang, Y., Leng, Y., Miao, L., Xin, J., and Wu, A. (2013): The colorimetric detection of Pb²⁺ by using sodium thiosulfate and hexadecyl trimethyl ammonium bromide modified gold nanoparticles, Dalton Transactions, 42, 5485-5490.

50.       Gao, Y., Xin, J., Shen, Z., Pan, W., Li, X., and Wu, A. (2013): A new rapid colorimetric detection method of Mn²⁺ based on tripolyphosphate modified silver nanoparticles, Sensors and Actuators B: Chemical, 181, 288-293.

51.       Zeng, L., Ren, W., Xiang, L., Zheng, J., Chen, B., and Wu, A. (2013): Multifunctional Fe₃O₄-TiO₂ nanocomposites for magnetic resonance imaging and potential photodynamic therapy, Nanoscale, 5, 2107-2113.

52.       Miao, L., Xin, J., Shen, Z., Zhang, Y., Wang, H., and Wu, A. (2013): Exploring a new rapid colorimetric detection method of Cu²⁺ with high sensitivity and selectivity, Sensors and Actuators B: Chemical, 176, 906-912.

53.       Wang, Z., Wu, D., Wu, G., Yang, N., and Wu, A. (2013): Modifying Fe₃O₄ microspheres with rhodamine hydrazide for selective detection and removal of Hg²⁺ ion in water, Journal of Hazardous Materials, 244–245, 621-627.

54.       Zhao, X., Hosmane, N. S., and Wu, A. (2012): ortho-Phenylenediamine: An Effective Spacer to Build Highly Magnetic Fe₃O₄/Au Nanocomposites, ChemPhysChem, 13, 4142-4147.

55.       Lou, S., Ye, J., Li, K., and Wu, A. (2012): A gold nanoparticle-based immunochromatographic assay: The influence of nanoparticulate size, Analyst, 137, 1174-1181.

56.       Zeng, L., Ren, W., Zheng, J., Wu, A., and Cui, P. (2012): Synthesis of water-soluble FeOOH nanospindles and their performance for magnetic resonance imaging, Applied Surface Science, 258, 2570-2575.

57.       Zeng, L., Ren, W., Zheng, J., Cui, P., and Wu, A. (2012): Ultrasmall water-soluble metal-iron oxide nanoparticles as T₁-weighted contrast agents for magnetic resonance imaging, Physical Chemistry Chemical Physics, 14, 2631-2636.

58.       Zeng, L., Wu, A., Wang, Y., Pu, S., and Ding, J. (2012): In-situ observation and relocation method of nanomaterial samples based on microscope systems, Microscopy Research and Technique, 75, 138-144.

59.       Xin, J., Miao, L., Chen, S., and Wu, A. (2012): Colorimetric detection of Cr³⁺ using tripolyphosphate modified gold nanoparticles in aqueous solutions, Analytical Methods, 4, 1259-1264. (Selected a Hot Paper by the journal)

60.       Xin, J., Zhang, F., Gao, Y., Feng, Y., Chen, S., and Wu, A. (2012): A rapid colorimetric detection method of trace Cr (VI) based on the redox etching of Ag-core-Au-shell nanoparticles at room temperature, Talanta, 101, 122-127.

61.       Yan, L., Lin, M., Zeng, C., Chen, Z., Zhang, S., Zhao, X., Wu, A., Wang, Y., Dai, L., Qu, J., Guo, M., and Liu, Y. (2012): Electroactive and biocompatible hydroxyl- functionalized graphene by ball milling, Journal of Materials Chemistry, 22, 8367-8371.

62.       Leng, Y., Zhang, F., Zhang, Y., Fu, X., Weng, Y., Chen, L., and Wu, A. (2012): A rapid and sensitive colorimetric assay method for Co²⁺ based on the modified Au nanoparticles (NPs): Understanding the involved interactions from experiments and simulations, Talanta, 94, 271-277.

63.       Blatnik, J., Luebke, L., Simonet, S., Nelson, M., Price, R., Leek, R., Zeng, L., Wu, A., and Brown, E. (2012): Dye Surface Coating Enables Visible Light Activation of TiO₂ Nanoparticles Leading to Degradation of Neighboring Biological Structures, Microscopy and Microanalysis, 18, 134-142.

64.       Arora, H. C., Jensen, M. P., Yuan, Y., Wu, A., Vogt, S., Paunesku, T., and Woloschak, G. E. (2012): Nanocarriers Enhance Doxorubicin Uptake in Drug-Resistant Ovarian Cancer Cells, Cancer Research, 72, 769-778.

65.       Pu, S., Tan, S., and Wu, A. (2011): Deposition of gold nanoparticles onto poly (DL-lactic acid) microbubbles using cetyltriethylammnonium bromide as a surface modification agent, Micro & Nano Letters, 6, 186-189.

66.       Thurn, K. T., Arora, H., Paunesku, T., Wu, A., Brown, E. M. B., Doty, C., Kremer, J., and Woloschak, G. (2011): Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells, Nanomedicine: Nanotechnology, Biology and Medicine, 7, 123-130. (Featured in Front Cover).

67.       Zhang, F., Zeng, L., Zhang, Y., Wang, H., and Wu, A. (2011): A colorimetric assay method for Co²⁺ based on thioglycolic acid functionalized hexadecyl trimethyl ammonium bromide modified Au nanoparticles (NPs), Nanoscale, 3, 2150-2154.

68.       Zhang, F., Zeng, L., Yang, C., Xin, J., Wang, H., and Wu, A. (2011): A one-step colorimetric method of analysis detection of Hg²⁺ based on an in situ formation of Au@HgS core-shell structures, Analyst, 136, 2825-2830.

69.       Wu, A., Paunesku, T., Zhang, Z., Vogt, S., Lai, B., Maser, J., Yaghmai, V., Li, D., Omary, R. A., and Woloschak, G. E. (2011): A Multimodal Nanocomposite for Biomedical Imaging, AIP Conference Proceedings, 1365, 379-383.

70.       Yin, X., Chen, S., and Wu, A. (2010): Green chemistry synthesis of gold nanoparticles using lactic acid as a reducing agent, Micro & Nano Letters, 5, 270-273.

71.       Wu, A., Ou, P., and Zeng, L. (2010): Biomedical applications of magnetic nanoparticles, Nano, 5, 245-270. (Review, Featured in Front Cover)

72.       Wu, A., Paunesku, T., Brown, E., Babbo, A., Cruz, C., Aslam, M., Dravid, V., and Woloschak, G. (2008) Titanium Dioxide Nanoparticles Assembled by DNA Molecules Hybridization and Loading of DNA Interacting Proteins, NANO, 3, 27-36.

73.       Wu, A., Jia, Z., Schaper, A., Noll, F., and Hampp, N. A. (2006): Simultaneous Removal of Thiolated Membrane Proteins Resulting in Nanostructured Lipid Layers, Langmuir, 22, 5213-5216.

74.       Wu, A., Cheng, W., Li, Z., Jiang, J., and Wang, E. (2006): Electrostatic-assembly metallized nanoparticles network by DNA template, Talanta, 68, 693-699.

75.       Wu, A., Li, Z., Zhou, H., and Wang, E. (2005): Nanoscale structures of circle - MgCl₂ constructed by plasmid DNA templates. Superlattices and Microstructures, 37, 151-161.

76.       Wu, A., Yu, L., Li, Z., Yang, H., and Wang, E. (2004): Atomic force microscope investigation of large-circle DNA molecules, Analytical Biochemistry, 325, 293-300.

77.       Wu, A., Li, Z., and Wang, E. (2004): DNA Network Structures on Various Solid Substrates Investigated by Atomic Force Microscopy, Analytical Sciences, 20, 1083-1086.

78.       Wu, A., Wei, G., and Li, Z. (2004): Biological samples investigated by atomic force microscopy, Chinese Journal of Analytical Chemistry, 32, 1538-1543.

79.       Wu, A., Li, Z., Yu, L., Wang, H., and Wang, E. (2002): A relocated technique of atomic force microscopy (AFM) samples and its application in molecular biology, Ultramicroscopy, 92, 201-207.

80.       Wu, A., Li, Z., Zhou, H., Zheng, J., and Wang, E. (2002): Construction and control of plasmid DNA network, Analyst, 127, 585-587.

81.       Wu, A., Li, Z., Yu, L. H., Wang, H., and Wang, E. (2001): Plasmid DNA network on a mica substrate investigated by atomic force microscopy, Analytical Sciences, 17, 583-584.

82.       Ma, H., Wan, C., Wu, A., and Zewail, A. H. (2007): DNA folding and melting observed in real time redefine the energy landscape, Proceedings of the National Academy of Sciences of the United States of America, 104, 712-716.

83.       Yu, L., Wu, A., Wang, H., Li, Z., and Suo, Q. (2001): Deoxyribonucleic acid sample preparation in scanning probe microscope, Chinese Journal of Analytical Chemistry, 29, 1470-1477.

84.       Brown, E. M. B., Paunesku, T., Wu, A., Thurn, K. T., Haley, B., Clark, J., Priester, T., and Woloschak, G. E. (2008): Methods for assessing DNA hybridization of peptide nucleic acid–titanium dioxide nanoconjugates, Analytical Biochemistry, 383, 226-235.

85.       Paunesku, T., Ke, T., Dharmakumar, R., Mascheri, N., Wu, A., Lai, B., Vogt, S., Maser, J., Thurn, K., Szolc-Kowalska, B., Larson, A., Bergan, R. C., Omary, R., Li, D., Lu, Z.-R., and Woloschak, G. E. (2008): Gadolinium-conjugated TiO₂-DNA oligonucleotide nanoconjugates show prolonged intracellular retention period and T₁-weighted contrast enhancement in magnetic resonance images, Nanomedicine-Nanotechnology Biology and Medicine 4, 201-207.

86.       Zheng, H., Li, Z., Wu, A., and Zhou, H. (2003): AFM studies of DNA structures on mica in the presence of alkaline earth metal ions, Biophysical Chemistry, 104, 37-43.

87.       Zheng, J., Li, Z., Wu, A., Zhou, H., Bai, H., and Song, Y. (2002): The structural transition of DNA-Tris(1,10-phenanthroline) cobalt(III) complexes in ethanol-water solution, Biochemical and Biophysical Research Communications, 299, 910-915.

88.       Yu, L., Li, Z., Wu, A., Wang, H., Suo, Q., Bi, X., and Huang, B. (2002): The AFM characterization of Ni(phen)(3)(2+) fixing effects on DNA, Chemical Journal of Chinese Universities-Chinese, 23, 46-48.

89.       Jia, J., Wang, B., Wu, A., Cheng, G., Li, Z., and Dong, S. (2002): A method to construct a third-generation horseradish peroxidase biosensor: Self-assembling gold nanoparticles to three-dimensional sol-gel network, Analytical Chemistry, 74, 2217-2223.

90.       Shen, Y., Liu, J., Wu, A., Jian, J., Bi, L., Liu, B., Li, Z., and Dong, S. (2002): Preparation of Pt nanoparticles assembled in multilayer films, Chemistry Letters, 550-551.

91.       Wang, L., Song, Y., Wu, A., Li, Z., Zhang, B., and Wang, E. (2002): Study of methanol adsorption on mica, graphite and ITO glass by using tapping mode atomic force microscopy, Applied Surface Science, 199, 67-73.

92.       Xu, L., Zhang, H., Wang, E., Wu, A., and Li, Z. (2002): Preparation, characterization and luminescence properties of ultrathin films containing polyoxometalates, Materials Letters, 54, 452-457.

93.       Xu, L., Zhang, H., Wang, E., Wu, A., and Li, Z. (2003): Preparation and characterization of photoluminescent ultrathin films based on polyoxometalates, Materials Chemistry and Physics, 77, 484-488.

94.       Zhang, C., Yang, Z., Ding, M., Wu, A., and Li, Z. (2001) The Surface Property and Morphology of the Polyimides Having Fluorinated Main Chains for Liquid Crystal Alignment, Chinese Journal of Applied Chemistry (In Chinese), 18, 544-547.

95.       Ni, Y., and Wu, A. (1999): Simultaneous determination of halide and thiocyanate ions by potentiometric precipitation titration and multivariate calibration, Analytica Chimica Acta, 390, 117-123.

96.       Jiang, M., Wang, E., Kang, Z., Lian, S., Wu, A., and Li, Z. (2003): In situ controllable synthesis of polyoxometalate nanoparticles in polyelectrolyte multilayers, Journal of Materials Chemistry, 13, 647-649.

97.       Zhang, H., Xu, L., Wang, E., Jiang, M., Wu, A., and Li, Z. (2003)： Photochromic behavior and luminescent properties of novel hybrid organic–inorganic film doped with Preyssler's heteropoly acid H12[EuP5W30O110] and polyvinylpyrrolidone, Materials Letters, 57, 1417-1422.

98.       Shen, Y., Liu, J., Wu, A., Jiang, J., Bi, L., Liu, B., Li, Z., and Dong, S. (2003): Preparation of multilayer films containing pt nanoparticles on a glassy carbon electrode and application as an electrocatalyst for dioxygen reduction, Langmuir, 19, 5397-5401.

99.       Zhou, H., Li, Z., Wu, A., Zheng, J., Zhang, J., and Wu, S. (2004): The influence of tip performance on scanning probe lithography, Applied Surface Science, 221, 402-407.

100.    Wang, J., Du, G., Ma, Y., Zhao, B., Yang, X., Zhang, Y., Liu, D., Li, W., Yang, H., Yang, S., Wu, A., and Li, Z. (2003): Study on NH₃ doping in ZnO film grown on R-plane of sapphire substrate, Faguang Xuebao (Chinese Journal of Luminescence), 24, 335-338 (In Chinese).

101.    Jiang, M., Zhang, H., Wang, E., Kang, Z., Lian, S., Xu, L., Wu, A., and Li, Z. (2004): Assembly and characterization of rare-earth-containing polyoxometalate Eu(P2Mo17O61)(2) (17-) and poly(allylamine hydrochloride) multilayer films. Chemical Research in Chinese Universities 20, 15-19.

102.    Zhou, H., Li, Z., Wu, A., Wei, G., and Liu, Z. (2004): Direct patterning of rhodamine 6G molecules on mica by dip-pen nanolithography, Applied Surface Science, 236, 18-24.

103.    Liu, J., Jin, Y., Wu, A., Li, Z., and Dong, S. (2004): Fabrication and Characterization of DNA/QPVP-Os Redox-Active Multilayer Film, Electroanalysis, 16, 1931-1937.

104.    Xu, L., Zhang, J., Cao, W., Wu, A., and Li, Z. (2004): Stable multilayer films based on photoinduced interaction between polyoxometalates and diazo resin, Materials Letters, 58, 3441-3446.

105.    Jiang, M., Wang, E., Wang, X., Wu, A., Kang, Z., Lian, S., Xu, L., and Li, Z. (2005): Self-assembly of lacunary Dawson type polyoxometalates and poly(allylamine hydrochloride) multilayer films: photoluminescent and electrochemical behavior, Applied Surface Science, 242, 199-206.

106.    Thurn, K. T., Brown, E. M. B., Wu, A., Vogt, S., Lai, B., Maser, J., Paunesku, T., and Woloschak, G. E. (2007): Nanoparticles for applications in cellular Imaging, Nanoscale Research Letters, 2, 430-441.

107.    Thurn, K. T., Paunesku, T., Wu, A., Brown, E. M. B., Lai, B., Vogt, S., Maser, J., Aslam, M., Dravid, V., Bergan, R., and Woloschak, G. E. (2009): Labeling TiO₂ Nanoparticles with Dyes for Optical Fluorescence Microscopy and Determination of TiO₂-DNA Nanoconjugate Stability, Small, 5, 1318-1325.

108.    Doty, C., Brown, E., Wu, A., Paunesku, T., and Woloschak, G (2009): Effects of fluorescent dye coating of metal oxide nanoparticles on DNA scission, Journal of the Robert H. Lurie Cancer Center, Northwestern University, 13, 72-76.

2)Patents, pending patents

I)      Patents ( A part list)

1.          Wu, A., Gong, A., Shen, Z., Ma, X., Xiang, L. (2013): A kind of ultrasonic/fluorescent double modal method of preparation of microcapsule contrast agents. China Patent, No. 201310755481.2 Dated: 31.12.2013.

2.          Leng, Y., Zhang, Y., Wu, A. (2013): Portable food safety testing reagent and its preparation method and application. China Patent, No. 201310511426.9 Dated: 24.10.2013.

3.          Shen, Z., Wu, A., Ma, X., Gong, A., Ren, W., Li, J. (2013): Targeted therapy combination with drugs and its preparation method and application. China Patent, No. 201310318107.6 Dated: 24.07.2013.

4.          Wu, A., Gao, Y., Shen, Z. (2013): Compositions, method and kits for the detection of mercury ion. China Patent, No. 201310091158.X Dated: 20.03.2013.

5.          Wu, A., Leng, Y., Zhang, Y. (2013): Portable food safety detection reagent and its preparation method and application. China Patent, No. 201310511426.9 Dated: 24.10.2013.

6.          Wu, A., Miao, L., Shen, Z., Zeng, L. (2012): A detection method of Cd²⁺. China Patent, No. 20120391120.X Dated:16.10.2012

7.          Wu, A., Yang, N., Shen, Z.(2012): A detection method of Ni(III) cations. China Patent, No. 201210310138.2 Dated:14.09.2012.

8.          Wu, A., Gao, Y., Shen, Z. (2012): A method for detecting manganese ion. China Patent, No. 201210310138.2 Dated: 28.08.2012.

9.          Shen, Z. Wu, A., Ren, W. (2012): Active targeting type small interference RNA transport carrier and its preparation method. China Patent, No. 201210475752.4  Dated: 20.11.2012.

10.       Zeng, L., Wu, A. (2012): A kind of inorganic composite nanoparticle and its preparation method. China Patent, No. 201210172056.6  Dated: 25.05. 2012.

11.       Wu, A., Wang, Z., Zhao, X. (2012): Used to test and the adsorption of mercury ion dual functional materials and their synthesis methods and applications. China Patent, No. 201210396580.1 Dated: 18.10.2012.

12.       Shen, Z., Wu, A. (2012): Tumor early diagnosis with invisible imaging material and its preparation method. China Patent, No. 201210230833.8 Dated: 03.07.2012.

13.       Wu, A., Miao, L., Xin, J. (2012): A rapid detection method of copper cations in aqueous solutions. China Patent, No. 201210097477.7 Dated: 01.04.2012.

14.       Wu, A., Ma, X., Shen, Z. (2012): Gd₂O₃-TiO₂ composite nanoparticles and its preparation method and application. China Patent, No. 201210539796.9 Dated: 12.12. 2012.

15.       Wu, A., Leng, Y. (2012): A rapid detection agent and its preparation and applications in multiple kinds of single metal cations. China Patent, No. 201210159826.3 Dated: 16.11.2011.

16.       Ren, W., Wu, A. (2011): Based on tumor cells active nanoparticles for targeted drug delivery system and its constrution method. China Patent, No. 201110397312.7 Dated: 05.12.2011.

17.       Wu, A., Zeng, L., Zhang, F., Cui, P. (2011): A Preparation method of water soluble materials with core-shell or core-corona- shell structures. China Patent, No. 201110000844.2 Dated: 05.01.2011.

18.       Zeng, L., Wu, A., Cui, P. (2011): Paramagnetic & up-conversion nanoparticulate composites: Preparation and Applications. China Patent, No. 201110032000.6 Dated: 28.11.2011.

19.       Zhang, Y., Wu, A., Nie, X. (2011)：Preparation and application of water-soluble nanocomposite. China Patent, No. 201110241124.5 Dated: 19.08.2011.

20.       Zhang, Y., Wu, A. (2011): A detection method of lead ion. China Patent, No. 201110299385.2 Dated: 08.10.2011.

21.       Leng, Y., Wu, A., Yin, X. (2011): A high-yield synthesis method of (200) faceted gold nanorods and their applications. China Patent, No. 201110363934.8 Dated: 16.11.2011.

22.       Leng, Y., Wu, A. (2011): A method for detection of Co²⁺ based on AuNPs solution. China Patent, No. 201110363954.5. Dated 16.11.2011.

23.       Xin, J., Wu, A. (2011): A green preparation method of silver nanoparticles with different shapes. China Patent, No. 201110378232.7 Dated: 24.11.2011.

24.       Xin, J., Wu, A. (2011): A detection method of Cr(VI) cations. China Patent, No. 201110378260.9 Dated: 24.11.2011.

25.       Wu, A., Zeng, L. (2010): Fe₃O₄-TiO₂ nanopcomposites: Preparation and application as contrast agents in magnetic resonance imaging. China Patent, No. 201010039632.0 Dated: 12.01.2010.

26.       Zhang, F., Wu, A., Zeng, L., Cui, P. (2010): A detection method of cations based on VA or VIA elemental compounds. China Patent, No. 201010251278.8 Dated: 01.08.2010.

27.       Zhang, F., Wu, A., Zeng, L. (2010): The detection method of metal ions. China Patent, No. 201010194041.0 Dated: 07.06.2010.

28.       Wu, A., Zeng, L., Cui, P. (2010): Synthesis method of nanoparticles/nanoparticle sol and their application in magnetic resonance imaging contrast agents. China Patent, No. 201010175917.7 Dated: 18.05.2010.

29.       Wu, A., Zeng, L.(2009): A relocation method for nanomaterials or micro-/nanodevices. China Patent, No. 200910152441.2 Dated: 14.09.2009.

30.       Wu, A., Paunesku, T., Woloschak, G. (2009): Multifunction nanoconjugates for imaging applications and targeted treatment, US 8557290B2 Dated 13.03.2009.

31.       Li, Z., Liu, Z., Ma, Z., Wu, A., Zhou, H., Wei G. (2004): A preparation method for gold film used as scanning probe microscope substrates. China Patent, No. 200410010647.9 Dated:16.01.2004.

32.       Wu, A., Li, Z., Ma, Z., Zheng, J., Wang, E. (2002): A horizontally dynamical molecule combing. China Patent, No. 02104270.5 Dated: 04.03.2002.

33.       Wu, A., Li, Z., Zheng, J., Zhou, H., Wang, E. (2002): A preparing method of controllable DNA network. China Patent, No. 02104271.3 Dated: 04.03.2002.

34.       Li, Z., Wu, A., Wang, E., Yu, L. (2001): An AFM controllable probe holder. China Patent, No. 01224491.0 Dated: 25.05.2001.

35.       Li, Z., Wu, A., Wang, H., Yu, L. (2001): An AFM multiprobes holder. China Patent, No. 01204082.7 Dated: 26.02.2001.

36.       Li, Z., Wu, A. (2001): A mechanical method for preparing controllable nanowire. China Patent, No. 01110205. 5 Dated: 02.04.2001.

37.       Li, Z., Wu, A., Wang, E. Yu, L. (2001): A physical chemistry method for preparing controllable nanowire. China Patent, No. 01110206.3 Dated: 02.04.2001.

38.       Li, Z., Zhou, H., Wu, A., Zheng, J., Li, J., Wang, E.(2001): Preparation of controllable metal nanowire. China Patent, No. 01140159.1 Dated: 28.11.2001.

39.       Li, Z., Wu, A., Wang, H., Yu, L. (1999): An AFM probe holder. China Patent, No. 99256948.6 Dated: 16.12.1999.

40.       Li, Z., Wang, H., Wu, A., Yu, L., Wang, E. (1999): A relocated method for SPM samples. China Patent, No. 99126338. 3 Dated: 16.12.1999.

II)  Pending Patents ( A part list)

1.        Li, J., Wu, A., Tian, Y. (2015): Active targeting anti-brain tumor and its preparation method. China Patent, No. 201510535764.5 Dated: 27.08.2015.

2.        Wu, A., Liu, H., Zhang, Y. (2015): A soil heavy metal fixatives and its preparation method and application. China Patent, No. 201510511727.0 Dated: 19.08.2015.

3.        Wu, A., Dong, C., Shen, Z., Wang, Z., Zhang, Y. (2015): A method for rapid on-time detection of metal ions based on smartphone. China Patent, No. 201510508573.X Dated: 18.08.2015.

4.        Muhammad. Z., Wu, A., Zeng, L., Ma, X., Chen, T.(2015): A composite nanoparticles with Janus structure and its preparation method and application. China Patent, No. 201510504659.5 Dated: 17.08.2015.

5.        Zeng, L., Wu, A. (2015): Nanocomposites preparation method and the application of a core-shell structure. China Patent, No. 201510405522.4 Dated: 09.07.2015.

6.        Shen, Z., Wu, A., Wu, X., Zhang, Y., Ruan, H. (2015): A composite meterial based on Surface-enhanced Raman Scattering technique and its preparation method. China Patent, No. 201510351619.1 Dated: 19.06.2015.

7.        Shen, Z., Wu, A., Wu, X. (2015): A composite meterial with Surface-enhanced Raman Scattering technique and its preparation method. China Patent, No. 201510169894.1 Dated: 10.04.2015.

8.        Wu, A., Chen, N., Zhang, Y. (2015): A nuclear magnetic resonance (NMR) methods of rapid detection of metal ions and small molecules. China Patent, No. 201510107195.4 Dated: 11.03.2015.

9.        Muhammad , Z., Wu, A., Ma, X. (2014): A kind of magnetic nanoparticles, preparation method and application. China Patent, No. 201410203774.4 Dated: 14.05.2014.

10.     Ren, W., Wu, A. (2014): A tumor treatment composite nanometer material and its preparation. China Patent, No. 201410175018.5 Dated: 28.04.2014.

11.     Li, J., Wu, A. (2014): The initiative targeted anti-tumor drugs and its preparation method. PCT, No. 2014/075727 Dated: 18.04.2014.

12.     Chen, T., Wu, A., Gong, A. (2014): A kind of imaging materials, the preparation methods and applications. China Patent, No. 201410398464.2 Dated: 14.08.2014.

13.     Chen, T., Wu, A. (2014): A new type of imaging materials and its preparation method and application. China Patent, No. 201410430551.1 Dated: 29.08.2014.

14.     Wu, A., Shi, Z., Xu, Y. (2014): A bismuth matrix composite nanometer material and its diagnosis and treatment of tumor. China Patent, No. 201410788424.9 Dated: 17.12.2014.

15.     Wu, A., Li, Y., Shen, Z. (2013): A kind of cysteine detection reagent and test method. China Patent, No. 201310367104.1 Dated: 21.08.2013.

16.     Wu, A., Li, Y., Shen, Z. (2013): A bivalent mercury ion detection reagent combination and test methods. China Patent, No. 201310382118.0 Dated: 28.08.2013.

17.     Li, J., Wu, A. (2013): The initiative targeted anti-tumor drugs and its preparation method. China Patent, No. 201310407938.0 Dated: 09.09.2013.

18.     Ren, W., Wu, A., Zeng, L., Shen, Z., Ma., X. (2013): Three of its preparation methods and used for the preparation of nanometer compound medicine combination USES for the treatment of tumor. China Patent, No. 201310103775.7 Dated: 27.03.2013.

19.     Wu, A., Yang, N., Gao, Y. (2013): A trivalent aluminium ion detection reagent and test method. China Patent, No. 201310386230.1 Dated: 29.08.2013.

20.     Shen, Z. Wu, A., Ren, W., Ma. X.(2012): Actively targeted delivery vectors of siRNA and the fabrication method. PCT Patent, No. 2013/070362 Dated:11.01.2013.

21.     Wu, A., and Zhao, X. (2011) A kind of magnetic MFe₂O₄/C/M’composites and their synthetic methods based on phenylenediamine as carbon sources, China Patent, No. 201110334595.0, dated 19.10.2011

22.     Ren, W., and Wu, A.(2011) A kind of magnetic MFe₂O₄/C/AOX composites and their synthetic methods based on catechol as carbon sources, China Patent, No. 201110397312.7, dated 05. 12. 2011

23.     Zhao, X., and Wu, A. (2011) A kind of active targeting drug delivery system for cancer cells based on nanoparticles and theirs prepared method, China Patent, No. 201110334606.5, dated 19.10.2011

24.     Leng, Y., and Wu, A. (2011) A highly sensitive colorimetric assay method for Co²⁺ detection, China Patent, No. 201110363954.5, dated 16. 11. 2011

25.     Xin, J., and Wu, A. (2011) A detection method of Cr(III) cations, China Patent, No. 201110337660.5, dated 31. 10. 2011

26.     Zeng L., Wu, A., and Cui, P. (2010) Fe₃O₄-TiO₂ nanopcomposites: Preparation and application as contrast agents in magnetic resonance imaging, China Patent, No. PCT/CN2010/077803, dated 15. 10. 2010

27.     Zeng L., and Wu, A. (2010) A detection method of cations in aqueous solutions, China Patent, No. 200910152440.8, dated 14. 09. 2009

3) Monograph

2.          Tan, M., and Wu, A. (2015): Nanomaterials for Tumor Tageting Theranostics, Higher Education Press, 453pp, Editor.

3.          Shi, Z., Xu, Y., and Wu, A. (2015):Advances in Nanotheranostics I, Springer Press, 103pp

Prof. Gayle E Woloschak, Northwestern University, USA

Prof. Shawn Chen, NIH, USA

Prof. Jian Yang, PSU, USA

Prof. Narayan Hosmane, NIU, USA

Prof. Norbert Hampp,University of Marburg, Germany

Dr. Gang Wei, University of Bremen, Germany

Prof. Wenlong Cheng, Monash Univeristy, Australia

------

已指导学生

马雪华  硕士研究生  430105-材料工程  

杨宁宁  硕士研究生  430117-化学工程  

冷玉敏  博士研究生  080501-材料物理与化学  

龚安  硕士研究生  085204-材料工程  

李天华  博士研究生  080501-材料物理与化学  

现指导学生

叶羽凡  硕士研究生  080501-材料物理与化学  

俞樟森  博士研究生  080501-材料物理与化学  

罗利嘉  博士研究生  080501-材料物理与化学  

徐裕  博士研究生  080501-材料物理与化学  

王胤杰  博士研究生  080501-材料物理与化学