071006-神经生物学

神经系统发育

2005-09--2008-06 中科院动物研究所 博士
2002-09--2005-06 东北师范大学 硕士
1998-09--2002-06 长春师范大学 学士

   

2011-07--2014-04 美国威斯康星州大学麦迪逊分校 博士后
2008-10--2011-06 美国墨西哥州大学 博士后

   

[1] Liu, Qiang, Luo, Xing, Liang, Ziqi, Qin, Dezhe, Xu, Mingyue, Wang, Min, Guo, Weixiang. Coordination between circadian neural circuit and intracellular molecular clock ensures rhythmic activation of adult neural stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2024, 第 7 作者  通讯作者  121(8): http://dx.doi.org/10.1073/pnas.2318030121.
[2] Yan, Jianfei, Wu, Junjie, Xu, Mingyue, Wang, Min, Guo, Weixiang. Disrupted de novo pyrimidine biosynthesis impairs adult hippocampal neurogenesis and cognition in pyridoxine-dependent epilepsy. SCIENCE ADVANCES[J]. 2024, 第 5 作者  通讯作者  10(14): http://dx.doi.org/10.1126/sciadv.adl2764.
[3] Xing Luo, Mingyue Xu, Weixiang Guo. Adult neurogenesis research in China. Dev Growth Differ[J]. 2023, 第 3 作者  通讯作者  
[4] Guo, Ye, Luo, Xing, Guo, Weixiang. The impact of amino acid metabolism on adult neurogenesis. BIOCHEMICAL SOCIETY TRANSACTIONS. 2023, 第 3 作者  通讯作者  51(1): 233-244, http://dx.doi.org/10.1042/BST20220762.
[5] Xing Luo, Mingyue Xu, Weixiang Guo. Adult neurogenesis research in China. Dev Growth Differ[J]. 2023, 第 3 作者  通讯作者  
[6] Guo, Ye, Luo, Xing, Guo, Weixiang. The impact of amino acid metabolism on adult neurogenesis. BIOCHEMICAL SOCIETY TRANSACTIONS. 2023, 第 3 作者  通讯作者  51(1): 233-244, http://dx.doi.org/10.1042/BST20220762.
[7] Xing Luo, Min Dai, Min Wang, Xiujie Wang, Weixiang Guo. Functional heterogeneity of Wnt-responsive and Hedgehog-responsive neural stem cells in the murine adult hippocampus. DEVELOPMENTAL CELL[J]. 2023, 第 5 作者
[8] Xu, Mingyue, Guo, Ye, Wang, Min, Luo, Xing, Shen, Xuning, Li, Zhimin, Wang, Lei, Guo, Weixiang. L-arginine homeostasis governs adult neural stem cell activation by modulating energy metabolism in vivo. EMBO JOURNAL. 2023, 第 8 作者  通讯作者  42(6): http://dx.doi.org/10.15252/embj.2022112647.
[9] Guo, Ye, Wu, Junjie, Wang, Min, Wang, Xin, Jian, Youli, Yang, Chonglin, Guo, Weixiang. The Metabolite Saccharopine Impairs Neuronal Development by Inhibiting the Neurotrophic Function of Glucose-6-Phosphate Isomerase. JOURNAL OF NEUROSCIENCE[J]. 2022, 第 7 作者  通讯作者  42(13): 2631-2646, http://dx.doi.org/10.1523/JNEUROSCI.1459-21.2022.
[10] Han, Xiu, Shen, Xuning, Wang, Min, Wang, Xin, Jian, Youli, Yang, Chonglin, Guo, Weixiang. Loss of RNA-Binding Protein HuR Leads to Defective Ependymal Cells and Hydrocephalus. JOURNAL OF NEUROSCIENCE[J]. 2022, 第 7 作者  通讯作者  42(2): 202-219, http://dx.doi.org/10.1523/JNEUROSCI.1317-21.2021.
[11] Changyong Tang, Weixiang Guo. Implantation of a mini-osmotic pump plus stereotactical injection of retrovirus to study newborn neuron development in adult mouse hippocampus. STAR PROTOCOLS[J]. 2021, 第 2 作者2(1): 100374, http://dx.doi.org/10.1016/j.xpro.2021.100374.
[12] Bingfang Zhang, Lei Wang, Aisheng Zhan, Min Wang, Lanxiang Tian, Weixiang Guo, Yongxin Pan. Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition. NATURE COMMUNICATIONS[J]. 2021, 第 6 作者  通讯作者  12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896063/.
[13] Zhao, YiFei, He, XiaoXiao, Song, ZiFei, Guo, Ye, Zhang, YanNing, Yu, HuaLi, He, ZiXuan, Xiong, WenCheng, Guo, Weixiang, Zhu, XiaoJuan. Human antigen R-regulated mRNA metabolism promotes the cell motility of migrating mouse neurons. DEVELOPMENT[J]. 2020, 第 9 作者  通讯作者  147(6): http://dx.doi.org/10.1242/dev.183509.
[14] Zhou, Zhengrong, Xu, Honglin, Li, Yuejia, Yang, Mengge, Zhang, Rui, Shiraishi, Aki, Kiyonari, Hiroshi, Liang, Xin, Huang, Xiahe, Wang, Yingchun, Xie, Qi, Liu, Shuai, Chen, Rongqing, Bao, Lan, Guo, Weixiang, Wang, Yu, Meng, Wenxiang. CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 第 15 作者117(36): 22193-22203, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486724/.
[15] 郭伟翔. Neural Stem Cell Niche and Adult Neurogenesis.. Neuroscientist. 2020, 第 1 作者  通讯作者  
[16] Tang, Changyong, Wang, Min, Wang, Peijian, Wang, Lei, Wu, Qingfeng, Guo, Weixiang. Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. NEURON[J]. 2019, 第 6 作者  通讯作者  101(1): 32-+, http://dx.doi.org/10.1016/j.neuron.2018.10.051.
[17] 郭伟翔. Lactate Homeostasis Regulated by Brain Endothelial Cells is Critical for Adult Hippocampal Neurogenesis. Cell Stem Cell. 2019, 第 1 作者  通讯作者  
[18] Zhou, Junxiang, Wang, Xin, Wang, Min, Chang, Yuwei, Zhang, Fengxia, Ban, Zhaonan, Tang, Ruofeng, Gan, Qiwen, Wu, Shaohuan, Guo, Ye, Zhang, Qian, Wang, Fengyang, Zhao, Liyuan, Jing, Yudong, Qian, Wenfeng, Wang, Guodong, Guo, Weixiang, Yang, Chonglin. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. JOURNAL OF CELL BIOLOGY[J]. 2019, 第 17 作者  通讯作者  218(2): 580-597, 
[19] Wang, Yuhan, Guo, Ye, Tang, Changyong, Han, Xiu, Xu, Mingyue, Sun, Jing, Zhao, Yifei, Zhang, Yiwen, Wang, Min, Cao, Xiaofeng, Zhu, Xiaojuan, Guo, Weixiang. Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis. CELL REPORTS[J]. 2019, 第 12 作者  通讯作者  29(10): 3101-+, http://dx.doi.org/10.1016/j.celrep.2019.10.127.
[20] Guo, Ye, Chen, Xu, Xing, Ruxiao, Wang, Min, Zhu, Xiaojuan, Guo, Weixiang. Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN-Ccd1 pathway. HUMAN MOLECULAR GENETICS[J]. 2018, 第 6 作者  通讯作者  27(3): 475-485, https://www.webofscience.com/wos/woscc/full-record/WOS:000424136000007.
[21] Zhang, Xingli, Wang, Yan, Yuan, Jia, Li, Ni, Pei, Siyu, Xu, Jing, Luo, Xuan, Mao, Chaoming, Liu, Junli, Yu, Tao, Gan, Shucheng, Zheng, Qianqian, Liang, Yinming, Guo, Weixiang, Qiu, Ju, Constantin, Gabriela, Jin, Jin, Qin, Jun, Xiao, Yichuan. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2018, 第 14 作者215(5): 1365-1382, https://www.webofscience.com/wos/woscc/full-record/WOS:000440819800010.
[22] Li, Cui, Wang, Qin, Jiang, Yisheng, Ye, Qing, Xu, Dan, Gao, Fei, Xu, Jesse W, Wang, Ruoke, Zhu, Xingliang, Shi, Lei, Yu, Lei, Zhang, Fuchun, Guo, Weixiang, Zhang, Linqi, Qin, ChengFeng, Xu, Zhiheng. Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice. CELL DISCOVERY[J]. 2018, 第 13 作者4(1): https://doaj.org/article/bef62efc5f0c4000aef9ec031fccf6b2.
[23] Guo Ye, He Xiaoxiao, Zhao Lu, Liu Lin, Song Huifang, Wang Xudong, Xu Jiahui, Ju Xingda, Guo Weixiang, Zhu Xiaojuan. Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex. CEREBRAL CORTEX[J]. 2017, 第 9 作者
[24] Liu, Xuezhao, Li, Yang, Wang, Xin, Xing, Ruxiao, Liu, Kai, Gan, Qiwen, Tang, Changyong, Gao, Zhiyang, Jian, Youli, Luo, Shouqing, Guo, Weixiang, Yang, Chonglin. The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. JOURNAL OF CELL BIOLOGY[J]. 2017, 第 11 作者  通讯作者  216(5): 1301-1320, https://www.webofscience.com/wos/woscc/full-record/WOS:000400382700014.
[25] Liu, Kai, Xing, Ruxiao, Jian, Youli, Gao, Zhiyang, Ma, Xinli, Sun, Xiaojuan, Li, Yang, Xu, Meng, Wang, Xin, Jing, Yudong, Guo, Weixiang, Yang, Chonglin. WDR91 is a Rab7 effector required for neuronal development. JOURNAL OF CELL BIOLOGY[J]. 2017, 第 11 作者  通讯作者  216(10): 3307-3321, https://www.webofscience.com/wos/woscc/full-record/WOS:000411962700027.
[26] Sun, Linlin, Zhao, JianYuan, Gu, Xiyao, Liang, Lingli, Wu, Shaogen, Mo, Kai, Feng, Jian, Guo, Weixiang, Zhang, Jun, Bekker, Alex, Zhao, Xinyu, Nestler, Eric J, Tao, YuanXiang. Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons. PAIN[J]. 2017, 第 8 作者158(6): 1153-1165, https://www.webofscience.com/wos/woscc/full-record/WOS:000402431700022.
[27] Li, Yang, Xu, Meng, Ding, Xiao, Yan, Chen, Song, Zhiqin, Chen, Lianwan, Huang, Xiahe, Wang, Xin, Jian, Youli, Tang, Guihua, Tang, Changyong, Di, Yingtong, Mu, Shuzhen, Liu, Xuezhao, Liu, Kai, Li, Ting, Wang, Yingchun, Miao, Long, Guo, Weixiang, Hao, Xiaojiang, Yang, Chonglin. Protein kinase C controls lysosome biogenesis independently of mTORC1. NATURE CELL BIOLOGY[J]. 2016, 第 19 作者18(10): 1065-1077, http://www.irgrid.ac.cn/handle/1471x/1140918.
[28] Wang, Feifei, Tidei, Joseph J, Polich, Eric D, Gao, Yu, Zhao, Huashan, PerroneBizzozero, Nora I, Guo, Weixiang, Zhao, Xinyu. Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2015, 第 7 作者112(36): E4995-E5004, https://www.webofscience.com/wos/woscc/full-record/WOS:000360994900006.
[29] Chow, Cynthia L, Guo, Weixiang, Trivedi, Parul, Zhao, Xinyu, Gubbels, Samuel P. Characterization of a unique cell population marked by transgene expression in the adult cochlea of nestin-CreER(T2)/tdTomato-reporter mice. JOURNAL OF COMPARATIVE NEUROLOGY[J]. 2015, 第 2 作者523(10): 1474-1487, https://www.webofscience.com/wos/woscc/full-record/WOS:000354737600003.
[30] Lai, Mingming, Guo, Ye, Ma, Jun, Yu, Huali, Zhao, Dongdong, Fan, Wenqiang, Ju, Xingda, Sheikh, Muhammad A, Malik, Yousra S, Xiong, Wencheng, Guo, Weixiang, Zhu, Xiaojuan. Myosin X regulates neuronal radial migration through interacting with N-cadherin. FRONTIERS IN CELLULAR NEUROSCIENCE[J]. 2015, 第 11 作者9: https://doaj.org/article/db6075737c0d4dff984d565cad3a9863.
[31] Yu, Huali, Sun, Dong, Wang, Nannan, Wang, Min, Lan, Yongsheng, Fan, Wenqiang, Zhao, Yang, Guo, Weixiang, Zhu, Xiaojuan. Headless Myo10 is a regulator of microtubule stability during neuronal development. JOURNAL OF NEUROCHEMISTRY[J]. 2015, 第 8 作者135(2): 261-273, https://www.webofscience.com/wos/woscc/full-record/WOS:000362828200006.
[32] Guo, Weixiang, Polich, Eric D, Su, Juan, Gao, Yu, Christopher, Devin M, Allan, Andrea M, Wang, Min, Wang, Feifei, Wang, Guangfu, Zhao, Xinyu. Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms. CELL REPORTS[J]. 2015, 第 1 作者11(10): 1651-1666, http://dx.doi.org/10.1016/j.celrep.2015.05.013.
[33] Gao, Yu, Su, Juan, Guo, Weixiang, Polich, Eric D, Magyar, Daniel P, Xing, Yina, Li, Hongda, Smrt, Richard D, Chang, Qiang, Zhao, Xinyu. Inhibition of miR-15a Promotes BDNF Expression and Rescues Dendritic Maturation Deficits in MeCP2-Deficient Neurons. STEM CELLS[J]. 2015, 第 3 作者33(5): 1618-1629, https://www.webofscience.com/wos/woscc/full-record/WOS:000353292600022.
[34] Li, Hongda, Zhong, Xiaofen, Chau, Kevin F, Santistevan, Nicholas J, Guo, Weixiang, Kong, Guangyao, Li, Xuekun, Kadakia, Mitul, Masliah, Jamie, Chi, Jingyi, Jin, Peng, Zhang, Jing, Zhao, Xinyu, Chang, Qiang. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. NATURE COMMUNICATIONS[J]. 2014, 第 5 作者5: https://www.webofscience.com/wos/woscc/full-record/WOS:000346082300001.
[35] Guo, Weixiang, Murthy, Adeline C, Zhang, Li, Johnson, Eric B, Schaller, Eric G, Allan, Andrea M, Zhao, Xinyu. Inhibition of GSK3 beta improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. HUMAN MOLECULAR GENETICS[J]. 2012, 第 1 作者21(3): 681-691, https://www.webofscience.com/wos/woscc/full-record/WOS:000299351000018.
[36] 郭伟翔. Isolation of multipotent neural stem/progenitor cells from both the dentate gyrus and subventricular zone of a single adult mouse.. 2012, 第 1 作者
[37] Guo, Weixiang, Allan, Andrea M, Zong, Ruiting, Zhang, Li, Johnson, Eric B, Schaller, Eric G, Murthy, Adeline C, Goggin, Samantha L, Eisch, Amelia J, Oostra, Ben A, Nelson, David L, Jin, Peng, Zhao, Xinyu. Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning. NATURE MEDICINE[J]. 2011, 第 1 作者17(5): 559-U75, https://www.webofscience.com/wos/woscc/full-record/WOS:000290250400031.
[38] Guo, Weixiang, Zhang, Li, Christopher, Devin M, Teng, ZhaoQian, Fausett, Sarah R, Liu, Changmei, George, Olivia L, Klingensmith, John, Jin, Peng, Zhao, Xinyu. RNA-Binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression. NEURON[J]. 2011, 第 1 作者70(5): 924-938, http://dx.doi.org/10.1016/j.neuron.2011.03.027.
[39] Luo, Yuping, Shan, Ge, Guo, Weixiang, Smrt, Richard D, Johnson, Eric B, Li, Xuekun, Pfeiffer, Rebecca L, Szulwach, Keith E, Duan, Ranhui, Barkho, Basam Z, Li, Wendi, Liu, Changmei, Jin, Peng, Zhao, Xinyu. Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells. PLOS GENETICS[J]. 2010, 第 3 作者6(4): http://dx.doi.org/10.1371/journal.pgen.1000898.

   

（1） 创新组专项，主持，专项级，2014-06--2018-06
（2） 领域前沿，主持，其他级，2014-06--2018-06
（3） ****，主持，院级级，2014-06--2018-06

现指导学生

陈旭  硕士研究生  071008-发育生物学  

邢如晓  硕士研究生  071009-细胞生物学  

王玉晗  博士研究生  071006-神经生物学  

胡凤  博士研究生  071006-神经生物学  

刘英浩  博士研究生  071006-神经生物学  

汤常永  博士研究生  071006-神经生物学