基本信息

王为善 男 博导 中国科学院微生物研究所
电子邮件: wangws@im.ac.cn
通信地址: 北京市朝阳区北辰西路一号院3号中国科学院微生物研究所H611室
邮政编码: 100101
电子邮件: wangws@im.ac.cn
通信地址: 北京市朝阳区北辰西路一号院3号中国科学院微生物研究所H611室
邮政编码: 100101
研究领域
研究方向:微生物系统代谢工程与合成生物学。首先系统认知微生物天然产物的代谢、调控网络,发掘有用的元、器件;然后利用这些认知基础,建立高产菌株工程改造、定向进化及高效筛选的新策略,进行需求导向的工业菌株开发,从而实现从“致知”到“致用”的研究。以第一或通讯作者在Nature Biotechnology, Science Advances, PNAS, Nature Communications, Science Bulletin, Metabolic Engineering, Traneds in Biotechnology, Current Opinion in Biotechnology等发表多篇文章;申请专利10余项,包括PCT专利2项。
教育背景
2009-09--2013-06 中国科学院大学 理学博士学位2006-09--2009-06 中国海洋大学 医学硕士学位2002-09--2006-06 山东农业大学 理学学士学位
工作经历
工作简历
2019-08~现在, 中国科学院微生物研究所, 研究员2016-09~2019-08,中国科学院微生物研究所, 副研究员2013-06~2016-09,中国科学院微生物研究所, 助理研究员
教授课程
微生物代谢工程
专利与奖励
2016年,入选中国科学院青年创新促进会。
2017年,获中国生物工程学会青年优秀论文一等奖。
2019年,获国家优秀青年科学基金项目资助。
2019年,获中科院青促会学术年会“学科交叉与创新奖”。
2020年,入选中国科学院青年创新促进会优秀会员。
出版信息
发表论文
[1] Shiwen Qiu, Bowen Yang, Zilong Li, Shanshan Li, Hao Yan, Zhenguo Xin, Jingfang Liu, Xuejin Zhao, Lixin Zhang, Wensheng Xiang, Weishan Wang. Building a highly efficient Streptomyces super-chassis for secondary metabolite production by reprogramming naturally-evolved multifaceted shifts. METABOLIC ENGINEERING[J]. 2024, 第 11 作者 通讯作者 81: 210-226, http://dx.doi.org/10.1016/j.ymben.2023.12.007.[2] Shanshan Li, Zilong Li, GaoYi Tan, Zhenguo Xin, Weishan Wang. In vitro allosteric transcription factor-based biosensing. TRENDS IN BIOTECHNOLOGY. 2023, 第 5 作者 通讯作者 41(8): 1080-1095, http://dx.doi.org/10.1016/j.tibtech.2023.03.001.[3] 卜瑞红, 杨志恒, 李子龙, 张国建, 王为善, , , , , . 热葡糖苷酶地芽胞杆菌NCIMB 11955高效电转感受态细胞电转体系的建立. 生物工程学报[J]. 2023, 第 5 作者39(8): 3508-3519, https://cjb.ijournals.cn/cjbcn/article/abstract/gc23083508?st=article_issue.[4] Zhiheng Yang, Zilong Li, Bixiao Li, Ruihong Bu, GaoYi Tan, Zhengduo Wang, Hao Yan, Zhenguo Xin, Guojian Zhang, Ming Li, Hua Xiang, Lixin Zhang, Weishan Wang. A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering. NATURE COMMUNICATIONS[J]. 2023, 第 13 作者 通讯作者 14(1): 1-14, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551041/.[5] Zhang, Chaobo, Zhao, Youbao, Li, Zilong, Wang, Weishan, Huang, Ying, Pan, Guohui, Fan, Keqiang. Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585. FRONTIERS IN MICROBIOLOGY[J]. 2022, 第 4 作者13: http://dx.doi.org/10.3389/fmicb.2022.1078293.[6] 刘文溪, 李子龙, 闫浩, 张立新, 王为善. 异源重构白色链霉菌土霉素生产菌株. 微生物学报[J]. 2022, 第 5 作者62(10): 3858-3870, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20221014?st=article_issue.[7] Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang. Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius. ACS SYNTHETIC BIOLOGY[J]. 2022, 第 3 作者11(6): 2163-2174, http://dx.doi.org/10.1021/acssynbio.2c00087.[8] 赵祥祥, 李珊珊, 刘光, 王忠, 杨志恒, 张权威, 梁敏东, 刘家坤, 李子龙, 童垚俊, 朱国良, 王馨叶, 蒋岚, 王为善, 谭高翼, 张立新. CaT-Smelor 2.0,一种耦合CRISPR-Cas12a与核酸适配体的多用生物传感检测平台. 科学通报:英文版[J]. 2021, 第 14 作者66(1): 69-77, http://lib.cqvip.com/Qikan/Article/Detail?id=7104049440.[9] Yang, Yiying, Sun, Qingqing, Liu, Yang, Yin, Hanzhi, Yang, Wenping, Wang, Yang, Liu, Ying, Li, Yuxian, Pang, Shen, Liu, Wenxi, Zhang, Qian, Yuan, Fang, Qiu, Shiwen, Li, Jiong, Wang, Xuefeng, Fan, Keqiang, Wang, Weishan, Li, Zilong, Yin, Shouliang. Development of a pyrF-based counterselectable system for targeted gene deletion in Streptomyces rimosus. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B[J]. 2021, 第 17 作者22(5): 383-396, http://dx.doi.org/10.1631/jzus.B2000606.[10] Li, Shanshan, Li, Zilong, Pang, Shen, Xiang, Wensheng, Wang, Weishan. Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces. CURRENT OPINION IN BIOTECHNOLOGY. 2021, 第 5 作者 通讯作者 69: 26-34, http://dx.doi.org/10.1016/j.copbio.2020.11.006.[11] Zhao, Xiangxiang, Wang, Zhengduo, Yang, Bowen, Li, Zilong, Tong, Yaojun, Bi, Yuhai, Li, Zhenghong, Xia, Xuekui, Chen, Xiangyin, Zhang, Lixin, Wang, Weishan, Tan, GaoYi. Integrating PCR-free amplification and synergistic sensing for ultrasensitive and rapid CRISPR/Cas12a-based SARS-CoV-2 antigen detection. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2021, 第 11 作者6(4): 283-291, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7264509&detailType=1.[12] Zhao, Xiangxiang, Li, Shanshan, Liu, Guang, Wang, Zhong, Yang, Zhiheng, Zhang, Quanwei, Liang, Mindong, Liu, Jiakun, Li, Zilong, Tong, Yaojun, Zhu, Guoliang, Wang, Xinye, Jiang, Lan, Wang, Weishan, Tan, GaoYi, Zhang, Lixin. A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes. SCIENCE BULLETIN[J]. 2021, 第 14 作者 通讯作者 66(1): 69-77, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6916571&detailType=1.[13] Yang, Zhiheng, Sun, Qingqing, Tan, Gaoyi, Zhang, Quanwei, Wang, Zhengduo, Li, Chuan, Qi, Fengxian, Wang, Weishan, Zhang, Lixin, Li, Zilong. Engineering thermophilic Geobacillus thermoglucosidasius for riboflavin production. MICROBIAL BIOTECHNOLOGY[J]. 2021, 第 8 作者 通讯作者 14(2): 363-373, https://doaj.org/article/bd019966daf949cc98e749fa637d7ea6.[14] Li, Shanshan, Yang, Bowen, Tan, GaoYi, Ouyang, LiMing, Qiu, Shiwen, Wang, Weishan, Xiang, Wensheng, Zhang, Lixin. Polyketide pesticides from actinomycetes. CURRENT OPINION IN BIOTECHNOLOGY. 2021, 第 6 作者 通讯作者 69: 299-307, http://dx.doi.org/10.1016/j.copbio.2021.05.006.[15] Zhang, Qian, Ren, JinWei, Wang, Weishan, Zhai, Jian, Yang, Jing, Liu, Ning, Huang, Ying, Chen, Yihua, Pan, Guohui, Fan, Keqiang. A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters. ACS CHEMICAL BIOLOGY[J]. 2020, 第 3 作者15(9): 2551-2557, https://www.webofscience.com/wos/woscc/full-record/WOS:000574920900024.[16] Wang, Weishan, Li, Shanshan, Li, Zilong, Zhang, Jingyu, Fan, Keqiang, Tan, Gaoyi, Ai, Guomin, Lam, Sin Man, Shui, Guanghou, Yang, Zhiheng, Lu, Hongzhong, Jin, Pinjiao, Li, Yihong, Chen, Xiangyin, Xia, Xuekui, Liu, Xueting, Dannelly, H Kathleen, Yang, Chen, Yang, Yi, Zhang, Siliang, Alterovitz, Gil, Xiang, Wensheng, Zhang, Lixin. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. NATURE BIOTECHNOLOGY[J]. 2020, 第 1 作者 通讯作者 38(1): 76-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000510337700016.[17] Cao, Zhixing, Yu, Jiaming, Wang, Weishan, Lu, Hongzhong, Xia, Xuekui, Xu, Hui, Yang, Xiuliang, Bao, Lianqun, Zhang, Qing, Wang, Huifeng, Zhang, Siliang, Zhang, Lixin. Multi-scale data-driven engineering for biosynthetic titer improvement. CURRENT OPINION IN BIOTECHNOLOGY. 2020, 第 3 作者65: 205-212, http://dx.doi.org/10.1016/j.copbio.2020.04.002.[18] 张立新, 杨弋, 赵玉政, 王为善, 郑俊克, 李珊珊, 陈显军, 张敬宇, 刘雪婷, 谭高翼. 细胞工厂代谢转换机制及其智能生物制造. 中国基础科学[J]. 2020, 第 4 作者1-9, http://lib.cqvip.com/Qikan/Article/Detail?id=00002EGM55987JP0MPDO3JP1MNR.[19] Wang, Xuefeng, Yin, Shouliang, Bai, Jing, Liu, Yang, Fan, Keqiang, Wang, Huizhuan, Yuan, Fang, Zhao, Baohua, Li, Zilong, Wang, Weishan. Heterologous production of chlortetracycline in an industrial grade Streptomyces rimosus host (vol 103, pg 6645, 2019). APPLIEDMICROBIOLOGYANDBIOTECHNOLOGY. 2020, 第 10 作者 通讯作者 104(5): 2271-2272, https://www.webofscience.com/wos/woscc/full-record/WOS:000529946400035.[20] Liang, Mindong, Li, Zilong, Wang, Weishan, Liu, Jiakun, Liu, Leshi, Zhu, Guoliang, Karthik, Loganathan, Wang, Man, Wang, KeFeng, Wang, Zhong, Yu, Jing, Shuai, Yuting, Yu, Jiaming, Zhang, Lu, Yang, Zhiheng, Li, Chuan, Zhang, Qian, Shi, Tong, Zhou, Liming, Xie, Feng, Dai, Huanqin, Liu, Xueting, Zhang, Jingyu, Liu, Guang, Zhuo, Ying, Zhang, Buchang, Liu, Chenli, Li, Shanshan, Xia, Xuekui, Tong, Yaojun, Liu, Yanwen, Alterovitz, Gil, Tan, GaoYi, Zhang, LiXin. A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. NATURE COMMUNICATIONS[J]. 2019, 第 3 作者10(1): [21] Wang, Junyang, Wang, Weishan, Wang, Huizhuan, Yuan, Fang, Xu, Zhen, Yang, Keqian, Li, Zilong, Chen, Yihua, Fan, Keqiang. Improvement of stress tolerance and riboflavin production of Bacillus subtilis by introduction of heat shock proteins from thermophilic bacillus strains. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 第 2 作者103(11): 4455-4465, https://www.webofscience.com/wos/woscc/full-record/WOS:000467209500016.[22] 刘乐诗, 谭高翼, 王为善, 李珊珊, 夏雪奎, 刘昌衡, 代焕琴, 王泽建, 张嗣良, 张立新. 微生物,高智商,大产业——合成生物学助力阿维菌素的高效智能制造. 生命科学[J]. 2019, 第 3 作者31(5): 516-525, http://lib.cqvip.com/Qikan/Article/Detail?id=7002257301.[23] Wang, Xuefeng, Yin, Shouliang, Bai, Jing, Liu, Yang, Fan, Keqiang, Wang, Huizhuan, Yuan, Fang, Zhao, Baohua, Li, Zilong, Wang, Weishan. Heterologous production of chlortetracycline in an industrial grade Streptomyces rimosus host. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 第 10 作者 通讯作者 103(16): 6645-6655, https://www.webofscience.com/wos/woscc/full-record/WOS:000477927800021.[24] Zhang, Lu, Liu, Leshi, Wang, KeFeng, Xu, Lan, Zhou, Liming, Wang, Weishan, Li, Chuan, Xu, Zheng, Shi, Tong, Chen, Haihong, Li, Yuanhang, Xu, Hui, Yang, XiuLiang, Zhu, Zhichun, Chen, Biqin, Li, Dan, Zhan, Guanghuang, Zhang, SiLiang, Zhang, LiXin, Tan, GaoYi. Phosphate limitation increases coenzyme Q(10) production in industrial Rhodobacter sphaeroides HY01. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2019, 第 6 作者4(4): 212-219, http://lib.cqvip.com/Qikan/Article/Detail?id=7103844777.[25] Yin, Hanzhi, Wang, Weishan, Fan, Keqiang, Li, Zilong. Regulatory perspective of antibiotic biosynthesis in Streptomyces. SCIENCE CHINA-LIFE SCIENCES[J]. 2019, 第 2 作者62(5): 698-700, http://lib.cqvip.com/Qikan/Article/Detail?id=74678871504849574853484948.[26] Cao, Jiaqian, Yao, Yongpeng, Fan, Keqiang, Tan, Gaoyi, Xiang, Wensheng, Xia, Xuekui, Li, Shanshan, Wang, Weishan, Zhang, Lixin. Harnessing a previously unidentified capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro. SCIENCE ADVANCES[J]. 2018, 第 8 作者 通讯作者 4(11): http://dx.doi.org/10.1126/sciadv.aau4602.[27] Li, Shanshan, Wang, Junyang, Xiang, Wensheng, Yang, Keqian, Li, Zilong, Wang, Weishan. An Autoregulated Fine-Tuning Strategy for Titer Improvement of Secondary Metabolites Using Native Promoters in Streptomyces. ACS SYNTHETIC BIOLOGY[J]. 2018, 第 6 作者 通讯作者 7(2): 522-530, http://dx.doi.org/10.1021/acssynbio.7b00318.[28] Yao, Yongpeng, Li, Shanshan, Cao, Jiaqian, Liu, Weiwei, Qi, Fengxian, Xiang, Wensheng, Yang, Keqian, Wang, Weishan, Zhang, Lixin. A novel signal transduction system for development of uric acid biosensors. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 第 11 作者102(17): 7489-7497, https://www.webofscience.com/wos/woscc/full-record/WOS:000441229200023.[29] Yao, Yongpeng, Li, Shanshan, Cao, Jiaqian, Liu, Weiwei, Fan, Keqiang, Xiang, Wensheng, Yang, Keqian, Kong, Deming, Wang, Weishan. Development of small molecule biosensors by coupling the recognition of the bacterial allosteric transcription factor with isothermal strand displacement amplification. CHEMICAL COMMUNICATIONS[J]. 2018, 第 9 作者 通讯作者 54(38): 4774-4777, http://dx.doi.org/10.1039/c8cc01764f.[30] Li, Xiao, Wang, Juan, Shi, Mingxin, Wang, Weishan, Corre, Christophe, Yang, Keqian. Evidence for the formation of ScbR/ScbR2 heterodimers and identification of one of the regulatory targets in Streptomyces coelicolor. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2017, 第 4 作者101(13): 5333-5340, https://www.webofscience.com/wos/woscc/full-record/WOS:000404146300011.[31] Li, Shanshan, Zhou, Li, Yao, Yongpeng, Fan, Keqiang, Li, Zilong, Zhang, Lixin, Wang, Weishan, Yang, Keqian. A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays. CHEMICAL COMMUNICATIONS[J]. 2017, 第 7 作者 通讯作者 53(1): 99-102, http://dx.doi.org/10.1039/c6cc07244e.[32] Wang, Weishan, Yang, Tongjian, Li, Yihong, Li, Shanshan, Yin, Shouliang, Styles, Kathryn, Corre, Christophe, Yang, Keqian. Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts. ACS SYNTHETIC BIOLOGY[J]. 2016, 第 1 作者5(7): 765-773, http://www.corc.org.cn/handle/1471x/2374521.[33] Jiang, Tianyu, Ke, Bowen, Chen, Hui, Wang, Weishan, Du, Lupei, Yang, Keqian, Li, Minyong. Bioluminescent Probe for Detecting Mercury(II) in Living Mice. ANALYTICAL CHEMISTRY[J]. 2016, 第 4 作者88(15): 7462-7465, [34] 尹守亮, 林智炜, 张玉秀, 王为善, 史明欣, 杨克迁. 工程改造龟裂链霉菌提高土霉素产量. 中国生物工程杂志[J]. 2016, 第 4 作者36(7): 72-82, https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20160711.[35] Yin, Shouliang, Li, Zilong, Wang, Xuefeng, Wang, Huizhuan, Jia, Xiaole, Ai, Guomin, Bai, Zishang, Shi, Mingxin, Yuan, Fang, Liu, Tiejun, Wang, Weishan, Yang, Keqian. Heterologous expression of oxytetracycline biosynthetic gene cluster in Streptomyces venezuelae WVR2006 to improve production level and to alter fermentation process. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 第 11 作者 通讯作者 100(24): 10563-10572, http://dx.doi.org/10.1007/s00253-016-7873-1.[36] 姚永鹏, 王为善, 杨克迁. 链霉菌中高效生产聚酮化合物的研究方法及进展. 微生物学报[J]. 2016, 第 2 作者56(3): 418-428, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20160307?st=article_issue.[37] 王俊阳, 王为善, 赵华, 杨克迁, , , , , . 细菌双杂交系统的改进. 生物工程学报[J]. 2016, 第 2 作者32(2): 231-240, https://cjb.ijournals.cn/cjbcn/article/abstract/gc16020231?st=article_issue.[38] Sidda, John D, Poon, Vincent, Song, Lijiang, Wang, Weishan, Yang, Keqian, Corre, Christophe. Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 第 4 作者14(27): 6390-6393, http://dx.doi.org/10.1039/c6ob00840b.[39] Jiang, Tianyu, Wang, Weishan, Wu, Xingkang, Wu, Wenxiao, Bai, Haixiu, Ma, Zhao, Shen, Yuemao, Yang, Keqian, Li, Minyong. Discovery of New Substrates for LuxAB Bacterial Bioluminescence. CHEMICAL BIOLOGY & DRUG DESIGN[J]. 2016, 第 2 作者88(2): 197-208, https://www.webofscience.com/wos/woscc/full-record/WOS:000381035500004.[40] Wang, Weishan, Li, Xiao, Li, Yue, Li, Shanshan, Fan, Keqiang, Yang, Keqian. A genetic biosensor for identification of transcriptional repressors of target promoters. SCIENTIFIC REPORTS[J]. 2015, 第 1 作者5: http://dx.doi.org/10.1038/srep15887.[41] Li, Xiao, Wang, Juan, Li, Shanshan, Ji, Junjie, Wang, Weishan, Yang, Keqian. ScbR- and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor. SCIENTIFIC REPORTS[J]. 2015, 第 5 作者 通讯作者 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000362344300002.[42] Yin, Shouliang, Wang, Weishan, Wang, Xuefeng, Zhu, Yaxin, Jia, Xiaole, Li, Shanshan, Yuan, Fang, Zhang, Yuxiu, Yang, Keqian. Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus. MICROBIAL CELL FACTORIES[J]. 2015, 第 2 作者14(1): http://dx.doi.org/10.1186/s12934-015-0231-7.[43] Li, Shanshan, Wang, Weishan, Li, Xiao, Fan, Keqiang, Yang, Keqian. Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor. SCIENTIFIC REPORTS[J]. 2015, 第 2 作者5: http://dx.doi.org/10.1038/srep15840.[44] Li, Shanshan, Wang, Junyang, Li, Xiao, Yin, Shouliang, Wang, Weishan, Yang, Keqian. Genome-wide identification and evaluation of constitutive promoters in streptomycetes. MICROBIAL CELL FACTORIES[J]. 2015, 第 5 作者 通讯作者 14(1): http://dx.doi.org/10.1186/s12934-015-0351-0.[45] 王俊阳, 王为善, 李肖, 赵华, 杨克迁, , , , , , . 转录调控研究的方法学进展. 生物工程学报[J]. 2015, 第 2 作者31(8): 1141-1150, https://cjb.ijournals.cn/cjbcn/article/abstract/gc15081141?st=article_issue.[46] 李宜鸿, 李珊珊, 艾国民, 王为善, 张部昌, 杨克迁, , , , , , , . 天蓝色链霉菌代谢物组测定方法优化及其代谢特征. 生物工程学报[J]. 2014, 第 4 作者30(4): 554-568, https://cjb.ijournals.cn/cjbcn/article/abstract/gc14040554?st=article_issue.[47] Wang, Weishan, Ji, Junjie, Li, Xiao, Wang, Juan, Li, Shanshan, Pan, Guohui, Fan, Keqiang, Yang, Keqian. Angucyclines as signals modulate the behaviors of Streptomyces coelicolor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 第 1 作者111(15): 5688-5693, http://dx.doi.org/10.1073/pnas.1324253111.[48] 冯晓洲, 王为善, 任晓慧, 刘新利, 毛相朝, 杨克迁, , , , , , , . 多杀菌素生物合成基因簇启动子探测和转录时序. 生物工程学报[J]. 2013, 第 2 作者29(7): 914-926, https://cjb.ijournals.cn/cjbcn/article/abstract/gc13000914?st=article_issue.[49] Liu, Zhanjun, Wang, Weishan, Zhu, Ying, Gong, Qianhong, Yu, Wengong, Lu, Xinzhi. Antibiotics at subinhibitory concentrations improve the quorum sensing behavior of Chromobacterium violaceum. FEMS MICROBIOLOGY LETTERS[J]. 2013, 第 2 作者341(1): 37-44, https://www.webofscience.com/wos/woscc/full-record/WOS:000316149500005.[50] Wang, Weishan, Li, Xiao, Wang, Juan, Xiang, Sihai, Feng, Xiaozhou, Yang, Keqian. An Engineered Strong Promoter for Streptomycetes. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2013, 第 1 作者79(14): 4484-4492, http://dx.doi.org/10.1128/AEM.00985-13.[51] Wang, Weishan, Zheng, Baicun, Gong, Weiguang, Fu, Lefeng, Feng, Zhongjun. Interaction of polymethacrylate-g-PEO comb copolymers with natural bentonite in aqueous systems. MICRO & NANO LETTERS[J]. 2012, 第 1 作者 通讯作者 7(7): 671-675, https://www.webofscience.com/wos/woscc/full-record/WOS:000306759800020.[52] Wang, Weishan, Zheng, Baicun, Feng, Zhongjun, Deng, Zuiliang, Fu, Lefeng. Adsorption of Polycarboxylate-based Superplasticizer onto Natural Bentonite. JOURNAL OF ADVANCED CONCRETE TECHNOLOGY[J]. 2012, 第 1 作者 通讯作者 10(10): 323-331, https://www.webofscience.com/wos/woscc/full-record/WOS:000314170400001.[53] Fan, Keqiang, Pan, Guohui, Peng, Xiaojing, Zheng, Jianting, Gao, Wubin, Wang, Juan, Wang, Weishan, Li, Yue, Yang, Keqian. Identification of JadG as the B Ring Opening Oxygenase Catalyzing the Oxidative C-C Bond Cleavage Reaction in Jadomycin Biosynthesis. CHEMISTRY & BIOLOGY[J]. 2012, 第 7 作者19(11): 1381-1390, http://dx.doi.org/10.1016/j.chembiol.2012.09.009.[54] Wang, Juan, Wang, Weishan, Wang, Linqi, Zhang, Guifeng, Fan, Keqiang, Tan, Huarong, Yang, Keqian. A novel role of 'pseudo' gamma-butyrolactone receptors in controlling gamma-butyrolactone biosynthesis in Streptomyces. MOLECULAR MICROBIOLOGY[J]. 2011, 第 2 作者82(1): 236-250, http://dx.doi.org/10.1111/j.1365-2958.2011.07811.x.[55] 王为善, 邹姗姗, 尹守亮, 官倩红, 于文功. 具有群体感应抑制活性海洋放线菌的分离和鉴定. 微生物学通报[J]. 2009, 第 1 作者1372-1377, http://lib.cqvip.com/Qikan/Article/Detail?id=31660201.[56] 史晓翀, 宫倩红, 于文功, 王为善, 魏岚. 一种AHL降解菌株的高效筛选方法. 中国海洋大学学报:自然科学版[J]. 2007, 第 4 作者37(5): 728-732, http://lib.cqvip.com/Qikan/Article/Detail?id=25507567.[57] Shanshan Li, Zilong Li, GaoYi Tan, Zhenguo Xin, Weishan Wang. In vitro allosteric transcription factor-based biosensing. TRENDS IN BIOTECHNOLOGY. 第 5 作者 通讯作者 http://dx.doi.org/10.1016/j.tibtech.2023.03.001.
科研活动
科研项目
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