1. 急/慢性脑疾病中神经炎症的机制与调控
2. 血脑屏障损伤与保护的细胞分子机制
3. 胶质淋巴系统功能障碍的病理意义及修复策略

招收硕士研究生

071006-神经生物学
071009-细胞生物学

急/慢性脑疾病中神经炎症的机制与调控
血脑屏障损伤与保护的细胞分子机制
胶质淋巴系统功能障碍的病理意义及修复策略

2016-09--2020-09   复旦大学   博士研究生
2013-09--2016-06   华南师范大学   硕士研究生
2009-09--2013-07   河南科技大学   学士

1. Xiaoyan Hu#, Min Yu# , Shilun Yang, Cheng Fang, Pengju Wei, Xun Zhang, Yinzhong Ma, Ziying Feng, Yukun Chen, Jingyu Yan, Ying Wang, Linhui Qiu, Dengpan Song, Fuyou Guo, Junlei Chang*. CD98hc controls CNS angiogenesis and blood-brain barrier integrity through localized regulation of the systemic integrin-FAK pathway. Nat Cardiovasc Res. 2026 May;5(5):456-478.
2. Mi Tian#, Xin Li#, Dongqing Qi, Pengju Wei*, Peng Jin*. Paricalcitol-mediated vitamin D receptor activation attenuates neuronal ferroptosis via cAMP-PKA-DRP1 signaling pathway after intracerebral hemorrhage. Neurotherapeutics. 2026 Jan;23(1):e00767.
3. Ruoyu Zhao#, Bin Sun#, Pengju Wei#, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu*, Yi Yang*, Zhenni Guo*. Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation. Adv Sci (Weinh). 2025 Dec;12(47):e03576.
4. Dongqing Qi#, Pengju Wei#, Yuhui Cui, Cameron Lenahan, Xiaogen Tao, Peng Jin*. Inhibition of C3a/C3aR by SB290157 Attenuates Neuroinflammation via PKC/P38/NLRP3 Signaling Pathway After Intracerebral Hemorrhage. Neurocrit Care. 2025 Aug;43(1):44-58.
5. Pengju Wei#, Kaihua Lin# Xuhui Chen, Cheng Fang, Linhui Qiu, Jun Hu*, Junlei Chang*. Sequential Proteomic Analysis Reveals the Key APOE4-Induced Pathological and Molecular Features at the Presymptomatic Stage in Alzheimer's Disease Mice. CNS Neurosci Ther. 2025 Mar;31(3):e70306.
6. Xiaowen Huang#, Pengju Wei#, Cheng Fang, Min Yu, Shilun Yang, Linhui Qiu, Yu Wang, Aimin Xu, Ruby Lai Chong Hoo, Junlei Chang. Compromised endothelial Wnt/β-catenin signaling mediates the blood-brain barrier disruption and leads to neuroinflammation in endotoxemia. J Neuroinflammation. 2024 Oct 19;21:265.
7. Ruoyu Zhao#, Pengju Wei#, Xin Sun, Dianhui Zhang, Qianyan He, Jie Liu, Junlei Chang, Yi Yang*, Zhen-Ni Guo*. Role of lipocalin 2 in stroke. Neurobiol Dis. 2023 Apr:179:106044.
8. Di Chen, Jiaying Li, Yichen Huang, Pengju Wei, Wanying Miao, Yaomei Yang, Yanqin Gao*. Interleukin 13 promotes long-term recovery after ischemic stroke by inhibiting the activation of STAT3. J Neuroinflammation. 2022 May 16;19:112.
9. Pengju Wei, Ke Wang, Chen Luo, Yichen Huang, Dilidaer Misilimu, Huimei Wen, Peng Jin, Chuhua Li, Ye Gong*, Yanqin Gao*. Cordycepin confers long-term neuroprotection via inhibiting neutrophil infiltration and neuroinflammation after traumatic brain injury. J Neuroinflammation. 2021 Jun 15;18(1):137.
10. Heng Yang#, Wei Ni#, Pengju Wei, Sicheng Li, Xinjie Gao, Jiabin Su, Hanqiang Jiang, Yu Lei, Liangfu Zhou*, Yuxiang Gu*. HDAC inhibition reduces white matter injury after intracerebral hemorrhage. J Cereb Blood Flow Metab. 2021 May;41(5):958-974.

主持项目

（1）国家自然科学基金-青年项目，32200785，ALPL在衰老过程中受Wnt/β-catenin通路调控引起血脑屏障功能障碍的机制研究，2023-01至2025-12，30万元，结题

（2）广东省基础与应用基础研究基金联合基金-青年项目, 2021A1515110237，脑血管内皮NF-κB/Wnt/β-catenin信号通路对外周炎症引起的血脑屏障损伤的介导作用和机制研究，2021-10至2024-09，10万元，结题

（3）中国博士后科学基金面上资助，2022M723393，衰老过程中ALPL表达上调并引发血脑屏障功能紊乱的机制研究，2022-11至2023-07，8万元，结题

（4）深圳市出站博士后留（深）科研资助，2024-01至2026-12，30万元，在研

参与项目

（1）国家自然科学基金-面上项目，82473099，星形胶质细胞通过上调FABP4的表达促进肺癌脑转移瘤脂代谢重编程和定植的作用及机制研究，2025-01至2028-12，49万元，在研

（2）深圳市基础研究重点项目, JCYJ20210324115800003，载脂蛋白E4（ApoE4）损伤线粒体促进阿尔茨海默病突触退化的机制研究，2021-08至2024-08，250万元，结题