071010-生物化学与分子生物学

RNA干扰相关蛋白与RNA复合物的结构与功能研究
结构生物学, RNA
RNA介导的抗病毒作用机理

2002-02--2005-01   中国科技大学   博士
1996-09--1999-07   中国农业科学院   硕士学位
1992-09--1996-07   武汉大学   学士学位

   

2011-04~现在, 中国科学院生物物理研究所, 研究员
2006-09~2011-02,memorial Sloan-kettering Cancer Center, Senior Research Scientist
2006-02~2006-08,美国佐治亚大学, 访问学者
2005-03~2006-02,中国科学院生物物理研究所, 助理研究员
1999-08~2001-09,安徽安科生物技术公司, 研究实习员

2014-06-05-今,Non-coding RNA杂志, 编委

molecular biology

   

（1） 中科院****终期优秀, 院级, 2015
（2） 中科院优秀导师奖, 一等奖, 研究所（学校）, 2015
（3） 细胞出版社中国年度论文奖, 其他, 2015

   

[1] Nature Communications. 2024,   通讯作者  
[2] 邓谢淑婷, 王久宇, 王艳丽. 针对第2大类CRISPR-Cas系统的acr基因的发现及Acr蛋白多样化的抑制机制. 中国科学：生命科学[J]. 2024, 第 3 作者54(3): 409-427, http://lib.cqvip.com/Qikan/Article/Detail?id=7111781758.
[3] Trost, Chantel N, Yang, Jing, Garcia, Bianca, HidalgoReyes, Yurima, Fung, Beatrice C M, Wang, Jiuyu, Lu, WangTing, Maxwell, Karen L, Wang, Yanli, Davidson, Alan R. An anti-CRISPR that pulls apart a CRISPR-Cas complex. NATURE. 2024, 第 9 作者  通讯作者  http://dx.doi.org/10.1038/s41586-024-07642-3.
[4] Deng, Xieshuting, Sun, Wei, Li, Xueyan, Wang, Jiuyu, Cheng, Zhi, Sheng, Gang, Wang, Yanli. An anti-CRISPR that represses its own transcription while blocking Cas9-target DNA binding. NATURE COMMUNICATIONS[J]. 2024, 第 7 作者  通讯作者  15(1): http://dx.doi.org/10.1038/s41467-024-45987-5.
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[6] Wei Sun, Xiaolong Zhao, Jinlong Wang, Xiaoqi Yang, Zhi Cheng, Shuo Liu, Jiuyu Wang, Gang Sheng, Yanli Wang. Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition. NUCLEIC ACIDS RESEARCH[J]. 2023, 第 9 作者  通讯作者  51(4): 1984-1995, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976890/.
[7] Yanli Wang. AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proceedings of the National Academy of Sciences of the United States of America[J]. 2023, 第 1 作者  通讯作者  120(31): e2303675120, https://www.pnas.org/doi/10.1073/pnas.2303675120?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.
[8] 王艳丽. 针对II型CRISPR-Cas系统的Acr基因的发现及Acr蛋白多样化的抑制机制. 中国科学:生命科学[J]. 2023, 第 1 作者  通讯作者  https://engine.scichina.com/doi/pdf/89B0BDB5F8CC46CE9831C0D947D4CE9B.
[9] Chen Peng, Sun Wei, Cheng Zhi, Yang Jing, Wang Min, Wang JiuYu, Chen HuiQing, Liu Liang, Wang YanLi. Structural Study on Anti-CRISPR Protein AcrVA2. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2021, 第 9 作者  通讯作者  48(1): 77-87, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6890297&detailType=1.
[10] 陈鹏, 孙伟, 程志, 杨晶, 王敏, 王久宇, 陈慧卿, 刘亮, 王艳丽. Anti-CRISPR蛋白AcrVA2的结构生物学研究. 生物化学与生物物理进展[J]. 2021, 第 9 作者48(1): 77-87, http://www.pibb.ac.cn/pibbcn/article/abstract/20200223?st=article_issue.
[11] 王康康, 王艳丽. 以CasX为例简述新型CRISPR-Cas系统的基本属性和研究方法. 微生物学通报[J]. 2021, 第 2 作者48(4): 1227-1238, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb21041227?st=article_issue.
[12] 尤李兰, 孙伟, 杨晓琪, 王艳丽. 诺贝尔化学奖授予CRISPR-Cas9基因编辑研究. 生物化学与生物物理进展[J]. 2020, 第 4 作者47(11): 1119-1126, http://lib.cqvip.com/Qikan/Article/Detail?id=7103402811.
[13] You LiLan, Sun Wei, Yang XiaoQi, Wang YanLi. Chemistry Nobel Honors CRISPR-Cas9. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2020, 第 4 作者  通讯作者  47(11): 1119-1126, http://dx.doi.org/10.16476/j.pibb.2020.0395.
[14] Mathony, Jan, Harteveld, Zander, Schmelas, Carolin, zu Belzen, Julius Upmeier, Aschenbrenner, Sabine, Sun, Wei, Hoffmann, Mareike D, Stengl, Christina, Scheck, Andreas, Georgeon, Sandrine, Rosset, Stephane, Wang, Yanli, Grimm, Dirk, Eils, Roland, Correia, Bruno E, Niopek, Dominik. Computational design of anti-CRISPR proteins with improved inhibition potency. NATURE CHEMICAL BIOLOGY[J]. 2020, 第 12 作者16(7): 725-+, http://dx.doi.org/10.1038/s41589-020-0518-9.
[15] Xue Huang, Wei Sun, Zhi Cheng, Minxuan Chen, Xueyan Li, Jiuyu Wang, Gang Sheng, Weimin Gong, Yanli Wang. Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. NATURE COMMUNICATIONS[J]. 2020, 第 9 作者  通讯作者  11(1): http://dx.doi.org/10.1038/s41467-020-19072-6.
[16] Yang, Jing, Li, Jiazhi, Wang, Jiuyu, Sheng, Gang, Wang, Min, Zhao, Hongtu, Yang, Yanhua, Wang, Yanli. Crystal structure of Cas1 in complex with branched DNA. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 第 8 作者  通讯作者  63(4): 516-528, https://www.sciengine.com/doi/10.1007/s11427-019-9827-x.
[17] 陈鹏, 孙伟, 程志, 杨晶, 王敏, 王久宇, 陈慧卿, 刘亮, 王艳丽. Anti-CRISPR蛋白AcrVA2的结构生物学研究. 生物化学与生物物理进展. 2020, 第 9 作者77-87, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzH9VRyF39XUyNdXdeQeJeAwqu5gEBeFLwXPlfq81zcLg&uniplatform=NZKPT.
[18] You, Lilan, Ma, Jun, Wang, Jiuyu, Artamonova, Daria, Wang, Min, Liu, Liang, Xiang, Hua, Severinov, Konstantin, Zhang, Xinzheng, Wang, Yanli. Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference. CELL[J]. 2019, 第 10 作者  通讯作者  176(1-2): 239-+, http://dx.doi.org/10.1016/j.cell.2018.10.052.
[19] Sun, Wei, Yang, Jing, Cheng, Zhi, Amrani, Nadia, Liu, Chao, Wang, Kangkang, Ibraheim, Raed, Edraki, Alireza, Huang, Xue, Wang, Min, Wang, Jiuyu, Liu, Liang, Sheng, Gang, Yang, Yanhua, Lou, Jizhong, Sontheimer, Erik J, Wang, Yanli. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. MOLECULAR CELL[J]. 2019, 第 17 作者  通讯作者  76(6): 938-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934045/.
[20] Chang, Lei, Sheng, Gang, Zhang, Yiwen, Shao, Shipeng, Wang, Yanli, Sun, Yujie. AgoFISH: cost-effective in situ labelling of genomic loci based on DNA-guided dTtAgo protein. NANOSCALE HORIZONS[J]. 2019, 第 5 作者  通讯作者  4(4): 918-923, 
[21] Annoj Thavalingam, Zhi Cheng, Bianca Garcia, Xue Huang, Megha Shah, Wei Sun, Min Wang, Lucas Harrington, Sungwon Hwang, Yurima HidalgoReyes, Erik J. Sontheimer, Jennifer Doudna, Alan R. Davidson, Trevor F. Moraes, Yanli Wang, Karen L. Maxwell. Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. NATURE COMMUNICATIONS[J]. 2019, 第 15 作者  通讯作者  10(1): 1-11, 
[22] Liu, Liang, Yin, Maolu, Wang, Min, Wang, Yanli. Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race. MOLECULAR CELL[J]. 2019, 第 4 作者  通讯作者  73(3): 611-+, http://dx.doi.org/10.1016/j.molcel.2018.11.011.
[23] WANG Yanli. Zoom in on DNA Cleavage by Cas9. 中国科学院院刊:英文版[J]. 2019, 第 1 作者33(4): 247-248, http://lib.cqvip.com/Qikan/Article/Detail?id=7101680921.
[24] Lei, Jinping, Sheng, Gang, Cheung, Peter PakHang, Wang, Shenglong, Li, Yu, Gao, Xin, Zhang, Yingkai, Wang, Yanli, Huang, Xuhui. Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 第 8 作者  通讯作者  116(3): 845-853, 
[25] Cao, Yuanwei, Sun, Wen, Wang, Jinfeng, Sheng, Gang, Xiang, Guanghai, Zhang, Tongtong, Shi, Wenyu, Li, Chun, Wang, Yanli, Zhao, Fangqing, Wang, Haoyi. Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 degrees C. CELL DISCOVERY. 2019, 第 9 作者5: http://dx.doi.org/10.1038/s41421-019-0105-y.
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[53] Liu, Rujuan, Xu, Hang, Wei, Zhiyi, Wang, Yanli, Lin, Yajing, Gong, Weimin. Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2009, 第 4 作者379(1): 92-97, http://dx.doi.org/10.1016/j.bbrc.2008.12.012.
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[57] Zhang, Cheng, Liu, Lin, Xu, Hang, Wei, Zhiyi, Wang, Yanli, Lin, Yajing, Gong, Weimin. Crystal structures of human IPP isomerase: New insights into the catalytic mechanism. JOURNAL OF MOLECULAR BIOLOGY[J]. 2007, 第 5 作者366(5): 1437-1446, http://dx.doi.org/10.1016/j.jmb.2006.10.092.

   

（ 1 ） 973干细胞导向项目, 参与, 国家级, 2011-01--2014-12
（ 2 ） ****, 主持, 部委级, 2011-06--2013-06
（ 3 ） crRNA介导的免疫系统的结构与功能研究, 主持, 国家级, 2015-01--2018-12
（ 4 ） RLR识别配体及免疫应答基因调控的结构基础与分子机制, 主持, 国家级, 2014-01--2018-12

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