基本信息
王艳丽 女 博导 中国科学院生物物理研究所
电子邮件： ylwang@ibp.ac.cn
通信地址： 北京市朝阳区大屯路15号中国科学院生物物理研究所
邮政编码： 100101
电子邮件： ylwang@ibp.ac.cn
通信地址： 北京市朝阳区大屯路15号中国科学院生物物理研究所
邮政编码： 100101
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
RNA干扰相关蛋白与RNA复合物的结构与功能研究
结构生物学, RNA
RNA介导的抗病毒作用机理
结构生物学, RNA
RNA介导的抗病毒作用机理
教育背景
2002-02--2005-01 中国科技大学 博士
1996-09--1999-07 中国农业科学院 硕士学位
1992-09--1996-07 武汉大学 学士学位
1996-09--1999-07 中国农业科学院 硕士学位
1992-09--1996-07 武汉大学 学士学位
工作经历
工作简历
2011-04~现在, 中国科学院生物物理研究所, 研究员
2006-09~2011-02,memorial Sloan-kettering Cancer Center, Senior Research Scientist
2006-02~2006-08,美国佐治亚大学, 访问学者
2005-03~2006-02,中国科学院生物物理研究所, 助理研究员
1999-08~2001-09,安徽安科生物技术公司, 研究实习员
2006-09~2011-02,memorial Sloan-kettering Cancer Center, Senior Research Scientist
2006-02~2006-08,美国佐治亚大学, 访问学者
2005-03~2006-02,中国科学院生物物理研究所, 助理研究员
1999-08~2001-09,安徽安科生物技术公司, 研究实习员
社会兼职
2014-06-05-今,Non-coding RNA杂志, 编委
教授课程
molecular biology
专利与奖励
奖励信息
（1） 中科院****终期优秀, 院级, 2015
（2） 中科院优秀导师奖, 一等奖, 研究所（学校）, 2015
（3） 细胞出版社中国年度论文奖, 其他, 2015
（2） 中科院优秀导师奖, 一等奖, 研究所（学校）, 2015
（3） 细胞出版社中国年度论文奖, 其他, 2015
出版信息
发表论文
[1] Nature Communications. 2024, 通讯作者
[2] 邓谢淑婷, 王久宇, 王艳丽. 针对第2大类CRISPR-Cas系统的acr基因的发现及Acr蛋白多样化的抑制机制. 中国科学：生命科学[J]. 2024, 第 3 作者54(3): 409-427, http://lib.cqvip.com/Qikan/Article/Detail?id=7111781758.
[3] Trost, Chantel N, Yang, Jing, Garcia, Bianca, HidalgoReyes, Yurima, Fung, Beatrice C M, Wang, Jiuyu, Lu, WangTing, Maxwell, Karen L, Wang, Yanli, Davidson, Alan R. An anti-CRISPR that pulls apart a CRISPR-Cas complex. NATURE. 2024, 第 9 作者 通讯作者 http://dx.doi.org/10.1038/s41586-024-07642-3.
[4] Deng, Xieshuting, Sun, Wei, Li, Xueyan, Wang, Jiuyu, Cheng, Zhi, Sheng, Gang, Wang, Yanli. An anti-CRISPR that represses its own transcription while blocking Cas9-target DNA binding. NATURE COMMUNICATIONS[J]. 2024, 第 7 作者 通讯作者 15(1): http://dx.doi.org/10.1038/s41467-024-45987-5.
[5] Li, Hui, Wang, Jinlon, Kuan, Tung Ariel, Tang, Bozeng, Feng, Li, Wang, Jiuyu, Cheng, Zhi, Sklenar, Jan, Hulin, Michelle, Li, Yufei, Zhai, Yi, Hou, Yingnan, Menke, Frank L H, Wang, Yanli, Ma, Wenbo. Pathogen protein modularity enables elaborate mimicry of a host phosphatase. CELL[J]. 2023, 第 14 作者 通讯作者 186(15): 3196-+, http://dx.doi.org/10.1016/j.cell.2023.05.049.
[6] Wei Sun, Xiaolong Zhao, Jinlong Wang, Xiaoqi Yang, Zhi Cheng, Shuo Liu, Jiuyu Wang, Gang Sheng, Yanli Wang. Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition. NUCLEIC ACIDS RESEARCH[J]. 2023, 第 9 作者 通讯作者 51(4): 1984-1995, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976890/.
[7] Yanli Wang. AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proceedings of the National Academy of Sciences of the United States of America[J]. 2023, 第 1 作者 通讯作者 120(31): e2303675120, https://www.pnas.org/doi/10.1073/pnas.2303675120?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.
[8] 王艳丽. 针对II型CRISPR-Cas系统的Acr基因的发现及Acr蛋白多样化的抑制机制. 中国科学:生命科学[J]. 2023, 第 1 作者 通讯作者 https://engine.scichina.com/doi/pdf/89B0BDB5F8CC46CE9831C0D947D4CE9B.
[9] Chen Peng, Sun Wei, Cheng Zhi, Yang Jing, Wang Min, Wang JiuYu, Chen HuiQing, Liu Liang, Wang YanLi. Structural Study on Anti-CRISPR Protein AcrVA2. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2021, 第 9 作者 通讯作者 48(1): 77-87, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6890297&detailType=1.
[10] 陈鹏, 孙伟, 程志, 杨晶, 王敏, 王久宇, 陈慧卿, 刘亮, 王艳丽. Anti-CRISPR蛋白AcrVA2的结构生物学研究. 生物化学与生物物理进展[J]. 2021, 第 9 作者48(1): 77-87, http://www.pibb.ac.cn/pibbcn/article/abstract/20200223?st=article_issue.
[11] 王康康, 王艳丽. 以CasX为例简述新型CRISPR-Cas系统的基本属性和研究方法. 微生物学通报[J]. 2021, 第 2 作者48(4): 1227-1238, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb21041227?st=article_issue.
[12] 尤李兰, 孙伟, 杨晓琪, 王艳丽. 诺贝尔化学奖授予CRISPR-Cas9基因编辑研究. 生物化学与生物物理进展[J]. 2020, 第 4 作者47(11): 1119-1126, http://lib.cqvip.com/Qikan/Article/Detail?id=7103402811.
[13] You LiLan, Sun Wei, Yang XiaoQi, Wang YanLi. Chemistry Nobel Honors CRISPR-Cas9. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2020, 第 4 作者 通讯作者 47(11): 1119-1126, http://dx.doi.org/10.16476/j.pibb.2020.0395.
[14] Mathony, Jan, Harteveld, Zander, Schmelas, Carolin, zu Belzen, Julius Upmeier, Aschenbrenner, Sabine, Sun, Wei, Hoffmann, Mareike D, Stengl, Christina, Scheck, Andreas, Georgeon, Sandrine, Rosset, Stephane, Wang, Yanli, Grimm, Dirk, Eils, Roland, Correia, Bruno E, Niopek, Dominik. Computational design of anti-CRISPR proteins with improved inhibition potency. NATURE CHEMICAL BIOLOGY[J]. 2020, 第 12 作者16(7): 725-+, http://dx.doi.org/10.1038/s41589-020-0518-9.
[15] Xue Huang, Wei Sun, Zhi Cheng, Minxuan Chen, Xueyan Li, Jiuyu Wang, Gang Sheng, Weimin Gong, Yanli Wang. Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. NATURE COMMUNICATIONS[J]. 2020, 第 9 作者 通讯作者 11(1): http://dx.doi.org/10.1038/s41467-020-19072-6.
[16] Yang, Jing, Li, Jiazhi, Wang, Jiuyu, Sheng, Gang, Wang, Min, Zhao, Hongtu, Yang, Yanhua, Wang, Yanli. Crystal structure of Cas1 in complex with branched DNA. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 第 8 作者 通讯作者 63(4): 516-528, https://www.sciengine.com/doi/10.1007/s11427-019-9827-x.
[17] 陈鹏, 孙伟, 程志, 杨晶, 王敏, 王久宇, 陈慧卿, 刘亮, 王艳丽. Anti-CRISPR蛋白AcrVA2的结构生物学研究. 生物化学与生物物理进展. 2020, 第 9 作者77-87, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzH9VRyF39XUyNdXdeQeJeAwqu5gEBeFLwXPlfq81zcLg&uniplatform=NZKPT.
[18] You, Lilan, Ma, Jun, Wang, Jiuyu, Artamonova, Daria, Wang, Min, Liu, Liang, Xiang, Hua, Severinov, Konstantin, Zhang, Xinzheng, Wang, Yanli. Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference. CELL[J]. 2019, 第 10 作者 通讯作者 176(1-2): 239-+, http://dx.doi.org/10.1016/j.cell.2018.10.052.
[19] Sun, Wei, Yang, Jing, Cheng, Zhi, Amrani, Nadia, Liu, Chao, Wang, Kangkang, Ibraheim, Raed, Edraki, Alireza, Huang, Xue, Wang, Min, Wang, Jiuyu, Liu, Liang, Sheng, Gang, Yang, Yanhua, Lou, Jizhong, Sontheimer, Erik J, Wang, Yanli. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. MOLECULAR CELL[J]. 2019, 第 17 作者 通讯作者 76(6): 938-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934045/.
[20] Chang, Lei, Sheng, Gang, Zhang, Yiwen, Shao, Shipeng, Wang, Yanli, Sun, Yujie. AgoFISH: cost-effective in situ labelling of genomic loci based on DNA-guided dTtAgo protein. NANOSCALE HORIZONS[J]. 2019, 第 5 作者 通讯作者 4(4): 918-923,
[21] Annoj Thavalingam, Zhi Cheng, Bianca Garcia, Xue Huang, Megha Shah, Wei Sun, Min Wang, Lucas Harrington, Sungwon Hwang, Yurima HidalgoReyes, Erik J. Sontheimer, Jennifer Doudna, Alan R. Davidson, Trevor F. Moraes, Yanli Wang, Karen L. Maxwell. Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. NATURE COMMUNICATIONS[J]. 2019, 第 15 作者 通讯作者 10(1): 1-11,
[22] Liu, Liang, Yin, Maolu, Wang, Min, Wang, Yanli. Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race. MOLECULAR CELL[J]. 2019, 第 4 作者 通讯作者 73(3): 611-+, http://dx.doi.org/10.1016/j.molcel.2018.11.011.
[23] WANG Yanli. Zoom in on DNA Cleavage by Cas9. 中国科学院院刊:英文版[J]. 2019, 第 1 作者33(4): 247-248, http://lib.cqvip.com/Qikan/Article/Detail?id=7101680921.
[24] Lei, Jinping, Sheng, Gang, Cheung, Peter PakHang, Wang, Shenglong, Li, Yu, Gao, Xin, Zhang, Yingkai, Wang, Yanli, Huang, Xuhui. Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 第 8 作者 通讯作者 116(3): 845-853,
[25] Cao, Yuanwei, Sun, Wen, Wang, Jinfeng, Sheng, Gang, Xiang, Guanghai, Zhang, Tongtong, Shi, Wenyu, Li, Chun, Wang, Yanli, Zhao, Fangqing, Wang, Haoyi. Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 degrees C. CELL DISCOVERY. 2019, 第 9 作者5: http://dx.doi.org/10.1038/s41421-019-0105-y.
[26] Zhao, Xiao, Liu, Liang, Liang, Jiayan, Cheng, Keman, Wang, Yongwei, Li, Xueyan, Shi, Jian, Wang, Yanli, Nie, Guangjun. A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment. CANCER LETTERS[J]. 2018, 第 8 作者431: 171-181, http://dx.doi.org/10.1016/j.canlet.2018.05.042.
[27] Liang, Liu, Xueyan, Li, Jun, Ma, Zongqiang, Li, Lilan, You, Jiuyu, Wang, Min, Wang, 章新政, 王艳丽. RNA介导切割RNA的Cas13a复合物分子结构. 科学新闻[J]. 2018, 第 16 作者45-45, http://lib.cqvip.com/Qikan/Article/Detail?id=675303202.
[28] Liang, Liu, Xueyan, Li, Jiuyu, Wang, Min, Wang, Peng, Chen, Maolu, Yin, Jiazhi, Li, Gang, Sheng, 王艳丽. C2c2依赖两个远离的活性中心发挥RNA酶活性. 科学新闻[J]. 2018, 第 17 作者33-33, http://lib.cqvip.com/Qikan/Article/Detail?id=675303185.
[29] Liang, Liu, Peng, Chen, Min, Wang, Xueyan, Li, Jiuyu, Wang, Maolu, Yin, 王艳丽. C2c1-sgRNA复合物结构揭示RNA介导的C2c1切割DNA的机制. 科学新闻[J]. 2018, 第 13 作者83-83, http://lib.cqvip.com/Qikan/Article/Detail?id=675303270.
[30] Song, Guangtao, Chen, Hui, Sheng, Gang, Wang, Yanli, Lou, Jizhong. Argonaute Facilitates the Lateral Diffusion of the Guide along Its Target and Prevents the Guide from Being Pushed Away by the Ribosome. BIOCHEMISTRY[J]. 2018, 第 4 作者 通讯作者 57(15): 2179-2183, https://www.webofscience.com/wos/woscc/full-record/WOS:000430514800002.
[31] Liu, Liang, Li, Xueyan, Wang, Jiuyu, Wang, Min, Chen, Peng, Yin, Maolu, Li, Jiazhi, Sheng, Gang, Wang, Yanli. Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities. CELL[J]. 2017, 第 9 作者 通讯作者 168(1-2): 121-+, http://dx.doi.org/10.1016/j.cell.2016.12.031.
[32] Maolu Yin, Jiuyu Wang, Min Wang, Xinmei Li, Mo Zhang, Qiang Wu, Yanli Wang. Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites. 细胞研究英文版[J]. 2017, 第 7 作者27(11): 1365-1377, http://lib.cqvip.com/Qikan/Article/Detail?id=673788627.
[33] Sheng, Gang, Gogakos, Tasos, Wang, Jiuyu, Zhao, Hongtu, Serganov, Artem, Juranek, Stefan, Tuschl, Thomas, Patel, Dinshaw J, Wang, Yanli. Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. NUCLEIC ACIDS RESEARCH[J]. 2017, 第 9 作者 通讯作者 45(15): 9149-9163, http://dx.doi.org/10.1093/nar/gkx547.
[34] Zhu, Lizhe, Jiang, Hanlun, Sheong, Fu Kit, Cui, Xuefeng, Wang, Yanli, Gao, Xin, Huang, Xuhui. Understanding the core of RNA interference: The dynamic aspects of Argonaute-mediated processes. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY[J]. 2017, 第 5 作者128: 39-46, http://dx.doi.org/10.1016/j.pbiomolbio.2016.09.008.
[35] Yin, Maolu, Wang, Jiuyu, Wang, Min, Li, Xinmei, Zhang, Mo, Wu, Qiang, Wang, Yanli. Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites. CELL RESEARCH[J]. 2017, 第 7 作者 通讯作者 27(11): 1365-1377, http://lib.cqvip.com/Qikan/Article/Detail?id=673788627.
[36] Liu, Liang, Chen, Peng, Wang, Min, Li, Xueyan, Wang, Jiuyu, Yin, Maolu, Wang, Yanli. C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism. MOLECULAR CELL[J]. 2017, 第 7 作者 通讯作者 65(2): 310-322, http://dx.doi.org/10.1016/j.molcel.2016.11.040.
[37] Liu, Liang, Li, Xueyan, Ma, Jun, Li, Zongqiang, You, Lilan, Wang, Jiuyu, Wang, Min, Zhang, Xinzheng, Wang, Yanli. The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a. CELL[J]. 2017, 第 9 作者 通讯作者 170(4): 714-+, http://dx.doi.org/10.1016/j.cell.2017.06.050.
[38] Swarts, Daan C, Szczepaniak, Malwina, Sheng, Gang, Chandradoss, Stanley D, Zhu, Yifan, Timmers, Elizabeth M, Zhang, Yong, Zhao, Hongtu, Lou, Jizhong, Wang, Yanli, Joo, Chirlmin, van der Oost, John. Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute. MOLECULAR CELL[J]. 2017, 第 10 作者 通讯作者 65(6): 985-+, http://dx.doi.org/10.1016/j.molcel.2017.01.033.
[39] 王久宇, 王艳丽. CRISPR-Cas系统PAM依赖的新间隔序列获取的结构及分子机制. 中国科学基金[J]. 2016, 第 2 作者30(5): 443-446, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5803188&detailType=1.
[40] 赵宏图, 王艳丽. CRISPR-Cas系统中crRNA产生及干扰机制的研究. 生命科学[J]. 2016, 第 2 作者28(5): 584-591, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5740212&detailType=1.
[41] Zhu, Lizhe, Jiang, Hanlun, Sheong, Fu Kit, Cui, Xuefeng, Gao, Xin, Wang, Yanli, Huang, Xuhui. A Flexible Domain-Domain Hinge Promotes an Induced-fit Dominant Mechanism for the Loading of Guide-DNA into Argonaute Protein in Thermus thermophilus. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2016, 第 6 作者120(10): 2709-2720, https://www.webofscience.com/wos/woscc/full-record/WOS:000372562000007.
[42] Wang, Jiuyu, Ma, Jun, Cheng, Zhi, Meng, Xu, You, Lilan, Wang, Min, Zhang, Xinzheng, Wang, Yanli. A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses. CELL RESEARCH[J]. 2016, 第 8 作者 通讯作者 26(10): 1165-1168, http://lib.cqvip.com/Qikan/Article/Detail?id=670592062.
[43] Yanli Wang. Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas System. Cell. 2015, 第 1 作者 通讯作者
[44] Huang, Ye, Tian, Miao, Zhang, Yichao, Sheng, Gang, Chen, Zhuo, Ma, Yuan, Chen, Yue, Peng, Yihong, Zhao, YiLei, Wang, Yanli, Zhang, Lihe, Yang, Zhenjun. D-Isonucleotide (isoNA) incorporation around cleavage site of passenger strand promotes the vibration of Ago2-PAZ domain and enhances in vitro potency of siRNA. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2015, 第 10 作者13(44): 10825-10833, http://dx.doi.org/10.1039/c5ob01119a.
[45] Wang, Jiuyu, Li, Jiazhi, Zhao, Hongtu, Sheng, Gang, Wang, Min, Yin, Maolu, Wang, Yanli. Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems. CELL[J]. 2015, 第 7 作者 通讯作者 163(4): 840-853, http://dx.doi.org/10.1016/j.cell.2015.10.008.
[46] Sheng, Gang, Zhao, Hongtu, Wang, Jiuyu, Rao, Yu, Tian, Wenwen, Swarts, Daan C, van der Oost, John, Patel, Dinshaw J, Wang, Yanli. Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 第 9 作者 通讯作者 111(2): 652-657, http://dx.doi.org/10.1073/pnas.1321032111.
[47] Zhao, Hongtu, Sheng, Gang, Wang, Jiuyu, Wang, Min, Bunkoczi, Gabor, Gong, Weimin, Wei, Zhiyi, Wang, Yanli. Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli. NATURE[J]. 2014, 第 8 作者 通讯作者 515(7525): 147-+, http://dx.doi.org/10.1038/nature13733.
[48] Swarts, Daan C, Jore, Matthijs M, Westra, Edze R, Zhu, Yifan, Janssen, Jorijn H, Snijders, Ambrosius P, Wang, Yanli, Patel, Dinshaw J, Berenguer, Jose, Brouns, Stan J J, van der Oost, John. DNA-guided DNA interference by a prokaryotic Argonaute. NATURE[J]. 2014, 第 7 作者507(7491): 258-+, http://dx.doi.org/10.1038/nature12971.
[49] Swarts, Daan C, Makarova, Kira, Wang, Yanli, Nakanishi, Kotaro, Ketting, Rene F, Koonin, Eugene V, Patel, Dinshaw J, van der Oost, John. The evolutionary journey of Argonaute proteins. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2014, 第 3 作者21(9): 743-753, https://www.webofscience.com/wos/woscc/full-record/WOS:000341404200003.
[50] Ruedel, Sabine, Wang, Yanli, Lenobel, Rene, Koerner, Roman, Hsiao, HeHsuan, Urlaub, Henning, Patel, Dinshaw, Meister, Gunter. Phosphorylation of human Argonaute proteins affects small RNA binding. NUCLEIC ACIDS RESEARCH[J]. 2011, 第 2 作者39(6): 2330-2343, http://dx.doi.org/10.1093/nar/gkq1032.
[51] Wang, Yanli, Ludwig, Janos, Schuberth, Christine, Goldeck, Marion, Schlee, Martin, Li, Haitao, Juranek, Stefan, Sheng, Gang, Micura, Ronald, Tuschl, Thomas, Hartmann, Gunther, Patel, Dinshaw J. Structural and functional insights into 5 '-ppp RNA pattern recognition by the innate immune receptor RIG-I. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2010, 第 1 作者17(7): 781-U19, https://www.webofscience.com/wos/woscc/full-record/WOS:000279631500002.
[52] Wang, Yanli, Juranek, Stefan, Li, Haitao, Sheng, Gang, Wardle, Greg S, Tuschl, Thomas, Patel, Dinshaw J. Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. NATURE[J]. 2009, 第 1 作者461(7265): 754-U3, https://www.webofscience.com/wos/woscc/full-record/WOS:000270547500028.
[53] Liu, Rujuan, Xu, Hang, Wei, Zhiyi, Wang, Yanli, Lin, Yajing, Gong, Weimin. Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2009, 第 4 作者379(1): 92-97, http://dx.doi.org/10.1016/j.bbrc.2008.12.012.
[54] Wang, Yanli, Juranek, Stefan, Li, Haitao, Sheng, Gang, Tuschl, Thomas, Patel, Dinshaw J. Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. NATURE[J]. 2008, 第 1 作者456(7224): 921-U72, https://www.webofscience.com/wos/woscc/full-record/WOS:000261768300038.
[55] Wang, Yanli, Sheng, Gang, Juranek, Stefan, Tuschl, Thomas, Patel, Dinshaw J. Structure of the guide-strand-containing argonaute silencing complex. NATURE[J]. 2008, 第 1 作者456(7219): 209-U34, https://www.webofscience.com/wos/woscc/full-record/WOS:000261039300033.
[56] Hou, Xiaowei, Wang, Yanli, Zhou, Zhongwei, Bao, Shilai, Lin, Yajing, Gong, Weimin. Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans. JOURNAL OF STRUCTURAL BIOLOGY[J]. 2007, 第 2 作者159(3): 523-528, http://dx.doi.org/10.1016/j.jsb.2007.04.007.
[57] Zhang, Cheng, Liu, Lin, Xu, Hang, Wei, Zhiyi, Wang, Yanli, Lin, Yajing, Gong, Weimin. Crystal structures of human IPP isomerase: New insights into the catalytic mechanism. JOURNAL OF MOLECULAR BIOLOGY[J]. 2007, 第 5 作者366(5): 1437-1446, http://dx.doi.org/10.1016/j.jmb.2006.10.092.
[2] 邓谢淑婷, 王久宇, 王艳丽. 针对第2大类CRISPR-Cas系统的acr基因的发现及Acr蛋白多样化的抑制机制. 中国科学：生命科学[J]. 2024, 第 3 作者54(3): 409-427, http://lib.cqvip.com/Qikan/Article/Detail?id=7111781758.
[3] Trost, Chantel N, Yang, Jing, Garcia, Bianca, HidalgoReyes, Yurima, Fung, Beatrice C M, Wang, Jiuyu, Lu, WangTing, Maxwell, Karen L, Wang, Yanli, Davidson, Alan R. An anti-CRISPR that pulls apart a CRISPR-Cas complex. NATURE. 2024, 第 9 作者 通讯作者 http://dx.doi.org/10.1038/s41586-024-07642-3.
[4] Deng, Xieshuting, Sun, Wei, Li, Xueyan, Wang, Jiuyu, Cheng, Zhi, Sheng, Gang, Wang, Yanli. An anti-CRISPR that represses its own transcription while blocking Cas9-target DNA binding. NATURE COMMUNICATIONS[J]. 2024, 第 7 作者 通讯作者 15(1): http://dx.doi.org/10.1038/s41467-024-45987-5.
[5] Li, Hui, Wang, Jinlon, Kuan, Tung Ariel, Tang, Bozeng, Feng, Li, Wang, Jiuyu, Cheng, Zhi, Sklenar, Jan, Hulin, Michelle, Li, Yufei, Zhai, Yi, Hou, Yingnan, Menke, Frank L H, Wang, Yanli, Ma, Wenbo. Pathogen protein modularity enables elaborate mimicry of a host phosphatase. CELL[J]. 2023, 第 14 作者 通讯作者 186(15): 3196-+, http://dx.doi.org/10.1016/j.cell.2023.05.049.
[6] Wei Sun, Xiaolong Zhao, Jinlong Wang, Xiaoqi Yang, Zhi Cheng, Shuo Liu, Jiuyu Wang, Gang Sheng, Yanli Wang. Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition. NUCLEIC ACIDS RESEARCH[J]. 2023, 第 9 作者 通讯作者 51(4): 1984-1995, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976890/.
[7] Yanli Wang. AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proceedings of the National Academy of Sciences of the United States of America[J]. 2023, 第 1 作者 通讯作者 120(31): e2303675120, https://www.pnas.org/doi/10.1073/pnas.2303675120?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.
[8] 王艳丽. 针对II型CRISPR-Cas系统的Acr基因的发现及Acr蛋白多样化的抑制机制. 中国科学:生命科学[J]. 2023, 第 1 作者 通讯作者 https://engine.scichina.com/doi/pdf/89B0BDB5F8CC46CE9831C0D947D4CE9B.
[9] Chen Peng, Sun Wei, Cheng Zhi, Yang Jing, Wang Min, Wang JiuYu, Chen HuiQing, Liu Liang, Wang YanLi. Structural Study on Anti-CRISPR Protein AcrVA2. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2021, 第 9 作者 通讯作者 48(1): 77-87, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6890297&detailType=1.
[10] 陈鹏, 孙伟, 程志, 杨晶, 王敏, 王久宇, 陈慧卿, 刘亮, 王艳丽. Anti-CRISPR蛋白AcrVA2的结构生物学研究. 生物化学与生物物理进展[J]. 2021, 第 9 作者48(1): 77-87, http://www.pibb.ac.cn/pibbcn/article/abstract/20200223?st=article_issue.
[11] 王康康, 王艳丽. 以CasX为例简述新型CRISPR-Cas系统的基本属性和研究方法. 微生物学通报[J]. 2021, 第 2 作者48(4): 1227-1238, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb21041227?st=article_issue.
[12] 尤李兰, 孙伟, 杨晓琪, 王艳丽. 诺贝尔化学奖授予CRISPR-Cas9基因编辑研究. 生物化学与生物物理进展[J]. 2020, 第 4 作者47(11): 1119-1126, http://lib.cqvip.com/Qikan/Article/Detail?id=7103402811.
[13] You LiLan, Sun Wei, Yang XiaoQi, Wang YanLi. Chemistry Nobel Honors CRISPR-Cas9. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2020, 第 4 作者 通讯作者 47(11): 1119-1126, http://dx.doi.org/10.16476/j.pibb.2020.0395.
[14] Mathony, Jan, Harteveld, Zander, Schmelas, Carolin, zu Belzen, Julius Upmeier, Aschenbrenner, Sabine, Sun, Wei, Hoffmann, Mareike D, Stengl, Christina, Scheck, Andreas, Georgeon, Sandrine, Rosset, Stephane, Wang, Yanli, Grimm, Dirk, Eils, Roland, Correia, Bruno E, Niopek, Dominik. Computational design of anti-CRISPR proteins with improved inhibition potency. NATURE CHEMICAL BIOLOGY[J]. 2020, 第 12 作者16(7): 725-+, http://dx.doi.org/10.1038/s41589-020-0518-9.
[15] Xue Huang, Wei Sun, Zhi Cheng, Minxuan Chen, Xueyan Li, Jiuyu Wang, Gang Sheng, Weimin Gong, Yanli Wang. Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. NATURE COMMUNICATIONS[J]. 2020, 第 9 作者 通讯作者 11(1): http://dx.doi.org/10.1038/s41467-020-19072-6.
[16] Yang, Jing, Li, Jiazhi, Wang, Jiuyu, Sheng, Gang, Wang, Min, Zhao, Hongtu, Yang, Yanhua, Wang, Yanli. Crystal structure of Cas1 in complex with branched DNA. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 第 8 作者 通讯作者 63(4): 516-528, https://www.sciengine.com/doi/10.1007/s11427-019-9827-x.
[17] 陈鹏, 孙伟, 程志, 杨晶, 王敏, 王久宇, 陈慧卿, 刘亮, 王艳丽. Anti-CRISPR蛋白AcrVA2的结构生物学研究. 生物化学与生物物理进展. 2020, 第 9 作者77-87, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzH9VRyF39XUyNdXdeQeJeAwqu5gEBeFLwXPlfq81zcLg&uniplatform=NZKPT.
[18] You, Lilan, Ma, Jun, Wang, Jiuyu, Artamonova, Daria, Wang, Min, Liu, Liang, Xiang, Hua, Severinov, Konstantin, Zhang, Xinzheng, Wang, Yanli. Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference. CELL[J]. 2019, 第 10 作者 通讯作者 176(1-2): 239-+, http://dx.doi.org/10.1016/j.cell.2018.10.052.
[19] Sun, Wei, Yang, Jing, Cheng, Zhi, Amrani, Nadia, Liu, Chao, Wang, Kangkang, Ibraheim, Raed, Edraki, Alireza, Huang, Xue, Wang, Min, Wang, Jiuyu, Liu, Liang, Sheng, Gang, Yang, Yanhua, Lou, Jizhong, Sontheimer, Erik J, Wang, Yanli. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. MOLECULAR CELL[J]. 2019, 第 17 作者 通讯作者 76(6): 938-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934045/.
[20] Chang, Lei, Sheng, Gang, Zhang, Yiwen, Shao, Shipeng, Wang, Yanli, Sun, Yujie. AgoFISH: cost-effective in situ labelling of genomic loci based on DNA-guided dTtAgo protein. NANOSCALE HORIZONS[J]. 2019, 第 5 作者 通讯作者 4(4): 918-923,
[21] Annoj Thavalingam, Zhi Cheng, Bianca Garcia, Xue Huang, Megha Shah, Wei Sun, Min Wang, Lucas Harrington, Sungwon Hwang, Yurima HidalgoReyes, Erik J. Sontheimer, Jennifer Doudna, Alan R. Davidson, Trevor F. Moraes, Yanli Wang, Karen L. Maxwell. Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. NATURE COMMUNICATIONS[J]. 2019, 第 15 作者 通讯作者 10(1): 1-11,
[22] Liu, Liang, Yin, Maolu, Wang, Min, Wang, Yanli. Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race. MOLECULAR CELL[J]. 2019, 第 4 作者 通讯作者 73(3): 611-+, http://dx.doi.org/10.1016/j.molcel.2018.11.011.
[23] WANG Yanli. Zoom in on DNA Cleavage by Cas9. 中国科学院院刊:英文版[J]. 2019, 第 1 作者33(4): 247-248, http://lib.cqvip.com/Qikan/Article/Detail?id=7101680921.
[24] Lei, Jinping, Sheng, Gang, Cheung, Peter PakHang, Wang, Shenglong, Li, Yu, Gao, Xin, Zhang, Yingkai, Wang, Yanli, Huang, Xuhui. Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 第 8 作者 通讯作者 116(3): 845-853,
[25] Cao, Yuanwei, Sun, Wen, Wang, Jinfeng, Sheng, Gang, Xiang, Guanghai, Zhang, Tongtong, Shi, Wenyu, Li, Chun, Wang, Yanli, Zhao, Fangqing, Wang, Haoyi. Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 degrees C. CELL DISCOVERY. 2019, 第 9 作者5: http://dx.doi.org/10.1038/s41421-019-0105-y.
[26] Zhao, Xiao, Liu, Liang, Liang, Jiayan, Cheng, Keman, Wang, Yongwei, Li, Xueyan, Shi, Jian, Wang, Yanli, Nie, Guangjun. A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment. CANCER LETTERS[J]. 2018, 第 8 作者431: 171-181, http://dx.doi.org/10.1016/j.canlet.2018.05.042.
[27] Liang, Liu, Xueyan, Li, Jun, Ma, Zongqiang, Li, Lilan, You, Jiuyu, Wang, Min, Wang, 章新政, 王艳丽. RNA介导切割RNA的Cas13a复合物分子结构. 科学新闻[J]. 2018, 第 16 作者45-45, http://lib.cqvip.com/Qikan/Article/Detail?id=675303202.
[28] Liang, Liu, Xueyan, Li, Jiuyu, Wang, Min, Wang, Peng, Chen, Maolu, Yin, Jiazhi, Li, Gang, Sheng, 王艳丽. C2c2依赖两个远离的活性中心发挥RNA酶活性. 科学新闻[J]. 2018, 第 17 作者33-33, http://lib.cqvip.com/Qikan/Article/Detail?id=675303185.
[29] Liang, Liu, Peng, Chen, Min, Wang, Xueyan, Li, Jiuyu, Wang, Maolu, Yin, 王艳丽. C2c1-sgRNA复合物结构揭示RNA介导的C2c1切割DNA的机制. 科学新闻[J]. 2018, 第 13 作者83-83, http://lib.cqvip.com/Qikan/Article/Detail?id=675303270.
[30] Song, Guangtao, Chen, Hui, Sheng, Gang, Wang, Yanli, Lou, Jizhong. Argonaute Facilitates the Lateral Diffusion of the Guide along Its Target and Prevents the Guide from Being Pushed Away by the Ribosome. BIOCHEMISTRY[J]. 2018, 第 4 作者 通讯作者 57(15): 2179-2183, https://www.webofscience.com/wos/woscc/full-record/WOS:000430514800002.
[31] Liu, Liang, Li, Xueyan, Wang, Jiuyu, Wang, Min, Chen, Peng, Yin, Maolu, Li, Jiazhi, Sheng, Gang, Wang, Yanli. Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities. CELL[J]. 2017, 第 9 作者 通讯作者 168(1-2): 121-+, http://dx.doi.org/10.1016/j.cell.2016.12.031.
[32] Maolu Yin, Jiuyu Wang, Min Wang, Xinmei Li, Mo Zhang, Qiang Wu, Yanli Wang. Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites. 细胞研究英文版[J]. 2017, 第 7 作者27(11): 1365-1377, http://lib.cqvip.com/Qikan/Article/Detail?id=673788627.
[33] Sheng, Gang, Gogakos, Tasos, Wang, Jiuyu, Zhao, Hongtu, Serganov, Artem, Juranek, Stefan, Tuschl, Thomas, Patel, Dinshaw J, Wang, Yanli. Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. NUCLEIC ACIDS RESEARCH[J]. 2017, 第 9 作者 通讯作者 45(15): 9149-9163, http://dx.doi.org/10.1093/nar/gkx547.
[34] Zhu, Lizhe, Jiang, Hanlun, Sheong, Fu Kit, Cui, Xuefeng, Wang, Yanli, Gao, Xin, Huang, Xuhui. Understanding the core of RNA interference: The dynamic aspects of Argonaute-mediated processes. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY[J]. 2017, 第 5 作者128: 39-46, http://dx.doi.org/10.1016/j.pbiomolbio.2016.09.008.
[35] Yin, Maolu, Wang, Jiuyu, Wang, Min, Li, Xinmei, Zhang, Mo, Wu, Qiang, Wang, Yanli. Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites. CELL RESEARCH[J]. 2017, 第 7 作者 通讯作者 27(11): 1365-1377, http://lib.cqvip.com/Qikan/Article/Detail?id=673788627.
[36] Liu, Liang, Chen, Peng, Wang, Min, Li, Xueyan, Wang, Jiuyu, Yin, Maolu, Wang, Yanli. C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism. MOLECULAR CELL[J]. 2017, 第 7 作者 通讯作者 65(2): 310-322, http://dx.doi.org/10.1016/j.molcel.2016.11.040.
[37] Liu, Liang, Li, Xueyan, Ma, Jun, Li, Zongqiang, You, Lilan, Wang, Jiuyu, Wang, Min, Zhang, Xinzheng, Wang, Yanli. The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a. CELL[J]. 2017, 第 9 作者 通讯作者 170(4): 714-+, http://dx.doi.org/10.1016/j.cell.2017.06.050.
[38] Swarts, Daan C, Szczepaniak, Malwina, Sheng, Gang, Chandradoss, Stanley D, Zhu, Yifan, Timmers, Elizabeth M, Zhang, Yong, Zhao, Hongtu, Lou, Jizhong, Wang, Yanli, Joo, Chirlmin, van der Oost, John. Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute. MOLECULAR CELL[J]. 2017, 第 10 作者 通讯作者 65(6): 985-+, http://dx.doi.org/10.1016/j.molcel.2017.01.033.
[39] 王久宇, 王艳丽. CRISPR-Cas系统PAM依赖的新间隔序列获取的结构及分子机制. 中国科学基金[J]. 2016, 第 2 作者30(5): 443-446, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5803188&detailType=1.
[40] 赵宏图, 王艳丽. CRISPR-Cas系统中crRNA产生及干扰机制的研究. 生命科学[J]. 2016, 第 2 作者28(5): 584-591, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5740212&detailType=1.
[41] Zhu, Lizhe, Jiang, Hanlun, Sheong, Fu Kit, Cui, Xuefeng, Gao, Xin, Wang, Yanli, Huang, Xuhui. A Flexible Domain-Domain Hinge Promotes an Induced-fit Dominant Mechanism for the Loading of Guide-DNA into Argonaute Protein in Thermus thermophilus. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2016, 第 6 作者120(10): 2709-2720, https://www.webofscience.com/wos/woscc/full-record/WOS:000372562000007.
[42] Wang, Jiuyu, Ma, Jun, Cheng, Zhi, Meng, Xu, You, Lilan, Wang, Min, Zhang, Xinzheng, Wang, Yanli. A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses. CELL RESEARCH[J]. 2016, 第 8 作者 通讯作者 26(10): 1165-1168, http://lib.cqvip.com/Qikan/Article/Detail?id=670592062.
[43] Yanli Wang. Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas System. Cell. 2015, 第 1 作者 通讯作者
[44] Huang, Ye, Tian, Miao, Zhang, Yichao, Sheng, Gang, Chen, Zhuo, Ma, Yuan, Chen, Yue, Peng, Yihong, Zhao, YiLei, Wang, Yanli, Zhang, Lihe, Yang, Zhenjun. D-Isonucleotide (isoNA) incorporation around cleavage site of passenger strand promotes the vibration of Ago2-PAZ domain and enhances in vitro potency of siRNA. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2015, 第 10 作者13(44): 10825-10833, http://dx.doi.org/10.1039/c5ob01119a.
[45] Wang, Jiuyu, Li, Jiazhi, Zhao, Hongtu, Sheng, Gang, Wang, Min, Yin, Maolu, Wang, Yanli. Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems. CELL[J]. 2015, 第 7 作者 通讯作者 163(4): 840-853, http://dx.doi.org/10.1016/j.cell.2015.10.008.
[46] Sheng, Gang, Zhao, Hongtu, Wang, Jiuyu, Rao, Yu, Tian, Wenwen, Swarts, Daan C, van der Oost, John, Patel, Dinshaw J, Wang, Yanli. Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 第 9 作者 通讯作者 111(2): 652-657, http://dx.doi.org/10.1073/pnas.1321032111.
[47] Zhao, Hongtu, Sheng, Gang, Wang, Jiuyu, Wang, Min, Bunkoczi, Gabor, Gong, Weimin, Wei, Zhiyi, Wang, Yanli. Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli. NATURE[J]. 2014, 第 8 作者 通讯作者 515(7525): 147-+, http://dx.doi.org/10.1038/nature13733.
[48] Swarts, Daan C, Jore, Matthijs M, Westra, Edze R, Zhu, Yifan, Janssen, Jorijn H, Snijders, Ambrosius P, Wang, Yanli, Patel, Dinshaw J, Berenguer, Jose, Brouns, Stan J J, van der Oost, John. DNA-guided DNA interference by a prokaryotic Argonaute. NATURE[J]. 2014, 第 7 作者507(7491): 258-+, http://dx.doi.org/10.1038/nature12971.
[49] Swarts, Daan C, Makarova, Kira, Wang, Yanli, Nakanishi, Kotaro, Ketting, Rene F, Koonin, Eugene V, Patel, Dinshaw J, van der Oost, John. The evolutionary journey of Argonaute proteins. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2014, 第 3 作者21(9): 743-753, https://www.webofscience.com/wos/woscc/full-record/WOS:000341404200003.
[50] Ruedel, Sabine, Wang, Yanli, Lenobel, Rene, Koerner, Roman, Hsiao, HeHsuan, Urlaub, Henning, Patel, Dinshaw, Meister, Gunter. Phosphorylation of human Argonaute proteins affects small RNA binding. NUCLEIC ACIDS RESEARCH[J]. 2011, 第 2 作者39(6): 2330-2343, http://dx.doi.org/10.1093/nar/gkq1032.
[51] Wang, Yanli, Ludwig, Janos, Schuberth, Christine, Goldeck, Marion, Schlee, Martin, Li, Haitao, Juranek, Stefan, Sheng, Gang, Micura, Ronald, Tuschl, Thomas, Hartmann, Gunther, Patel, Dinshaw J. Structural and functional insights into 5 '-ppp RNA pattern recognition by the innate immune receptor RIG-I. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2010, 第 1 作者17(7): 781-U19, https://www.webofscience.com/wos/woscc/full-record/WOS:000279631500002.
[52] Wang, Yanli, Juranek, Stefan, Li, Haitao, Sheng, Gang, Wardle, Greg S, Tuschl, Thomas, Patel, Dinshaw J. Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. NATURE[J]. 2009, 第 1 作者461(7265): 754-U3, https://www.webofscience.com/wos/woscc/full-record/WOS:000270547500028.
[53] Liu, Rujuan, Xu, Hang, Wei, Zhiyi, Wang, Yanli, Lin, Yajing, Gong, Weimin. Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2009, 第 4 作者379(1): 92-97, http://dx.doi.org/10.1016/j.bbrc.2008.12.012.
[54] Wang, Yanli, Juranek, Stefan, Li, Haitao, Sheng, Gang, Tuschl, Thomas, Patel, Dinshaw J. Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. NATURE[J]. 2008, 第 1 作者456(7224): 921-U72, https://www.webofscience.com/wos/woscc/full-record/WOS:000261768300038.
[55] Wang, Yanli, Sheng, Gang, Juranek, Stefan, Tuschl, Thomas, Patel, Dinshaw J. Structure of the guide-strand-containing argonaute silencing complex. NATURE[J]. 2008, 第 1 作者456(7219): 209-U34, https://www.webofscience.com/wos/woscc/full-record/WOS:000261039300033.
[56] Hou, Xiaowei, Wang, Yanli, Zhou, Zhongwei, Bao, Shilai, Lin, Yajing, Gong, Weimin. Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans. JOURNAL OF STRUCTURAL BIOLOGY[J]. 2007, 第 2 作者159(3): 523-528, http://dx.doi.org/10.1016/j.jsb.2007.04.007.
[57] Zhang, Cheng, Liu, Lin, Xu, Hang, Wei, Zhiyi, Wang, Yanli, Lin, Yajing, Gong, Weimin. Crystal structures of human IPP isomerase: New insights into the catalytic mechanism. JOURNAL OF MOLECULAR BIOLOGY[J]. 2007, 第 5 作者366(5): 1437-1446, http://dx.doi.org/10.1016/j.jmb.2006.10.092.
科研活动
科研项目
（ 1 ） 973干细胞导向项目, 参与, 国家级, 2011-01--2014-12
（ 2 ） ****, 主持, 部委级, 2011-06--2013-06
（ 3 ） crRNA介导的免疫系统的结构与功能研究, 主持, 国家级, 2015-01--2018-12
（ 4 ） RLR识别配体及免疫应答基因调控的结构基础与分子机制, 主持, 国家级, 2014-01--2018-12
（ 2 ） ****, 主持, 部委级, 2011-06--2013-06
（ 3 ） crRNA介导的免疫系统的结构与功能研究, 主持, 国家级, 2015-01--2018-12
（ 4 ） RLR识别配体及免疫应答基因调控的结构基础与分子机制, 主持, 国家级, 2014-01--2018-12
指导学生
已指导学生
田文文 02 19182
陈琳 02 19183
赵宏图 01 19183
现指导学生
尹茂鲁 01 19183
尤李兰 02 19183
李佳智 01 19183
陈鹏 02 19183
李雪岩 02 19183
陈敏轩 02 19182
程志 02 19183
李新美 01 19183