代谢与干细胞命运

2014-09--2017-06   中国科学院大学   博士研究生

   

2017-07~现在, 中国科学院广州生物医药与健康研究院, 副研究员

   

（1） 广东省精准医学科学技术奖一等奖, 一等奖, 其他, 2023
（2） 广东省科学技术奖自然科学一等奖, 一等奖, 省级, 2020

   

（1） A new role of Iridium(III) Complexes in regulating pluripotency acquisition via mitochondrial remodulation, SCIENCE CHINA Life Sciences, 2026, 第 5 作者
（2） Post-transcriptional control of endogenous retroviruses by L1td1 suppresses totipotency acquisition in pluripotent stem cells, CELL DISCOVERY, 2026, 第 1 作者  通讯作者
（3） Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development, NATURE COMMUNICATIONS, 2025, 第 2 作者
（4） BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells, EMBO JOURNAL, 2023, 第 2 作者
（5） MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, CELL DEATH AND DIFFERENTIATION, 2022, 第 7 作者
（6） Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms, Science Advances, 2022, 第 7 作者
（7） Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, CELL DEATH AND DIFFERENTIATION, 2022, 第 1 作者
（8） NAD+is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1, NAD+is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1, Life Medicine, 2022, 第 1 作者
（9） Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space, Science China-Life Sciences, 2021, 第 8 作者
（10） Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade, NATURE METABOLISM, 2020, 第 4 作者
（11） Topology-dependent, bifurcated mitochondrial quality control under starvation, AUTOPHAGY, 2020, 第 6 作者
（12） Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming, EMBO JOURNAL, 2020, 第 5 作者
（13） Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition, SCIENCE ADVANCES, 2019, 第 1 作者
（14） Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming, CELL METABOLISM, 2018, 第 9 作者
（15） Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, CELL DEATH & DISEASE, 2018, 第 7 作者
（16） BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, AUTOPHAGY, 2017, 第 6 作者
（17） Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, CELL DEATH & DISEASE, 2017, 第 3 作者
（18） Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming, STEM CELLS, 2016, 第 1 作者
（19） Mitochondrial Membrane Potential‐dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration, CNS NEUROSCIENCE & THERAPEUTICS, 2016, 第 5 作者
（20） Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming, CELL METABOLISM, 2016, 第 4 作者
（21） Gadd45a is a heterochromatin relaxer that enhances iPS cell generation, EMBO REPORTS, 2016, 第 7 作者
（22） Tbx3 isoforms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 第 2 作者