基本信息
王延轶  女  博导  中国科学院武汉病毒研究所
电子邮件: wangyy@wh.iov.cn
通信地址: 武汉市武昌小洪山中区44号中科院武汉病毒研究所
邮政编码: 430071

招生信息

   
招生专业
071010-生物化学与分子生物学
100102-免疫学
招生方向
抗感染免疫应答,病毒免疫逃逸

教育背景

2007-09--2010-06   武汉大学   博士
2004-08--2006-06   美国科罗拉多大学医学院   硕士
2000-09--2004-06   北京大学   学士

工作经历

   
工作简历
2018-10~现在, 中科院武汉病毒所, 所长
2015-12~2018-10,中科院武汉病毒所, 副所长
2014-12~2015-12,中科院武汉病毒所, 所长助理
2014-07~2015-06,武昌区卫生和计划生育委员会(挂职), 副主任
2012-03~现在, 中科院武汉病毒所, 研究员
2010-11~2012-02,武汉大学生命科学学院, 副教授
2006-08~2010-10,武汉大学生命科学学院, 讲师
社会兼职
2019-12-01-今,中国青年科技工作者协会, 副理事长
2019-12-01-今,武汉市青年联合会(第十四届), 副主席
2018-12-01-今,武汉微生物学会, 理事长
2017-05-31-今,湖北省青年联合会, 副秘书长
2014-10-31-2017-05-31,武汉市青年联合会, 委员
2014-07-01-2015-06-30,武昌区卫生和计划生育委员会, 副主任
2013-12-01-今,湖北省妇女联合会执行委员会,
2013-01-01-今,中国免疫学会青年工作委员会, 副主任委员

教授课程

现代生物学进展
免疫学

专利与奖励

   
奖励信息
(1) 国家万人计划中青年科技创新领军人才, , 国家级, 2019
(2) 第十二届中国科学院杰出青年, 院级, 2017
(3) 享受政府特殊津贴专家, 国家级, 2016
(4) 国家自然科学奖, 二等奖, 国家级, 2015
(5) 国家百千万人才工程“有突出贡献中年青年专家”, 国家级, 2015
(6) 湖北省青年五四奖章, 省级, 2015
(7) 湖北省青年五四奖章, 省级, 2015
(8) 教育部自然科学奖, 一等奖, 部委级, 2015
(9) 国家杰出青年科学基金, 国家级, 2014
(10) 中组部万人计划首批青年拔尖人才, , 部委级, 2013
(11) 武汉市优秀科技工作者, , 市地级, 2013
(12) 武汉市青年科技奖, , 市地级, 2012
(13) 武汉大学“珞珈青年学者”, , 研究所(学校), 2012
(14) 中国免疫学青年学者奖, , 其他, 2010
(15) 武汉大学青年教师教学竞赛二等奖, , 研究所(学校), 2010
(16) 武汉大学学生工作先进个人, , 研究所(学校), 2008
专利成果
[1] 王延轶, 付辉, 冉勇, 朱海, 石正旺, 袁克湖, 张克山, 林季敏, 马涛, 易俊伟, 杨年松, 严义勇. 编码非洲猪瘟病毒抗原的DNA序列、由其编码的抗原的组合物及其在免疫学检测中的应用. CN: CN110093356B, 2021-07-20.

出版信息

   
发表论文
[1] Wang, DongPeng, Zhang, HongYan, Liao, BoWei, Tong, Zhen, Xu, ZhiSheng, Wang, YanYi, Yang, Yan. SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5. VIROLOGICA SINICA[J]. 2021, 36(2): 231-240, https://www.webofscience.com/wos/woscc/full-record/WOS:000557131800001.
[2] Fu, YuZhi, Wang, SuYun, Zheng, ZhouQin, Huang, Yi, Li, WeiWei, Xu, ZhiSheng, Wang, YanYi. SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 18(3): 613-620, http://dx.doi.org/10.1038/s41423-020-00571-x.
[3] Lian, DongSheng, Chen, XiangYuan, Zeng, HuaSong, Wang, YanYi. Capillary electrophoresis based on nucleic acid analysis for diagnosing inherited diseases. CLINICAL CHEMISTRY AND LABORATORY MEDICINEnull. 2021, 59(2): 249-266, http://dx.doi.org/10.1515/cclm-2020-0186.
[4] Zhang, Wei, Du, RongHui, Li, Bei, Zheng, XiaoShuang, Yang, XingLou, Hu, Ben, Wang, YanYi, Xiao, GengFu, Yan, Bing, Shi, ZhengLi, Zhou, Peng. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. EMERGING MICROBES & INFECTIONS[J]. 2020, 9(1): 386-389, http://dx.doi.org/10.1080/22221751.2020.1729071.
[5] Shan, Chao, Yao, YanFeng, Yang, XingLou, Zhou, YiWu, Gao, Ge, Peng, Yun, Yang, Lian, Hu, Xue, Xiong, Jin, Jiang, RenDi, Zhang, HuaJun, Gao, XiaoXiao, Peng, Cheng, Min, Juan, Chen, Ying, Si, HaoRui, Wu, Jia, Zhou, Peng, Wang, YanYi, Wei, HongPing, Pang, Wei, Hu, ZhengFei, Lv, LongBao, Zheng, YongTang, Shi, ZhengLi, Yuan, ZhiMing. Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques. CELL RESEARCH[J]. 2020, 30(8): 670-677, http://lib.cqvip.com/Qikan/Article/Detail?id=7102918057.
[6] 王延轶. SRP54NegativelyRegulatesIFN-BetaProductionandAntiviralResponsebyTargetingRIG-IandMDA5. VirologicaSinica. 2020, [7] 王延轶. Human Cytomegalovirus Protein UL94 Targets MITA to Evade Antiviral Immune Response.. Journal of Virology. 2020, [8] Yang, Qi, Tang, Jielin, Xu, Chonghui, Zhao, He, Zhou, Yuan, Wang, Yanyi, Yang, Min, Chen, Xinwen, Chen, Jizheng. Histone deacetylase 4 inhibits NF-kappa B activation by facilitating I kappa B alpha sumoylation. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2020, 12(12): 933-945, https://www.webofscience.com/wos/woscc/full-record/WOS:000634891000004.
[9] Xiong, MeiGuang, Xu, ZhiSheng, Li, YuHui, Wang, SuYun, Wang, YanYi, Ran, Yong. RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization. EMBO REPORTS[J]. 2020, 21(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054668/.
[10] Fu, YuZhi, Wang, SuYun, Zheng, ZhouQin, Huang, Yi, Li, WeiWei, Xu, ZhiSheng, Wang, YanYi. SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response. CELLULAR & MOLECULAR IMMUNOLOGY. 2020, 1-8, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588591/.
[11] Zou, HongMei, Huang, ZheFu, Yang, Yan, Luo, WeiWei, Wang, SuYun, Luo, MinHua, Fu, YuZhi, Wang, YanYi. Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response. JOURNAL OF VIROLOGY[J]. 2020, 94(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307088/.
[12] HongYan Zhang, BoWei Liao, ZhiSheng Xu, Yong Ran, DongPeng Wang, Yan Yang, WeiWei Luo, YanYi Wang. USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA.. PLoS Pathogens[J]. 2020, 16(1): https://doaj.org/article/ac1cfb79f25f49b1ac96310bc67d87ed.
[13] Zhi-Sheng Xu, Ting Shu, Liang Kang, Di Wu, Xing Zhou, Bo-Wei Liao, Xiu-Lian Sun, Xi Zhou, Yan-Yi Wang. Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients. Signal Transduction and Targeted Therapy. 2020, https://www.nature.com/articles/s41392-020-0211-1.
[14] Li, WeiWei, Nie, Ying, Yang, Yan, Ran, Yong, Luo, WeiWei, Xiong, MeiGuang, Wang, SuYun, Xu, ZhiSheng, Wang, YanYi. Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(38): 23707-23716, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519224/.
[15] Ran, Yong, Xiong, Meiguang, Xu, Zhisheng, Luo, Weiwei, Wang, Suyun, Wang, YanYi. YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking. JOURNAL OF IMMUNOLOGY[J]. 2019, 203(6): 1560-1570, https://www.webofscience.com/wos/woscc/full-record/WOS:000484842100015.
[16] Yang, Qi, Tang, Jielin, Pei, Rongjuan, Gao, XiaoXiao, Guo, Jing, Xu, Chonghui, Wang, Yun, Wang, Qian, Wu, Chunchen, Zhou, Yuan, Hu, Xue, Zhao, He, Wang, Yanyi, Chen, Xinwen, Chen, Jizheng. Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2019, 11(2): 158-169, http://lib.cqvip.com/Qikan/Article/Detail?id=7001603102.
[17] Xu, ZhiSheng, Zhang, HongXia, Li, WeiWei, Ran, Yong, Liu, TianTian, Xiong, MeiGuang, Li, QingLan, Wang, SuYun, Wu, Min, Shu, HongBing, Xia, Huimin, Wang, YanYi. FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(21): 10447-10452, https://www.webofscience.com/wos/woscc/full-record/WOS:000468403400046.
[18] 王延轶. RNF152 positively regulatesTLR/IL signaling by enhancing signaling MyD88 oligomerizationo. EMBO Reports. 2019, [19] YuZhi Fu, Yi Guo, HongMei Zou, Shan Su, SuYun Wang, Qing Yang, MinHua Luo, YanYi Wang. Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response.. PLoS Pathogens[J]. 2019, 15(5): https://doaj.org/article/65ce37c2e1a147088143dc8d2dae55b8.
[20] 王延轶. Human Cytomegalovirus DNA Polymerase 1 Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-B-mediated transcription.. J. Virol.. 2019, [21] Fu, YuZhi, Su, Shan, Zou, HongMei, Guo, Yi, Wang, SuYun, Li, Shu, Luo, MinHua, Wang, YanYi. Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3-and NF-kappa B-Mediated Transcription. JOURNAL OF VIROLOGY[J]. 2019, 93(11): [22] 王延轶. Human Cytomegalovirus Protein UL31 Inhiibits DNA Sensing of cGAS to Mediate Immune Evasion. Cell Host&Microbe. 2018, [23] HongXia Zhang, ZhiSheng Xu, Hen Lin, Mi Li, Tian Xia, Kaisa Cui, SuYun Wang, Youjun Li, HongBing Shu, YanYi Wang. TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis. NATURE COMMUNICATIONS[J]. 2018, 9(1): http://www.corc.org.cn/handle/1471x/2373249.
[24] Xiong, Meiguang, Wang, Suyun, Wang, YanYi, Ran, Yong. The Regulation of cGAS. VIROLOGICA SINICAnull. 2018, 33(2): 117-124, http://lib.cqvip.com/Qikan/Article/Detail?id=675245650.
[25] Gao, Xiaoxiao, Chen, Dan, Hu, Xue, Zhou, Yuan, Wang, Yun, Wu, Chunchen, Chen, Jizheng, Wang, Yanyi, Pei, Rongjuan, Chen, Xinwen. PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria. JOURNAL OF INNATE IMMUNITY[J]. 2018, 10(4): 315-327, http://www.corc.org.cn/handle/1471x/2373237.
[26] Huang, ZheFu, Zou, HongMei, Liao, BoWei, Zhang, HongYan, Yang, Yan, Fu, YuZhi, Wang, SuYun, Luo, MinHua, Wang, YanYi. Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion. CELL HOST & MICROBE[J]. 2018, 24(1): 69-+, http://dx.doi.org/10.1016/j.chom.2018.05.007.
[27] Yang, Bo, Liu, XiJuan, Yao, Yongxuan, Jiang, Xuan, Wang, XianZhang, Yang, Hong, Sun, JinYan, Miao, Yun, Wang, Wei, Huang, ZhenLi, Wang, Yanyi, Tang, Qiyi, Rayner, Simon, Britt, William J, McVoy, Michael A, Luo, MinHua, Zhao, Fei. WDR5 Facilitates Human Cytomegalovirus Replication by Promoting Capsid Nuclear Egress. JOURNAL OF VIROLOGY[J]. 2018, 92(9): http://202.127.146.157/handle/2RYDP1HH/4884.
[28] Yong Ran, ZhaoYi Pan, YanYi Wang, ZheFu Huang, Ying Nie, HongYan Zhang, SuYun Wang. GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome. Public Library of Science. 2017, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902019715413ZK.
[29] Yan, BingRu, Zhou, Lu, Hu, MingMing, Li, Mi, Lin, Heng, Yang, Yan, Wang, YanYi, Shu, HongBing. PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation. PLOS PATHOGENS[J]. 2017, 13(9): http://www.corc.org.cn/handle/1471x/2373394.
[30] Liu, Shuhui, Zhao, Kaitao, Su, Xi, Lu, Lu, Zhao, He, Zhang, Xianwen, Wang, Yun, Wu, Chunchen, Chen, Jizheng, Zhou, Yuan, Hu, Xue, Wang, Yanyi, Lu, Mengji, Chen, Xinwen, Pei, Rongjuan. MITA/STING and Its Alternative Splicing Isoform MRP Restrict Hepatitis B Virus Replication. PLOS ONE[J]. 2017, 12(1): http://www.corc.org.cn/handle/1471x/2373477.
[31] Yuzhi Fu, Shan Su, YiQun Gao, PeiPei Wang, ZheFu Huang, MingMing Hu, WeiWei Luo, Shu Li, MinHua Luo, YanYi Wang, HongBing Shu. Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity. CELL HOST & MICROBE[J]. 2017, 21(2): 231-243, http://www.corc.org.cn/handle/1471x/2373468.
[32] Zhen Tong, ZhouQin Zheng, Huan Lian, WeiWei Luo, Pan Cao, HongBing Shu, Chen Li, YanYi Wang, Shu Li, SuYun Wang. iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA. Public Library of Science. 2017, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902014211399ZK.
[33] Nie, Ying, Ran, Yong, Zhang, HongYan, Huang, ZheFu, Pan, ZhaoYi, Wang, SuYun, Wang, YanYi. GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome. PLOS PATHOGENS[J]. 2017, 13(4): http://www.corc.org.cn/handle/1471x/2373428.
[34] An, Bolin, Wang, Xinyu, Cui, Mengkui, Gui, Xinrui, Mao, Xiuhai, Liu, Yan, Li, Ke, Chu, Cenfeng, Pu, Jiahua, Ren, Susu, Wang, Yanyi, Zhong, Guisheng, Lu, Timothy K, Liu, Cong, Zhong, Chao. Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains. ACS NANO[J]. 2017, 11(7): 6985-6995, http://ir.sic.ac.cn/handle/331005/25783.
[35] Luo, WeiWei, Li, Shu, Li, Chen, Zheng, ZhouQin, Cao, Pan, Tong, Zhen, Lian, Huan, Wang, SuYun, Shu, HongBing, Wang, YanYi. iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA. PLOS PATHOGENS[J]. 2017, 13(11): http://202.127.146.157/handle/2RYDP1HH/4387.
[36] Xu, ZhiSheng, Zhang, HongXia, Zhang, YuLong, Liu, TianTian, Ran, Yong, Chen, LiuTing, Wang, YanYi, Shu, HongBing. PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2016, 8(3): 221-231, https://www.webofscience.com/wos/woscc/full-record/WOS:000380253100005.
[37] Liu, TianTian, Yang, Qing, Li, Mi, Zhong, Bo, Ran, Yong, Liu, LiLi, Yang, Yan, Wang, YanYi, Shu, HongBing. LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner. JOURNAL OF IMMUNOLOGY[J]. 2016, 196(12): 5101-5111, https://www.webofscience.com/wos/woscc/full-record/WOS:000377937500027.
[38] Ran, Yong, Zhang, Jing, Liu, LiLi, Pan, ZhaoYi, Nie, Ying, Zhang, HongYan, Wang, YanYi. Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2016, 8(1): 31-43, [39] Yang, Yan, Wang, SuYun, Huang, ZheFu, Zou, HongMei, Yan, BingRu, Luo, WeiWei, Wang, YanYi. The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response. CELL RESEARCH[J]. 2016, 26(3): 288-303, https://www.webofscience.com/wos/woscc/full-record/WOS:000372063100006.
[40] 舒红兵, 王延轶. 内质网蛋白ZDHHC1三调控DNA病毒通过MITA/STING诱导天然免疫信号转导的分子机制. 科学新闻. 2015, 86-86, http://lib.cqvip.com/Qikan/Article/Detail?id=663926401.
[41] Zhu, Kun, Wang, Xiang, Ju, LinGao, Zhu, Yuan, Yao, Jie, Wang, Yanyi, Wu, Min, Li, LianYun. WDR82 Negatively Regulates Cellular Antiviral Response by Mediating TRAF3 Polyubiquitination in Multiple Cell Lines. JOURNAL OF IMMUNOLOGY[J]. 2015, 195(11): 5358-5366, https://www.webofscience.com/wos/woscc/full-record/WOS:000365606100030.
[42] Ran, Yong, Shu, HongBing, Wang, YanYi. MITA/STING: A central and multifaceted mediator in innate immune response. CYTOKINE & GROWTH FACTOR REVIEWSnull. 2014, 25(6): 631-639, http://dx.doi.org/10.1016/j.cytogfr.2014.05.003.
[43] Chen, Honghe, Pei, Rongjuan, Zhu, Wandi, Zeng, Rui, Wang, Yun, Wang, Yanyi, Lu, Mengji, Chen, Xinwen. An Alternative Splicing Isoform of MITA Antagonizes MITA-Mediated Induction of Type I IFNs. JOURNAL OF IMMUNOLOGY[J]. 2014, 192(3): 1162-1170, https://www.webofscience.com/wos/woscc/full-record/WOS:000331264200036.
[44] Ning, YunJia, Wang, Manli, Deng, Maping, Shen, Shu, Liu, Wei, Cao, WuChun, Deng, Fei, Wang, YanYi, Hu, Zhihong, Wang, Hualin. Viral suppression of innate immunity via spatial isolation of TBK1/IKK epsilon from mitochondrial antiviral platform. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2014, 6(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000339916900006.
[45] Hu, MingMing, Yang, Qing, Zhang, Jing, Liu, ShiMeng, Zhang, Yu, Lin, Heng, Huang, ZheFu, Wang, YanYi, Zhang, XiaoDong, Zhong, Bo, Shu, HongBing. TRIM38 inhibits TNF alpha- and IL-1 beta-triggered NF-kappa B activation by mediating lysosome-dependent degradation of TAB2/3. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 111(4): 1509-1514, https://www.webofscience.com/wos/woscc/full-record/WOS:000330231100068.
[46] Shu, HongBing, Wang, YanYi. Adding to the STING. IMMUNITYnull. 2014, 41(6): 871-873, http://dx.doi.org/10.1016/j.immuni.2014.12.002.
[47] Yong Ran, Hong-Bing Shu, Yan-Yi Wang. MITA/STING: A central and multifaceted mediator in innate immune response. Cytokine and Growth Factor Reviews. 2014, 25(6): 631-639, http://dx.doi.org/10.1016/j.cytogfr.2014.05.003.
[48] Zhou, Qian, Lin, Heng, Wang, Suyun, Wang, Shuai, Ran, Yong, Liu, Ying, Ye, Wen, Xiong, Xiaozhe, Zhong, Bo, Shu, HongBing, Wang, YanYi. The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling. CELL HOST & MICROBE[J]. 2014, 16(4): 450-461, https://www.webofscience.com/wos/woscc/full-record/WOS:000343826100009.
[49] Ning Yunjia, Wang Manli, Deng Maping, Shu Shen, Wei Liu, Cao Wuchun, Fei Deng, Wang Yanyi, Hu Zhihong, Wang Hualin. Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform. Journal of Molecular Cell Biology[J]. 2014, 6(4): 324-337, [50] 舒红兵. E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2013, 110(13): 5115-5120, https://www.webofscience.com/wos/woscc/full-record/WOS:000318031900058.
[51] 王延轶. The E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation.. PNAS. 2013, [52] Liu, Zhigang, Wu, ShuWen, Lei, CaoQi, Zhou, Qian, Li, Shu, Shu, HongBing, Wang, YanYi. Heat shock cognate 71 (HSC71) regulates cellular antiviral response by impairing formation of VISA aggregates. PROTEIN & CELL[J]. 2013, 4(5): 373-382, https://www.webofscience.com/wos/woscc/full-record/WOS:000318714600007.
[53] Nie, Ying, Wang, YanYi. Innate immune responses to DNA viruses. PROTEIN & CELL[J]. 2013, 4(1): 1-7, https://www.webofscience.com/wos/woscc/full-record/WOS:000313409900001.
[54] 舒红兵. Linear Ubiquitination of NEMO Brakes the Antiviral Response. CELL HOST & MICROBEnull. 2012, 12(2): 129-131, [55] 王延轶. The E3 ubiquitin ligase MIB1 mediates NF-κB activation through negative regulation of the basal IκBα level.. 2012, [56] Liu Lijuan, Liu Tiantian, Ran Yong, Li Ying, Zhang Xiaodong, Shu Hongbing, Wang Yanyi. The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation. 细胞研究:英文版[J]. 2012, 603-606, http://lib.cqvip.com/Qikan/Article/Detail?id=41272770.
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发表著作
(1) 抗病毒天然免疫, Antiviral Innate Immunity, 科学出版社, 2009-09, 第 3 作者

科研活动

   
科研项目
( 1 ) WWP2 调节TLR3 信号转导的机制, 主持, 国家级, 2012-01--2015-12
( 2 ) 丙型肝炎病毒感染及防治的基础研究, 参与, 国家级, 2009-01--2013-12
( 3 ) 抑郁症的蛋白质组学和多肽组学研究, 参与, 国家级, 2009-01--2013-12
( 4 ) 动物病毒-宿主相互作用机制的研究, 主持, 国家级, 2014-01--2018-12
( 5 ) 抗病毒天然免疫信号转导, 主持, 国家级, 2013-01--2015-12
( 6 ) 病毒与宿主相互作用的分子机理, 主持, 国家级, 2014-01--2016-12
( 7 ) 慢性丙型病毒性肝炎免疫逃逸与免疫病理研究, 主持, 国家级, 2015-01--2019-12
( 8 ) 细胞抗病毒反应的分子机制, 主持, 国家级, 2015-01--2019-12
( 9 ) DNA病毒与宿主天然免疫相互作用的分子机制, 主持, 部委级, 2016-08--2020-12
( 10 ) 病毒与宿主相互作用的分子机理, 参与, 国家级, 2017-01--2019-12
( 11 ) 病毒与宿主天然免疫的相互作用机制, 主持, 部委级, 2018-01--2022-12
( 12 ) 非洲猪瘟病毒免疫应答与疫苗策略研究, 参与, 部委级, 2019-01--2021-12
参与会议
(1)TRIM8 modulate TNF-alpha and IL-1beta triggered NF-kappaB activation by tarteting TAK1 for K63-linked polyubiquitination   中国免疫学会青年工作委员会2013年学术年会   2013-01-20
(2)TRIM8 modulates NF-κB activation pathways triggered by proinflammatory cytokines   第九届海峡两岸细胞生物学学术研讨会   2012-09-23
(3)WWP2 negatively regulates TLR3-mediated innate immune responses by targeting TRIF for ubiquitination and degradation   第四届“细胞结构与功能的信号基础研讨会”长白山会议   2012-08-10
(4)DDB1 is a cellular substrate of NS3/4A protease and required for HCV replication   2011-10-15
(5)WDR5在VISA信号复合物组装及细胞抗病毒反应中的作用机制   中国免疫学会第六次全国会员代表大会暨第七届学术会议    王延轶   2010-10-22

指导学生

已指导学生

刘丽丽  硕士研究生  071010-生物化学与分子生物学  

潘召义  硕士研究生  085238-生物工程  

聂映  博士研究生  071010-生物化学与分子生物学  

章红艳  博士研究生  100102-免疫学  

黄哲夫  博士研究生  100102-免疫学  

现指导学生

李伟伟  博士研究生  071010-生物化学与分子生物学  

邹红梅  博士研究生  100102-免疫学  

王东鹏  博士研究生  071010-生物化学与分子生物学  

廖博威  博士研究生  071010-生物化学与分子生物学  

熊梅光  博士研究生  071010-生物化学与分子生物学  

郑周沁  博士研究生  100102-免疫学  

童珍  博士研究生  100102-免疫学  

李宇辉  硕士研究生  071010-生物化学与分子生物学  

邹家鹏  硕士研究生  071010-生物化学与分子生物学  

杜文恬  硕士研究生  071005-微生物学