基本信息
王业飞 男 硕导 中国科学院青岛生物能源与过程研究所
电子邮件： wangyf@qibebt.ac.cn
通信地址： 山东省青岛市崂山区松岭路189号
邮政编码： 266101
电子邮件： wangyf@qibebt.ac.cn
通信地址： 山东省青岛市崂山区松岭路189号
邮政编码： 266101
招生信息
招生专业
071010-生物化学与分子生物学
071011-生物物理学
0710Z2-计算生物学
071011-生物物理学
0710Z2-计算生物学
招生方向
蛋白质结构与功能关系的实验与计算模拟研究
教育背景
2005-09--2010-06 山东大学化学与化工学院 理论与计算化学博士，硕博连读
1999-09--2003-06 兰州大学化学与化工学院 化学学士
1999-09--2003-06 兰州大学化学与化工学院 化学学士
工作经历
工作简历
2018-01~现在, 中国科学院青岛生物能源与过程研究所, 副研究员
2010-12~2017-12,中国科学院青岛生物能源与过程研究所, 助理研究员
2010-12~2017-12,中国科学院青岛生物能源与过程研究所, 助理研究员
专利与奖励
专利成果
（ 1 ） 一种改良性能的黄素单核苷酸结合荧光蛋白质, 发明, 2015, 第 3 作者, 专利号: ZL 201210160241.3
（ 2 ） 一种改良性能的纤维素内切酶Cel7B突变体, 发明, 2018, 第 3 作者, 专利号: ZL201510049724.X
（ 2 ） 一种改良性能的纤维素内切酶Cel7B突变体, 发明, 2018, 第 3 作者, 专利号: ZL201510049724.X
出版信息
发表论文
[1] Yao, Xingzhe, Chen, Chao, Wang, Yefei, Dong, Sheng, Liu, YaJun, Li, Yifei, Cui, Zhenling, Gong, Weibin, Perrett, Sarah, Yao, Lishan, Lamed, Raphael, Bayer, Edward A, Cui, Qiu, Feng, Yingang. Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules. SCIENCE ADVANCES[J]. 2020, 6(43): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608827/.
[2] Wang, Yefei, An, Liaoyuan, Yang, Ying, Yao, Lishan. Generating Five Independent Molecular Alignments for Simultaneous Protein Structure and Dynamics Determination Using Nuclear Magnetic Resonance Spectroscopy. ANALYTICAL CHEMISTRY[J]. 2020, 92(23): 15263-15269, https://www.webofscience.com/wos/woscc/full-record/WOS:000596727600002.
[3] Li, Jingwen, Wang, Yefei, An, Liaoyuan, Chen, Jingfei, Yao, Lishan. Direct Observation of CH/CH van der Waals Interactions in Proteins by NMR. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(9): 3194-3197, http://www.irgrid.ac.cn/handle/1471x/1755477.
[4] Han, Ping, Guo, Ruiyou, Wang, Yefei, Yao, Lishan, Liu, Chengbu. Bidirectional Electron-Transfer in Polypeptides with Various Secondary Structures. SCIENTIFIC REPORTS[J]. 2017, 7(1): http://www.irgrid.ac.cn/handle/1471x/1755889.
[5] Zhang, Ning, Wang, Yefei, An, Liaoyuan, Song, Xiangfei, Huang, Qingshan, Liu, Zhijun, Yao, Lishan. Entropy Drives the Formation of Salt Bridges in the Protein GB3. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(26): 7601-7604, http://www.irgrid.ac.cn/handle/1471x/1755774.
[6] 王业飞. Observation of a-Helical Hydrogen Bond Cooperativity in an Intact Protein. Journal of the American Chemical Society. 2016, [7] Wang, Yefei, Zhang, Shujun, Song, Xiangfei, Yao, Lishan. Cellulose Chain Binding Free Energy Drives the Processive Move of Cellulases on the Cellulose Surface. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2016, 113(9): 1873-1880, http://ir.qibebt.ac.cn/handle/337004/8479.
[8] Wang, Yefei, Song, Xiangfei, Zhang, Shujun, Li, Jingwen, Shu, Zhiyu, He, Chunyan, Huang, Qingshan, Yao, Lishan. Improving the activity of Trichoderma reesei cel7B through stabilizing the transition state. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2016, 113(6): 1171-1177, http://dx.doi.org/10.1002/bit.25887.
[9] Wang, Yefei, Wang, Jia, Yao, Lishan. Computational Study of Peptide Plane Stacking with Polar and Ionizable Amino Acid Side Chains. JOURNAL OF PHYSICAL CHEMISTRY A[J]. 2015, 119(14): 3471-3478, http://www.irgrid.ac.cn/handle/1471x/1001372.
[10] Song, Xiangfei, Wang, Yefei, Zhang, Shujun, Yan, Shihai, Li, Tong, Yao, Lishan. Characterization of the Dielectric Constant in the Trichoderma reesei Cel7B Active Site. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2015, 55(7): 1369-1376, https://www.webofscience.com/wos/woscc/full-record/WOS:000358821300010.
[11] Zhang, Shujun, Wang, Yefei, Song, Xiangfei, Hong, Jingbo, Zhang, Yu, Yao, Lishan. Improving Trichoderma reesei Cel7B Thermostability by Targeting the Weak Spots. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2014, 54(10): 2826-2833, http://dx.doi.org/10.1021/ci500339v.
[12] An, Liaoyuan, Wang, Yefei, Zhang, Ning, Yan, Shihai, Bax, Ad, Yao, Lishan. Protein Apparent Dielectric Constant and Its Temperature Dependence from Remote Chemical Shift Effects. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2014, 136(37): 12816-12819, http://ir.qibebt.ac.cn/handle/337004/6238.
[13] Song, Xiangfei, Wang, Yefei, Shu, Zhiyu, Hong, Jingbo, Li, Tong, Yao, Lishan. Engineering a More Thermostable Blue Light Photo Receptor Bacillus subtilis YtvA LOV Domain by a Computer Aided Rational Design Method. PLOS COMPUTATIONAL BIOLOGY[J]. 2013, 9(7): http://www.irgrid.ac.cn/handle/1471x/830045.
[2] Wang, Yefei, An, Liaoyuan, Yang, Ying, Yao, Lishan. Generating Five Independent Molecular Alignments for Simultaneous Protein Structure and Dynamics Determination Using Nuclear Magnetic Resonance Spectroscopy. ANALYTICAL CHEMISTRY[J]. 2020, 92(23): 15263-15269, https://www.webofscience.com/wos/woscc/full-record/WOS:000596727600002.
[3] Li, Jingwen, Wang, Yefei, An, Liaoyuan, Chen, Jingfei, Yao, Lishan. Direct Observation of CH/CH van der Waals Interactions in Proteins by NMR. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(9): 3194-3197, http://www.irgrid.ac.cn/handle/1471x/1755477.
[4] Han, Ping, Guo, Ruiyou, Wang, Yefei, Yao, Lishan, Liu, Chengbu. Bidirectional Electron-Transfer in Polypeptides with Various Secondary Structures. SCIENTIFIC REPORTS[J]. 2017, 7(1): http://www.irgrid.ac.cn/handle/1471x/1755889.
[5] Zhang, Ning, Wang, Yefei, An, Liaoyuan, Song, Xiangfei, Huang, Qingshan, Liu, Zhijun, Yao, Lishan. Entropy Drives the Formation of Salt Bridges in the Protein GB3. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(26): 7601-7604, http://www.irgrid.ac.cn/handle/1471x/1755774.
[6] 王业飞. Observation of a-Helical Hydrogen Bond Cooperativity in an Intact Protein. Journal of the American Chemical Society. 2016, [7] Wang, Yefei, Zhang, Shujun, Song, Xiangfei, Yao, Lishan. Cellulose Chain Binding Free Energy Drives the Processive Move of Cellulases on the Cellulose Surface. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2016, 113(9): 1873-1880, http://ir.qibebt.ac.cn/handle/337004/8479.
[8] Wang, Yefei, Song, Xiangfei, Zhang, Shujun, Li, Jingwen, Shu, Zhiyu, He, Chunyan, Huang, Qingshan, Yao, Lishan. Improving the activity of Trichoderma reesei cel7B through stabilizing the transition state. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2016, 113(6): 1171-1177, http://dx.doi.org/10.1002/bit.25887.
[9] Wang, Yefei, Wang, Jia, Yao, Lishan. Computational Study of Peptide Plane Stacking with Polar and Ionizable Amino Acid Side Chains. JOURNAL OF PHYSICAL CHEMISTRY A[J]. 2015, 119(14): 3471-3478, http://www.irgrid.ac.cn/handle/1471x/1001372.
[10] Song, Xiangfei, Wang, Yefei, Zhang, Shujun, Yan, Shihai, Li, Tong, Yao, Lishan. Characterization of the Dielectric Constant in the Trichoderma reesei Cel7B Active Site. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2015, 55(7): 1369-1376, https://www.webofscience.com/wos/woscc/full-record/WOS:000358821300010.
[11] Zhang, Shujun, Wang, Yefei, Song, Xiangfei, Hong, Jingbo, Zhang, Yu, Yao, Lishan. Improving Trichoderma reesei Cel7B Thermostability by Targeting the Weak Spots. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2014, 54(10): 2826-2833, http://dx.doi.org/10.1021/ci500339v.
[12] An, Liaoyuan, Wang, Yefei, Zhang, Ning, Yan, Shihai, Bax, Ad, Yao, Lishan. Protein Apparent Dielectric Constant and Its Temperature Dependence from Remote Chemical Shift Effects. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2014, 136(37): 12816-12819, http://ir.qibebt.ac.cn/handle/337004/6238.
[13] Song, Xiangfei, Wang, Yefei, Shu, Zhiyu, Hong, Jingbo, Li, Tong, Yao, Lishan. Engineering a More Thermostable Blue Light Photo Receptor Bacillus subtilis YtvA LOV Domain by a Computer Aided Rational Design Method. PLOS COMPUTATIONAL BIOLOGY[J]. 2013, 9(7): http://www.irgrid.ac.cn/handle/1471x/830045.
科研活动
科研项目
（ 1 ） 酶催化中静电作用的核磁共振研究, 主持, 国家级, 2019-01--2022-12
（ 2 ） 里氏木霉外切纤维素酶CBH I的水解机理研究和理性设计, 主持, 国家级, 2017-01--2019-12
（ 3 ） 酶促手性芳基邻二醇化合物的氧化级联不对称合成, 主持, 市地级, 2019-01--2021-12
（ 2 ） 里氏木霉外切纤维素酶CBH I的水解机理研究和理性设计, 主持, 国家级, 2017-01--2019-12
（ 3 ） 酶促手性芳基邻二醇化合物的氧化级联不对称合成, 主持, 市地级, 2019-01--2021-12