基本信息

钱文峰  男  博导  中国科学院遗传与发育生物学研究所
电子邮件: wfqian@genetics.ac.cn
通信地址: 北京市朝阳区北辰西路1号院2号,遗传发育所,3号楼212室
邮政编码: 100101

招生信息

   
招生专业
071007-遗传学
0710Z2-计算生物学
0710Z1-基因组学
招生方向
翻译调控
细胞谱系追踪
蛋白定向进化

教育背景

2006-09--2012-08   University of Michigan   博士
2002-09--2006-07   北京大学   本科

工作经历

2012年12月起,在遗传与发育生物学研究所任研究员;

2014年入选“青年****”;

2018年获“益海嘉里”优秀导师奖;

​2019年获“优秀青年科学基金”。

教授课程

群体遗传与分子进化
生物统计学与实验设计
分子遗传学
遗传发育学系列讲座
基因组学和生物信息学前沿系列讲座
Biostatistics

专利与奖励

   
奖励信息
(1) 国际分子进化学会Walter Fitch Award Finalist, , 其他, 2012
(2) 国家自费留学生奖学金, 特等奖, 其他, 2012

出版信息

   
发表论文
[1] Zhao, Taolan, Chen, YanMing, Li, Yu, Wang, Jia, Chen, Siyu, Gao, Ning, Qian, Wenfeng. Disome-seq reveals widespread ribosome collisions that promote cotranslational protein folding. GENOME BIOLOGY[J]. 2021, 22(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784341/.
[2] KeJia Shan, Changshuo Wei, Yu Wang, Qing Huan, Wenfeng Qian. Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural process. 创新(英文). 2021, 2(4): 43-55, http://lib.cqvip.com/Qikan/Article/Detail?id=7105596287.
[3] Wang, Yu, Huan, Qing, Li, Ke, Qian, Wenfeng. Single-cell transcriptome atlas of the leaf and root of rice seedlings. JOURNAL OF GENETICS AND GENOMICS[J]. 2021, 48(10): 881-898, http://dx.doi.org/10.1016/j.jgg.2021.06.001.
[4] Zhang, Qian, Wang, Zihao, Zhang, Wenfeng, Wen, Qingbo, Li, Xinyu, Zhou, Jun, Wu, Xueying, Guo, Yongqing, Liu, Yangli, Wei, Changshuo, Qian, Wenfeng, Tian, Ye. The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels. NATURE CELL BIOLOGY[J]. 2021, 23(8): 870-+, http://dx.doi.org/10.1038/s41556-021-00724-8.
[5] Wei, Changshuo, Chen, YanMing, Chen, Ying, Qian, Wenfeng. The Missing Expression Level-Evolutionary Rate Anticorrelation in Viruses Does Not Support Protein Function as a Main Constraint on Sequence Evolution. GENOME BIOLOGY AND EVOLUTION[J]. 2021, 13(4): http://dx.doi.org/10.1093/gbe/evab049.
[6] Wenfeng Qian, Jianzhi Zhang. Codon usage bias and nuclear mRNA concentration: Correlation vs. causation. Proceedings of the National Academy of Sciences of the United States of America. 2021, 118(20): [7] 肇涛澜, 张硕, 钱文峰. 翻译延伸的顺式调控机理与生物学效应. 遗传[J]. 2020, 42(7): 613-631, http://lib.cqvip.com/Qikan/Article/Detail?id=7102265735.
[8] Zhou, Junxiang, Wang, Xin, Wang, Min, Chang, Yuwei, Zhang, Fengxia, Ban, Zhaonan, Tang, Ruofeng, Gan, Qiwen, Wu, Shaohuan, Guo, Ye, Zhang, Qian, Wang, Fengyang, Zhao, Liyuan, Jing, Yudong, Qian, Wenfeng, Wang, Guodong, Guo, Weixiang, Yang, Chonglin. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. JOURNAL OF CELL BIOLOGY[J]. 2019, 218(2): 580-597, [9] Chen, Ying, Chen, Siyu, Li, Ke, Zhang, Yuliang, Huang, Xiahe, Li, Ting, Wu, Shaohuan, Wang, Yingchun, Carey, Lucas B, Qian, Wenfeng. Overdosage of Balanced Protein Complexes Reduces Proliferation Rate in Aneuploid Cells. CELL SYSTEMS[J]. 2019, 9(2): 129-+, http://dx.doi.org/10.1016/j.cels.2019.06.007.
[10] Chen, Ying, Li, Ke, Chu, Xiao, Carey, Lucas B, Qian, Wenfeng. Synchronized replication of genes encoding the same protein complex in fast-proliferating cells. GENOME RESEARCH[J]. 2019, 29(12): 1929-1938, https://www.webofscience.com/wos/woscc/full-record/WOS:000500554200001.
[11] Zhao, Taolan, Huan, Qing, Sun, Jing, Liu, Chunyan, Hou, Xiuli, Yu, Xiang, Silverman, Ian M, Zhang, Yi, Gregory, Brian D, Liu, ChunMing, Qian, Wenfeng, Cao, Xiaofeng. Impact of poly(A)-tail G-content on Arabidopsis PAB binding and their role in enhancing translational efficiency. GENOME BIOLOGY[J]. 2019, 20(1): http://dx.doi.org/10.1186/s13059-019-1799-8.
[12] Huan, Qing, Zhang, Yuliang, Wu, Shaohuan, Qian, Wenfeng. HeteroMeth: A Database of Cell-to-cell Heterogeneity in DNA Methylation. GENOMICS PROTEOMICS & BIOINFORMATICS. 2018, 16(4): 234-243, http://lib.cqvip.com/Qikan/Article/Detail?id=676657189.
[13] Duan, Chaorui, Huan, Qing, Chen, Xiaoshu, Wu, Shaohuan, Carey, Lucas B, He, Xionglei, Qian, Wenfeng. Reduced intrinsic DNA curvature leads to increased mutation rate. GENOME BIOLOGY[J]. 2018, 19(1): https://doaj.org/article/91e4d101fe1c4c1eb23526b6d8a39264.
[14] Chen, Siyu, Li, Ke, Cao, Wenqing, Wang, Jia, Zhao, Tong, Huan, Qing, Yang, YuFei, Wu, Shaohuan, Qian, Wenfeng. Codon-Resolution Analysis Reveals a Direct and Context-Dependent Impact of Individual Synonymous Mutations on mRNA Level. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 34(11): 2944-2958, https://www.webofscience.com/wos/woscc/full-record/WOS:000416178700016.
[15] Yang, YuFei, Cao, Wenqing, Wu, Shaohuan, Qian, Wenfeng. Genetic Interaction Network as an Important Determinant of Gene Order in Genome Evolution. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 34(12): 3254-3266, https://www.webofscience.com/wos/woscc/full-record/WOS:000416178900019.
[16] Wu, Shaohuan, Li, Ke, Li, Yingshu, Zhao, Tong, Li, Ting, Yang, YuFei, Qian, Wenfeng. Independent regulation of gene expression level and noise by histone modifications. PLOS COMPUTATIONAL BIOLOGY[J]. 2017, 13(6): https://doaj.org/article/911b9bf9e6d3439ca06ed0300974220a.
[17] Han, Yingying, Chu, Xiao, Yu, Haopeng, Ma, YingKe, Wang, XiuJie, Qian, Wenfeng, Jiao, Yuling. Single-cell transcriptome analysis reveals widespread monoallelic gene expression in individual rice mesophyll cells. SCIENCE BULLETIN[J]. 2017, 62(19): 1304-1314, http://lib.cqvip.com/Qikan/Article/Detail?id=673594777.
[18] Yang, YuFei, Zhang, Xiaoqing, Ma, Xuehua, Zhao, Taolan, Sun, Qiushi, Huan, Qing, Wu, Shaohuan, Du, Zhuo, Qian, Wenfeng. Trans-splicing enhances translational efficiency in C. elegans. GENOME RESEARCH[J]. 2017, 27(9): 1525-1535, https://www.webofscience.com/wos/woscc/full-record/WOS:000408790600006.
[19] Zhang, Biyao, Wu, Shaohuan, Zhang, Yue, Xu, Ting, Guo, Feifei, Tang, Huashan, Li, Xiang, Wang, Pengfei, Qian, Wenfeng, Xue, Yongbiao. A High Temperature-Dependent Mitochondrial Lipase EXTRA GLUME1 Promotes Floral Phenotypic Robustness against Temperature Fluctuation in Rice (Oryza sativa L.). PLOS GENETICS[J]. 2016, 12(7): http://www.corc.org.cn/handle/1471x/2375406.
[20] Li, Chuan, Qian, Wenfeng, Maclean, Calum J, Zhang, Jianzhi. The fitness landscape of a tRNA gene. SCIENCE[J]. 2016, 352(6287): 837-840, https://www.webofscience.com/wos/woscc/full-record/WOS:000375663000044.
[21] Qian, Wenfeng, Zhang, Jianzhi. Genomic evidence for adaptation by gene duplication. GENOME RESEARCH[J]. 2014, 24(8): 1356-1362, https://www.webofscience.com/wos/woscc/full-record/WOS:000339860200010.
[22] Park, Chungoo, Qian, Wenfeng, Zhang, Jianzhi. Genomic evidence for elevated mutation rates in highly expressed genes. EMBO REPORTS[J]. 2012, 13(12): 1123-1129, https://www.webofscience.com/wos/woscc/full-record/WOS:000311971700022.
[23] Qian, Wenfeng, He, Xionglei, Chan, Edwin, Xu, Huailiang, Zhang, Jianzhi. Measuring the evolutionary rate of protein-protein interaction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 108(21): 8725-8730, https://www.webofscience.com/wos/woscc/full-record/WOS:000290908000044.
[24] Qian, Wenfeng, Liao, BenYang, Chang, Andrew YingFei, Zhang, Jianzhi. Maintenance of duplicate genes and their functional redundancy by reduced expression. TRENDS IN GENETICS[J]. 2010, 26(10): 425-430, http://dx.doi.org/10.1016/j.tig.2010.07.002.
[25] He, Xionglei, Qian, Wenfeng, Wang, Zhi, Li, Ying, Zhang, Jianzhi. Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. NATURE GENETICS[J]. 2010, 42(3): 272-U120, http://159.226.149.42:8080/handle/152453/4909.
[26] Qian, Wenfeng, Zhang, Jianzhi. Protein Subcellular Relocalization in the Evolution of Yeast Singleton and Duplicate Genes. GENOME BIOLOGY AND EVOLUTION[J]. 2009, 1: 198-204, https://www.webofscience.com/wos/woscc/full-record/WOS:000275269200020.
[27] Zhang, Zhihua, Qian, Wenfeng, Zhang, Jianzhi. Positive selection for elevated gene expression noise in yeast. MOLECULAR SYSTEMS BIOLOGY[J]. 2009, 5: 299-299, https://www.webofscience.com/wos/woscc/full-record/WOS:000275390100007.
[28] Qian, Wenfeng, Zhang, Jianzhi. Evolutionary dynamics of nematode operons: Easy come, slow go. GENOME RESEARCH[J]. 2008, 18(3): 412-421, http://dx.doi.org/10.1101/gr.7112608.
[29] Qian, Wenfeng, Zhang, Jianzhi. Gene dosage and gene duplicability. GENETICS[J]. 2008, 179(4): 2319-2324, https://www.webofscience.com/wos/woscc/full-record/WOS:000258591200048.

科研活动

   
科研项目
( 1 ) 所创新领域前沿课题, 主持, 市地级, 2013-01--2016-01
( 2 ) 青年****, 主持, 国家级, 2012-12--2017-12
( 3 ) 水稻优质高效的多模块耦合模拟计算, 主持, 部委级, 2013-08--2018-12
( 4 ) 基于实验进化的同源重组速率进化规律的研究, 主持, 国家级, 2014-01--2016-12
( 5 ) 胚胎干细胞和细胞转分化与重编程过程中表观遗传修饰的谱系鉴定与关系分析, 参与, 国家级, 2014-01--2018-12
( 6 ) 基于Ribo-Seq的生物进化中翻译缓冲机制的研究, 主持, 国家级, 2016-01--2019-12
( 7 ) 肿瘤发生、发展和治疗过程中细胞进化模式及机制研究, 参与, 国家级, 2018-01--2019-12

指导学生

已指导学生

张晓庆  博士研究生  0710J3-生物信息学  

吴少欢  博士研究生  071021-生物信息学  

段朝瑞  博士研究生  0710J3-生物信息学  

陈思羽  博士研究生  071007-遗传学  

楚霄  博士研究生  071007-遗传学  

现指导学生

曹文清  博士研究生  0710J3-生物信息学  

张宇亮  博士研究生  0710J3-生物信息学  

陈瑛  博士研究生  0710J3-生物信息学  

王嘉  博士研究生  0710J3-生物信息学  

单科家  博士研究生  0710J3-生物信息学  

孔金辉  硕士研究生  085238-生物工程  

王瑜  博士研究生  0710J3-生物信息学  

陈燕鸣  博士研究生  0710J3-生物信息学  

魏昌硕  硕士研究生  0710J3-生物信息学