基本信息
钱文峰 男 博导 中国科学院遗传与发育生物学研究所
电子邮件： wfqian@genetics.ac.cn
通信地址： 北京市朝阳区北辰西路1号院2号,遗传发育所，3号楼212室
邮政编码： 100101
招生信息
招生专业
071007-遗传学0710Z2-计算生物学0710Z1-基因组学
招生方向
翻译调控细胞谱系追踪蛋白定向进化
教育背景
2006-09--2012-08 University of Michigan 博士2002-09--2006-07 北京大学 本科
工作经历
2012年12月起，在遗传与发育生物学研究所任研究员；
2014年入选“青年****”；
2018年获“益海嘉里”优秀导师奖；
2019年获“优秀青年科学基金”。
教授课程
群体遗传与分子进化生物统计学与实验设计分子遗传学遗传发育学系列讲座基因组学和生物信息学前沿系列讲座Biostatistics
专利与奖励
奖励信息
（1） 国际分子进化学会Walter Fitch Award Finalist, , 其他, 2012（2） 国家自费留学生奖学金, 特等奖, 其他, 2012
出版信息
发表论文
[1] Liu, Yang, Jiao, Bingke, Champer, Jackson, Qian, Wenfeng. Overriding Mendelian inheritance in Arabidopsis with a CRISPR toxin-antidote gene drive that impairs pollen germination. NATURE PLANTS[J]. 2024, 第 4 作者 通讯作者 10(6): http://dx.doi.org/10.1038/s41477-024-01692-1.[2] Chen, LianGe, Lan, Tianlong, Zhang, Shuo, Zhao, Mengkai, Luo, Guangyu, Gao, Yi, Zhang, Yuliang, Du, Qingwei, Lu, Houze, Li, Bimeng, Jiao, Bingke, Hu, Zhangli, Ma, Yingxin, Zhao, Qiao, Wang, Ying, Qian, Wenfeng, Dai, Junbiao, Jiao, Yuling. A designer synthetic chromosome fragment functions in moss. NATURE PLANTS[J]. 2024, 第 16 作者 通讯作者 10(2): http://dx.doi.org/10.1038/s41477-023-01595-7.[3] Yu, Wenfei, Zhang, Shuo, Zhao, Shijun, Chen, Liange, Cao, Jie, Ye, Hao, Yan, Jianbin, Zhao, Qiao, Mo, Beixin, Wang, Ying, Jiao, Yuling, Ma, Yixing, Huang, Xiaoluo, Qian, Wenfeng, Dai, Junbiao. Designing a synthetic moss genome using GenoDesigner. NATURE PLANTS. 2024, 第 14 作者 通讯作者 10(6): http://dx.doi.org/10.1038/s41477-024-01693-0.[4] Wang, Jia, Zhang, Geyu, Qian, Wenfeng, Li, Ke. Decoding the Heterogeneity and Specialized Function of Translation Machinery Through Ribosome Profiling in Yeast Mutants of Initiation Factors. ADVANCED BIOLOGY[J]. 2024, 第 3 作者 通讯作者 8(2): http://dx.doi.org/10.1002/adbi.202300494.[5] Kong, Jinhui, Zhang, Shuo, Qian, Wenfeng, Li, Ke. Synonymous somatic mutations that alter proximal out-of-frame downstream ATGs are associated with aberrant gene expression levels in cancer cells. JOURNAL OF GENETICS AND GENOMICS[J]. 2023, 第 3 作者50(6): 447-449, http://dx.doi.org/10.1016/j.jgg.2023.02.013.[6] Sun, Baocheng, Wang, Yu, Yang, Qun, Gao, Han, Niu, Haiyu, Li, Yansong, Ma, Qun, Huan, Qing, Qian, Wenfeng, Ren, Bo. A high-resolution transcriptomic atlas depicting nitrogen fixation and nodule development in soybean. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2023, 第 9 作者 通讯作者 65(6): 1536-1552, http://dx.doi.org/10.1111/jipb.13495.[7] Li, Ke, Kong, Jinhui, Zhang, Shuo, Zhao, Tong, Qian, Wenfeng. Distance-dependent inhibition of translation initiation by downstream out-of-frame AUGs is consistent with a Brownian ratchet process of ribosome scanning. Genome Biology[J]. 2022, 第 5 作者 通讯作者 23: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02829-1.[8] Zhao, Taolan, Chen, YanMing, Li, Yu, Wang, Jia, Chen, Siyu, Gao, Ning, Qian, Wenfeng. Disome-seq reveals widespread ribosome collisions that promote cotranslational protein folding. GENOME BIOLOGY[J]. 2021, 第 7 作者 通讯作者 22(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784341/.[9] KeJia Shan, Changshuo Wei, Yu Wang, Qing Huan, Wenfeng Qian. Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural process. 创新(英文)[J]. 2021, 第 5 作者2(4): 100159, https://doaj.org/article/a0297591f49e4f3aa2ba6d3b93d4901b.[10] Wang, Yu, Huan, Qing, Li, Ke, Qian, Wenfeng. Single-cell transcriptome atlas of the leaf and root of rice seedlings. JOURNAL OF GENETICS AND GENOMICS[J]. 2021, 第 4 作者 通讯作者 48(10): 881-898, http://dx.doi.org/10.1016/j.jgg.2021.06.001.[11] Zhang, Qian, Wang, Zihao, Zhang, Wenfeng, Wen, Qingbo, Li, Xinyu, Zhou, Jun, Wu, Xueying, Guo, Yongqing, Liu, Yangli, Wei, Changshuo, Qian, Wenfeng, Tian, Ye. The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels. NATURE CELL BIOLOGY[J]. 2021, 第 11 作者23(8): 870-+, http://dx.doi.org/10.1038/s41556-021-00724-8.[12] Wei, Changshuo, Chen, YanMing, Chen, Ying, Qian, Wenfeng. The Missing Expression Level-Evolutionary Rate Anticorrelation in Viruses Does Not Support Protein Function as a Main Constraint on Sequence Evolution. GENOME BIOLOGY AND EVOLUTION[J]. 2021, 第 4 作者 通讯作者 13(4): http://dx.doi.org/10.1093/gbe/evab049.[13] Wenfeng Qian, Jianzhi Zhang. Codon usage bias and nuclear mRNA concentration: Correlation vs. causation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021, 第 1 作者118(20): [14] Wang, Qing, Su, Qingmei, Nian, Jinqiang, Zhang, Jian, Guo, Meng, Dong, Guojun, Hu, Jiang, Wang, Rongsheng, Wei, Changshuo, Li, Guanwen, Wang, Wan, Guo, HuiShan, Lin, Shaoyang, Qian, Wenfeng, Xie, Xianzhi, Qian, Qian, Chen, Fan, Zuo, Jianru. The Ghd7 transcription factor represses ARE1 expression to enhance nitrogen utilization and grain yield in rice. MOLECULAR PLANT[J]. 2021, 第 14 作者14(6): 1012-1023, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7064966&detailType=1.[15] Luo, Wei, Huan, Qing, Xu, Yunyuan, Qian, Wenfeng, Chong, Kang, Zhang, Jingyu. Integrated global analysis reveals a vitamin E-vitamin K1 sub-network, downstream of COLD1, underlying rice chilling tolerance divergence. CELL REPORTS[J]. 2021, 第 4 作者36(3): http://dx.doi.org/10.1016/j.celrep.2021.109397.[16] Wei, Changshuo, Shan, KeJia, Wang, Weiguang, Zhang, Shuya, Huan, Qing, Qian, Wenfeng. Evidence for a mouse origin of the SARS-CoV-2 Omicron variant. JOURNAL OF GENETICS AND GENOMICS[J]. 2021, 第 6 作者 通讯作者 48(12): 1111-1121, http://dx.doi.org/10.1016/j.jgg.2021.12.003.[17] 肇涛澜, 张硕, 钱文峰. 翻译延伸的顺式调控机理与生物学效应. 遗传[J]. 2020, 第 3 作者42(7): 613-631, http://www.chinagene.cn/CN/10.16288/j.yczz.20-074.[18] Zhao, Taolan, Huan, Qing, Sun, Jing, Liu, Chunyan, Hou, Xiuli, Yu, Xiang, Silverman, Ian M, Zhang, Yi, Gregory, Brian D, Liu, ChunMing, Qian, Wenfeng, Cao, Xiaofeng. Impact of poly(A)-tail G-content on Arabidopsis PAB binding and their role in enhancing translational efficiency. GENOME BIOLOGY[J]. 2019, 第 11 作者 通讯作者 20(1): http://dx.doi.org/10.1186/s13059-019-1799-8.[19] Zhou, Junxiang, Wang, Xin, Wang, Min, Chang, Yuwei, Zhang, Fengxia, Ban, Zhaonan, Tang, Ruofeng, Gan, Qiwen, Wu, Shaohuan, Guo, Ye, Zhang, Qian, Wang, Fengyang, Zhao, Liyuan, Jing, Yudong, Qian, Wenfeng, Wang, Guodong, Guo, Weixiang, Yang, Chonglin. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. JOURNAL OF CELL BIOLOGY[J]. 2019, 第 15 作者218(2): 580-597, [20] Chen, Ying, Chen, Siyu, Li, Ke, Zhang, Yuliang, Huang, Xiahe, Li, Ting, Wu, Shaohuan, Wang, Yingchun, Carey, Lucas B, Qian, Wenfeng. Overdosage of Balanced Protein Complexes Reduces Proliferation Rate in Aneuploid Cells. CELL SYSTEMS[J]. 2019, 第 10 作者 通讯作者 9(2): 129-+, http://dx.doi.org/10.1016/j.cels.2019.06.007.[21] Chen, Ying, Li, Ke, Chu, Xiao, Carey, Lucas B, Qian, Wenfeng. Synchronized replication of genes encoding the same protein complex in fast-proliferating cells. GENOME RESEARCH[J]. 2019, 第 5 作者 通讯作者 29(12): 1929-1938, https://www.webofscience.com/wos/woscc/full-record/WOS:000500554200001.[22] Huan, Qing, Zhang, Yuliang, Wu, Shaohuan, Qian, Wenfeng. HeteroMeth: A Database of Cell-to-cell Heterogeneity in DNA Methylation. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2018, 第 4 作者 通讯作者 16(4): 234-243, http://lib.cqvip.com/Qikan/Article/Detail?id=676657189.[23] Duan, Chaorui, Huan, Qing, Chen, Xiaoshu, Wu, Shaohuan, Carey, Lucas B, He, Xionglei, Qian, Wenfeng. Reduced intrinsic DNA curvature leads to increased mutation rate. GENOME BIOLOGY[J]. 2018, 第 7 作者 通讯作者 19(1): https://doaj.org/article/91e4d101fe1c4c1eb23526b6d8a39264.[24] Chen, Siyu, Li, Ke, Cao, Wenqing, Wang, Jia, Zhao, Tong, Huan, Qing, Yang, YuFei, Wu, Shaohuan, Qian, Wenfeng. Codon-Resolution Analysis Reveals a Direct and Context-Dependent Impact of Individual Synonymous Mutations on mRNA Level. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 第 9 作者 通讯作者 34(11): 2944-2958, https://www.webofscience.com/wos/woscc/full-record/WOS:000416178700016.[25] Yang, YuFei, Cao, Wenqing, Wu, Shaohuan, Qian, Wenfeng. Genetic Interaction Network as an Important Determinant of Gene Order in Genome Evolution. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 第 4 作者 通讯作者 34(12): 3254-3266, https://www.webofscience.com/wos/woscc/full-record/WOS:000416178900019.[26] Wu, Shaohuan, Li, Ke, Li, Yingshu, Zhao, Tong, Li, Ting, Yang, YuFei, Qian, Wenfeng. Independent regulation of gene expression level and noise by histone modifications. PLOS COMPUTATIONAL BIOLOGY[J]. 2017, 第 7 作者 通讯作者 13(6): https://doaj.org/article/911b9bf9e6d3439ca06ed0300974220a.[27] Han, YingYing, Chu, Xiao, Yu, HaoPeng, Ma, YingKe, Wang, XiuJie, Qian, WenFeng, Jiao, YuLing. Single-cell transcriptome analysis reveals widespread monoallelic gene expression in individual rice mesophyll cells. SCIENCE BULLETIN[J]. 2017, 第 6 作者 通讯作者 62(19): 1304-1314, http://lib.cqvip.com/Qikan/Article/Detail?id=673594777.[28] Yang, YuFei, Zhang, Xiaoqing, Ma, Xuehua, Zhao, Taolan, Sun, Qiushi, Huan, Qing, Wu, Shaohuan, Du, Zhuo, Qian, Wenfeng. Trans-splicing enhances translational efficiency in C. elegans. GENOME RESEARCH[J]. 2017, 第 9 作者 通讯作者 27(9): 1525-1535, https://www.webofscience.com/wos/woscc/full-record/WOS:000408790600006.[29] Zhang, Biyao, Wu, Shaohuan, Zhang, Yue, Xu, Ting, Guo, Feifei, Tang, Huashan, Li, Xiang, Wang, Pengfei, Qian, Wenfeng, Xue, Yongbiao. A High Temperature-Dependent Mitochondrial Lipase EXTRA GLUME1 Promotes Floral Phenotypic Robustness against Temperature Fluctuation in Rice (Oryza sativa L.). PLOS GENETICS[J]. 2016, 第 9 作者12(7): http://www.corc.org.cn/handle/1471x/2375406.[30] Li, Chuan, Qian, Wenfeng, Maclean, Calum J, Zhang, Jianzhi. The fitness landscape of a tRNA gene. SCIENCE[J]. 2016, 第 2 作者352(6287): 837-840, https://www.webofscience.com/wos/woscc/full-record/WOS:000375663000044.[31] Qian, Wenfeng, Zhang, Jianzhi. Genomic evidence for adaptation by gene duplication. GENOME RESEARCH[J]. 2014, 第 1 作者24(8): 1356-1362, http://dx.doi.org/10.1101/gr.172098.114.[32] Park, Chungoo, Qian, Wenfeng, Zhang, Jianzhi. Genomic evidence for elevated mutation rates in highly expressed genes. EMBO REPORTS[J]. 2012, 第 2 作者13(12): 1123-1129, https://www.webofscience.com/wos/woscc/full-record/WOS:000311971700022.[33] Qian, Wenfeng, He, Xionglei, Chan, Edwin, Xu, Huailiang, Zhang, Jianzhi. Measuring the evolutionary rate of protein-protein interaction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 第 1 作者108(21): 8725-8730, https://www.webofscience.com/wos/woscc/full-record/WOS:000290908000044.[34] Qian, Wenfeng, Liao, BenYang, Chang, Andrew YingFei, Zhang, Jianzhi. Maintenance of duplicate genes and their functional redundancy by reduced expression. TRENDS IN GENETICS[J]. 2010, 第 1 作者26(10): 425-430, http://dx.doi.org/10.1016/j.tig.2010.07.002.[35] He, Xionglei, Qian, Wenfeng, Wang, Zhi, Li, Ying, Zhang, Jianzhi. Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. NATURE GENETICS[J]. 2010, 第 2 作者42(3): 272-U120, http://159.226.149.42:8080/handle/152453/4909.[36] Qian, Wenfeng, Zhang, Jianzhi. Protein Subcellular Relocalization in the Evolution of Yeast Singleton and Duplicate Genes. GENOME BIOLOGY AND EVOLUTION[J]. 2009, 第 1 作者 通讯作者 1: 198-204, https://www.webofscience.com/wos/woscc/full-record/WOS:000275269200020.[37] Zhang, Zhihua, Qian, Wenfeng, Zhang, Jianzhi. Positive selection for elevated gene expression noise in yeast. MOLECULAR SYSTEMS BIOLOGY[J]. 2009, 第 2 作者5(1): 299-299, https://www.webofscience.com/wos/woscc/full-record/WOS:000275390100007.[38] Qian, Wenfeng, Zhang, Jianzhi. Evolutionary dynamics of nematode operons: Easy come, slow go. GENOME RESEARCH[J]. 2008, 第 1 作者18(3): 412-421, http://dx.doi.org/10.1101/gr.7112608.[39] Qian, Wenfeng, Zhang, Jianzhi. Gene dosage and gene duplicability. GENETICS[J]. 2008, 第 1 作者179(4): 2319-2324, https://www.webofscience.com/wos/woscc/full-record/WOS:000258591200048.
科研活动
科研项目
（ 1 ） 所创新领域前沿课题, 主持, 市地级, 2013-01--2016-01（ 2 ） 青年****, 主持, 国家级, 2012-12--2017-12（ 3 ） 水稻优质高效的多模块耦合模拟计算, 主持, 部委级, 2013-08--2018-12（ 4 ） 基于实验进化的同源重组速率进化规律的研究, 主持, 国家级, 2014-01--2016-12（ 5 ） 胚胎干细胞和细胞转分化与重编程过程中表观遗传修饰的谱系鉴定与关系分析, 参与, 国家级, 2014-01--2018-12（ 6 ） 基于Ribo-Seq的生物进化中翻译缓冲机制的研究, 主持, 国家级, 2016-01--2019-12（ 7 ） 肿瘤发生、发展和治疗过程中细胞进化模式及机制研究, 参与, 国家级, 2018-01--2019-12
指导学生
已指导学生
张晓庆 博士研究生 0710J3-生物信息学
吴少欢 博士研究生 071021-生物信息学
段朝瑞 博士研究生 0710J3-生物信息学
陈思羽 博士研究生 071007-遗传学
楚霄 博士研究生 071007-遗传学
现指导学生
曹文清 博士研究生 0710J3-生物信息学
张宇亮 博士研究生 0710J3-生物信息学
陈瑛 博士研究生 0710J3-生物信息学
王嘉 博士研究生 0710J3-生物信息学
单科家 博士研究生 0710J3-生物信息学
孔金辉 硕士研究生 085238-生物工程
王瑜 博士研究生 0710J3-生物信息学
陈燕鸣 博士研究生 0710J3-生物信息学
魏昌硕 硕士研究生 0710J3-生物信息学