基本信息
胡志红  女  博导  中国科学院武汉病毒研究所
电子邮件: huzh@wh.iov.cn
通信地址: 湖北省武汉市小洪山中区44号
邮政编码: 430071

研究领域

主要研究方向为病毒功能基因组学. 近期主要研究杆状病毒口服感染的分子机理、新疆出血热病毒的致病机理、病毒的分类进化等。

招生信息

胡志红,女,博士,研究员,1986年获武汉大学病毒学专业学士学位,1989年获中国科学院武汉病毒研究所理学硕士学位,1998年获荷兰Wageningen Agriculture University(现Wageningen University)病毒学专业博士学位。曾人选国家万人计划领军人才,新世纪百千万人才工程国家级人选,中国科学院“****”入选者,国家杰出青年基金获得者。兼任中国微生物学会理事、中国微生物学会病毒学专业委员会副主任委员;《科学通报》、《中国病毒学》、《病毒学报》等编委。长期从事病毒学特别是系统病毒学,主要研究病毒与宿主相互作用的分子机理,及其在生物技术中的应用。目前主持国家重点研发计划项目(政府间国际科技创新合作重点专项)、国家自然科学基金创新群体项目及面上项目、中国科学院战略先导性专项(B类)、中国科学院前沿科学重点研究项目、湖北省科技条件平台建设等在研课题,主要研究方向为蜱传布尼亚病毒的感染及致病机理、杆状病毒的感染机理、杆状病毒载体系统的理性设计与人工合成等。在Science、Cell Research、 PNAS、PLoS Pathogens、Journal of Virology、ACS synthetic biology等学术期刊发表论文200余篇,其中,SCI源论文150余篇,获授权专利13项。代表论文:J. Virol. 84:7233–42;81: 9377-85。曾荣获中国科学院青年科学家二等奖,湖北省自然科学一等奖、中国青年五四奖章、全国“三八红旗手”、全国“巾帼建功标兵”、中国科学院优秀研究生导师、中国科学院十大杰出妇女等荣誉称号。

电子邮箱:huzh@wh.iov.cn

招生专业
071005-微生物学
招生方向
病毒学

教育背景

1994-02--1998-09   Wageningen Agricultural University   博士
1986-09--1989-06   中国科学院武汉病毒研究所   硕士
1982-09--1986-06   武汉大学病毒系   学士
学历
1994--1998 荷兰农业大学 博士研究生
1986-1989 中国科学院武汉病毒研究所 硕士研究生
1982-1986 武汉大学 病毒及分子生物学系 本科生
学位
1998.9.8 荷兰农业大学 病毒学专业 理学博士学位、
1989 中国科学院武汉病毒研究所 硕士学位
1986 武汉大学 病毒学 学士学位

工作经历

   
工作简历
1989-07~现在, 中国科学院武汉病毒研究所, 助理研究员、副研究员、研究员
社会兼职
2018-08-01-2020-07-31,国际无脊椎动物病理学会, 主席
2017-01-01-今,Intervirology, 副主编
2014-01-01-今,Journal of Invertebrate Pathology, 副主编
2013-11-25-2018-11-25,中国科学院武汉病毒研究所第十届学术委员会, 委员
2013-11-01-2018-11-01,湖北省暨武汉微生物学会第十二届理事会, 常务理事
2013-07-01-2016-07-31,科技部基础性工作专项第一届专家, 顾问成员
2013-06-01-2016-05-31,中国科学院中-非联合研究中心学术委员会, 专家
2013-06-01-2018-05-31,科技基础性工作专项重点项目“我国重要自然宿主及媒介昆虫的病毒病原调查”项目, 专家组专家
2013-01-01-今,Protein Expression and Purification, 期刊编委
2013-01-01-今,Science Bulletin, 期刊编委
2012-12-20-2017-12-20,国家重大科学研究计划“重要病毒转录复制蛋白复合体的结构功能研究”, 项目专家组成员
2012-06-01-今,病毒学国家重点实验室第二届学术委员会, 委员
2012-03-01-2016-12-31,中国典型培养物保藏中心第三届顾问委员会, 副主任委员
2011-12-22-今,国家重点基础研究发展计划(973计划)项目“病毒与细胞相互作用导致炎症的基础研究”, 项目专家组专家
2011-12-09-今,国际病毒学杂志第三届编辑委员会, 委员
2011-10-01-2016-10-30,微生物学杂志第六届编辑委员会, 编委
2011-10-01-2016-10-31,中国微生物学会病毒学专业委员会, 副主任委员
2011-10-01-2016-10-31,中国微生物学会国际交流工作委员会, 委员
2011-10-01-2016-10-31,中国微生物学会第十届理事会, 理事

教授课程

病毒与病毒病
分子病毒学
合成生物学

专利与奖励

获得授权专利情况:

1.     专利名称:寄生蜂传递病毒防治害虫方法,发明人:彭辉银,陈新文,姜芸,张帆,周显明,胡志红,金峰(专利号:ZL97109294.X,公告日期: 2002/12/1

2.     专利名称:中国棉铃虫重组病毒,发明人:陈新文、胡志红J.M.Valk、孙修炼(专利号:ZL00114307.7,公告日期:2003/2/19

3.     专利名称:中国棉铃虫重组基因工程病毒,发明人:王华林、陈新文、孙修炼、胡志红(专利号:ZL00131154.9,公告日期:2003/5/21

4.     专利名称:超氧化物歧化酶在昆虫病毒杀虫中的应用,发明人:孙修炼、周明哲、 胡志红(专利号:ZL02154122.1,公告日期:2005/4/20

5.     专利名称:一种用于检测乙型肝炎病毒的生物用品,发明人:王华林、周颖、邓菲、袁丽、胡志红(专利号:ZL200610018346.X,公告日期:2008/11/26

6.     专利名称:王华林、夏骏、邓菲、袁丽、胡志红,发明人:一种基于液相芯片检测禽流感病毒H5N1亚型的方法(专利号:ZL200610018603.X,公告日期:2009/6/3

7.     专利名称:高效表达SARS冠状病毒S蛋白的重组杆状病毒及构建,发明人:李娟、王华林、邓菲、胡志红(专利号ZL200710052485.9,公告日期:2010/7/21

8.     专利名称:重组杆状病毒AcBac*-GP41及其构建方法,发明人:苏正元、李娟、王华林、邓菲、胡志红、袁丽(专利号:ZL200710052629.0,公告日期:2011/4/6

9.     专利名称:用于检测乙型肝炎病毒共价闭合DNA的生物用品及其应用,发明人:许君、尹飞飞、王华林、邓菲、胡志红(专利号:ZL200810197526.8,公告日期:2012.5.30

10.  专利名称:用液相芯片检测呼吸道传染病病原的引物和探针及方法,发明人:王华林、尹飞飞、邓菲、胡志红(专利号:ZL201110067021.1,公告日期:2013.2.13)

11.  专利名称:用液相芯片检测虫媒或接触传播病原的引物和探针及方法,发明人:王华林、尹飞飞、邓菲、胡志红、袁勤芬(专利号:ZL201110067025.x,公告日期:2013/8/28

12.  专利名称:用于杆状病毒滴度测定的重组细胞系及其测定办法,发明人:邓菲、邓马平、张艳芳、王华林、胡志红(专利号:ZL201310538492.5,公告日期:2016.4.13

13.  专利名称:一种杆状病毒基因组的合成方法及其在重组杆状病毒构建中

的应用,发明人:商雨、胡志红、邓菲、王曼丽、王华林(专利号:ZL201710144998.6,公告日期:2019.9.17


奖励信息
(1) “万人计划”百千万工程领军人才, 国家级, 2014
(2) 湖北省重大人才工程“高端人才引领培养计划”培养导师, 一等奖, 省级, 2013
(3) 中国科学院“朱李月华优秀教师”奖, 一等奖, 院级, 2012
(4) 湖北省自然科学奖, 一等奖, 省级, 2011
(5) 武汉市十佳女科技工作者, , 市地级, 2010
(6) 中国科学院优秀研究生指导教师, , 院级, 2010
(7) 新世纪百千万人才工程国家级人选, , 国家级, 2009
(8) 中国科学院武汉教育基地2008年度“优秀教师”, 一等奖, 院级, 2008
(9) 第八届“ 中国青年五四奖章”, 一等奖, 国家级, 2004
(10) 湖北省技术发明奖, 三等奖, 省级, 2004
(11) 武汉市科技进步奖, 一等奖, 市地级, 2002
(12) 湖北省自然科学, 二等奖, 省级, 2001
(13) 中国科学院青年科学家, 二等奖, 国家级, 1999
(14) 中科院科技进步奖, 三等奖, 院级, 1998
专利成果
[1] 商雨, 胡志红, 邓菲, 王曼丽, 王华林. 一种杆状病毒基因组的合成方法及其在重组杆状病毒构建中的应用. CN: CN106754896B, 2019-09-17.

[2] 邓菲, 邓马平, 张艳芳, 王华林, 胡志红. 用于杆状病毒滴度测定的重组细胞系及其测定方法. 中国: CN103571795A, 2014-02-12.

[3] 王华林, 王曼丽, 干盈盈, 邓菲, 胡志红. 表达gp64基因的新型基因工程重组病毒的构建方法. 中国: CN102382803A, 2012-03-21.

[4] 王华林, 董思聪, 王曼丽, 沈姝, 邓菲, 胡志红. 用于提高杆状病毒对哺乳动物细胞转导效率的方法. 中国: CN102199629A, 2011.09.28.

[5] 王华林, 尹飞飞, 邓菲, 胡志红, 袁勤芬. 用液相芯片检测虫媒或接触传播病原的引物和探针及方法. 中国: CN102181532A, 2011-09-14.

[6] 王华林, 尹飞飞, 邓菲, 胡志红. 用液相芯片检测呼吸道传染病病原的引物和探针及方法. 中国: CN102181576A, 2011-09-14.

[7] 尹飞飞, 王华林, 邓菲, 胡志红. 用于检测乙型肝炎病毒耐药突变位点的引物及方法. 中国: CN102181575A, 2011-09-14.

[8] 王华林, 夏 骏, 袁 丽, 邓 菲, 胡志红. 一种用于检测禽流感病毒H5N1亚型的液相芯片. 中国: CN100494402, 2009.06.03.

[9] 王华林, 丘志娟, 邓 菲, 袁 丽, 胡志红. 一种乙型肝炎病毒基因分型的方法. 中国: CN101402993, 2009-04-08.

[10] 许 君, 尹飞飞, 王华林, 邓 菲, 胡志红. 用于检测乙型肝炎病毒共价闭合DNA的生物用品及其应用. 中国: CN101397592, 2009-04-01.

[11] 王华林, 周 颖, 邓 菲, 袁 丽, 胡志红. 一种用于检测乙型肝炎病毒的生物用品. 中国: CN100436598, 2008.11.26.

[12] 苏正元, 李 娟, 王华林, 邓 菲, 胡志红, 袁 丽. 重组杆状病毒AcBac ΔCC -GP41及其构建方法. 中国: CN101113460, 2008-01-30.

[13] 李 娟, 王华林, 邓 菲, 胡志红. 高效表达SARS冠状病毒S蛋白的重组杆状病毒及构建. 中国: CN101100680, 2008-01-09.

[14] 王华林, 许君, 邓菲, 胡志红. 一种抑制乙型肝炎病毒的天然提取物及其主要活性成份. 中国: CN101028382, 2007.09.05.

[15] 王汉中, 陈新文, 胡志红. 带有棉铃虫单粒包埋核型多角体病毒基因和P10基因启动子序列的快速供体质粒及构建方法. 中国: CN1317387, 2007-05-23.

[16] 王华林, 王慧媛, 邓菲, 袁丽, 胡志红. 杆状病毒的gp64和p35基因的联合应用. 中国: CN1654658, 2005-08-17.

[17] 孙修炼, 周明哲, 胡志红. 超氧化物歧化酶在昆虫病毒杀虫中的应用. 中国: CN1197467, 2005-04-20.

[18] 王汉中, 陈新文, 胡志红. 棉铃虫单粒包埋核型多角体病毒穿梭表达载体及制备方法. 中国: CN1429910, 2003-07-16.

[19] 吴东, 陈新文, 胡志红. 表达多角体和几丁质酶融合蛋白的重组棉铃虫单核衣壳核多角体病毒及其制备方法. 中国: CN1429902, 2003-07-16.

[20] 吴东, 彭辉银, 孙修炼, 陈新文, 张双民, 胡志红. 中国棉铃虫病毒几丁质酶基因. 中国: CN1308126, 2001.08.15.

[21] 陈新文, 胡志红, J·M·Vlak(休斯特·福拉克), 张友清, 孙修练. 中国棉铃虫病毒基因工程株1号. 中国: CN1297043, 2001-05-30.

[22] 胡志红, 陈新文, 孙修炼, 刘岚, 冯枞棣. 中国棉铃虫病毒组织蛋白酶基因. 中国: CN1295128, 2001-05-16.

[23] 王华林, 陈新文, 孙修炼, 胡志红. 中国棉铃虫基因工程病毒. 中国: CN1291649, 2001-04-18.

[24] 彭辉银, 陈新文, 姜云, 张帆, 周显明, 胡志红, 金锋. 寄生蜂传递病毒防治害虫方法. 中国: CN1060015, 2001-01-03.

[25] 陈新文, 胡志红, J.M.福拉克(J.M.Valk), 孙修炼. 中国棉玲虫重组病毒. 中国: CN1258741, 2000-07-05.

出版信息

   
发表论文
[1] Xu, Mingyue, Wang, Bo, Deng, Fei, Wang, Hualin, Wang, Manli, Hu, Zhihong, Liu, Jia. Establishment of a Reverse Genetic System of Severe Fever with Thrombocytopenia Syndrome Virus Based on a C4 Strain. VIROLOGICA SINICA[J]. 2021, 36(5): 958-967, http://dx.doi.org/10.1007/s12250-021-00359-x.
[2] Wang, Jun, Liu, Xiaoping, Zhu, Qiong, Wu, Qiaoli, Tang, Shuang, Zhang, Lei, Fan, Zhaojun, Hu, Zhihong, Wang, Hualin, Deng, Fei, Shen, Shu. Identification, Isolation, and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse. VIROLOGICA SINICAnull. 2021, 36(1): 155-158, https://www.webofscience.com/wos/woscc/full-record/WOS:000551050900001.
[3] Liu, Jia, Li, Yufeng, Liu, Qian, Yao, Qun, Wang, Xi, Zhang, Huanyu, Chen, Rong, Ren, Liang, Min, Juan, Deng, Fei, Yan, Bing, Liu, Liang, Hu, Zhihong, Wang, Manli, Zhou, Yiwu. SARS-CoV-2 cell tropism and multiorgan infection. CELL DISCOVERYnull. 2021, 7(1): https://doaj.org/article/3715a80a1d6044f5af696ca036fe44a5.
[4] Yuan, Chuanfei, Xing, Longsheng, Wang, Manli, Hu, Zhihong, Zou, Zhen. Microbiota modulates gut immunity and promotes baculovirus infection in Helicoverpa armigera. INSECT SCIENCE[J]. 2021, 28(6): 1766-1779, http://dx.doi.org/10.1111/1744-7917.12894.
[5] Chen, Tong, Duan, Xiaoyan, Hu, Hengrui, Shang, Yu, Hu, Yangbo, Deng, Fei, Wang, Hualin, Wang, Manli, Hu, Zhihong. Systematic Analysis of 42 Autographa Californica Multiple Nucleopolyhedrovirus Genes Identifies An Additional Six Genes Involved in the Production of Infectious Budded Virus. VIROLOGICA SINICA[J]. 2021, 36(4): 762-773, http://dx.doi.org/10.1007/s12250-021-00355-1.
[6] He, Lihong, Shao, Wei, Li, Jiang, Deng, Fei, Wang, Hualin, Hu, Zhihong, Wang, Manli. Systematic analysis of nuclear localization of Autographa californica multiple nucleopolyhedrovirus proteins. JOURNAL OF GENERAL VIROLOGY[J]. 2021, 102(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000635958900004.
[7] Abulimiti Moming, Shen Shi, Shu Shen, Jie Qiao, Xihong Yue, Bo Wang, Juntao Ding, Zhihong Hu, Fei Deng, Yujiang Zhang, Surong Sun. Fine mapping epitope on Glycoprotein-Gn from Severe Fever with Thrombocytopenia Syndrome Virus. PLOS ONE[J]. 2021, 16(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924767/.
[8] Liu, Jia, Li, Yufeng, Liu, Liang, Hu, Xudong, Wang, Xi, Hu, Hengrui, Hu, Zhihong, Zhou, Yiwu, Wang, Manli. Infection of human sweat glands by SARS-CoV-2. CELL DISCOVERYnull. 2020, 6(1): http://dx.doi.org/10.1038/s41421-020-00229-y.
[9] Cao, Ruiyuan, Hu, Hengrui, Li, Yufeng, Wang, Xi, Xu, Mingyue, Liu, Jia, Zhang, Huanyu, Yan, Yunzheng, Zhao, Lei, Li, Wei, Zhang, Tianhong, Xiao, Dian, Guo, Xiaojia, Li, Yuexiang, Yang, Jingjing, Hu, Zhihong, Wang, Manli, Zhong, Wu. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS INFECTIOUS DISEASES[J]. 2020, 6(9): 2524-2531, http://dx.doi.org/10.1021/acsinfecdis.0c00522.
[10] Li, Yimeng, Hu, Liangbo, Chen, Tong, Chang, Meng, Deng, Fei, Hu, Zhihong, Wang, Hualin, Wang, Manli. Host AAA plus ATPase TER94 Plays Critical Roles in Building the Baculovirus Viral Replication Factory and Virion Morphogenesis. JOURNAL OF VIROLOGY[J]. 2020, 94(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000518387200013.
[11] Wang, Jun, Yang, Minglu, Xiao, Haibing, Huang, GuoHua, Deng, Fei, Hu, Zhihong. Genome Analysis of Dasineura jujubifolia Toursvirus 2, A Novel Ascovirus. VIROLOGICA SINICA[J]. 2020, 35(2): 134-142, http://lib.cqvip.com/Qikan/Article/Detail?id=7101909877.
[12] Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong, Gengfu Xiao . Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research[J]. 2020, https://www.nature.com/articles/s41422-020-0282-0.
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[181] 卢玉蓉, 吴东, 孙修炼, 邓菲, 袁丽, JMVlak, 胡志红, 冯枞棣. 含外源类蜗牛毒素基因的AcMNPV的虫体感染性研究. 中国病毒学[J]. 2004, 19(3): 276-280, http://lib.cqvip.com/Qikan/Article/Detail?id=9859169.
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发表著作
(1) 普通病毒学, General Virology, 科学出版社, 2002-10, 第 2 作者
(2) 费氏病毒学, Fields Virology, 无, 2005-10, 第 2 作者
(3) 甲型H1N1流感防治手册, H1N1 influenza prevention and control manual, 湖北科学出版社, 2009-05, 第 1 作者

科研活动

   
科研项目
( 1 ) 我国重要自然宿主及媒介昆虫的病毒病原调查, 主持, 国家级, 2013-06--2018-05
( 2 ) 杆状病毒口服感染分子机制的研究, 主持, 国家级, 2012-01--2016-12
( 3 ) 病毒与宿主相互作用的分子机理, 主持, 国家级, 2014-01--2016-12
( 4 ) 杆状病毒与宿主昆虫的信息流识别及互作网络, 主持, 部委级, 2014-07--2019-06
( 5 ) 针对核苷(酸)类药物应答不佳患者的优化联合治疗方案, 主持, 国家级, 2012-01--2015-12
( 6 ) P33介导的杆状病毒二硫键形成通路中底物蛋白的研究, 主持, 国家级, 2016-01--2019-12
( 7 ) “万人计划”百千万工程领军人才支持项目, 主持, 研究所(学校), 2015-01--2017-12
( 8 ) 欧洲病毒资源库走向全球, 主持, 国家级, 2016-12--2019-11
( 9 ) 杆状病毒感染昆虫中肠的作用机理研究, 主持, 部委级, 2016-08--2020-12
( 10 ) 病毒与宿主相互作用的分子机理, 主持, 国家级, 2017-01--2019-12
( 11 ) 湖北省高致病性病毒病原自然科技资源库, 主持, 省级, 2017-08--2019-08
( 12 ) 天然和人造噬藻体控藻关键技术研究, 主持, 部委级, 2011-01--2013-12
( 13 ) 昆虫病毒感染关键步骤的分子机理研究, 主持, 国家级, 2009-01--2013-12
( 14 ) 杆状病毒和昆虫细胞间的相互作用, 主持, 国家级, 2008-01--2012-12
( 15 ) 最小杆状病毒的人工合成, 主持, 国家级, 2019-01--2022-12
参与会议
(1)The role of baculovirus P26 in suppressing the insect melanization response   国际无脊椎动物病理学和微生物防治研讨会暨第52届无脊椎动物病理学年会及国际生物防治组织第17次无脊椎害虫微生物和线虫防治工作组会   2019-07-28
(2)The baculovirus per os infectivity factor (PIF) complex and its conservation in other invertebrate large DNA viruses   2018年国际无脊椎病理和微生物防治会议暨51届无脊椎病理年会   2018-08-12
(3)The Scientific progress report of EVAg project from WIV   “欧洲病毒资源库:走向全球”(EVAg)第7次全体联盟成员单位年会 赴Julius Kühn-Institut(JKI)开展“杆状病毒人工合成”合作研究   2018-04-25
(4)Basic research -supporting the development of baculoviruses as biopesticides.   2017年国际无脊椎动物病理学年会暨组织成立50周年庆典。   2017-08-11
(5)The mid-term scientific report of EVAg project from WIV. The technical report of EVAg project from WIV.   “欧洲病毒资源库:走向全球”(EVAg)项目中期评审会议 “欧洲病毒资源库:走向全球”(EVAg)项目技术交流会议   2017-04-27
(6)Structural and functional analyses of the sulfhydryl oxidase P33 of Autographa californica multiple nucleopolyhedrovirus   2016年国际无脊椎病理和微生物防治会议暨49届无脊椎病理年会   2016-07-24
(7)Construction and rescue of a synthetic baculovirus, AcMNPV-WIV-Syn1.0, that retains the properties of the parental virus.   2015年国际无脊椎病理和微生物防治会议暨48届无脊椎病理年会   2015-08-09
(8)Construction and rescue of a synthetic baculovirus, AcMNPV-WIV-Syn1.0, that retains the properties of the parental virus   第三十四届美国病毒学年会   2015-07-10
(9)Post-translational cleavage of P74 of the Helicoverpa armigera single nucleopolyhedrovirus facilitates per os infection   2014国际无脊椎病理和微生物防治会议暨47届无脊椎病理年会   2014-08-03
(10)Virus infection and replication, virus-host interactions, and virus and innate immunity   第33届美国病毒学会年会   2014-06-20
(11)无   关于天花研究项目的第2次独立专家咨询小组会议   2013-11-05
(12)The conference includes hot research areas, such as invertebrate pathology, microbial pest control and so on.   第4届国际昆虫病原微生物和微生物控制论坛   2013-09-11
(13)An ODV-specific baculovirus core gene ha72 is essential for BV production and involved in ODV occlusion   第46届国际无脊椎动物病理学会年会   2013-08-11
(14)Functional studies on the per os infectivity factor 3 (PIF3) of HearNPV   2012国际无脊椎动物病理学和微生物生防   2012-08-05
(15)Comprehensive proteomics analyses on the two progeny phenotypes of a baculovirus   第三十一届美国病毒学年会   2012-07-21
(16)Proteomic studies on BV/ODV phenotypes and implications for baculoviral pathology   第44届无脊椎动物病理学年会   胡志红   2011-08-07
(17)HA44 IS AN ESSENTIAL GENE FOR HELICOVERPA ARMIGERA NUCLEOPOLYHEDROVIRUS REPLICATION AND ITS COILED-COIL DOMAIN IS FUNCTIONAL IMPORTANT.   第三十届美国病毒学年会   胡志红   2011-07-16

指导学生

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许君  博士研究生  071005-微生物学  

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董春升  博士研究生  071005-微生物学  

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